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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for MNT_HEY1_HEY2
Z-value: 0.77
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Transcription factors associated with MNT_HEY1_HEY2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000070444.10 | MAX network transcriptional repressor | |
| ENSG00000164683.12 | hes related family bHLH transcription factor with YRPW motif 1 | |
| ENSG00000135547.4 | hes related family bHLH transcription factor with YRPW motif 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MNT | hg19_v2_chr17_-_2304365_2304412 | -0.68 | 1.4e-01 | Click! |
| HEY1 | hg19_v2_chr8_-_80680078_80680101 | -0.51 | 3.0e-01 | Click! |
| HEY2 | hg19_v2_chr6_+_126070726_126070768 | -0.29 | 5.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_58145889 Show fit | 2.50 |
ENST00000547853.1
|
cyclin-dependent kinase 4 |
|
| chr12_+_112451222 Show fit | 0.84 |
ENST00000552052.1
|
endoplasmic reticulum protein 29 |
|
| chr8_+_104383759 Show fit | 0.61 |
ENST00000415886.2
|
collagen triple helix repeat containing 1 |
|
| chr6_+_138188351 Show fit | 0.57 |
ENST00000421450.1
|
tumor necrosis factor, alpha-induced protein 3 |
|
| chr3_-_53080644 Show fit | 0.57 |
ENST00000497586.1
|
Scm-like with four mbt domains 1 |
|
| chr9_+_96928516 Show fit | 0.57 |
ENST00000602703.1
|
RP11-2B6.3 |
|
| chr1_-_26232951 Show fit | 0.51 |
ENST00000426559.2
ENST00000455785.2 |
stathmin 1 |
|
| chr17_-_6915616 Show fit | 0.50 |
ENST00000575889.1
|
Uncharacterized protein |
|
| chr1_+_154193325 Show fit | 0.49 |
ENST00000428931.1
ENST00000441890.1 ENST00000271877.7 ENST00000412596.1 ENST00000368504.1 ENST00000437652.1 |
ubiquitin associated protein 2-like |
|
| chr13_+_27998681 Show fit | 0.48 |
ENST00000381140.4
|
general transcription factor IIIA |
Network of associatons between targets according to the STRING database.
First level regulatory network of MNT_HEY1_HEY2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.2 | GO:1904637 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) |
| 0.2 | 1.4 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 0.0 | 1.3 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.0 | 1.1 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.2 | 0.9 | GO:0043335 | protein unfolding(GO:0043335) |
| 0.1 | 0.9 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
| 0.1 | 0.9 | GO:0043932 | ossification involved in bone remodeling(GO:0043932) |
| 0.3 | 0.8 | GO:0090291 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of osteoclast proliferation(GO:0090291) negative regulation of CD40 signaling pathway(GO:2000349) |
| 0.0 | 0.7 | GO:1904263 | positive regulation of TORC1 signaling(GO:1904263) |
| 0.1 | 0.6 | GO:0070829 | response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.2 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.0 | 1.2 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.0 | 1.1 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 1.0 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.0 | 0.9 | GO:0090544 | BAF-type complex(GO:0090544) |
| 0.0 | 0.8 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 0.8 | GO:0044665 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 0.6 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.0 | 0.6 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.1 | 0.5 | GO:0070876 | SOSS complex(GO:0070876) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.5 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 1.1 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 0.8 | GO:0003756 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.0 | 0.8 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.0 | 0.7 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.0 | 0.7 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 0.6 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 0.1 | 0.6 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 0.0 | 0.6 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.0 | 0.5 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.3 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 1.3 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.9 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 0.8 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.7 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 0.1 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.0 | 0.1 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 0.8 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 0.8 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 0.6 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.0 | 0.5 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.0 | 0.4 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.3 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 0.3 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.1 | 0.2 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |
| 0.0 | 0.2 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |