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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for LHX3

Z-value: 0.65

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Transcription factors associated with LHX3

Gene Symbol Gene ID Gene Info
LHX3
ENSG00000107187.11 LIM homeobox 3

Activity profile of LHX3 motif

Sorted Z-values of LHX3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_78934441 0.59 ENST00000546865.1
ENST00000547089.1
RP11-171L9.1
RP11-171L9.1
chrX_+_107288280 0.46 ENST00000458383.1
VSIG1
V-set and immunoglobulin domain containing 1
chr11_-_63376013 0.42 ENST00000540943.1
PLA2G16
phospholipase A2, group XVI
chr6_-_47445214 0.36 ENST00000604014.1
RP11-385F7.1
RP11-385F7.1
chr2_+_29001711 0.28 ENST00000418910.1
PPP1CB
protein phosphatase 1, catalytic subunit, beta isozyme
chr10_+_18549645 0.28 ENST00000396576.2
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr9_-_128246769 0.26 ENST00000444226.1
MAPKAP1
mitogen-activated protein kinase associated protein 1
chr15_-_75748143 0.26 ENST00000568431.1
ENST00000568309.1
ENST00000568190.1
ENST00000570115.1
ENST00000564778.1
SIN3A
SIN3 transcription regulator family member A
chr4_-_120243545 0.24 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr17_-_8263538 0.23 ENST00000535173.1
AC135178.1
HCG1985372; Uncharacterized protein; cDNA FLJ37541 fis, clone BRCAN2026340
chr12_-_42631529 0.21 ENST00000548917.1
YAF2
YY1 associated factor 2
chr8_-_57123815 0.21 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
PLAG1
pleiomorphic adenoma gene 1
chr2_+_234826016 0.20 ENST00000324695.4
ENST00000433712.2
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr16_+_28565230 0.19 ENST00000317058.3
CCDC101
coiled-coil domain containing 101
chr14_+_29241910 0.18 ENST00000399387.4
ENST00000552957.1
ENST00000548213.1
C14orf23
chromosome 14 open reading frame 23
chr19_-_6279932 0.17 ENST00000252674.7
MLLT1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
chr11_-_327537 0.17 ENST00000602735.1
IFITM3
interferon induced transmembrane protein 3
chr11_-_16419067 0.17 ENST00000533411.1
SOX6
SRY (sex determining region Y)-box 6
chr16_-_28937027 0.16 ENST00000358201.4
RABEP2
rabaptin, RAB GTPase binding effector protein 2
chr19_+_50016411 0.16 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr5_+_81601166 0.15 ENST00000439350.1
ATP6AP1L
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr14_-_45252031 0.15 ENST00000556405.1
RP11-398E10.1
RP11-398E10.1
chr4_+_74301880 0.15 ENST00000395792.2
ENST00000226359.2
AFP
alpha-fetoprotein
chr4_+_71384257 0.15 ENST00000339336.4
AMTN
amelotin
chr16_+_89334512 0.14 ENST00000602042.1
AC137932.1
AC137932.1
chr19_+_50016610 0.14 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr11_-_559377 0.14 ENST00000486629.1
C11orf35
chromosome 11 open reading frame 35
chr19_+_11457175 0.14 ENST00000458408.1
ENST00000586451.1
ENST00000588592.1
CCDC159
coiled-coil domain containing 159
chr8_-_66750978 0.14 ENST00000523253.1
PDE7A
phosphodiesterase 7A
chr14_-_36990354 0.13 ENST00000518149.1
NKX2-1
NK2 homeobox 1
chr3_-_47517302 0.13 ENST00000441517.2
ENST00000545718.1
SCAP
SREBF chaperone
chr8_+_91233750 0.13 ENST00000523406.1
LINC00534
long intergenic non-protein coding RNA 534
chr19_-_11457162 0.12 ENST00000590482.1
TMEM205
transmembrane protein 205
chrX_-_39186610 0.12 ENST00000429281.1
ENST00000448597.1
RP11-265P11.2
RP11-265P11.2
chrM_+_10053 0.12 ENST00000361227.2
MT-ND3
mitochondrially encoded NADH dehydrogenase 3
chr19_-_43969796 0.12 ENST00000244333.3
LYPD3
LY6/PLAUR domain containing 3
chr2_-_228582709 0.11 ENST00000541617.1
ENST00000409456.2
ENST00000409287.1
ENST00000258403.3
SLC19A3
solute carrier family 19 (thiamine transporter), member 3
chr1_-_24126051 0.11 ENST00000445705.1
GALE
UDP-galactose-4-epimerase
chr18_+_61616510 0.10 ENST00000408945.3
HMSD
histocompatibility (minor) serpin domain containing
chr17_-_39093672 0.10 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
KRT23
keratin 23 (histone deacetylase inducible)
chr14_-_101295407 0.10 ENST00000596284.1
AL117190.2
AL117190.2
chr12_+_59989918 0.10 ENST00000547379.1
ENST00000549465.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr19_+_48949030 0.10 ENST00000253237.5
GRWD1
glutamate-rich WD repeat containing 1
chr5_-_1882858 0.09 ENST00000511126.1
ENST00000231357.2
IRX4
iroquois homeobox 4
chr2_-_99871570 0.09 ENST00000333017.2
ENST00000409679.1
ENST00000423306.1
LYG2
lysozyme G-like 2
chr12_-_10282836 0.09 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A
chr2_-_207078154 0.09 ENST00000447845.1
GPR1
G protein-coupled receptor 1
chr10_-_115904361 0.08 ENST00000428953.1
ENST00000543782.1
C10orf118
chromosome 10 open reading frame 118
chr1_-_160924589 0.08 ENST00000368029.3
ITLN2
intelectin 2
chr17_-_72772425 0.08 ENST00000578822.1
NAT9
N-acetyltransferase 9 (GCN5-related, putative)
chr5_-_88120083 0.08 ENST00000509373.1
MEF2C
myocyte enhancer factor 2C
chr14_-_21566731 0.08 ENST00000360947.3
ZNF219
zinc finger protein 219
chr12_-_10282742 0.08 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chr13_-_81801115 0.08 ENST00000567258.1
LINC00564
long intergenic non-protein coding RNA 564
chr19_+_11457232 0.08 ENST00000587531.1
CCDC159
coiled-coil domain containing 159
chr2_-_14541060 0.08 ENST00000418420.1
ENST00000417751.1
LINC00276
long intergenic non-protein coding RNA 276
chr5_+_140529630 0.08 ENST00000543635.1
PCDHB6
protocadherin beta 6
chr2_-_166930131 0.08 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr13_+_24144796 0.07 ENST00000403372.2
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr7_+_107224364 0.07 ENST00000491150.1
BCAP29
B-cell receptor-associated protein 29
chr2_-_99279928 0.07 ENST00000414521.2
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr17_-_71223839 0.07 ENST00000579872.1
ENST00000580032.1
FAM104A
family with sequence similarity 104, member A
chr9_-_100000957 0.07 ENST00000366109.2
ENST00000607322.1
RP11-498P14.5
RP11-498P14.5
chr16_+_15489603 0.07 ENST00000568766.1
ENST00000287594.7
RP11-1021N1.1
MPV17L
Uncharacterized protein
MPV17 mitochondrial membrane protein-like
chr17_-_72772462 0.07 ENST00000582870.1
ENST00000581136.1
ENST00000357814.3
ENST00000579218.1
ENST00000583476.1
ENST00000580301.1
ENST00000583757.1
ENST00000582524.1
NAT9
N-acetyltransferase 9 (GCN5-related, putative)
chr9_+_125132803 0.06 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr3_-_20053741 0.06 ENST00000389050.4
PP2D1
protein phosphatase 2C-like domain containing 1
chr4_+_3344141 0.06 ENST00000306648.7
RGS12
regulator of G-protein signaling 12
chr3_+_101443476 0.06 ENST00000327230.4
ENST00000494050.1
CEP97
centrosomal protein 97kDa
chr6_-_49712147 0.06 ENST00000433368.2
ENST00000354620.4
CRISP3
cysteine-rich secretory protein 3
chr6_+_26104104 0.06 ENST00000377803.2
HIST1H4C
histone cluster 1, H4c
chr7_-_115799942 0.06 ENST00000484212.1
TFEC
transcription factor EC
chr5_+_147691979 0.06 ENST00000274565.4
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr4_-_36245561 0.06 ENST00000506189.1
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr8_+_119294456 0.06 ENST00000366457.2
AC023590.1
Uncharacterized protein
chr1_+_244214577 0.06 ENST00000358704.4
ZBTB18
zinc finger and BTB domain containing 18
chr18_+_6774000 0.05 ENST00000532723.1
ARHGAP28
Rho GTPase activating protein 28
chr5_-_59783882 0.05 ENST00000505507.2
ENST00000502484.2
PDE4D
phosphodiesterase 4D, cAMP-specific
chr4_-_103940791 0.05 ENST00000510559.1
ENST00000394789.3
ENST00000296422.7
SLC9B1
solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1
chr14_-_21567009 0.05 ENST00000556174.1
ENST00000554478.1
ENST00000553980.1
ENST00000421093.2
ZNF219
zinc finger protein 219
chr17_-_28661065 0.05 ENST00000328886.4
ENST00000538566.2
TMIGD1
transmembrane and immunoglobulin domain containing 1
chr9_-_21482312 0.05 ENST00000448696.3
IFNE
interferon, epsilon
chr6_-_159466136 0.05 ENST00000367066.3
ENST00000326965.6
TAGAP
T-cell activation RhoGTPase activating protein
chr4_+_71384300 0.05 ENST00000504451.1
AMTN
amelotin
chr12_+_4385230 0.05 ENST00000536537.1
CCND2
cyclin D2
chr6_+_83072923 0.05 ENST00000535040.1
TPBG
trophoblast glycoprotein
chr7_+_97361388 0.05 ENST00000350485.4
ENST00000346867.4
TAC1
tachykinin, precursor 1
chr6_-_49712123 0.04 ENST00000263045.4
CRISP3
cysteine-rich secretory protein 3
chr6_-_49712091 0.04 ENST00000371159.4
CRISP3
cysteine-rich secretory protein 3
chr3_+_2933893 0.04 ENST00000397459.2
CNTN4
contactin 4
chr15_+_75970672 0.04 ENST00000435356.1
AC105020.1
Uncharacterized protein; cDNA FLJ12988 fis, clone NT2RP3000080
chr5_-_88120151 0.04 ENST00000506716.1
MEF2C
myocyte enhancer factor 2C
chr17_-_27418537 0.04 ENST00000408971.2
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr19_+_49199209 0.04 ENST00000522966.1
ENST00000425340.2
ENST00000391876.4
FUT2
fucosyltransferase 2 (secretor status included)
chr18_+_72201829 0.04 ENST00000582365.1
CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr7_-_105332084 0.04 ENST00000472195.1
ATXN7L1
ataxin 7-like 1
chr1_-_48866517 0.04 ENST00000371841.1
SPATA6
spermatogenesis associated 6
chr18_+_28956740 0.04 ENST00000308128.4
ENST00000359747.4
DSG4
desmoglein 4
chr3_-_141747950 0.04 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr17_+_68071389 0.04 ENST00000283936.1
ENST00000392671.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr19_+_48949087 0.04 ENST00000598711.1
GRWD1
glutamate-rich WD repeat containing 1
chr3_+_167582561 0.03 ENST00000463642.1
ENST00000464514.1
RP11-298O21.6
RP11-298O21.7
RP11-298O21.6
RP11-298O21.7
chr6_-_49712072 0.03 ENST00000423399.2
CRISP3
cysteine-rich secretory protein 3
chr4_-_68829144 0.03 ENST00000508048.1
TMPRSS11A
transmembrane protease, serine 11A
chr12_-_118628350 0.03 ENST00000537952.1
ENST00000537822.1
TAOK3
TAO kinase 3
chr1_-_24126023 0.03 ENST00000429356.1
GALE
UDP-galactose-4-epimerase
chr9_-_116065551 0.03 ENST00000297894.5
RNF183
ring finger protein 183
chr18_-_53303123 0.03 ENST00000569357.1
ENST00000565124.1
ENST00000398339.1
TCF4
transcription factor 4
chr4_-_68829226 0.03 ENST00000396188.2
TMPRSS11A
transmembrane protease, serine 11A
chr2_-_188312971 0.03 ENST00000410068.1
ENST00000447403.1
ENST00000410102.1
CALCRL
calcitonin receptor-like
chr7_-_87342564 0.03 ENST00000265724.3
ENST00000416177.1
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr10_+_104263743 0.03 ENST00000369902.3
ENST00000369899.2
ENST00000423559.2
SUFU
suppressor of fused homolog (Drosophila)
chr15_+_65843130 0.03 ENST00000569894.1
PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr12_-_7656357 0.03 ENST00000396620.3
ENST00000432237.2
ENST00000359156.4
CD163
CD163 molecule
chr4_-_23891658 0.03 ENST00000507380.1
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr1_+_197237352 0.03 ENST00000538660.1
ENST00000367400.3
ENST00000367399.2
CRB1
crumbs homolog 1 (Drosophila)
chrX_-_110655306 0.02 ENST00000371993.2
DCX
doublecortin
chr5_-_39274617 0.02 ENST00000510188.1
FYB
FYN binding protein
chr6_+_72926145 0.02 ENST00000425662.2
ENST00000453976.2
RIMS1
regulating synaptic membrane exocytosis 1
chr12_-_52761262 0.02 ENST00000257901.3
KRT85
keratin 85
chrX_-_52827141 0.02 ENST00000375511.3
SPANXN5
SPANX family, member N5
chr5_+_140557371 0.02 ENST00000239444.2
PCDHB8
protocadherin beta 8
chr1_-_231005310 0.02 ENST00000470540.1
C1orf198
chromosome 1 open reading frame 198
chr10_-_74283694 0.01 ENST00000398763.4
ENST00000418483.2
ENST00000489666.2
MICU1
mitochondrial calcium uptake 1
chr5_+_166711804 0.01 ENST00000518659.1
ENST00000545108.1
TENM2
teneurin transmembrane protein 2
chr18_+_616711 0.01 ENST00000579494.1
CLUL1
clusterin-like 1 (retinal)
chr1_+_15668240 0.01 ENST00000444385.1
FHAD1
forkhead-associated (FHA) phosphopeptide binding domain 1
chr17_+_68071458 0.01 ENST00000589377.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr7_-_36764142 0.01 ENST00000258749.5
ENST00000535891.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr18_+_616672 0.01 ENST00000338387.7
CLUL1
clusterin-like 1 (retinal)
chr4_+_113568207 0.01 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chr6_+_114178512 0.01 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chrX_+_9431324 0.01 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
TBL1X
transducin (beta)-like 1X-linked
chr12_-_11287243 0.01 ENST00000539585.1
TAS2R30
taste receptor, type 2, member 30
chr15_+_86686953 0.01 ENST00000421325.2
AGBL1
ATP/GTP binding protein-like 1
chr14_+_62164340 0.01 ENST00000557538.1
ENST00000539097.1
HIF1A
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
chr12_+_40787194 0.01 ENST00000425730.2
ENST00000454784.4
MUC19
mucin 19, oligomeric
chr7_+_39017504 0.01 ENST00000403058.1
POU6F2
POU class 6 homeobox 2
chr8_+_92261516 0.01 ENST00000276609.3
ENST00000309536.2
SLC26A7
solute carrier family 26 (anion exchanger), member 7
chrX_-_55057403 0.01 ENST00000396198.3
ENST00000335854.4
ENST00000455688.1
ENST00000330807.5
ALAS2
aminolevulinate, delta-, synthase 2
chr9_-_215744 0.01 ENST00000382387.2
C9orf66
chromosome 9 open reading frame 66
chr17_-_60142609 0.01 ENST00000397786.2
MED13
mediator complex subunit 13
chr15_+_64680003 0.01 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chr5_+_179135246 0.01 ENST00000508787.1
CANX
calnexin
chr2_+_135596106 0.01 ENST00000356140.5
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chrX_-_19504642 0.00 ENST00000469203.2
MAP3K15
mitogen-activated protein kinase kinase kinase 15
chr12_+_8309630 0.00 ENST00000396570.3
ZNF705A
zinc finger protein 705A
chr4_+_158493642 0.00 ENST00000507108.1
ENST00000455598.1
ENST00000509450.1
RP11-364P22.1
RP11-364P22.1
chrM_-_14670 0.00 ENST00000361681.2
MT-ND6
mitochondrially encoded NADH dehydrogenase 6
chr3_+_121902511 0.00 ENST00000490131.1
CASR
calcium-sensing receptor
chr1_-_150944411 0.00 ENST00000368949.4
CERS2
ceramide synthase 2
chrM_+_14741 0.00 ENST00000361789.2
MT-CYB
mitochondrially encoded cytochrome b
chr8_+_11961898 0.00 ENST00000400085.3
ZNF705D
zinc finger protein 705D
chr16_+_15489629 0.00 ENST00000396385.3
MPV17L
MPV17 mitochondrial membrane protein-like
chr11_+_27015628 0.00 ENST00000318627.2
FIBIN
fin bud initiation factor homolog (zebrafish)
chr4_-_23891693 0.00 ENST00000264867.2
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.0 0.2 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.0 0.4 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.2 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0 0.3 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.3 GO:0098912 membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912) positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.2 GO:0050955 thermoception(GO:0050955)
0.0 0.2 GO:0042488 positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) positive regulation of tooth mineralization(GO:0070172)
0.0 0.1 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.0 0.1 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716) negative regulation of cholesterol metabolic process(GO:0090206)
0.0 0.3 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.1 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.0 0.1 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.0 0.1 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.1 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.0 GO:0046878 positive regulation of saliva secretion(GO:0046878)
0.0 0.1 GO:0021759 globus pallidus development(GO:0021759)
0.0 0.1 GO:0009253 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 0.2 GO:0060252 positive regulation of glial cell proliferation(GO:0060252) prostate gland growth(GO:0060736)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0042587 glycogen granule(GO:0042587)
0.0 0.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.1 0.3 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.3 GO:0050115 myosin-light-chain-phosphatase activity(GO:0050115)
0.0 0.3 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.1 GO:0003978 UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978)
0.0 0.1 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 0.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0005132 type I interferon receptor binding(GO:0005132)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS