ISMARA results: MBD2

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for MBD2

Z-value: 1.16

Motif logo

Transcription factors associated with MBD2

Gene Symbol	Gene ID	Gene Info
MBD2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000134046.7	methyl-CpG binding domain protein 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MBD2	hg19_v2_chr18_-_51751132_51751158	-0.91	1.2e-02	Click!

Activity profile of MBD2 motif

Sorted Z-values of MBD2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_74212073 Show fit	1.90	ENST00000441217.1	AC073046.25 Ensembl NCBI GeneCards UniProt NextProt Show fit	AC073046.25
chr19_-_14201507 Show fit	1.04	ENST00000533683.2	SAMD1 Ensembl NCBI GeneCards UniProt NextProt Show fit	sterile alpha motif domain containing 1
chr19_-_14201776 Show fit	0.69	ENST00000269724.5	SAMD1 Ensembl NCBI GeneCards UniProt NextProt Show fit	sterile alpha motif domain containing 1
chr8_+_61592073 Show fit	0.53	ENST00000526846.1	CHD7 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromodomain helicase DNA binding protein 7
chr16_+_2022036 Show fit	0.50	ENST00000568546.1	TBL3 Ensembl NCBI GeneCards UniProt NextProt Show fit	transducin (beta)-like 3
chr1_-_22469459 Show fit	0.49	ENST00000290167.6	WNT4 Ensembl NCBI GeneCards UniProt NextProt Show fit	wingless-type MMTV integration site family, member 4
chr18_-_72264805 Show fit	0.46	ENST00000577806.1	LINC00909 Ensembl NCBI GeneCards UniProt NextProt Show fit	long intergenic non-protein coding RNA 909
chr22_-_19419205 Show fit	0.46	ENST00000340170.4 ENST00000263208.5	HIRA Ensembl NCBI GeneCards UniProt NextProt Show fit	histone cell cycle regulator
chr10_+_104180580 Show fit	0.46	ENST00000425536.1	FBXL15 Ensembl NCBI GeneCards UniProt NextProt Show fit	F-box and leucine-rich repeat protein 15
chr16_+_2059872 Show fit	0.45	ENST00000567649.1	NPW Ensembl NCBI GeneCards UniProt NextProt Show fit	neuropeptide W

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of MBD2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0021553	olfactory nerve development(GO:0021553)
0.1	0.6	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.2	0.5	GO:0021919	BMP signaling pathway involved in spinal cord dorsal/ventral patterning(GO:0021919)
0.2	0.5	GO:0061183	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129) dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) renal vesicle induction(GO:0072034) regulation of testosterone biosynthetic process(GO:2000224)
0.1	0.5	GO:0072344	rescue of stalled ribosome(GO:0072344)
0.0	0.5	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.5	GO:0016578	histone deubiquitination(GO:0016578)
0.0	0.5	GO:0050667	homocysteine metabolic process(GO:0050667)
0.0	0.5	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1	0.4	GO:1901421	positive regulation of response to alcohol(GO:1901421)

Showing 1 to 10 of 91 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)
0.1	0.5	GO:0034388	Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0	0.5	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	0.5	GO:0000124	SAGA complex(GO:0000124)
0.0	0.5	GO:0071011	precatalytic spliceosome(GO:0071011)
0.1	0.4	GO:1990730	VCP-NSFL1C complex(GO:1990730)
0.0	0.4	GO:0032059	bleb(GO:0032059)
0.0	0.4	GO:0071564	npBAF complex(GO:0071564)
0.0	0.3	GO:1990130	Iml1 complex(GO:1990130)
0.0	0.3	GO:0071203	WASH complex(GO:0071203)

Showing 1 to 10 of 26 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.7	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.6	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.6	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.6	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1	0.5	GO:0045545	syndecan binding(GO:0045545)
0.0	0.5	GO:0019826	oxygen sensor activity(GO:0019826)
0.0	0.5	GO:0030515	snoRNA binding(GO:0030515)
0.0	0.5	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.0	0.4	GO:0005537	mannose binding(GO:0005537)
0.0	0.4	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)

Showing 1 to 10 of 49 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
1.2	PID BMP PATHWAY	BMP receptor signaling
0.7	PID CD40 PATHWAY	CD40/CD40L signaling
0.2	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	PID IL5 PATHWAY	IL5-mediated signaling events

Showing 1 to 4 of 4 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
0.4	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.4	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.4	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.4	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.3	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.3	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.2	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.2	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade

Showing 1 to 10 of 12 entries

Results for MBD2

Z-value: 1.16

Motif logo

Transcription factors associated with MBD2

Activity-expression correlation:

Activity profile of MBD2 motif

Sorted Z-values of MBD2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of MBD2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: