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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for MAFA

Z-value: 0.63

Motif logo

Transcription factors associated with MAFA

Gene Symbol Gene ID Gene Info
ENSG00000182759.3 MAF bZIP transcription factor A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MAFAhg19_v2_chr8_-_144512576_144512576-0.542.7e-01Click!

Activity profile of MAFA motif

Sorted Z-values of MAFA motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_39258461 0.49 ENST00000440582.1
keratin associated protein 4-16, pseudogene
chr13_-_30951282 0.33 ENST00000420219.1
long intergenic non-protein coding RNA 426
chrX_-_153141783 0.33 ENST00000458029.1
L1 cell adhesion molecule
chr3_+_172361483 0.25 ENST00000598405.1
HCG1787166; PRO1163; Uncharacterized protein
chr11_+_777562 0.25 ENST00000530083.1
Protein LOC100506518
chr11_-_104817919 0.25 ENST00000533252.1
caspase 4, apoptosis-related cysteine peptidase
chr17_-_47925379 0.22 ENST00000352793.2
ENST00000334568.4
ENST00000398154.1
ENST00000436235.1
ENST00000326219.5
tachykinin 4 (hemokinin)
chr7_-_150754935 0.20 ENST00000297518.4
cyclin-dependent kinase 5
chr12_+_56546363 0.18 ENST00000551834.1
ENST00000552568.1
myosin, light chain 6B, alkali, smooth muscle and non-muscle
chr18_-_2982869 0.18 ENST00000584915.1
lipin 2
chr13_-_30951074 0.18 ENST00000416261.1
long intergenic non-protein coding RNA 426
chr12_-_123215306 0.17 ENST00000356987.2
ENST00000436083.2
hydroxycarboxylic acid receptor 1
chr6_+_7727030 0.17 ENST00000283147.6
bone morphogenetic protein 6
chr14_+_50779029 0.16 ENST00000245448.6
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
chr17_-_42019836 0.16 ENST00000225992.3
pancreatic polypeptide
chr17_+_31318886 0.16 ENST00000269053.3
ENST00000394638.1
sperm acrosome associated 3
chr19_+_38880695 0.15 ENST00000587947.1
ENST00000338502.4
sprouty-related, EVH1 domain containing 3
chr10_+_120967072 0.14 ENST00000392870.2
G protein-coupled receptor kinase 5
chr19_-_50464338 0.14 ENST00000426971.2
ENST00000447370.2
sialic acid binding Ig-like lectin 11
chr4_+_74606223 0.13 ENST00000307407.3
ENST00000401931.1
interleukin 8
chr17_-_17109579 0.13 ENST00000321560.3
phospholipase D family, member 6
chrX_-_47509994 0.12 ENST00000343894.4
ELK1, member of ETS oncogene family
chr13_-_103426081 0.11 ENST00000376022.1
ENST00000376021.4
testis expressed 30
chr9_+_100000717 0.11 ENST00000375205.2
ENST00000357054.1
ENST00000395220.1
ENST00000375202.2
ENST00000411667.2
coiled-coil domain containing 180
chr19_+_21541732 0.11 ENST00000311015.3
zinc finger protein 738
chr1_-_45956868 0.11 ENST00000451835.2
testis-specific kinase 2
chr4_+_6784401 0.10 ENST00000425103.1
ENST00000307659.5
KIAA0232
chr12_+_79258444 0.10 ENST00000261205.4
synaptotagmin I
chr7_-_155160629 0.10 ENST00000378120.5
B-cell acute lymphoblastic leukemia expressed
chr14_+_24605389 0.10 ENST00000382708.3
ENST00000561435.1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr14_+_24600484 0.10 ENST00000267426.5
fat storage-inducing transmembrane protein 1
chr7_-_151433342 0.10 ENST00000433631.2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr12_-_105478339 0.10 ENST00000424857.2
ENST00000258494.9
aldehyde dehydrogenase 1 family, member L2
chr13_-_28194541 0.10 ENST00000316334.3
ligand of numb-protein X 2
chr13_+_28194873 0.10 ENST00000302979.3
polymerase (RNA) I polypeptide D, 16kDa
chr9_-_28670283 0.09 ENST00000379992.2
leucine rich repeat and Ig domain containing 2
chr10_+_135122906 0.09 ENST00000368554.4
zinc finger protein 511
chr3_-_196439065 0.09 ENST00000399942.4
ENST00000409690.3
centrosomal protein 19kDa
chr11_+_111411384 0.09 ENST00000375615.3
ENST00000525126.1
ENST00000436913.2
ENST00000533265.1
layilin
chr5_+_138629628 0.09 ENST00000508689.1
ENST00000514528.1
matrin 3
chr5_+_138629337 0.09 ENST00000394805.3
ENST00000512876.1
ENST00000513678.1
matrin 3
chr2_+_85811525 0.09 ENST00000306384.4
vesicle-associated membrane protein 5
chr3_+_185304059 0.08 ENST00000427465.2
SUMO1/sentrin/SMT3 specific peptidase 2
chr2_+_33172221 0.08 ENST00000354476.3
latent transforming growth factor beta binding protein 1
chr19_+_33182823 0.08 ENST00000397061.3
nudix (nucleoside diphosphate linked moiety X)-type motif 19
chr19_+_21541777 0.08 ENST00000380870.4
ENST00000597810.1
ENST00000594245.1
zinc finger protein 738
chr10_-_135171510 0.08 ENST00000278025.4
ENST00000368552.3
fucose mutarotase
chr6_-_143832793 0.08 ENST00000438118.2
fucosidase, alpha-L- 2, plasma
chr4_-_22517620 0.08 ENST00000502482.1
ENST00000334304.5
G protein-coupled receptor 125
chr15_+_80696666 0.08 ENST00000303329.4
aryl-hydrocarbon receptor nuclear translocator 2
chr17_+_18759612 0.08 ENST00000432893.2
ENST00000414602.1
ENST00000574522.1
ENST00000570450.1
ENST00000419071.2
phosphoribosyl pyrophosphate synthetase-associated protein 2
chr12_+_79258547 0.08 ENST00000457153.2
synaptotagmin I
chr19_+_6740888 0.08 ENST00000596673.1
thyroid hormone receptor interactor 10
chr1_-_57045228 0.08 ENST00000371250.3
phosphatidic acid phosphatase type 2B
chr21_+_19617140 0.08 ENST00000299295.2
ENST00000338326.3
chondrolectin
chr19_+_18451439 0.07 ENST00000597431.2
pyroglutamyl-peptidase I
chr11_+_111412053 0.07 ENST00000530962.1
layilin
chr1_+_163039143 0.07 ENST00000531057.1
ENST00000527809.1
ENST00000367908.4
regulator of G-protein signaling 4
chr1_+_66458072 0.07 ENST00000423207.2
phosphodiesterase 4B, cAMP-specific
chr5_+_138629389 0.07 ENST00000504045.1
ENST00000504311.1
ENST00000502499.1
matrin 3
chr17_-_3796334 0.07 ENST00000381771.2
ENST00000348335.2
ENST00000158166.5
calcium/calmodulin-dependent protein kinase kinase 1, alpha
chr2_+_102624977 0.07 ENST00000441002.1
interleukin 1 receptor, type II
chr1_-_32403903 0.07 ENST00000344035.6
ENST00000356536.3
protein tyrosine phosphatase type IVA, member 2
chr13_-_103426112 0.06 ENST00000376032.4
ENST00000376029.3
testis expressed 30
chr16_-_89119355 0.06 ENST00000537498.1
CTD-2555A7.2
chr3_-_131736593 0.06 ENST00000514999.1
copine IV
chr14_+_81421921 0.06 ENST00000554263.1
ENST00000554435.1
thyroid stimulating hormone receptor
chr15_-_41047421 0.06 ENST00000560460.1
ENST00000338376.3
ENST00000560905.1
regulator of microtubule dynamics 3
chrX_+_68725084 0.06 ENST00000252338.4
family with sequence similarity 155, member B
chr7_-_30029574 0.06 ENST00000426154.1
ENST00000421434.1
ENST00000434476.2
secernin 1
chr6_-_143832820 0.06 ENST00000002165.6
fucosidase, alpha-L- 2, plasma
chr6_+_97372645 0.06 ENST00000536676.1
ENST00000544166.1
kelch-like family member 32
chrX_+_118892545 0.06 ENST00000343905.3
sosondowah ankyrin repeat domain family member D
chr3_+_141121164 0.06 ENST00000510338.1
ENST00000504673.1
zinc finger and BTB domain containing 38
chr7_-_30029367 0.06 ENST00000242059.5
secernin 1
chrX_-_106959631 0.06 ENST00000486554.1
ENST00000372390.4
TSC22 domain family, member 3
chr4_+_2470664 0.05 ENST00000314289.8
ENST00000541204.1
ENST00000502316.1
ENST00000507247.1
ENST00000509258.1
ENST00000511859.1
ring finger protein 4
chr14_-_54317532 0.05 ENST00000418927.1
AL162759.1
chr6_-_24489842 0.05 ENST00000230036.1
glycosylphosphatidylinositol specific phospholipase D1
chr5_+_60933634 0.05 ENST00000505642.1
chromosome 5 open reading frame 64
chr16_+_58074069 0.05 ENST00000570065.1
matrix metallopeptidase 15 (membrane-inserted)
chr7_-_108168580 0.05 ENST00000453085.1
patatin-like phospholipase domain containing 8
chr11_+_33563618 0.05 ENST00000526400.1
KIAA1549-like
chrX_-_43741594 0.05 ENST00000536181.1
ENST00000378069.4
monoamine oxidase B
chr6_+_147525541 0.05 ENST00000367481.3
ENST00000546097.1
syntaxin binding protein 5 (tomosyn)
chr3_+_140770183 0.05 ENST00000310546.2
splA/ryanodine receptor domain and SOCS box containing 4
chr9_+_97488939 0.05 ENST00000277198.2
ENST00000297979.5
chromosome 9 open reading frame 3
chr6_+_42896865 0.04 ENST00000372836.4
ENST00000394142.3
canopy FGF signaling regulator 3
chr12_-_2027639 0.04 ENST00000586184.1
ENST00000587995.1
ENST00000585732.1
calcium channel, voltage-dependent, alpha 2/delta subunit 4
chr1_+_174769006 0.04 ENST00000489615.1
RAB GTPase activating protein 1-like
chr6_-_99797522 0.04 ENST00000389677.5
failed axon connections homolog (Drosophila)
chr5_-_114505591 0.04 ENST00000508894.1
tripartite motif containing 36
chr3_+_196439275 0.04 ENST00000296333.5
phosphatidylinositol glycan anchor biosynthesis, class X
chr5_+_138629417 0.04 ENST00000510056.1
ENST00000511249.1
ENST00000503811.1
ENST00000511378.1
matrin 3
chr9_+_2622085 0.04 ENST00000382099.2
very low density lipoprotein receptor
chr3_+_52422899 0.04 ENST00000480649.1
dynein, axonemal, heavy chain 1
chr7_-_30029328 0.04 ENST00000425819.2
ENST00000409570.1
secernin 1
chr1_-_54872059 0.04 ENST00000371320.3
single stranded DNA binding protein 3
chrX_+_74493896 0.04 ENST00000373383.4
ENST00000373379.1
uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
chr3_+_107241882 0.04 ENST00000416476.2
bobby sox homolog (Drosophila)
chr17_+_41363854 0.04 ENST00000588693.1
ENST00000588659.1
ENST00000541594.1
ENST00000536052.1
ENST00000331615.3
transmembrane protein 106A
chr10_-_102289611 0.04 ENST00000299166.4
ENST00000370320.4
ENST00000531258.1
ENST00000370322.1
ENST00000535773.1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
SEC31 homolog B (S. cerevisiae)
chr3_+_131100515 0.04 ENST00000537561.1
ENST00000359850.3
ENST00000521288.1
ENST00000502852.1
nudix (nucleoside diphosphate linked moiety X)-type motif 16
chr8_-_114389353 0.04 ENST00000343508.3
CUB and Sushi multiple domains 3
chr3_+_75955817 0.04 ENST00000487694.3
ENST00000602589.1
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr17_-_39728303 0.04 ENST00000588431.1
ENST00000246662.4
keratin 9
chr8_+_85095553 0.03 ENST00000521268.1
RALY RNA binding protein-like
chr11_-_2182388 0.03 ENST00000421783.1
ENST00000397262.1
ENST00000250971.3
ENST00000381330.4
ENST00000397270.1
insulin
INS-IGF2 readthrough
chr11_-_93276514 0.03 ENST00000526869.1
single-pass membrane protein with coiled-coil domains 4
chr1_+_78354175 0.03 ENST00000401035.3
ENST00000457030.1
ENST00000330010.8
nexilin (F actin binding protein)
chr4_+_106067943 0.03 ENST00000380013.4
ENST00000394764.1
ENST00000413648.2
tet methylcytosine dioxygenase 2
chr15_-_23086259 0.03 ENST00000538684.1
non imprinted in Prader-Willi/Angelman syndrome 1
chr3_+_196439170 0.03 ENST00000392391.3
ENST00000314118.4
phosphatidylinositol glycan anchor biosynthesis, class X
chr10_-_135171178 0.03 ENST00000368551.1
fucose mutarotase
chr6_+_97372596 0.02 ENST00000369261.4
kelch-like family member 32
chr12_-_22487618 0.02 ENST00000404299.3
ENST00000396037.4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr9_+_131549610 0.02 ENST00000223865.8
TBC1 domain family, member 13
chr6_+_97372734 0.02 ENST00000539200.1
kelch-like family member 32
chr10_+_124221036 0.02 ENST00000368984.3
HtrA serine peptidase 1
chr8_+_85095769 0.02 ENST00000518566.1
RALY RNA binding protein-like
chr4_+_72053017 0.02 ENST00000351898.6
solute carrier family 4 (sodium bicarbonate cotransporter), member 4
chr8_-_89339705 0.02 ENST00000286614.6
matrix metallopeptidase 16 (membrane-inserted)
chr5_+_179286013 0.02 ENST00000499601.2
Uncharacterized protein
chr1_-_45956822 0.02 ENST00000372086.3
ENST00000341771.6
testis-specific kinase 2
chr16_-_29415350 0.02 ENST00000524087.1
nuclear pore complex interacting protein family, member B11
chr10_-_118897567 0.02 ENST00000369206.5
ventral anterior homeobox 1
chr5_-_39270725 0.02 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYN binding protein
chr2_-_30143525 0.02 ENST00000431873.1
anaplastic lymphoma receptor tyrosine kinase
chr5_+_139739772 0.02 ENST00000506757.2
ENST00000230993.6
ENST00000506545.1
ENST00000432095.2
ENST00000507527.1
solute carrier family 4, sodium bicarbonate cotransporter, member 9
chr9_+_2621798 0.02 ENST00000382100.3
very low density lipoprotein receptor
chr16_-_21436459 0.02 ENST00000448012.2
ENST00000504841.2
ENST00000419180.2
nuclear pore complex interacting protein family, member B3
chr14_+_50779071 0.02 ENST00000426751.2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
chrX_+_3189861 0.02 ENST00000457435.1
ENST00000420429.2
chromosome X open reading frame 28
chr6_+_116692102 0.01 ENST00000359564.2
dermatan sulfate epimerase
chr15_-_90456114 0.01 ENST00000398333.3
C15orf38-AP3S2 readthrough
chr22_+_41075277 0.01 ENST00000381433.2
melanin-concentrating hormone receptor 1
chr20_+_306221 0.01 ENST00000342665.2
SRY (sex determining region Y)-box 12
chr4_+_72052964 0.01 ENST00000264485.5
ENST00000425175.1
solute carrier family 4 (sodium bicarbonate cotransporter), member 4
chr20_-_23066953 0.01 ENST00000246006.4
CD93 molecule
chr12_+_108525517 0.01 ENST00000332082.4
WSC domain containing 2
chr11_+_33563821 0.01 ENST00000321505.4
ENST00000265654.5
ENST00000389726.3
KIAA1549-like
chr16_+_67312049 0.01 ENST00000565899.1
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr5_-_114505624 0.01 ENST00000513154.1
tripartite motif containing 36
chr12_+_53817633 0.01 ENST00000257863.4
ENST00000550311.1
ENST00000379791.3
anti-Mullerian hormone receptor, type II
chr16_-_87525651 0.01 ENST00000268616.4
zinc finger, CCHC domain containing 14
chrX_-_53310791 0.01 ENST00000375365.2
IQ motif and Sec7 domain 2
chr12_+_54943134 0.01 ENST00000243052.3
phosphodiesterase 1B, calmodulin-dependent
chr14_+_36295638 0.01 ENST00000543183.1
breast cancer metastasis-suppressor 1-like
chrX_-_153141434 0.01 ENST00000407935.2
ENST00000439496.1
L1 cell adhesion molecule
chr11_+_118826999 0.01 ENST00000264031.2
uroplakin 2
chr1_-_38325256 0.01 ENST00000373036.4
metal-regulatory transcription factor 1
chr4_-_151936865 0.01 ENST00000535741.1
LPS-responsive vesicle trafficking, beach and anchor containing
chr10_-_49701686 0.01 ENST00000417247.2
Rho GTPase activating protein 22
chr11_+_72929402 0.01 ENST00000393596.2
purinergic receptor P2Y, G-protein coupled, 2
chr1_-_13331692 0.01 ENST00000353410.5
ENST00000376173.3
PRAME family member 3
chr1_-_32403370 0.01 ENST00000534796.1
protein tyrosine phosphatase type IVA, member 2
chr1_-_216978709 0.00 ENST00000360012.3
estrogen-related receptor gamma
chr6_+_147525661 0.00 ENST00000321680.6
ENST00000367480.3
syntaxin binding protein 5 (tomosyn)
chr2_+_26915584 0.00 ENST00000302909.3
potassium channel, subfamily K, member 3
chrX_-_65858865 0.00 ENST00000374719.3
ENST00000450752.1
ENST00000451436.2
ectodysplasin A2 receptor
chr17_-_41623009 0.00 ENST00000393664.2
ets variant 4
chr19_+_12949251 0.00 ENST00000251472.4
microtubule associated serine/threonine kinase 1
chr10_-_70231639 0.00 ENST00000551118.2
ENST00000358410.3
ENST00000399180.2
ENST00000399179.2
DNA replication helicase/nuclease 2
chr16_-_29517141 0.00 ENST00000550665.1
Uncharacterized protein
chr8_-_63998590 0.00 ENST00000260116.4
tocopherol (alpha) transfer protein
chr6_+_31021973 0.00 ENST00000570223.1
ENST00000566475.1
ENST00000426185.1
HLA complex group 22
chrX_-_63425561 0.00 ENST00000374869.3
ENST00000330258.3
APC membrane recruitment protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of MAFA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.2 GO:0090031 positive regulation of steroid hormone biosynthetic process(GO:0090031)
0.0 0.2 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.0 0.1 GO:0010636 positive regulation of mitochondrial fusion(GO:0010636)
0.0 0.2 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0 0.1 GO:0009258 10-formyltetrahydrofolate catabolic process(GO:0009258)
0.0 0.2 GO:0000270 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 0.2 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 0.1 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897)
0.0 0.1 GO:0032690 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.0 0.1 GO:0038194 thyroid-stimulating hormone signaling pathway(GO:0038194)
0.0 0.1 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.1 GO:2000535 regulation of entry of bacterium into host cell(GO:2000535)
0.0 0.0 GO:2000742 anterior head development(GO:0097065) regulation of anterior head development(GO:2000742) positive regulation of anterior head development(GO:2000744)
0.0 0.0 GO:0046709 IDP metabolic process(GO:0046707) IDP catabolic process(GO:0046709)
0.0 0.0 GO:0046338 phosphatidylethanolamine catabolic process(GO:0046338)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.2 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.0 0.2 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.1 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.0 0.1 GO:0008537 proteasome activator complex(GO:0008537)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0004560 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
0.0 0.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.1 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.0 0.2 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.1 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.0 0.1 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.0 0.1 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
0.0 0.2 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.1 GO:0050436 microfibril binding(GO:0050436)
0.0 0.2 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.1 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.0 0.1 GO:0042806 fucose binding(GO:0042806)
0.0 0.1 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189)
0.0 0.1 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.2 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.1 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors