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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for MAFF_MAFG
Z-value: 1.21
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Transcription factors associated with MAFF_MAFG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MAFF | hg19_v2_chr22_+_38597889_38598021 | -0.53 | 2.8e-01 | Click! |
| MAFG | hg19_v2_chr17_-_79885576_79885624 | -0.43 | 3.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAFF_MAFG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.1 | 1.0 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.0 | 0.9 | GO:0036297 | interstrand cross-link repair(GO:0036297) |
| 0.2 | 0.8 | GO:1905167 | positive regulation of lysosomal protein catabolic process(GO:1905167) |
| 0.1 | 0.8 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
| 0.1 | 0.7 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.0 | 0.7 | GO:0046520 | sphingoid biosynthetic process(GO:0046520) |
| 0.0 | 0.7 | GO:0060124 | positive regulation of growth hormone secretion(GO:0060124) |
| 0.0 | 0.7 | GO:0042832 | defense response to protozoan(GO:0042832) |
| 0.1 | 0.6 | GO:0035694 | mitochondrial protein catabolic process(GO:0035694) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.1 | 0.7 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.0 | 0.7 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
| 0.0 | 0.6 | GO:0017059 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 0.1 | 0.4 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
| 0.0 | 0.3 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
| 0.0 | 0.3 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.0 | 0.3 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 0.0 | 0.3 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.0 | 0.3 | GO:0098563 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | GO:0004177 | aminopeptidase activity(GO:0004177) |
| 0.3 | 0.8 | GO:0016964 | alpha-2 macroglobulin receptor activity(GO:0016964) |
| 0.0 | 0.8 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.0 | 0.7 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.0 | 0.7 | GO:0008409 | 5'-3' exonuclease activity(GO:0008409) |
| 0.0 | 0.7 | GO:0042287 | MHC protein binding(GO:0042287) |
| 0.1 | 0.6 | GO:0016454 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
| 0.0 | 0.6 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.0 | 0.6 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.0 | 0.6 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.0 | 0.5 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.5 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.4 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 0.3 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.2 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.0 | 0.2 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 0.2 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.2 | REACTOME INTEGRATION OF PROVIRUS | Genes involved in Integration of provirus |
| 0.0 | 0.2 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |