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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for LHX6
Z-value: 0.81
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Transcription factors associated with LHX6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| LHX6 | hg19_v2_chr9_-_124990680_124990719 | -0.60 | 2.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_37723336 Show fit | 1.56 |
ENST00000450180.1
|
G protein-coupled receptor 141 |
|
| chr16_-_55866997 Show fit | 0.77 |
ENST00000360526.3
ENST00000361503.4 |
carboxylesterase 1 |
|
| chr19_+_36239576 Show fit | 0.73 |
ENST00000587751.1
|
lin-37 homolog (C. elegans) |
|
| chr2_+_113763031 Show fit | 0.53 |
ENST00000259211.6
|
interleukin 36, alpha |
|
| chr7_+_63505799 Show fit | 0.46 |
ENST00000550760.3
|
zinc finger protein 727 |
|
| chr6_-_30685214 Show fit | 0.41 |
ENST00000425072.1
|
mediator of DNA-damage checkpoint 1 |
|
| chr12_-_102133191 Show fit | 0.40 |
ENST00000392924.1
ENST00000266743.2 ENST00000392927.3 |
synaptonemal complex protein 3 |
|
| chr6_-_30684898 Show fit | 0.39 |
ENST00000422266.1
ENST00000416571.1 |
mediator of DNA-damage checkpoint 1 |
|
| chr19_-_52307357 Show fit | 0.35 |
ENST00000594900.1
|
formyl peptide receptor 1 |
|
| chr10_-_99205607 Show fit | 0.34 |
ENST00000477692.2
ENST00000485122.2 ENST00000370886.5 ENST00000370885.4 ENST00000370902.3 ENST00000370884.5 |
exosome component 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of LHX6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.1 | GO:0090119 | vesicle-mediated cholesterol transport(GO:0090119) |
| 0.0 | 0.8 | GO:0031573 | intra-S DNA damage checkpoint(GO:0031573) |
| 0.1 | 0.4 | GO:0002729 | positive regulation of natural killer cell cytokine production(GO:0002729) |
| 0.0 | 0.4 | GO:0035093 | spermatogenesis, exchange of chromosomal proteins(GO:0035093) |
| 0.1 | 0.3 | GO:0046092 | deoxycytidine metabolic process(GO:0046092) |
| 0.0 | 0.3 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.0 | 0.3 | GO:0002430 | complement receptor mediated signaling pathway(GO:0002430) |
| 0.0 | 0.3 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.0 | 0.3 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 0.1 | 0.2 | GO:0006258 | UDP-glucose catabolic process(GO:0006258) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0000800 | lateral element(GO:0000800) |
| 0.0 | 0.3 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 0.3 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.0 | 0.3 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.1 | 0.2 | GO:0033597 | mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298) |
| 0.0 | 0.2 | GO:0030936 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.0 | 0.2 | GO:0097123 | cyclin A1-CDK2 complex(GO:0097123) |
| 0.0 | 0.2 | GO:0033503 | HULC complex(GO:0033503) |
| 0.0 | 0.2 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
| 0.0 | 0.2 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.1 | GO:0047374 | methylumbelliferyl-acetate deacetylase activity(GO:0047374) |
| 0.0 | 0.5 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.1 | 0.3 | GO:0004137 | deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797) |
| 0.0 | 0.3 | GO:0004982 | N-formyl peptide receptor activity(GO:0004982) |
| 0.0 | 0.3 | GO:0046979 | TAP2 binding(GO:0046979) |
| 0.0 | 0.3 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.1 | 0.2 | GO:0047273 | galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273) |
| 0.1 | 0.2 | GO:0033878 | hormone-sensitive lipase activity(GO:0033878) |
| 0.1 | 0.2 | GO:0004739 | pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739) |
| 0.0 | 0.2 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 0.8 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 0.8 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 0.3 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 0.8 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 0.7 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.3 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.0 | 0.3 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.0 | 0.3 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.3 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.0 | 0.3 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |