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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for MIXL1_GSX1_BSX_MEOX2_LHX4
Z-value: 0.97
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Transcription factors associated with MIXL1_GSX1_BSX_MEOX2_LHX4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000185155.7 | Mix paired-like homeobox | |
| ENSG00000169840.4 | GS homeobox 1 | |
| ENSG00000188909.4 | brain specific homeobox | |
| ENSG00000106511.5 | mesenchyme homeobox 2 | |
| ENSG00000121454.4 | LIM homeobox 4 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| LHX4 | hg19_v2_chr1_+_180199393_180199426 | 0.59 | 2.1e-01 | Click! |
| MIXL1 | hg19_v2_chr1_+_226411319_226411366 | -0.51 | 3.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_77427676 Show fit | 1.27 |
ENST00000257663.3
|
transmembrane protein 60 |
|
| chr4_-_36245561 Show fit | 1.21 |
ENST00000506189.1
|
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
|
| chr3_-_143567262 Show fit | 1.12 |
ENST00000474151.1
ENST00000316549.6 |
solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 |
|
| chr2_+_17997763 Show fit | 1.11 |
ENST00000281047.3
|
mesogenin 1 |
|
| chr5_-_24645078 Show fit | 0.96 |
ENST00000264463.4
|
cadherin 10, type 2 (T2-cadherin) |
|
| chr16_+_53412368 Show fit | 0.93 |
ENST00000565189.1
|
RP11-44F14.2 |
|
| chr1_+_62439037 Show fit | 0.93 |
ENST00000545929.1
|
InaD-like (Drosophila) |
|
| chr13_-_86373536 Show fit | 0.84 |
ENST00000400286.2
|
SLIT and NTRK-like family, member 6 |
|
| chr5_+_136070614 Show fit | 0.81 |
ENST00000502421.1
|
CTB-1I21.1 |
|
| chrX_+_22050546 Show fit | 0.76 |
ENST00000379374.4
|
phosphate regulating endopeptidase homolog, X-linked |
Network of associatons between targets according to the STRING database.
First level regulatory network of MIXL1_GSX1_BSX_MEOX2_LHX4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.1 | 1.3 | GO:0019276 | UDP-N-acetylgalactosamine metabolic process(GO:0019276) |
| 0.1 | 1.2 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.0 | 1.1 | GO:0007379 | segment specification(GO:0007379) |
| 0.1 | 0.8 | GO:0060005 | vestibular reflex(GO:0060005) |
| 0.1 | 0.8 | GO:1904383 | response to sodium phosphate(GO:1904383) |
| 0.1 | 0.7 | GO:0090234 | regulation of kinetochore assembly(GO:0090234) |
| 0.1 | 0.7 | GO:1902998 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.0 | 0.7 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
| 0.0 | 0.7 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 0.7 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.1 | 0.7 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.0 | 0.7 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.0 | 0.7 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
| 0.0 | 0.7 | GO:0071141 | SMAD protein complex(GO:0071141) |
| 0.1 | 0.6 | GO:0097224 | sperm connecting piece(GO:0097224) |
| 0.0 | 0.6 | GO:0032982 | myosin filament(GO:0032982) |
| 0.1 | 0.5 | GO:0005587 | collagen type IV trimer(GO:0005587) |
| 0.0 | 0.5 | GO:0000439 | core TFIIH complex(GO:0000439) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.5 | GO:0035248 | alpha-1,4-N-acetylgalactosaminyltransferase activity(GO:0035248) |
| 0.0 | 1.3 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.1 | 1.2 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.0 | 1.0 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.0 | 0.9 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.1 | 0.8 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.0 | 0.8 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 0.8 | GO:0004177 | aminopeptidase activity(GO:0004177) |
| 0.0 | 0.7 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
| 0.0 | 0.7 | GO:0051787 | misfolded protein binding(GO:0051787) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 0.8 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 0.6 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 0.5 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 0.4 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 0.3 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 0.1 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 0.9 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.9 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.9 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.0 | 0.8 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 0.8 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.7 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 0.7 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 0.6 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 0.6 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |