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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for MBD2

Z-value: 1.16

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Transcription factors associated with MBD2

Gene Symbol Gene ID Gene Info
MBD2
ENSG00000134046.7 methyl-CpG binding domain protein 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MBD2hg19_v2_chr18_-_51751132_51751158-0.911.2e-02Click!

Activity profile of MBD2 motif

Sorted Z-values of MBD2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_74212073 1.90 ENST00000441217.1
AC073046.25
AC073046.25
chr19_-_14201507 1.04 ENST00000533683.2
SAMD1
sterile alpha motif domain containing 1
chr19_-_14201776 0.69 ENST00000269724.5
SAMD1
sterile alpha motif domain containing 1
chr8_+_61592073 0.53 ENST00000526846.1
CHD7
chromodomain helicase DNA binding protein 7
chr16_+_2022036 0.50 ENST00000568546.1
TBL3
transducin (beta)-like 3
chr1_-_22469459 0.49 ENST00000290167.6
WNT4
wingless-type MMTV integration site family, member 4
chr18_-_72264805 0.46 ENST00000577806.1
LINC00909
long intergenic non-protein coding RNA 909
chr22_-_19419205 0.46 ENST00000340170.4
ENST00000263208.5
HIRA
histone cell cycle regulator
chr10_+_104180580 0.46 ENST00000425536.1
FBXL15
F-box and leucine-rich repeat protein 15
chr16_+_2059872 0.45 ENST00000567649.1
NPW
neuropeptide W
chr6_+_139349903 0.45 ENST00000461027.1
ABRACL
ABRA C-terminal like
chr10_+_129845670 0.45 ENST00000467366.1
PTPRE
protein tyrosine phosphatase, receptor type, E
chr12_-_58159361 0.44 ENST00000546567.1
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr11_+_64685026 0.43 ENST00000526559.1
PPP2R5B
protein phosphatase 2, regulatory subunit B', beta
chr1_-_156698591 0.39 ENST00000368219.1
ISG20L2
interferon stimulated exonuclease gene 20kDa-like 2
chr10_-_17659234 0.38 ENST00000466335.1
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr1_+_43148059 0.37 ENST00000321358.7
ENST00000332220.6
YBX1
Y box binding protein 1
chr17_-_4889508 0.35 ENST00000574606.2
CAMTA2
calmodulin binding transcription activator 2
chr8_-_145688231 0.35 ENST00000530374.1
CYHR1
cysteine/histidine-rich 1
chr16_-_30905584 0.35 ENST00000380317.4
BCL7C
B-cell CLL/lymphoma 7C
chr6_-_43596899 0.35 ENST00000307126.5
ENST00000452781.1
GTPBP2
GTP binding protein 2
chr12_+_122064673 0.35 ENST00000537188.1
ORAI1
ORAI calcium release-activated calcium modulator 1
chr8_-_57123815 0.34 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
PLAG1
pleiomorphic adenoma gene 1
chr6_+_2245982 0.34 ENST00000530346.1
ENST00000524770.1
ENST00000532124.1
ENST00000531092.1
ENST00000456943.2
ENST00000529893.1
GMDS-AS1
GMDS antisense RNA 1 (head to head)
chr1_-_156698181 0.34 ENST00000313146.6
ISG20L2
interferon stimulated exonuclease gene 20kDa-like 2
chr2_+_181845532 0.34 ENST00000602475.1
UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr3_-_39195037 0.33 ENST00000273153.5
CSRNP1
cysteine-serine-rich nuclear protein 1
chr19_+_36545833 0.32 ENST00000401500.2
ENST00000270301.7
ENST00000427823.2
WDR62
WD repeat domain 62
chr19_+_56152361 0.32 ENST00000585995.1
ENST00000592996.1
ZNF581
CCDC106
zinc finger protein 581
coiled-coil domain containing 106
chr3_+_112930946 0.30 ENST00000462425.1
BOC
BOC cell adhesion associated, oncogene regulated
chr6_+_17281573 0.30 ENST00000379052.5
RBM24
RNA binding motif protein 24
chr11_+_64851729 0.30 ENST00000526791.1
ENST00000526945.1
ZFPL1
zinc finger protein-like 1
chr5_+_14143728 0.29 ENST00000344204.4
ENST00000537187.1
TRIO
trio Rho guanine nucleotide exchange factor
chr17_-_42276574 0.29 ENST00000589805.1
ATXN7L3
ataxin 7-like 3
chr9_+_103189405 0.29 ENST00000395067.2
MSANTD3
Myb/SANT-like DNA-binding domain containing 3
chr12_-_49453557 0.29 ENST00000547610.1
KMT2D
lysine (K)-specific methyltransferase 2D
chr12_-_117319236 0.29 ENST00000257572.5
HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr14_+_103851712 0.28 ENST00000440884.3
ENST00000416682.2
ENST00000429436.2
ENST00000303622.9
MARK3
MAP/microtubule affinity-regulating kinase 3
chr11_+_76092353 0.28 ENST00000530460.1
ENST00000321844.4
RP11-111M22.2
Homo sapiens putative uncharacterized protein FLJ37770-like (LOC100506127), mRNA.
chr17_+_27920486 0.28 ENST00000394859.3
ANKRD13B
ankyrin repeat domain 13B
chr2_-_46769694 0.28 ENST00000522587.1
ATP6V1E2
ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2
chr11_-_75236867 0.28 ENST00000376282.3
ENST00000336898.3
GDPD5
glycerophosphodiester phosphodiesterase domain containing 5
chr17_+_54671047 0.28 ENST00000332822.4
NOG
noggin
chr10_+_104404218 0.27 ENST00000302424.7
TRIM8
tripartite motif containing 8
chr19_+_36606354 0.27 ENST00000589996.1
ENST00000591296.1
TBCB
tubulin folding cofactor B
chr5_-_176778523 0.27 ENST00000513877.1
ENST00000515209.1
ENST00000514458.1
ENST00000502560.1
LMAN2
lectin, mannose-binding 2
chr8_-_67525524 0.27 ENST00000517885.1
MYBL1
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr20_-_48532019 0.27 ENST00000289431.5
SPATA2
spermatogenesis associated 2
chr1_+_43148625 0.26 ENST00000436427.1
YBX1
Y box binding protein 1
chr12_-_57400227 0.26 ENST00000300101.2
ZBTB39
zinc finger and BTB domain containing 39
chr16_-_2059797 0.26 ENST00000563630.1
ZNF598
zinc finger protein 598
chr1_+_11539204 0.25 ENST00000294484.6
ENST00000389575.3
PTCHD2
patched domain containing 2
chr16_-_2059748 0.25 ENST00000562103.1
ENST00000431526.1
ZNF598
zinc finger protein 598
chr19_-_46476791 0.25 ENST00000263257.5
NOVA2
neuro-oncological ventral antigen 2
chr20_+_3767547 0.25 ENST00000344256.6
ENST00000379598.5
CDC25B
cell division cycle 25B
chr11_-_89224638 0.24 ENST00000535633.1
ENST00000263317.4
NOX4
NADPH oxidase 4
chr8_-_141645645 0.24 ENST00000519980.1
ENST00000220592.5
AGO2
argonaute RISC catalytic component 2
chr11_-_75141206 0.24 ENST00000376292.4
KLHL35
kelch-like family member 35
chr22_-_39096661 0.24 ENST00000216039.5
JOSD1
Josephin domain containing 1
chr17_+_43299241 0.23 ENST00000328118.3
FMNL1
formin-like 1
chr11_+_64851666 0.23 ENST00000525509.1
ENST00000294258.3
ENST00000526334.1
ZFPL1
zinc finger protein-like 1
chr14_+_53019822 0.23 ENST00000321662.6
GPR137C
G protein-coupled receptor 137C
chr1_-_40237020 0.22 ENST00000327582.5
OXCT2
3-oxoacid CoA transferase 2
chr9_+_103189458 0.22 ENST00000398977.2
MSANTD3
Myb/SANT-like DNA-binding domain containing 3
chr14_-_103523745 0.22 ENST00000361246.2
CDC42BPB
CDC42 binding protein kinase beta (DMPK-like)
chr22_+_29279552 0.22 ENST00000544604.2
ZNRF3
zinc and ring finger 3
chr10_-_44070016 0.22 ENST00000374446.2
ENST00000426961.1
ENST00000535642.1
ZNF239
zinc finger protein 239
chr19_-_36606181 0.21 ENST00000221859.4
POLR2I
polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
chr19_+_35491174 0.21 ENST00000317991.5
ENST00000504615.2
GRAMD1A
GRAM domain containing 1A
chr22_+_41487711 0.21 ENST00000263253.7
EP300
E1A binding protein p300
chr10_+_75545391 0.21 ENST00000604524.1
ENST00000605216.1
ENST00000398706.2
ZSWIM8
zinc finger, SWIM-type containing 8
chrX_+_12156582 0.21 ENST00000380682.1
FRMPD4
FERM and PDZ domain containing 4
chr12_-_29936731 0.21 ENST00000552618.1
ENST00000539277.1
ENST00000551659.1
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr20_-_56284816 0.21 ENST00000395819.3
ENST00000341744.3
PMEPA1
prostate transmembrane protein, androgen induced 1
chr12_+_7037461 0.21 ENST00000396684.2
ATN1
atrophin 1
chr6_+_1389989 0.21 ENST00000259806.1
FOXF2
forkhead box F2
chr14_+_23564700 0.21 ENST00000554203.1
C14orf119
chromosome 14 open reading frame 119
chr6_+_125474992 0.21 ENST00000528193.1
TPD52L1
tumor protein D52-like 1
chr2_+_220306238 0.21 ENST00000435853.1
SPEG
SPEG complex locus
chr17_+_6544356 0.20 ENST00000574838.1
TXNDC17
thioredoxin domain containing 17
chr1_+_3689325 0.20 ENST00000444870.2
ENST00000452264.1
SMIM1
small integral membrane protein 1 (Vel blood group)
chr1_-_32801825 0.20 ENST00000329421.7
MARCKSL1
MARCKS-like 1
chr6_-_91296737 0.20 ENST00000369332.3
ENST00000369329.3
MAP3K7
mitogen-activated protein kinase kinase kinase 7
chr19_-_46148820 0.20 ENST00000587152.1
EML2
echinoderm microtubule associated protein like 2
chr22_+_19419425 0.20 ENST00000333130.3
MRPL40
mitochondrial ribosomal protein L40
chr19_-_10341948 0.20 ENST00000590320.1
ENST00000592342.1
ENST00000588952.1
S1PR2
DNMT1
sphingosine-1-phosphate receptor 2
DNA (cytosine-5-)-methyltransferase 1
chr10_+_115803650 0.20 ENST00000369295.2
ADRB1
adrenoceptor beta 1
chr12_-_93835665 0.20 ENST00000552442.1
ENST00000550657.1
UBE2N
ubiquitin-conjugating enzyme E2N
chr20_-_1447467 0.19 ENST00000353088.2
ENST00000350991.4
NSFL1C
NSFL1 (p97) cofactor (p47)
chr19_+_56152262 0.19 ENST00000325333.5
ENST00000590190.1
ZNF580
zinc finger protein 580
chr19_-_4124079 0.19 ENST00000394867.4
ENST00000262948.5
MAP2K2
mitogen-activated protein kinase kinase 2
chr20_-_39317868 0.19 ENST00000373313.2
MAFB
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
chr19_+_36545781 0.19 ENST00000388999.3
WDR62
WD repeat domain 62
chr10_+_75545329 0.19 ENST00000604729.1
ENST00000603114.1
ZSWIM8
zinc finger, SWIM-type containing 8
chr17_-_29151686 0.19 ENST00000544695.1
CRLF3
cytokine receptor-like factor 3
chr3_+_184097836 0.19 ENST00000204604.1
ENST00000310236.3
CHRD
chordin
chr14_-_77787198 0.19 ENST00000261534.4
POMT2
protein-O-mannosyltransferase 2
chr16_+_57769635 0.19 ENST00000379661.3
ENST00000562592.1
ENST00000566726.1
KATNB1
katanin p80 (WD repeat containing) subunit B 1
chr1_-_27693349 0.19 ENST00000374040.3
ENST00000357582.2
ENST00000493901.1
MAP3K6
mitogen-activated protein kinase kinase kinase 6
chr9_+_100745615 0.19 ENST00000339399.4
ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr1_+_43855560 0.18 ENST00000562955.1
SZT2
seizure threshold 2 homolog (mouse)
chr17_-_42277203 0.18 ENST00000587097.1
ATXN7L3
ataxin 7-like 3
chr1_+_226411319 0.18 ENST00000542034.1
ENST00000366810.5
MIXL1
Mix paired-like homeobox
chr2_+_5832799 0.18 ENST00000322002.3
SOX11
SRY (sex determining region Y)-box 11
chr20_-_30310797 0.18 ENST00000422920.1
BCL2L1
BCL2-like 1
chr6_+_42981922 0.18 ENST00000326974.4
ENST00000244670.8
KLHDC3
kelch domain containing 3
chr19_+_18496957 0.18 ENST00000252809.3
GDF15
growth differentiation factor 15
chr15_-_80215984 0.18 ENST00000485386.1
ENST00000479961.1
ST20
ST20-MTHFS
suppressor of tumorigenicity 20
ST20-MTHFS readthrough
chr3_+_14989076 0.18 ENST00000413118.1
ENST00000425241.1
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr2_-_219537134 0.18 ENST00000295704.2
RNF25
ring finger protein 25
chr5_+_76506706 0.18 ENST00000340978.3
ENST00000346042.3
ENST00000264917.5
ENST00000342343.4
ENST00000333194.4
PDE8B
phosphodiesterase 8B
chr12_+_122516626 0.18 ENST00000319080.7
MLXIP
MLX interacting protein
chr9_+_132597722 0.18 ENST00000372429.3
ENST00000315480.4
ENST00000358355.1
USP20
ubiquitin specific peptidase 20
chr8_+_37654424 0.18 ENST00000315215.7
GPR124
G protein-coupled receptor 124
chr19_-_49622348 0.18 ENST00000408991.2
C19orf73
chromosome 19 open reading frame 73
chr1_+_179851893 0.18 ENST00000531630.2
TOR1AIP1
torsin A interacting protein 1
chr16_-_28074822 0.18 ENST00000395724.3
ENST00000380898.2
ENST00000447459.2
GSG1L
GSG1-like
chr17_+_36861735 0.18 ENST00000378137.5
ENST00000325718.7
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr19_+_36208877 0.18 ENST00000420124.1
ENST00000222270.7
ENST00000341701.1
KMT2B
Histone-lysine N-methyltransferase 2B
chr14_+_103243813 0.18 ENST00000560371.1
ENST00000347662.4
ENST00000392745.2
ENST00000539721.1
ENST00000560463.1
TRAF3
TNF receptor-associated factor 3
chr17_-_80231557 0.17 ENST00000392334.2
ENST00000314028.6
CSNK1D
casein kinase 1, delta
chr3_+_133292851 0.17 ENST00000503932.1
CDV3
CDV3 homolog (mouse)
chr20_-_47804894 0.17 ENST00000371828.3
ENST00000371856.2
ENST00000360426.4
ENST00000347458.5
ENST00000340954.7
ENST00000371802.1
ENST00000371792.1
ENST00000437404.2
STAU1
staufen double-stranded RNA binding protein 1
chr5_-_176900610 0.17 ENST00000477391.2
ENST00000393565.1
ENST00000309007.5
DBN1
drebrin 1
chr11_+_65383227 0.17 ENST00000355703.3
PCNXL3
pecanex-like 3 (Drosophila)
chr11_-_67141090 0.17 ENST00000312438.7
CLCF1
cardiotrophin-like cytokine factor 1
chr5_+_167718604 0.17 ENST00000265293.4
WWC1
WW and C2 domain containing 1
chr4_-_170192000 0.17 ENST00000502315.1
SH3RF1
SH3 domain containing ring finger 1
chr17_-_41623259 0.17 ENST00000538265.1
ENST00000591713.1
ETV4
ets variant 4
chr11_-_2160611 0.16 ENST00000416167.2
IGF2
insulin-like growth factor 2 (somatomedin A)
chr11_+_111473108 0.16 ENST00000304987.3
SIK2
salt-inducible kinase 2
chr22_-_42739533 0.16 ENST00000515426.1
TCF20
transcription factor 20 (AR1)
chr4_+_6202448 0.16 ENST00000508601.1
RP11-586D19.1
RP11-586D19.1
chr2_-_208031542 0.16 ENST00000423015.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chrX_+_68725084 0.16 ENST00000252338.4
FAM155B
family with sequence similarity 155, member B
chr20_-_1447547 0.16 ENST00000476071.1
NSFL1C
NSFL1 (p97) cofactor (p47)
chr3_+_184097905 0.16 ENST00000450923.1
CHRD
chordin
chr20_+_34894247 0.16 ENST00000373913.3
DLGAP4
discs, large (Drosophila) homolog-associated protein 4
chr19_+_35491330 0.16 ENST00000411896.2
ENST00000424536.2
GRAMD1A
GRAM domain containing 1A
chr16_+_2732476 0.16 ENST00000301738.4
ENST00000564195.1
KCTD5
potassium channel tetramerization domain containing 5
chr17_-_41623009 0.16 ENST00000393664.2
ETV4
ets variant 4
chr12_+_50479101 0.16 ENST00000551966.1
SMARCD1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr16_+_67062996 0.16 ENST00000561924.2
CBFB
core-binding factor, beta subunit
chr3_+_71803201 0.16 ENST00000304411.2
GPR27
G protein-coupled receptor 27
chr5_+_156569944 0.16 ENST00000521769.1
ITK
IL2-inducible T-cell kinase
chr15_+_90544532 0.16 ENST00000268154.4
ZNF710
zinc finger protein 710
chr6_+_44238203 0.16 ENST00000451188.2
TMEM151B
transmembrane protein 151B
chr8_-_93115445 0.16 ENST00000523629.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr19_-_11373128 0.16 ENST00000294618.7
DOCK6
dedicator of cytokinesis 6
chr19_+_38879061 0.16 ENST00000587013.1
SPRED3
sprouty-related, EVH1 domain containing 3
chr19_+_49622646 0.15 ENST00000334186.4
PPFIA3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr16_+_89787393 0.15 ENST00000289816.5
ENST00000568064.1
ZNF276
zinc finger protein 276
chr1_+_156698708 0.15 ENST00000519086.1
RRNAD1
ribosomal RNA adenine dimethylase domain containing 1
chr20_-_48532046 0.15 ENST00000543716.1
SPATA2
spermatogenesis associated 2
chr17_-_48227877 0.15 ENST00000316878.6
PPP1R9B
protein phosphatase 1, regulatory subunit 9B
chr17_+_43299156 0.15 ENST00000331495.3
FMNL1
formin-like 1
chr7_+_129251531 0.15 ENST00000393232.1
ENST00000353868.4
ENST00000539636.1
ENST00000454688.1
ENST00000223190.4
ENST00000311967.2
NRF1
nuclear respiratory factor 1
chr19_-_663171 0.15 ENST00000606896.1
ENST00000589762.2
RNF126
ring finger protein 126
chr1_+_153606513 0.15 ENST00000368694.3
CHTOP
chromatin target of PRMT1
chr3_+_184098065 0.15 ENST00000348986.3
CHRD
chordin
chrY_+_2803322 0.15 ENST00000383052.1
ENST00000155093.3
ENST00000449237.1
ENST00000443793.1
ZFY
zinc finger protein, Y-linked
chr22_-_50746027 0.15 ENST00000425954.1
ENST00000449103.1
PLXNB2
plexin B2
chr17_+_80477571 0.15 ENST00000335255.5
FOXK2
forkhead box K2
chr11_-_64545941 0.15 ENST00000377387.1
SF1
splicing factor 1
chr15_-_72766533 0.15 ENST00000562573.1
RP11-1007O24.3
RP11-1007O24.3
chr1_+_156698743 0.15 ENST00000524343.1
RRNAD1
ribosomal RNA adenine dimethylase domain containing 1
chr14_-_74416829 0.15 ENST00000534936.1
FAM161B
family with sequence similarity 161, member B
chr9_-_131644202 0.15 ENST00000320665.6
ENST00000436267.2
CCBL1
cysteine conjugate-beta lyase, cytoplasmic
chr1_+_110009215 0.15 ENST00000369872.3
SYPL2
synaptophysin-like 2
chr9_-_136933615 0.15 ENST00000371834.2
BRD3
bromodomain containing 3
chr1_-_43855479 0.14 ENST00000290663.6
ENST00000372457.4
MED8
mediator complex subunit 8
chr13_-_46626820 0.14 ENST00000428921.1
ZC3H13
zinc finger CCCH-type containing 13
chr11_+_67033881 0.14 ENST00000308595.5
ENST00000526285.1
ADRBK1
adrenergic, beta, receptor kinase 1
chr9_+_34989638 0.14 ENST00000453597.3
ENST00000335998.3
ENST00000312316.5
DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr12_+_50478977 0.14 ENST00000381513.4
SMARCD1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr3_-_196295437 0.14 ENST00000429115.1
WDR53
WD repeat domain 53
chr10_-_17659357 0.14 ENST00000326961.6
ENST00000361271.3
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr17_-_27949911 0.14 ENST00000492276.2
ENST00000345068.5
ENST00000584602.1
CORO6
coronin 6
chr2_+_48541776 0.14 ENST00000413569.1
ENST00000340553.3
FOXN2
forkhead box N2
chr14_+_74416989 0.14 ENST00000334571.2
ENST00000554920.1
COQ6
coenzyme Q6 monooxygenase
chr5_+_10564432 0.14 ENST00000296657.5
ANKRD33B
ankyrin repeat domain 33B
chr16_+_67226019 0.14 ENST00000379378.3
E2F4
E2F transcription factor 4, p107/p130-binding
chr5_+_176853702 0.13 ENST00000507633.1
ENST00000393576.3
ENST00000355958.5
ENST00000528793.1
ENST00000512684.1
GRK6
G protein-coupled receptor kinase 6
chr15_+_91073193 0.13 ENST00000560098.1
ENST00000268184.6
CRTC3
CREB regulated transcription coactivator 3
chr11_-_2160180 0.13 ENST00000381406.4
IGF2
insulin-like growth factor 2 (somatomedin A)
chr10_-_11653753 0.13 ENST00000609104.1
USP6NL
USP6 N-terminal like
chr16_-_1823114 0.13 ENST00000177742.3
ENST00000397375.2
MRPS34
mitochondrial ribosomal protein S34
chr4_+_53525573 0.13 ENST00000503051.1
USP46-AS1
USP46 antisense RNA 1
chr12_-_48213568 0.13 ENST00000080059.7
ENST00000354334.3
ENST00000430670.1
ENST00000552960.1
ENST00000440293.1
HDAC7
histone deacetylase 7
chr17_+_48133459 0.13 ENST00000320031.8
ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr10_+_106400859 0.13 ENST00000369701.3
SORCS3
sortilin-related VPS10 domain containing receptor 3
chr11_+_46354455 0.13 ENST00000343674.6
DGKZ
diacylglycerol kinase, zeta
chr1_-_19811996 0.13 ENST00000264203.3
ENST00000401084.2
CAPZB
capping protein (actin filament) muscle Z-line, beta
chr16_+_3019246 0.13 ENST00000318782.8
ENST00000293978.8
PAQR4
progestin and adipoQ receptor family member IV
chr19_+_4007644 0.13 ENST00000262971.2
PIAS4
protein inhibitor of activated STAT, 4
chr3_-_128206759 0.13 ENST00000430265.2
GATA2
GATA binding protein 2
chr13_-_80915059 0.13 ENST00000377104.3
SPRY2
sprouty homolog 2 (Drosophila)
chr3_+_49591881 0.13 ENST00000296452.4
BSN
bassoon presynaptic cytomatrix protein
chr1_-_19811962 0.13 ENST00000375142.1
ENST00000264202.6
CAPZB
capping protein (actin filament) muscle Z-line, beta
chr3_-_183979251 0.13 ENST00000296238.3
CAMK2N2
calcium/calmodulin-dependent protein kinase II inhibitor 2

Network of associatons between targets according to the STRING database.

First level regulatory network of MBD2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0021553 olfactory nerve development(GO:0021553)
0.2 0.5 GO:0021919 BMP signaling pathway involved in spinal cord dorsal/ventral patterning(GO:0021919)
0.2 0.5 GO:0061183 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129) dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) renal vesicle induction(GO:0072034) regulation of testosterone biosynthetic process(GO:2000224)
0.1 0.4 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.1 0.5 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.1 0.2 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.1 0.2 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.1 0.2 GO:0035283 rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.1 0.6 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 0.2 GO:0061386 noradrenergic neuron differentiation(GO:0003357) closure of optic fissure(GO:0061386)
0.1 0.2 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
0.1 0.3 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.1 0.2 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 0.2 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.1 0.2 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.1 0.2 GO:1903721 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721)
0.0 0.3 GO:0001555 oocyte growth(GO:0001555)
0.0 0.2 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.0 0.4 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.1 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.0 0.3 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
0.0 0.1 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0 0.3 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0006117 acetaldehyde metabolic process(GO:0006117)
0.0 0.2 GO:0021849 neuroblast division in subventricular zone(GO:0021849)
0.0 0.2 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.0 0.1 GO:0048007 synaptic vesicle recycling via endosome(GO:0036466) antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 0.3 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.0 0.2 GO:1904100 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.0 0.2 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.0 0.2 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.0 0.1 GO:0071922 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.2 GO:0090625 siRNA loading onto RISC involved in RNA interference(GO:0035087) mRNA cleavage involved in gene silencing by siRNA(GO:0090625)
0.0 0.1 GO:0010725 regulation of primitive erythrocyte differentiation(GO:0010725) eosinophil fate commitment(GO:0035854)
0.0 0.4 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.1 GO:0042137 sequestering of neurotransmitter(GO:0042137)
0.0 0.2 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.0 0.2 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.0 0.1 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.0 0.2 GO:0090170 regulation of Golgi inheritance(GO:0090170)
0.0 0.2 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.0 0.2 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.3 GO:2000467 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0 0.1 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.0 0.2 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.3 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.1 GO:0042631 cellular response to water deprivation(GO:0042631)
0.0 0.2 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
0.0 0.5 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.2 GO:0090309 maintenance of DNA methylation(GO:0010216) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.1 GO:1902174 positive regulation of keratinocyte apoptotic process(GO:1902174)
0.0 0.1 GO:0070535 histone H2A K63-linked ubiquitination(GO:0070535)
0.0 0.2 GO:0023041 neuronal signal transduction(GO:0023041)
0.0 0.4 GO:0051014 actin filament severing(GO:0051014)
0.0 0.1 GO:0061113 pancreas morphogenesis(GO:0061113)
0.0 0.1 GO:0042335 cuticle development(GO:0042335)
0.0 0.1 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.0 0.1 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
0.0 0.2 GO:0051013 microtubule severing(GO:0051013)
0.0 0.2 GO:0048295 positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.0 0.1 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
0.0 0.1 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.0 0.3 GO:0060252 positive regulation of glial cell proliferation(GO:0060252)
0.0 0.1 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.0 0.1 GO:0097065 anterior head development(GO:0097065) regulation of anterior head development(GO:2000742) positive regulation of anterior head development(GO:2000744)
0.0 0.2 GO:0007144 female meiosis I(GO:0007144)
0.0 0.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.3 GO:0040034 regulation of development, heterochronic(GO:0040034) regulation of timing of cell differentiation(GO:0048505)
0.0 0.3 GO:0002115 store-operated calcium entry(GO:0002115)
0.0 0.1 GO:0010624 regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626)
0.0 0.1 GO:1902499 positive regulation of protein autoubiquitination(GO:1902499)
0.0 0.1 GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609)
0.0 0.1 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.0 0.2 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0 0.5 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.3 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.0 GO:0071629 cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071629)
0.0 0.5 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 0.4 GO:0031935 regulation of chromatin silencing(GO:0031935)
0.0 0.1 GO:1902683 positive regulation of long-term neuronal synaptic plasticity(GO:0048170) regulation of receptor localization to synapse(GO:1902683)
0.0 0.0 GO:0061582 intestinal epithelial cell migration(GO:0061582)
0.0 0.1 GO:0080009 mRNA methylation(GO:0080009)
0.0 0.2 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.0 0.2 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 0.3 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.3 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 0.1 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.0 0.1 GO:0048073 regulation of eye pigmentation(GO:0048073)
0.0 0.5 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.1 GO:0045075 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0 0.2 GO:0002934 desmosome organization(GO:0002934)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.1 0.2 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.1 0.6 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.1 0.4 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.0 0.2 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.0 0.1 GO:0035525 NF-kappaB p50/p65 complex(GO:0035525)
0.0 0.3 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.3 GO:0071203 WASH complex(GO:0071203)
0.0 0.5 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.1 GO:0045293 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.0 0.1 GO:0034667 integrin alpha3-beta1 complex(GO:0034667)
0.0 0.5 GO:0000124 SAGA complex(GO:0000124)
0.0 0.1 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.4 GO:0032059 bleb(GO:0032059)
0.0 0.3 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.1 GO:0016938 kinesin I complex(GO:0016938)
0.0 0.1 GO:0045298 tubulin complex(GO:0045298)
0.0 0.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.5 GO:0071011 precatalytic spliceosome(GO:0071011)
0.0 0.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 0.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.1 GO:0061689 tricellular tight junction(GO:0061689)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.1 0.2 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.1 0.3 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.1 0.2 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.1 0.2 GO:0098808 mRNA cap binding(GO:0098808)
0.1 0.2 GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity(GO:0030272)
0.1 0.2 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.1 0.2 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.1 0.5 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.2 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.0 0.5 GO:0019826 oxygen sensor activity(GO:0019826)
0.0 0.2 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 0.2 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.1 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.0 0.6 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.0 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.0 0.7 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.1 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.0 0.4 GO:0005537 mannose binding(GO:0005537)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.2 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 0.2 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.1 GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
0.0 0.2 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.1 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 0.2 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.2 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.6 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.2 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.1 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.4 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.1 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.0 0.6 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.5 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.2 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.1 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.2 GO:0050321 tau-protein kinase activity(GO:0050321)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.2 PID BMP PATHWAY BMP receptor signaling
0.0 0.7 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.0 PID IL5 PATHWAY IL5-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.4 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.4 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.1 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.4 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.2 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.1 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.4 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.3 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition