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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for MXI1_MYC_MYCN
Z-value: 3.07
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Transcription factors associated with MXI1_MYC_MYCN
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000119950.16 | MAX interactor 1, dimerization protein | |
| ENSG00000136997.10 | MYC proto-oncogene, bHLH transcription factor | |
| ENSG00000134323.10 | MYCN proto-oncogene, bHLH transcription factor |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MXI1 | hg19_v2_chr10_+_111967345_111967442 | -0.86 | 2.8e-02 | Click! |
| MYC | hg19_v2_chr8_+_128747757_128747800 | 0.82 | 4.4e-02 | Click! |
| MYCN | hg19_v2_chr2_+_16080659_16080686 | 0.41 | 4.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MXI1_MYC_MYCN
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.0 | GO:0006364 | rRNA processing(GO:0006364) |
| 0.1 | 6.9 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.9 | 6.4 | GO:0046985 | positive regulation of hemoglobin biosynthetic process(GO:0046985) |
| 0.3 | 4.2 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
| 0.1 | 4.2 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.1 | 4.0 | GO:0042339 | keratan sulfate metabolic process(GO:0042339) |
| 0.7 | 3.5 | GO:0071051 | polyadenylation-dependent snoRNA 3'-end processing(GO:0071051) |
| 0.4 | 3.5 | GO:0045905 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.1 | 3.5 | GO:1903959 | regulation of anion transmembrane transport(GO:1903959) |
| 0.3 | 3.3 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 7.1 | GO:0034709 | methylosome(GO:0034709) |
| 0.2 | 5.5 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.1 | 5.1 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 5.0 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 4.6 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 4.6 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 4.4 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 4.2 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 4.1 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 0.0 | 4.0 | GO:0043209 | myelin sheath(GO:0043209) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.5 | GO:0000987 | core promoter proximal region sequence-specific DNA binding(GO:0000987) |
| 0.8 | 7.1 | GO:0044020 | histone methyltransferase activity (H4-R3 specific)(GO:0044020) |
| 0.2 | 5.7 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 4.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 4.0 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.2 | 3.8 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.1 | 3.7 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.0 | 3.5 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.3 | 3.3 | GO:0004372 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.1 | 3.2 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 5.5 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 5.0 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 4.9 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 3.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 3.0 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 2.9 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 2.8 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 2.6 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 2.4 | PID LKB1 PATHWAY | LKB1 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.5 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 7.9 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 6.5 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 6.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.2 | 4.8 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.1 | 4.7 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 0.1 | 3.6 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.1 | 3.5 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 3.4 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.2 | 3.1 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |