Project
NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
Navigation
Downloads
Results for MECOM
Z-value: 0.96
Motif logo
Transcription factors associated with MECOM
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MECOM | hg19_v2_chr3_-_169381166_169381181 | -0.63 | 1.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrY_+_15418467 Show fit | 0.66 |
ENST00000595988.1
|
Uncharacterized protein |
|
| chr5_+_159895275 Show fit | 0.49 |
ENST00000517927.1
|
microRNA 146a |
|
| chr21_+_45595354 Show fit | 0.45 |
ENST00000411956.1
|
AP001056.1 |
|
| chr10_+_90484301 Show fit | 0.40 |
ENST00000404190.1
|
lipase, family member K |
|
| chr3_-_145968857 Show fit | 0.37 |
ENST00000433593.2
ENST00000476202.1 ENST00000460885.1 |
phospholipid scramblase 4 |
|
| chr12_-_15038779 Show fit | 0.36 |
ENST00000228938.5
ENST00000539261.1 |
matrix Gla protein |
|
| chr11_-_33891362 Show fit | 0.35 |
ENST00000395833.3
|
LIM domain only 2 (rhombotin-like 1) |
|
| chr3_-_145968923 Show fit | 0.34 |
ENST00000493382.1
ENST00000354952.2 ENST00000383083.2 |
phospholipid scramblase 4 |
|
| chr4_+_189321881 Show fit | 0.34 |
ENST00000512839.1
ENST00000513313.1 |
long intergenic non-protein coding RNA 1060 |
|
| chr19_-_36391434 Show fit | 0.33 |
ENST00000396901.1
ENST00000585925.1 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta |
Network of associatons between targets according to the STRING database.
First level regulatory network of MECOM
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0017121 | phospholipid scrambling(GO:0017121) |
| 0.0 | 0.5 | GO:2000582 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 0.0 | 0.4 | GO:1905068 | positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068) |
| 0.0 | 0.4 | GO:0001502 | cartilage condensation(GO:0001502) |
| 0.0 | 0.4 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
| 0.0 | 0.3 | GO:0070245 | positive regulation of thymocyte apoptotic process(GO:0070245) |
| 0.1 | 0.2 | GO:2000909 | regulation of intestinal cholesterol absorption(GO:0030300) regulation of cholesterol import(GO:0060620) regulation of intestinal lipid absorption(GO:1904729) regulation of sterol import(GO:2000909) |
| 0.1 | 0.2 | GO:0018963 | insecticide metabolic process(GO:0017143) phthalate metabolic process(GO:0018963) cellular response to luteinizing hormone stimulus(GO:0071373) |
| 0.0 | 0.2 | GO:0006210 | pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) beta-alanine metabolic process(GO:0019482) thymine metabolic process(GO:0019859) uracil metabolic process(GO:0019860) |
| 0.0 | 0.2 | GO:1902952 | positive regulation of dendritic spine maintenance(GO:1902952) regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.0 | 0.4 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.0 | 0.4 | GO:0090543 | Flemming body(GO:0090543) |
| 0.0 | 0.3 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 0.1 | 0.2 | GO:0005595 | collagen type XII trimer(GO:0005595) |
| 0.0 | 0.2 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.0 | 0.2 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.0 | 0.1 | GO:0008275 | gamma-tubulin small complex(GO:0008275) |
| 0.0 | 0.1 | GO:0014802 | terminal cisterna(GO:0014802) |
| 0.0 | 0.1 | GO:0005851 | eukaryotic translation initiation factor 2B complex(GO:0005851) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.0 | 0.5 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.0 | 0.4 | GO:0004465 | lipoprotein lipase activity(GO:0004465) |
| 0.0 | 0.4 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.0 | 0.3 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.0 | 0.2 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.0 | 0.2 | GO:0070573 | metallodipeptidase activity(GO:0070573) |
| 0.0 | 0.2 | GO:0030020 | extracellular matrix structural constituent conferring tensile strength(GO:0030020) |
| 0.0 | 0.1 | GO:0047946 | glutamine N-acyltransferase activity(GO:0047946) |
| 0.0 | 0.1 | GO:0004464 | leukotriene-C4 synthase activity(GO:0004464) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.2 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 0.2 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |