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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for MAFB
Z-value: 1.73
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Transcription factors associated with MAFB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MAFB | hg19_v2_chr20_-_39317868_39317884 | -0.00 | 9.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_+_32546485 Show fit | 1.59 |
ENST00000345122.3
ENST00000432921.1 ENST00000433497.1 |
Rho GTPase activating protein 5 |
|
| chr2_-_55277512 Show fit | 1.43 |
ENST00000402434.2
|
reticulon 4 |
|
| chr14_+_32546145 Show fit | 1.42 |
ENST00000556611.1
ENST00000539826.2 |
Rho GTPase activating protein 5 |
|
| chr2_-_55277692 Show fit | 1.38 |
ENST00000394611.2
|
reticulon 4 |
|
| chr6_-_75994025 Show fit | 1.26 |
ENST00000518161.1
|
transmembrane protein 30A |
|
| chr2_-_55277654 Show fit | 1.25 |
ENST00000337526.6
ENST00000317610.7 ENST00000357732.4 |
reticulon 4 |
|
| chr2_-_55277436 Show fit | 1.23 |
ENST00000354474.6
|
reticulon 4 |
|
| chr2_-_178129551 Show fit | 1.19 |
ENST00000430047.1
|
nuclear factor, erythroid 2-like 2 |
|
| chr2_+_191745560 Show fit | 1.16 |
ENST00000338435.4
|
glutaminase |
|
| chr14_-_54955721 Show fit | 1.06 |
ENST00000554908.1
|
glia maturation factor, beta |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAFB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 5.5 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 0.0 | 4.2 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.1 | 1.8 | GO:0070863 | positive regulation of protein exit from endoplasmic reticulum(GO:0070863) |
| 0.1 | 1.8 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.2 | 1.7 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 0.2 | 1.6 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 0.0 | 1.6 | GO:0010324 | membrane invagination(GO:0010324) |
| 0.0 | 1.6 | GO:0030879 | mammary gland development(GO:0030879) |
| 0.1 | 1.5 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
| 0.0 | 1.5 | GO:0006334 | nucleosome assembly(GO:0006334) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.2 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 4.2 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 2.0 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.1 | 1.8 | GO:0005652 | nuclear lamina(GO:0005652) |
| 0.1 | 1.5 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.1 | 1.5 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 1.5 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.1 | 1.4 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.1 | 1.3 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.1 | 1.3 | GO:0030126 | COPI vesicle coat(GO:0030126) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.9 | GO:0044389 | ubiquitin-like protein ligase binding(GO:0044389) |
| 0.1 | 4.4 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.1 | 2.2 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 2.1 | GO:0061733 | peptide-lysine-N-acetyltransferase activity(GO:0061733) |
| 0.1 | 1.9 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.2 | 1.6 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.0 | 1.5 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.1 | 1.4 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.0 | 1.4 | GO:0061650 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
| 0.2 | 1.2 | GO:0050115 | myosin-light-chain-phosphatase activity(GO:0050115) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.6 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 5.3 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 4.6 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 2.2 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 1.2 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 1.2 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.0 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 0.9 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 0.8 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.8 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.1 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.0 | 1.9 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 1.8 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 1.4 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.1 | 1.3 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 1.3 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 1.2 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 1.1 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.1 | 1.1 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.1 | 1.1 | REACTOME ACYL CHAIN REMODELLING OF PG | Genes involved in Acyl chain remodelling of PG |