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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for MAFK
Z-value: 1.38
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Transcription factors associated with MAFK
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MAFK | hg19_v2_chr7_+_1570322_1570360 | -0.89 | 1.7e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_113953705 Show fit | 1.87 |
ENST00000452675.1
|
RP11-367G18.1 |
|
| chr7_+_141490017 Show fit | 1.27 |
ENST00000247883.4
|
taste receptor, type 2, member 5 |
|
| chr7_-_17598506 Show fit | 0.89 |
ENST00000451792.1
|
AC017060.1 |
|
| chr1_+_87012922 Show fit | 0.73 |
ENST00000263723.5
|
chloride channel accessory 4 |
|
| chr10_-_96829246 Show fit | 0.70 |
ENST00000371270.3
ENST00000535898.1 ENST00000539050.1 |
cytochrome P450, family 2, subfamily C, polypeptide 8 |
|
| chr2_+_90458201 Show fit | 0.68 |
ENST00000603238.1
|
Uncharacterized protein |
|
| chr17_+_50939459 Show fit | 0.64 |
ENST00000412360.1
|
Uncharacterized protein |
|
| chr6_-_146057144 Show fit | 0.63 |
ENST00000367519.3
|
epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) |
|
| chr1_+_160709055 Show fit | 0.62 |
ENST00000368043.3
ENST00000368042.3 ENST00000458602.2 ENST00000458104.2 |
SLAM family member 7 |
|
| chr11_-_104817919 Show fit | 0.60 |
ENST00000533252.1
|
caspase 4, apoptosis-related cysteine peptidase |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAFK
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | GO:0007635 | chemosensory behavior(GO:0007635) |
| 0.1 | 1.1 | GO:0071395 | response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395) |
| 0.1 | 0.8 | GO:0002933 | lipid hydroxylation(GO:0002933) |
| 0.0 | 0.8 | GO:0071157 | negative regulation of cell cycle arrest(GO:0071157) |
| 0.1 | 0.7 | GO:1903265 | positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265) |
| 0.1 | 0.7 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.1 | 0.6 | GO:0070444 | oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445) |
| 0.0 | 0.6 | GO:0035745 | T-helper 2 cell cytokine production(GO:0035745) |
| 0.0 | 0.6 | GO:0032007 | negative regulation of TOR signaling(GO:0032007) |
| 0.1 | 0.5 | GO:2000501 | regulation of natural killer cell chemotaxis(GO:2000501) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 0.7 | GO:0097169 | AIM2 inflammasome complex(GO:0097169) |
| 0.0 | 0.7 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 0.6 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.0 | 0.4 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.0 | 0.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 0.4 | GO:0046540 | U4/U6 x U5 tri-snRNP complex(GO:0046540) |
| 0.0 | 0.4 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 0.4 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.1 | 0.3 | GO:0000811 | GINS complex(GO:0000811) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.0 | 1.0 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.0 | 1.0 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 0.8 | GO:0047086 | phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086) |
| 0.1 | 0.8 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.0 | 0.8 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 0.7 | GO:0033695 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
| 0.0 | 0.7 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.7 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.0 | 0.6 | GO:0045294 | alpha-catenin binding(GO:0045294) gamma-catenin binding(GO:0045295) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 0.9 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.9 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.7 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.4 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.0 | 0.4 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 0.2 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.2 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 0.1 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 0.9 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.9 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 0.9 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 0.8 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.7 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 0.0 | 0.6 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.6 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 0.5 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 0.5 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |