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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for MEF2B

Z-value: 0.41

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Transcription factors associated with MEF2B

Gene Symbol Gene ID Gene Info
MEF2B
ENSG00000213999.11 myocyte enhancer factor 2B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MEF2Bhg19_v2_chr19_-_19302931_19302974-0.767.8e-02Click!

Activity profile of MEF2B motif

Sorted Z-values of MEF2B motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_72268721 0.29 ENST00000419131.1
ENST00000388743.2
EYA1
eyes absent homolog 1 (Drosophila)
chr12_+_25205446 0.25 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
LRMP
lymphoid-restricted membrane protein
chr12_+_25205568 0.19 ENST00000548766.1
ENST00000556887.1
LRMP
lymphoid-restricted membrane protein
chr5_-_42811986 0.19 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
SEPP1
selenoprotein P, plasma, 1
chr6_-_33160231 0.18 ENST00000395194.1
ENST00000457788.1
ENST00000341947.2
ENST00000357486.1
ENST00000374714.1
ENST00000374713.1
ENST00000395197.1
ENST00000374712.1
ENST00000361917.1
ENST00000374708.4
COL11A2
collagen, type XI, alpha 2
chr5_-_111091948 0.18 ENST00000447165.2
NREP
neuronal regeneration related protein
chr9_+_97766469 0.17 ENST00000433691.2
C9orf3
chromosome 9 open reading frame 3
chr12_+_25205666 0.16 ENST00000547044.1
LRMP
lymphoid-restricted membrane protein
chr12_+_25205628 0.16 ENST00000554942.1
LRMP
lymphoid-restricted membrane protein
chr1_-_23751189 0.16 ENST00000374601.3
ENST00000450454.2
TCEA3
transcription elongation factor A (SII), 3
chr8_-_72268968 0.15 ENST00000388740.3
EYA1
eyes absent homolog 1 (Drosophila)
chr8_-_72268889 0.15 ENST00000388742.4
EYA1
eyes absent homolog 1 (Drosophila)
chr1_+_77333117 0.15 ENST00000477717.1
ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr5_+_53751445 0.15 ENST00000302005.1
HSPB3
heat shock 27kDa protein 3
chr5_-_42812143 0.15 ENST00000514985.1
SEPP1
selenoprotein P, plasma, 1
chr12_+_44229846 0.13 ENST00000551577.1
ENST00000266534.3
TMEM117
transmembrane protein 117
chr7_-_105332084 0.13 ENST00000472195.1
ATXN7L1
ataxin 7-like 1
chr18_+_12407895 0.12 ENST00000590956.1
ENST00000336990.4
ENST00000440960.1
ENST00000588729.1
SLMO1
slowmo homolog 1 (Drosophila)
chr3_-_176914191 0.12 ENST00000437738.1
ENST00000424913.1
ENST00000443315.1
TBL1XR1
transducin (beta)-like 1 X-linked receptor 1
chr8_+_1993173 0.11 ENST00000523438.1
MYOM2
myomesin 2
chr11_+_1860200 0.11 ENST00000381911.1
TNNI2
troponin I type 2 (skeletal, fast)
chr12_+_52445191 0.11 ENST00000243050.1
ENST00000394825.1
ENST00000550763.1
ENST00000394824.2
ENST00000548232.1
ENST00000562373.1
NR4A1
nuclear receptor subfamily 4, group A, member 1
chr16_+_31225337 0.11 ENST00000322122.3
TRIM72
tripartite motif containing 72
chr12_-_49393092 0.11 ENST00000421952.2
DDN
dendrin
chr11_+_1860682 0.10 ENST00000381906.1
TNNI2
troponin I type 2 (skeletal, fast)
chr3_-_188665428 0.10 ENST00000444488.1
TPRG1-AS1
TPRG1 antisense RNA 1
chr3_-_137834436 0.09 ENST00000327532.2
ENST00000467030.1
DZIP1L
DAZ interacting zinc finger protein 1-like
chr3_-_176914238 0.09 ENST00000430069.1
ENST00000428970.1
TBL1XR1
transducin (beta)-like 1 X-linked receptor 1
chr9_+_97766409 0.09 ENST00000425634.2
C9orf3
chromosome 9 open reading frame 3
chr17_-_42188598 0.09 ENST00000591714.1
HDAC5
histone deacetylase 5
chr15_+_100106244 0.08 ENST00000557942.1
MEF2A
myocyte enhancer factor 2A
chr3_+_159570722 0.08 ENST00000482804.1
SCHIP1
schwannomin interacting protein 1
chr7_+_143013198 0.08 ENST00000343257.2
CLCN1
chloride channel, voltage-sensitive 1
chr15_+_100106155 0.08 ENST00000557785.1
ENST00000558049.1
ENST00000449277.2
MEF2A
myocyte enhancer factor 2A
chr4_+_160203650 0.08 ENST00000514565.1
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr12_+_119616447 0.08 ENST00000281938.2
HSPB8
heat shock 22kDa protein 8
chr15_+_100106126 0.08 ENST00000558812.1
ENST00000338042.6
MEF2A
myocyte enhancer factor 2A
chr10_-_96829246 0.08 ENST00000371270.3
ENST00000535898.1
ENST00000539050.1
CYP2C8
cytochrome P450, family 2, subfamily C, polypeptide 8
chr14_+_76776957 0.08 ENST00000512784.1
ESRRB
estrogen-related receptor beta
chr8_+_1993152 0.08 ENST00000262113.4
MYOM2
myomesin 2
chr15_+_42651691 0.08 ENST00000357568.3
ENST00000349748.3
ENST00000318023.7
ENST00000397163.3
CAPN3
calpain 3, (p94)
chr5_+_138609782 0.08 ENST00000361059.2
ENST00000514694.1
ENST00000504203.1
ENST00000502929.1
ENST00000394800.2
ENST00000509644.1
ENST00000505016.1
MATR3
matrin 3
chr7_+_75931861 0.08 ENST00000248553.6
HSPB1
heat shock 27kDa protein 1
chr6_+_12007963 0.08 ENST00000607445.1
RP11-456H18.2
RP11-456H18.2
chrX_+_70521584 0.07 ENST00000373829.3
ENST00000538820.1
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr7_-_16872932 0.07 ENST00000419572.2
ENST00000412973.1
AGR2
anterior gradient 2
chr5_-_16509101 0.07 ENST00000399793.2
FAM134B
family with sequence similarity 134, member B
chr12_-_131200810 0.07 ENST00000536002.1
ENST00000544034.1
RIMBP2
RP11-662M24.2
RIMS binding protein 2
RP11-662M24.2
chr12_+_14561422 0.06 ENST00000541056.1
ATF7IP
activating transcription factor 7 interacting protein
chr4_-_25865159 0.06 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr11_+_1860832 0.06 ENST00000252898.7
TNNI2
troponin I type 2 (skeletal, fast)
chr1_+_84630645 0.06 ENST00000394839.2
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr8_+_107282368 0.06 ENST00000521369.2
RP11-395G23.3
RP11-395G23.3
chr6_+_139094657 0.05 ENST00000332797.6
CCDC28A
coiled-coil domain containing 28A
chr6_+_42984723 0.05 ENST00000332245.8
KLHDC3
kelch domain containing 3
chr3_+_186739636 0.05 ENST00000440338.1
ENST00000448044.1
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr15_+_40531243 0.05 ENST00000558055.1
ENST00000455577.2
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr11_+_7598239 0.05 ENST00000525597.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr8_-_62602327 0.05 ENST00000445642.3
ENST00000517847.2
ENST00000389204.4
ENST00000517661.1
ENST00000517903.1
ENST00000522603.1
ENST00000522349.1
ENST00000522835.1
ENST00000541428.1
ENST00000518306.1
ASPH
aspartate beta-hydroxylase
chr14_+_56046990 0.05 ENST00000438792.2
ENST00000395314.3
ENST00000395308.1
KTN1
kinectin 1 (kinesin receptor)
chr17_-_27467418 0.05 ENST00000528564.1
MYO18A
myosin XVIIIA
chr17_-_42200958 0.05 ENST00000336057.5
HDAC5
histone deacetylase 5
chr8_-_95565673 0.05 ENST00000437199.1
ENST00000297591.5
ENST00000421249.2
KIAA1429
KIAA1429
chr6_-_137314371 0.04 ENST00000432330.1
ENST00000418699.1
RP11-55K22.5
RP11-55K22.5
chr2_-_208031542 0.04 ENST00000423015.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr8_+_107282389 0.04 ENST00000577661.1
ENST00000445937.1
RP11-395G23.3
OXR1
RP11-395G23.3
oxidation resistance 1
chr6_-_169654139 0.04 ENST00000366787.3
THBS2
thrombospondin 2
chr15_+_40531621 0.04 ENST00000560346.1
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr11_+_12108410 0.04 ENST00000527997.1
RP13-631K18.5
RP13-631K18.5
chr4_+_41362796 0.04 ENST00000508501.1
ENST00000512946.1
ENST00000313860.7
ENST00000512632.1
ENST00000512820.1
LIMCH1
LIM and calponin homology domains 1
chr12_-_371994 0.04 ENST00000343164.4
ENST00000436453.1
ENST00000445055.2
ENST00000546319.1
SLC6A13
solute carrier family 6 (neurotransmitter transporter), member 13
chr14_-_22005343 0.04 ENST00000327430.3
SALL2
spalt-like transcription factor 2
chr14_+_56046914 0.04 ENST00000413890.2
ENST00000395309.3
ENST00000554567.1
ENST00000555498.1
KTN1
kinectin 1 (kinesin receptor)
chr17_-_42200996 0.04 ENST00000587135.1
ENST00000225983.6
ENST00000393622.2
ENST00000588703.1
HDAC5
histone deacetylase 5
chr17_-_39211463 0.04 ENST00000542910.1
ENST00000398477.1
KRTAP2-2
keratin associated protein 2-2
chr4_+_41362615 0.04 ENST00000509638.1
LIMCH1
LIM and calponin homology domains 1
chr18_-_47792851 0.04 ENST00000398545.4
CCDC11
coiled-coil domain containing 11
chr9_-_23779367 0.04 ENST00000440102.1
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr3_+_138067521 0.03 ENST00000494949.1
MRAS
muscle RAS oncogene homolog
chr22_+_19706958 0.03 ENST00000395109.2
SEPT5
septin 5
chr15_+_68346501 0.03 ENST00000249636.6
PIAS1
protein inhibitor of activated STAT, 1
chr11_-_18034701 0.03 ENST00000265965.5
SERGEF
secretion regulating guanine nucleotide exchange factor
chr17_+_20059302 0.03 ENST00000395530.2
SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr11_+_47293795 0.03 ENST00000422579.1
MADD
MAP-kinase activating death domain
chr11_+_7597639 0.03 ENST00000533792.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr1_+_145525015 0.03 ENST00000539363.1
ENST00000538811.1
ITGA10
integrin, alpha 10
chr3_+_8543561 0.03 ENST00000397386.3
LMCD1
LIM and cysteine-rich domains 1
chr11_-_47374246 0.03 ENST00000545968.1
ENST00000399249.2
ENST00000256993.4
MYBPC3
myosin binding protein C, cardiac
chr2_+_220299547 0.03 ENST00000312358.7
SPEG
SPEG complex locus
chr10_-_31146615 0.02 ENST00000444692.2
ZNF438
zinc finger protein 438
chr20_+_11898507 0.02 ENST00000378226.2
BTBD3
BTB (POZ) domain containing 3
chr19_-_16008880 0.02 ENST00000011989.7
ENST00000221700.6
CYP4F2
cytochrome P450, family 4, subfamily F, polypeptide 2
chrX_-_11284095 0.02 ENST00000303025.6
ENST00000534860.1
ARHGAP6
Rho GTPase activating protein 6
chr9_+_100263912 0.02 ENST00000259365.4
TMOD1
tropomodulin 1
chr15_-_52970820 0.02 ENST00000261844.7
ENST00000399202.4
ENST00000562135.1
FAM214A
family with sequence similarity 214, member A
chr3_-_11610255 0.02 ENST00000424529.2
VGLL4
vestigial like 4 (Drosophila)
chr12_-_45269769 0.02 ENST00000548826.1
NELL2
NEL-like 2 (chicken)
chr1_+_212782012 0.02 ENST00000341491.4
ENST00000366985.1
ATF3
activating transcription factor 3
chrX_-_138304939 0.02 ENST00000448673.1
FGF13
fibroblast growth factor 13
chr1_+_84630367 0.02 ENST00000370680.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr3_-_39234074 0.02 ENST00000340369.3
ENST00000421646.1
ENST00000396251.1
XIRP1
xin actin-binding repeat containing 1
chr6_+_152128686 0.02 ENST00000206249.3
ESR1
estrogen receptor 1
chr19_-_51220176 0.02 ENST00000359082.3
ENST00000293441.1
SHANK1
SH3 and multiple ankyrin repeat domains 1
chr12_+_15699286 0.02 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
PTPRO
protein tyrosine phosphatase, receptor type, O
chr3_+_127634069 0.02 ENST00000405109.1
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr14_+_58797974 0.01 ENST00000417477.2
ARID4A
AT rich interactive domain 4A (RBP1-like)
chr11_-_104480019 0.01 ENST00000536529.1
ENST00000545630.1
ENST00000538641.1
RP11-886D15.1
RP11-886D15.1
chr3_+_54157480 0.01 ENST00000490478.1
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr6_-_123958051 0.01 ENST00000546248.1
TRDN
triadin
chr3_+_46924829 0.01 ENST00000313049.5
PTH1R
parathyroid hormone 1 receptor
chr17_+_42248063 0.01 ENST00000293414.1
ASB16
ankyrin repeat and SOCS box containing 16
chrX_-_63450480 0.01 ENST00000362002.2
ASB12
ankyrin repeat and SOCS box containing 12
chr5_-_131347583 0.01 ENST00000379255.1
ENST00000430403.1
ENST00000544770.1
ENST00000379246.1
ENST00000414078.1
ENST00000441995.1
ACSL6
acyl-CoA synthetase long-chain family member 6
chr20_+_58251716 0.01 ENST00000355648.4
PHACTR3
phosphatase and actin regulator 3
chr3_+_127634312 0.01 ENST00000407609.3
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr3_+_138067314 0.01 ENST00000423968.2
MRAS
muscle RAS oncogene homolog
chr9_-_16728161 0.01 ENST00000603713.1
ENST00000603313.1
BNC2
basonuclin 2
chr6_+_152128371 0.01 ENST00000443427.1
ESR1
estrogen receptor 1
chr19_+_37096194 0.01 ENST00000460670.1
ENST00000292928.2
ENST00000439428.1
ZNF382
zinc finger protein 382
chr20_+_32581738 0.01 ENST00000333552.5
RALY
RALY heterogeneous nuclear ribonucleoprotein
chr22_+_32340481 0.01 ENST00000397492.1
YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
chr10_+_102758105 0.01 ENST00000429732.1
LZTS2
leucine zipper, putative tumor suppressor 2
chr9_-_74980113 0.01 ENST00000376962.5
ENST00000376960.4
ENST00000237937.3
ZFAND5
zinc finger, AN1-type domain 5
chr18_+_3252206 0.01 ENST00000578562.2
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr20_+_32581525 0.00 ENST00000246194.3
ENST00000413297.1
RALY
RALY heterogeneous nuclear ribonucleoprotein
chr6_+_12007897 0.00 ENST00000437559.1
RP11-456H18.2
RP11-456H18.2
chr1_+_145524891 0.00 ENST00000369304.3
ITGA10
integrin, alpha 10
chr1_-_150693305 0.00 ENST00000368987.1
HORMAD1
HORMA domain containing 1
chr14_-_70546897 0.00 ENST00000394330.2
ENST00000533541.1
ENST00000216568.7
SLC8A3
solute carrier family 8 (sodium/calcium exchanger), member 3
chr2_+_239047337 0.00 ENST00000409223.1
ENST00000305959.4
KLHL30
kelch-like family member 30
chr15_+_40226304 0.00 ENST00000559624.1
ENST00000382727.2
ENST00000263791.5
ENST00000560648.1
EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4
chr19_+_49927006 0.00 ENST00000576655.1
CTD-3148I10.1
golgi-associated, olfactory signaling regulator
chr1_-_150693318 0.00 ENST00000442853.1
ENST00000368995.4
ENST00000368993.2
ENST00000361824.2
ENST00000322343.7
HORMAD1
HORMA domain containing 1
chr20_+_44657845 0.00 ENST00000243964.3
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr10_-_69455873 0.00 ENST00000433211.2
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr14_+_101359265 0.00 ENST00000599197.1
AL117190.3
Esophagus cancer-related gene-2 interaction susceptibility protein; Uncharacterized protein

Network of associatons between targets according to the STRING database.

First level regulatory network of MEF2B

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0 0.2 GO:0060023 soft palate development(GO:0060023)
0.0 0.3 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.0 0.1 GO:0099640 axo-dendritic protein transport(GO:0099640)
0.0 0.2 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.0 0.1 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.2 GO:0060613 fat pad development(GO:0060613)
0.0 0.0 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.1 GO:0060480 lung goblet cell differentiation(GO:0060480) lobar bronchus epithelium development(GO:0060481)
0.0 0.0 GO:1903028 positive regulation of opsonization(GO:1903028)
0.0 0.1 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
0.0 0.1 GO:0002933 lipid hydroxylation(GO:0002933)
0.0 0.1 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
0.0 0.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.0 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.0 0.2 GO:0005861 troponin complex(GO:0005861)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.2 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 0.1 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.0 0.2 GO:0031014 troponin T binding(GO:0031014)
0.0 0.0 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.1 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0 0.1 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)