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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for MLX_USF2_USF1_PAX2
Z-value: 1.50
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Transcription factors associated with MLX_USF2_USF1_PAX2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000108788.7 | MAX dimerization protein MLX | |
| ENSG00000105698.11 | upstream transcription factor 2, c-fos interacting | |
| ENSG00000158773.10 | upstream transcription factor 1 | |
| ENSG00000075891.17 | paired box 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| USF2 | hg19_v2_chr19_+_35759968_35760042 | -0.77 | 7.3e-02 | Click! |
| MLX | hg19_v2_chr17_+_40719073_40719092 | -0.70 | 1.2e-01 | Click! |
| USF1 | hg19_v2_chr1_-_161014731_161014788 | -0.36 | 4.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_+_96928516 Show fit | 2.52 |
ENST00000602703.1
|
RP11-2B6.3 |
|
| chr12_-_58145889 Show fit | 2.40 |
ENST00000547853.1
|
cyclin-dependent kinase 4 |
|
| chr3_+_112280857 Show fit | 1.71 |
ENST00000492406.1
ENST00000468642.1 |
solute carrier family 35, member A5 |
|
| chr14_-_54955376 Show fit | 1.44 |
ENST00000553333.1
|
glia maturation factor, beta |
|
| chr8_+_103876528 Show fit | 1.43 |
ENST00000522939.1
ENST00000524007.1 |
HCG15011, isoform CRA_a; Protein LOC100996457 |
|
| chr6_-_109703634 Show fit | 1.19 |
ENST00000324953.5
ENST00000310786.4 ENST00000275080.7 ENST00000413644.2 |
CD164 molecule, sialomucin |
|
| chr1_-_11865982 Show fit | 1.16 |
ENST00000418034.1
|
methylenetetrahydrofolate reductase (NAD(P)H) |
|
| chrX_-_119693745 Show fit | 1.15 |
ENST00000371323.2
|
cullin 4B |
|
| chr6_-_109703600 Show fit | 1.10 |
ENST00000512821.1
|
CD164 molecule, sialomucin |
|
| chr18_+_9136758 Show fit | 1.04 |
ENST00000383440.2
ENST00000262126.4 ENST00000577992.1 |
ankyrin repeat domain 12 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MLX_USF2_USF1_PAX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.1 | GO:1902962 | regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) |
| 0.1 | 3.0 | GO:0006293 | nucleotide-excision repair, preincision complex stabilization(GO:0006293) |
| 0.3 | 2.8 | GO:1904636 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) |
| 0.2 | 2.6 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 0.0 | 2.6 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.3 | 2.4 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 0.1 | 2.1 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.0 | 1.9 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.3 | 1.8 | GO:0071638 | negative regulation of monocyte chemotactic protein-1 production(GO:0071638) |
| 0.3 | 1.7 | GO:0033274 | response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.8 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 0.3 | 2.5 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.0 | 2.2 | GO:0044665 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.3 | 2.0 | GO:0000221 | vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) |
| 0.3 | 2.0 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.0 | 2.0 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.2 | 1.9 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 0.2 | 1.6 | GO:0033503 | HULC complex(GO:0033503) |
| 0.2 | 1.5 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 0.1 | 1.2 | GO:0030905 | retromer, tubulation complex(GO:0030905) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.8 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.2 | 2.7 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.1 | 2.6 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.1 | 2.5 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.1 | 2.3 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.0 | 2.3 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 2.1 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 1.8 | GO:0005402 | sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) |
| 0.0 | 1.8 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.3 | 1.7 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 2.1 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 2.0 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 2.0 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 1.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.3 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 1.2 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 1.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.1 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 1.0 | ST STAT3 PATHWAY | STAT3 Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 2.4 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.1 | 2.2 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 2.2 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.1 | 2.1 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.0 | 2.0 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 1.6 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 1.4 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 1.3 | REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS | Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
| 0.0 | 1.3 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |