ISMARA results: MECP2

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for MECP2

Z-value: 1.54

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Transcription factors associated with MECP2

Gene Symbol	Gene ID	Gene Info
MECP2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000169057.15	methyl-CpG binding protein 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MECP2	hg19_v2_chrX_-_153363125_153363182	0.93	6.4e-03	Click!

Activity profile of MECP2 motif

Sorted Z-values of MECP2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr22_-_50699972 Show fit	1.37	ENST00000395778.3	MAPK12 Ensembl NCBI GeneCards UniProt NextProt Show fit	mitogen-activated protein kinase 12
chr9_-_138987115 Show fit	1.33	ENST00000277554.2	NACC2 Ensembl NCBI GeneCards UniProt NextProt Show fit	NACC family member 2, BEN and BTB (POZ) domain containing
chr9_-_35658007 Show fit	1.33	ENST00000602361.1	RMRP Ensembl NCBI GeneCards UniProt NextProt Show fit	RNA component of mitochondrial RNA processing endoribonuclease
chr1_+_895930 Show fit	1.03	ENST00000338591.3	KLHL17 Ensembl NCBI GeneCards UniProt NextProt Show fit	kelch-like family member 17
chr14_-_103989033 Show fit	0.94	ENST00000553878.1 ENST00000557530.1	CKB Ensembl NCBI GeneCards UniProt NextProt Show fit	creatine kinase, brain
chr19_+_33685490 Show fit	0.93	ENST00000253193.7	LRP3 Ensembl NCBI GeneCards UniProt NextProt Show fit	low density lipoprotein receptor-related protein 3
chr11_+_842928 Show fit	0.93	ENST00000397408.1	TSPAN4 Ensembl NCBI GeneCards UniProt NextProt Show fit	tetraspanin 4
chr12_+_132312931 Show fit	0.88	ENST00000360564.1 ENST00000545671.1 ENST00000545790.1	MMP17 Ensembl NCBI GeneCards UniProt NextProt Show fit	matrix metallopeptidase 17 (membrane-inserted)
chr19_+_13228917 Show fit	0.87	ENST00000586171.1	NACC1 Ensembl NCBI GeneCards UniProt NextProt Show fit	nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr11_+_842808 Show fit	0.84	ENST00000397397.2 ENST00000397411.2 ENST00000397396.1	TSPAN4 Ensembl NCBI GeneCards UniProt NextProt Show fit	tetraspanin 4

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of MECP2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.0	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.1	2.0	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.1	2.0	GO:0031581	hemidesmosome assembly(GO:0031581)
0.1	1.8	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0	1.8	GO:0007219	Notch signaling pathway(GO:0007219)
0.1	1.7	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	1.7	GO:0071526	semaphorin-plexin signaling pathway(GO:0071526)
0.0	1.7	GO:0070126	mitochondrial translational termination(GO:0070126)
0.1	1.6	GO:0006183	GTP biosynthetic process(GO:0006183)
0.0	1.6	GO:0030574	collagen catabolic process(GO:0030574)

Showing 1 to 10 of 874 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.7	GO:0005796	Golgi lumen(GO:0005796)
0.0	1.9	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	1.6	GO:0001669	acrosomal vesicle(GO:0001669)
0.0	1.5	GO:0030056	hemidesmosome(GO:0030056)
0.1	1.4	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	1.4	GO:0005747	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0	1.4	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.0	1.3	GO:0045171	intercellular bridge(GO:0045171)
0.0	1.3	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0	1.3	GO:0030173	integral component of Golgi membrane(GO:0030173)

Showing 1 to 10 of 246 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.7	GO:0005178	integrin binding(GO:0005178)
0.1	2.4	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.1	2.3	GO:0004707	MAP kinase activity(GO:0004707)
0.0	2.3	GO:0003954	NADH dehydrogenase activity(GO:0003954)
0.2	2.2	GO:0019826	oxygen sensor activity(GO:0019826)
0.0	1.7	GO:0017091	AU-rich element binding(GO:0017091)
0.1	1.5	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.2	1.2	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.0	1.2	GO:0005179	hormone activity(GO:0005179)
0.4	1.1	GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity(GO:0008413) 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity(GO:0035539)

Showing 1 to 10 of 501 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.7	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	2.7	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	2.6	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	2.1	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	2.1	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.0	2.0	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	1.9	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	1.8	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	1.7	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.0	1.6	ST GAQ PATHWAY	G alpha q Pathway

Showing 1 to 10 of 63 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.8	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.1	2.7	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	2.1	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0	1.9	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.0	1.8	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	1.7	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	1.6	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.0	1.5	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0	1.5	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	1.4	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix

Showing 1 to 10 of 97 entries

Results for MECP2

Z-value: 1.54

Motif logo

Transcription factors associated with MECP2

Activity-expression correlation:

Activity profile of MECP2 motif

Sorted Z-values of MECP2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of MECP2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: