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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for MECOM

Z-value: 0.96

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Transcription factors associated with MECOM

Gene Symbol Gene ID Gene Info
MECOM
ENSG00000085276.13 MDS1 and EVI1 complex locus

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MECOMhg19_v2_chr3_-_169381166_169381181-0.631.8e-01Click!

Activity profile of MECOM motif

Sorted Z-values of MECOM motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrY_+_15418467 0.66 ENST00000595988.1
AC010877.1
Uncharacterized protein
chr5_+_159895275 0.49 ENST00000517927.1
MIR146A
microRNA 146a
chr21_+_45595354 0.45 ENST00000411956.1
AP001056.1
AP001056.1
chr10_+_90484301 0.40 ENST00000404190.1
LIPK
lipase, family member K
chr3_-_145968857 0.37 ENST00000433593.2
ENST00000476202.1
ENST00000460885.1
PLSCR4
phospholipid scramblase 4
chr12_-_15038779 0.36 ENST00000228938.5
ENST00000539261.1
MGP
matrix Gla protein
chr11_-_33891362 0.35 ENST00000395833.3
LMO2
LIM domain only 2 (rhombotin-like 1)
chr3_-_145968923 0.34 ENST00000493382.1
ENST00000354952.2
ENST00000383083.2
PLSCR4
phospholipid scramblase 4
chr4_+_189321881 0.34 ENST00000512839.1
ENST00000513313.1
LINC01060
long intergenic non-protein coding RNA 1060
chr19_-_36391434 0.33 ENST00000396901.1
ENST00000585925.1
NFKBID
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
chr6_-_132022635 0.31 ENST00000315453.2
OR2A4
olfactory receptor, family 2, subfamily A, member 4
chr12_-_47219733 0.31 ENST00000547477.1
ENST00000447411.1
ENST00000266579.4
SLC38A4
solute carrier family 38, member 4
chr9_+_26746951 0.30 ENST00000523363.1
RP11-18A15.1
RP11-18A15.1
chr8_+_86999516 0.30 ENST00000521564.1
ATP6V0D2
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
chr10_+_78078088 0.30 ENST00000496424.2
C10orf11
chromosome 10 open reading frame 11
chr19_-_53632912 0.29 ENST00000601215.1
ZNF415
zinc finger protein 415
chr4_+_130014836 0.27 ENST00000502887.1
C4orf33
chromosome 4 open reading frame 33
chr2_+_181988620 0.26 ENST00000428474.1
ENST00000424655.1
AC104820.2
AC104820.2
chr5_-_96209315 0.25 ENST00000504056.1
CTD-2260A17.2
Uncharacterized protein
chr4_+_117220016 0.25 ENST00000604093.1
MTRNR2L13
MT-RNR2-like 13 (pseudogene)
chr15_-_40401062 0.25 ENST00000354670.4
ENST00000559701.1
ENST00000557870.1
ENST00000558774.1
BMF
Bcl2 modifying factor
chr1_-_152539248 0.25 ENST00000368789.1
LCE3E
late cornified envelope 3E
chr2_+_17997763 0.24 ENST00000281047.3
MSGN1
mesogenin 1
chr1_-_161193349 0.21 ENST00000469730.2
ENST00000463273.1
ENST00000464492.1
ENST00000367990.3
ENST00000470459.2
ENST00000468465.1
ENST00000463812.1
APOA2
apolipoprotein A-II
chr4_-_52883786 0.21 ENST00000343457.3
LRRC66
leucine rich repeat containing 66
chr2_+_172543919 0.21 ENST00000452242.1
ENST00000340296.4
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr3_-_139195350 0.21 ENST00000232217.2
RBP2
retinol binding protein 2, cellular
chr4_+_26324474 0.20 ENST00000514675.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr8_-_38008783 0.20 ENST00000276449.4
STAR
steroidogenic acute regulatory protein
chr3_-_178984759 0.20 ENST00000349697.2
ENST00000497599.1
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr12_-_10320190 0.20 ENST00000543993.1
ENST00000339968.6
OLR1
oxidized low density lipoprotein (lectin-like) receptor 1
chr13_+_102142296 0.20 ENST00000376162.3
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr9_-_112970436 0.20 ENST00000400613.4
C9orf152
chromosome 9 open reading frame 152
chr14_-_82089405 0.19 ENST00000554211.1
RP11-799P8.1
RP11-799P8.1
chr12_+_28605426 0.19 ENST00000542801.1
CCDC91
coiled-coil domain containing 91
chr6_+_49431073 0.19 ENST00000335783.3
CENPQ
centromere protein Q
chr4_-_122148620 0.19 ENST00000509841.1
TNIP3
TNFAIP3 interacting protein 3
chr8_+_97773202 0.18 ENST00000519484.1
CPQ
carboxypeptidase Q
chr3_+_177534653 0.18 ENST00000436078.1
RP11-91K9.1
RP11-91K9.1
chr2_+_172543967 0.18 ENST00000534253.2
ENST00000263811.4
ENST00000397119.3
ENST00000410079.3
ENST00000438879.1
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr19_-_35981358 0.17 ENST00000484218.2
ENST00000338897.3
KRTDAP
keratinocyte differentiation-associated protein
chr8_-_6420565 0.17 ENST00000338312.6
ANGPT2
angiopoietin 2
chr5_+_67485704 0.16 ENST00000520762.1
RP11-404L6.2
Uncharacterized protein
chr1_-_98386543 0.16 ENST00000423006.2
ENST00000370192.3
ENST00000306031.5
DPYD
dihydropyrimidine dehydrogenase
chr17_+_70036164 0.16 ENST00000602013.1
AC007461.1
Uncharacterized protein
chr4_+_26323764 0.16 ENST00000514730.1
ENST00000507574.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr15_+_39311432 0.16 ENST00000560709.1
RP11-62C7.2
RP11-62C7.2
chr3_-_119379427 0.15 ENST00000264231.3
ENST00000468801.1
ENST00000538678.1
POPDC2
popeye domain containing 2
chr1_-_68962744 0.15 ENST00000525124.1
DEPDC1
DEP domain containing 1
chr6_-_75912508 0.15 ENST00000416123.2
COL12A1
collagen, type XII, alpha 1
chr12_+_113344811 0.15 ENST00000551241.1
ENST00000553185.1
ENST00000550689.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr10_-_14596140 0.14 ENST00000496330.1
FAM107B
family with sequence similarity 107, member B
chr15_+_40532837 0.14 ENST00000560806.1
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr1_+_207038699 0.14 ENST00000367098.1
IL20
interleukin 20
chrX_-_149999722 0.14 ENST00000418547.1
CD99L2
CD99 molecule-like 2
chr4_+_96012585 0.13 ENST00000502683.1
BMPR1B
bone morphogenetic protein receptor, type IB
chr19_+_23257988 0.13 ENST00000594318.1
ENST00000600223.1
ENST00000593635.1
CTD-2291D10.4
ZNF730
CTD-2291D10.4
zinc finger protein 730
chr10_-_5652705 0.13 ENST00000425246.1
RP11-336A10.5
RP11-336A10.5
chr12_-_8815299 0.13 ENST00000535336.1
MFAP5
microfibrillar associated protein 5
chr5_+_171621176 0.13 ENST00000398186.4
EFCAB9
EF-hand calcium binding domain 9
chr1_+_171060018 0.12 ENST00000367755.4
ENST00000392085.2
ENST00000542847.1
ENST00000538429.1
ENST00000479749.1
FMO3
flavin containing monooxygenase 3
chr9_+_127023704 0.12 ENST00000373596.1
ENST00000425237.1
NEK6
NIMA-related kinase 6
chrX_-_43741594 0.12 ENST00000536181.1
ENST00000378069.4
MAOB
monoamine oxidase B
chr13_+_31309645 0.12 ENST00000380490.3
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr2_-_157189180 0.12 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr1_-_45452240 0.12 ENST00000372183.3
ENST00000372182.4
ENST00000360403.2
EIF2B3
eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
chr12_-_76879852 0.12 ENST00000548341.1
OSBPL8
oxysterol binding protein-like 8
chr15_-_38852251 0.12 ENST00000558432.1
RASGRP1
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
chr12_-_12715266 0.12 ENST00000228862.2
DUSP16
dual specificity phosphatase 16
chr12_+_27863706 0.12 ENST00000081029.3
ENST00000538315.1
ENST00000542791.1
MRPS35
mitochondrial ribosomal protein S35
chrX_-_19765692 0.12 ENST00000432234.1
SH3KBP1
SH3-domain kinase binding protein 1
chr15_-_83837983 0.12 ENST00000562702.1
HDGFRP3
Hepatoma-derived growth factor-related protein 3
chr3_-_145968900 0.12 ENST00000460350.1
PLSCR4
phospholipid scramblase 4
chr2_+_172544011 0.11 ENST00000508530.1
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr16_+_9449445 0.11 ENST00000564305.1
RP11-243A14.1
RP11-243A14.1
chr7_-_15601595 0.11 ENST00000342526.3
AGMO
alkylglycerol monooxygenase
chr13_-_113242439 0.11 ENST00000375669.3
ENST00000261965.3
TUBGCP3
tubulin, gamma complex associated protein 3
chr18_-_24722995 0.11 ENST00000581714.1
CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr3_-_161089289 0.10 ENST00000497137.1
SPTSSB
serine palmitoyltransferase, small subunit B
chr7_-_8302207 0.10 ENST00000407906.1
ICA1
islet cell autoantigen 1, 69kDa
chr15_-_55562451 0.10 ENST00000568803.1
RAB27A
RAB27A, member RAS oncogene family
chr10_+_116524547 0.10 ENST00000436932.1
RP11-106M7.1
RP11-106M7.1
chr22_+_29138013 0.10 ENST00000216027.3
ENST00000398941.2
HSCB
HscB mitochondrial iron-sulfur cluster co-chaperone
chr15_-_48470544 0.10 ENST00000267836.6
MYEF2
myelin expression factor 2
chr17_+_38121772 0.10 ENST00000577447.1
GSDMA
gasdermin A
chr6_-_52860171 0.09 ENST00000370963.4
GSTA4
glutathione S-transferase alpha 4
chrX_+_15525426 0.09 ENST00000342014.6
BMX
BMX non-receptor tyrosine kinase
chr6_-_52859968 0.09 ENST00000370959.1
GSTA4
glutathione S-transferase alpha 4
chr5_+_125695805 0.09 ENST00000513040.1
GRAMD3
GRAM domain containing 3
chr1_-_52520828 0.09 ENST00000610127.1
TXNDC12
thioredoxin domain containing 12 (endoplasmic reticulum)
chr5_-_127674883 0.09 ENST00000507835.1
FBN2
fibrillin 2
chr2_+_190541153 0.09 ENST00000313581.4
ENST00000438402.2
ENST00000431575.2
ENST00000281412.6
ANKAR
ankyrin and armadillo repeat containing
chr8_+_105602961 0.09 ENST00000521923.1
RP11-127H5.1
Uncharacterized protein
chr5_+_56471592 0.09 ENST00000511209.1
GPBP1
GC-rich promoter binding protein 1
chrX_+_155227246 0.09 ENST00000244174.5
ENST00000424344.3
IL9R
interleukin 9 receptor
chr5_+_121465207 0.09 ENST00000296600.4
ZNF474
zinc finger protein 474
chr16_-_80673633 0.08 ENST00000561616.1
CDYL2
chromodomain protein, Y-like 2
chr1_-_110155671 0.08 ENST00000351050.3
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr7_-_100844193 0.08 ENST00000440203.2
ENST00000379423.3
ENST00000223114.4
MOGAT3
monoacylglycerol O-acyltransferase 3
chr11_+_58695096 0.08 ENST00000525608.1
ENST00000526351.1
GLYATL1
glycine-N-acyltransferase-like 1
chr5_-_64920115 0.08 ENST00000381018.3
ENST00000274327.7
TRIM23
tripartite motif containing 23
chr12_-_86650077 0.08 ENST00000552808.2
ENST00000547225.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr2_+_242289502 0.08 ENST00000451310.1
SEPT2
septin 2
chr3_+_99986036 0.08 ENST00000471098.1
TBC1D23
TBC1 domain family, member 23
chr15_+_100348193 0.08 ENST00000558188.1
CTD-2054N24.2
Uncharacterized protein
chr12_-_112443830 0.08 ENST00000550037.1
ENST00000549425.1
TMEM116
transmembrane protein 116
chr7_-_8302164 0.08 ENST00000447326.1
ENST00000406470.2
ICA1
islet cell autoantigen 1, 69kDa
chr1_+_47901689 0.08 ENST00000334793.5
FOXD2
forkhead box D2
chr1_+_248031277 0.07 ENST00000537741.1
OR2W3
olfactory receptor, family 2, subfamily W, member 3
chr5_-_133340682 0.07 ENST00000265333.3
VDAC1
voltage-dependent anion channel 1
chr15_-_48470558 0.07 ENST00000324324.7
MYEF2
myelin expression factor 2
chr2_+_27805971 0.07 ENST00000413371.2
ZNF512
zinc finger protein 512
chr6_+_27215494 0.07 ENST00000230582.3
PRSS16
protease, serine, 16 (thymus)
chr3_+_152552685 0.07 ENST00000305097.3
P2RY1
purinergic receptor P2Y, G-protein coupled, 1
chr7_+_44240520 0.07 ENST00000496112.1
ENST00000223369.2
YKT6
YKT6 v-SNARE homolog (S. cerevisiae)
chr2_-_1629176 0.07 ENST00000366424.2
AC144450.2
AC144450.2
chr12_-_39734783 0.07 ENST00000552961.1
KIF21A
kinesin family member 21A
chr4_-_100065419 0.07 ENST00000504125.1
ENST00000505590.1
ADH4
alcohol dehydrogenase 4 (class II), pi polypeptide
chr16_+_28943260 0.07 ENST00000538922.1
ENST00000324662.3
ENST00000567541.1
CD19
CD19 molecule
chr2_-_237416181 0.06 ENST00000409907.3
IQCA1
IQ motif containing with AAA domain 1
chr3_+_99357319 0.06 ENST00000452013.1
ENST00000261037.3
ENST00000273342.4
COL8A1
collagen, type VIII, alpha 1
chr5_-_138862326 0.06 ENST00000330794.4
TMEM173
transmembrane protein 173
chr3_-_178103144 0.06 ENST00000417383.1
ENST00000418585.1
ENST00000411727.1
ENST00000439810.1
RP11-33A14.1
RP11-33A14.1
chr5_+_20616500 0.06 ENST00000512688.1
RP11-774D14.1
RP11-774D14.1
chr6_-_154831779 0.06 ENST00000607772.1
CNKSR3
CNKSR family member 3
chr17_+_22022437 0.06 ENST00000540040.1
MTRNR2L1
MT-RNR2-like 1
chr22_-_31688431 0.06 ENST00000402249.3
ENST00000443175.1
ENST00000215912.5
ENST00000441972.1
PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr9_-_13175823 0.06 ENST00000545857.1
MPDZ
multiple PDZ domain protein
chr2_+_108145913 0.06 ENST00000443205.1
AC096669.3
AC096669.3
chrX_+_129473916 0.06 ENST00000545805.1
ENST00000543953.1
ENST00000218197.5
SLC25A14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr20_-_45984401 0.06 ENST00000311275.7
ZMYND8
zinc finger, MYND-type containing 8
chr1_+_218683438 0.06 ENST00000443836.1
C1orf143
chromosome 1 open reading frame 143
chr11_+_94300474 0.06 ENST00000299001.6
PIWIL4
piwi-like RNA-mediated gene silencing 4
chr5_+_96211643 0.06 ENST00000437043.3
ENST00000510373.1
ERAP2
endoplasmic reticulum aminopeptidase 2
chr2_-_237416071 0.06 ENST00000309507.5
ENST00000431676.2
IQCA1
IQ motif containing with AAA domain 1
chr1_+_160160283 0.05 ENST00000368079.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr15_-_30261066 0.05 ENST00000558447.1
TJP1
tight junction protein 1
chr14_-_25479811 0.05 ENST00000550887.1
STXBP6
syntaxin binding protein 6 (amisyn)
chr3_-_109035342 0.05 ENST00000478945.1
DPPA2
developmental pluripotency associated 2
chr12_+_53836339 0.05 ENST00000549135.1
PRR13
proline rich 13
chr3_+_119013185 0.05 ENST00000264245.4
ARHGAP31
Rho GTPase activating protein 31
chr19_-_54106751 0.05 ENST00000600193.1
CTB-167G5.5
Uncharacterized protein
chr1_+_160160346 0.05 ENST00000368078.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr9_+_109213096 0.05 ENST00000425709.1
RP11-308N19.1
RP11-308N19.1
chr5_+_167956121 0.05 ENST00000338333.4
FBLL1
fibrillarin-like 1
chr14_-_69261310 0.05 ENST00000336440.3
ZFP36L1
ZFP36 ring finger protein-like 1
chr15_-_30686052 0.05 ENST00000562729.1
CHRFAM7A
CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
chr3_+_4344988 0.05 ENST00000358065.4
SETMAR
SET domain and mariner transposase fusion gene
chr1_-_152009460 0.05 ENST00000271638.2
S100A11
S100 calcium binding protein A11
chr1_+_154955797 0.05 ENST00000368433.1
ENST00000315144.10
ENST00000368432.1
ENST00000368431.3
ENST00000292180.3
FLAD1
flavin adenine dinucleotide synthetase 1
chr10_-_18940501 0.05 ENST00000377304.4
NSUN6
NOP2/Sun domain family, member 6
chr17_-_29648761 0.05 ENST00000247270.3
ENST00000462804.2
EVI2A
ecotropic viral integration site 2A
chr3_+_39448180 0.05 ENST00000301821.6
ENST00000458478.1
ENST00000443003.1
RPSA
ribosomal protein SA
chr20_-_45985414 0.05 ENST00000461685.1
ENST00000372023.3
ENST00000540497.1
ENST00000435836.1
ENST00000471951.2
ENST00000352431.2
ENST00000396281.4
ENST00000355972.4
ENST00000360911.3
ZMYND8
zinc finger, MYND-type containing 8
chr8_+_72740402 0.05 ENST00000521467.1
RP11-383H13.1
Protein LOC100132891; cDNA FLJ53548
chr1_-_157069590 0.05 ENST00000454449.2
ETV3L
ets variant 3-like
chr11_+_47586982 0.05 ENST00000426530.2
ENST00000534775.1
PTPMT1
protein tyrosine phosphatase, mitochondrial 1
chr2_+_27805880 0.05 ENST00000379717.1
ENST00000355467.4
ENST00000556601.1
ENST00000416005.2
ZNF512
zinc finger protein 512
chr15_+_78441663 0.05 ENST00000299518.2
ENST00000558554.1
ENST00000557826.1
ENST00000561279.1
ENST00000559186.1
ENST00000560770.1
ENST00000559881.1
ENST00000559205.1
ENST00000441490.2
IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha
chr1_-_85156417 0.05 ENST00000422026.1
SSX2IP
synovial sarcoma, X breakpoint 2 interacting protein
chr19_-_53632925 0.05 ENST00000595174.1
ZNF415
zinc finger protein 415
chr12_+_113344582 0.05 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr16_+_71879861 0.05 ENST00000427980.2
ENST00000568581.1
ATXN1L
IST1
ataxin 1-like
increased sodium tolerance 1 homolog (yeast)
chr19_-_48894762 0.05 ENST00000600980.1
ENST00000330720.2
KDELR1
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
chr2_-_56150910 0.04 ENST00000424836.2
ENST00000438672.1
ENST00000440439.1
ENST00000429909.1
ENST00000424207.1
ENST00000452337.1
ENST00000355426.3
ENST00000439193.1
ENST00000421664.1
EFEMP1
EGF containing fibulin-like extracellular matrix protein 1
chr4_-_40859132 0.04 ENST00000543538.1
ENST00000502841.1
ENST00000504305.1
ENST00000513516.1
ENST00000510670.1
APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr8_+_22857048 0.04 ENST00000251822.6
RHOBTB2
Rho-related BTB domain containing 2
chr20_-_45985172 0.04 ENST00000536340.1
ZMYND8
zinc finger, MYND-type containing 8
chr11_+_12115543 0.04 ENST00000537344.1
ENST00000532179.1
ENST00000526065.1
MICAL2
microtubule associated monooxygenase, calponin and LIM domain containing 2
chr14_+_24584056 0.04 ENST00000561001.1
DCAF11
DDB1 and CUL4 associated factor 11
chr13_+_111855399 0.04 ENST00000426768.2
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr11_+_65266507 0.04 ENST00000544868.1
MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr22_+_30279144 0.04 ENST00000401950.2
ENST00000333027.3
ENST00000445401.1
ENST00000323630.5
ENST00000351488.3
MTMR3
myotubularin related protein 3
chr12_+_12202774 0.04 ENST00000589718.1
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr11_+_58695174 0.04 ENST00000317391.4
GLYATL1
glycine-N-acyltransferase-like 1
chr5_+_92919043 0.04 ENST00000327111.3
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr1_-_208084729 0.04 ENST00000310833.7
ENST00000356522.4
CD34
CD34 molecule
chr5_-_115910091 0.04 ENST00000257414.8
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr7_-_6007070 0.04 ENST00000337579.3
RSPH10B
radial spoke head 10 homolog B (Chlamydomonas)
chr11_+_47587129 0.04 ENST00000326656.8
ENST00000326674.9
PTPMT1
protein tyrosine phosphatase, mitochondrial 1
chr21_-_28338732 0.04 ENST00000284987.5
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr8_+_134203303 0.04 ENST00000519433.1
ENST00000517423.1
ENST00000377863.2
ENST00000220856.6
WISP1
WNT1 inducible signaling pathway protein 1
chrX_-_19905577 0.04 ENST00000379697.3
SH3KBP1
SH3-domain kinase binding protein 1
chr3_+_108541545 0.04 ENST00000295756.6
TRAT1
T cell receptor associated transmembrane adaptor 1
chr15_-_55562479 0.04 ENST00000564609.1
RAB27A
RAB27A, member RAS oncogene family
chr12_+_21207503 0.04 ENST00000545916.1
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr3_-_193272741 0.04 ENST00000392443.3
ATP13A4
ATPase type 13A4
chr15_-_102285007 0.04 ENST00000560292.2
RP11-89K11.1
Uncharacterized protein
chr5_+_140165876 0.04 ENST00000504120.2
ENST00000394633.3
ENST00000378133.3
PCDHA1
protocadherin alpha 1
chr2_-_38056538 0.04 ENST00000413792.1
LINC00211
long intergenic non-protein coding RNA 211
chr3_-_111314230 0.04 ENST00000317012.4
ZBED2
zinc finger, BED-type containing 2
chr1_+_172422026 0.04 ENST00000367725.4
C1orf105
chromosome 1 open reading frame 105
chr2_-_224467093 0.03 ENST00000305409.2
SCG2
secretogranin II
chrX_+_86772787 0.03 ENST00000373114.4
KLHL4
kelch-like family member 4
chr1_+_161035655 0.03 ENST00000600454.1
AL591806.1
Uncharacterized protein
chr8_+_134203273 0.03 ENST00000250160.6
WISP1
WNT1 inducible signaling pathway protein 1
chr4_-_100065389 0.03 ENST00000512499.1
ADH4
alcohol dehydrogenase 4 (class II), pi polypeptide
chr14_-_38028689 0.03 ENST00000553425.1
RP11-356O9.2
RP11-356O9.2
chr8_-_6420930 0.03 ENST00000325203.5
ANGPT2
angiopoietin 2
chr8_-_17942432 0.03 ENST00000381733.4
ENST00000314146.10
ASAH1
N-acylsphingosine amidohydrolase (acid ceramidase) 1

Network of associatons between targets according to the STRING database.

First level regulatory network of MECOM

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:2000909 regulation of intestinal cholesterol absorption(GO:0030300) regulation of cholesterol import(GO:0060620) regulation of intestinal lipid absorption(GO:1904729) regulation of sterol import(GO:2000909)
0.1 0.2 GO:0018963 insecticide metabolic process(GO:0017143) phthalate metabolic process(GO:0018963) cellular response to luteinizing hormone stimulus(GO:0071373)
0.0 0.4 GO:1905068 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.2 GO:0006210 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) beta-alanine metabolic process(GO:0019482) thymine metabolic process(GO:0019859) uracil metabolic process(GO:0019860)
0.0 0.5 GO:2000582 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.1 GO:0051866 general adaptation syndrome(GO:0051866)
0.0 0.8 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.3 GO:0070245 positive regulation of thymocyte apoptotic process(GO:0070245)
0.0 0.1 GO:0045208 MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209)
0.0 0.1 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
0.0 0.0 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0 0.2 GO:1902952 positive regulation of dendritic spine maintenance(GO:1902952) regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.0 0.1 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.0 0.1 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.0 0.1 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.1 GO:1990258 box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258)
0.0 0.1 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700) regulation of penile erection(GO:0060405)
0.0 0.1 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.2 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.0 GO:0072387 flavin-containing compound biosynthetic process(GO:0042727) flavin adenine dinucleotide metabolic process(GO:0072387)
0.0 0.4 GO:0001502 cartilage condensation(GO:0001502)
0.0 0.0 GO:1904562 phosphatidylinositol 5-phosphate metabolic process(GO:1904562)
0.0 0.0 GO:0072011 glomerular endothelium development(GO:0072011)
0.0 0.1 GO:1901350 cell-cell signaling involved in cell-cell junction organization(GO:1901350)
0.0 0.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.1 GO:1904220 regulation of serine C-palmitoyltransferase activity(GO:1904220)
0.0 0.0 GO:2000371 regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.0 0.1 GO:2001300 lipoxin metabolic process(GO:2001300)
0.0 0.4 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.1 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.0 0.1 GO:0032057 negative regulation of translational initiation in response to stress(GO:0032057)
0.0 0.1 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.2 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.0 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.0 0.0 GO:0019417 sulfur oxidation(GO:0019417)
0.0 0.1 GO:0071104 response to interleukin-9(GO:0071104)
0.0 0.1 GO:0097403 cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.0 0.2 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.1 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.2 GO:0007379 segment specification(GO:0007379)
0.0 0.1 GO:0090204 protein localization to nuclear pore(GO:0090204)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005595 collagen type XII trimer(GO:0005595)
0.0 0.4 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.3 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.1 GO:0008275 gamma-tubulin small complex(GO:0008275)
0.0 0.4 GO:0090543 Flemming body(GO:0090543)
0.0 0.2 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.2 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.5 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.1 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.1 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 0.1 GO:0071547 piP-body(GO:0071547)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0047946 glutamine N-acyltransferase activity(GO:0047946)
0.0 0.1 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.0 0.8 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.4 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.2 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0 0.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.1 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 0.1 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.2 GO:0070573 metallodipeptidase activity(GO:0070573)
0.0 0.5 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.4 GO:0000150 recombinase activity(GO:0000150)
0.0 0.1 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537) chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.1 GO:1990259 protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)
0.0 0.2 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.1 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.0 0.0 GO:0005055 laminin receptor activity(GO:0005055)
0.0 0.1 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.0 GO:0090541 MIT domain binding(GO:0090541)
0.0 0.1 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.1 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 0.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.0 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.1 GO:0034584 piRNA binding(GO:0034584)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.0 GO:0005046 KDEL sequence binding(GO:0005046)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.2 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.2 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism