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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for LEF1

Z-value: 0.67

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Transcription factors associated with LEF1

Gene Symbol Gene ID Gene Info
ENSG00000138795.5 lymphoid enhancer binding factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LEF1hg19_v2_chr4_-_109087906_1090879530.483.4e-01Click!

Activity profile of LEF1 motif

Sorted Z-values of LEF1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_94965667 0.96 ENST00000542176.1
ENST00000278499.2
sestrin 3
chr15_+_96869165 0.69 ENST00000421109.2
nuclear receptor subfamily 2, group F, member 2
chr6_+_144606817 0.49 ENST00000433557.1
utrophin
chr3_-_169381166 0.48 ENST00000486748.1
MDS1 and EVI1 complex locus
chr2_-_178129551 0.44 ENST00000430047.1
nuclear factor, erythroid 2-like 2
chrX_-_45629661 0.42 ENST00000602507.1
ENST00000602461.1
RP6-99M1.2
chr1_-_116383738 0.41 ENST00000320238.3
nescient helix loop helix 2
chr1_+_6845578 0.38 ENST00000467404.2
ENST00000439411.2
calmodulin binding transcription activator 1
chr4_-_23891693 0.37 ENST00000264867.2
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chrX_-_80457385 0.35 ENST00000451455.1
ENST00000436386.1
ENST00000358130.2
high mobility group nucleosome binding domain 5
chr5_+_112074029 0.31 ENST00000512211.2
adenomatous polyposis coli
chr14_-_54418598 0.31 ENST00000609748.1
ENST00000558961.1
bone morphogenetic protein 4
chr15_-_52944231 0.29 ENST00000546305.2
family with sequence similarity 214, member A
chr21_+_17791648 0.28 ENST00000602892.1
ENST00000418813.2
ENST00000435697.1
long intergenic non-protein coding RNA 478
chr8_+_42873548 0.28 ENST00000533338.1
ENST00000534420.1
hook microtubule-tethering protein 3
Uncharacterized protein
chr4_+_113152978 0.27 ENST00000309703.6
adaptor-related protein complex 1 associated regulatory protein
chr14_+_38065052 0.26 ENST00000556845.1
tetratricopeptide repeat domain 6
chr17_-_8263538 0.26 ENST00000535173.1
HCG1985372; Uncharacterized protein; cDNA FLJ37541 fis, clone BRCAN2026340
chr1_+_6845497 0.26 ENST00000473578.1
ENST00000557126.1
calmodulin binding transcription activator 1
chr14_-_71107921 0.26 ENST00000553982.1
ENST00000500016.1
CTD-2540L5.5
CTD-2540L5.6
chr12_+_80838126 0.25 ENST00000266688.5
protein tyrosine phosphatase, receptor type, Q
chr3_+_107244229 0.25 ENST00000456419.1
ENST00000402163.2
bobby sox homolog (Drosophila)
chr7_+_74379083 0.24 ENST00000361825.7
GATS protein-like 1
chr11_-_85430204 0.24 ENST00000389958.3
ENST00000527794.1
synaptotagmin-like 2
chr13_+_97928395 0.23 ENST00000445661.2
muscleblind-like splicing regulator 2
chr11_-_85430088 0.23 ENST00000533057.1
ENST00000533892.1
synaptotagmin-like 2
chr4_+_95972822 0.23 ENST00000509540.1
ENST00000440890.2
bone morphogenetic protein receptor, type IB
chr1_+_100111479 0.23 ENST00000263174.4
palmdelphin
chrX_+_106045891 0.22 ENST00000357242.5
ENST00000310452.2
ENST00000481617.2
ENST00000276175.3
TBC1 domain family, member 8B (with GRAM domain)
chr4_-_36245561 0.22 ENST00000506189.1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_-_108231101 0.22 ENST00000544443.1
ENST00000415432.2
vav 3 guanine nucleotide exchange factor
chr1_-_116383322 0.22 ENST00000429731.1
nescient helix loop helix 2
chr7_-_84122033 0.22 ENST00000424555.1
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr6_+_64282447 0.22 ENST00000370650.2
ENST00000578299.1
protein tyrosine phosphatase type IVA, member 1
chr4_+_30721968 0.22 ENST00000361762.2
protocadherin 7
chr8_-_124665190 0.22 ENST00000325995.7
kelch-like family member 38
chr5_+_67584174 0.21 ENST00000320694.8
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr4_-_139163491 0.20 ENST00000280612.5
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr1_+_100111580 0.20 ENST00000605497.1
palmdelphin
chr14_+_75746664 0.20 ENST00000557139.1
FBJ murine osteosarcoma viral oncogene homolog
chr6_+_114178512 0.20 ENST00000368635.4
myristoylated alanine-rich protein kinase C substrate
chr8_-_17579726 0.20 ENST00000381861.3
microtubule associated tumor suppressor 1
chr1_-_211752073 0.20 ENST00000367001.4
solute carrier family 30 (zinc transporter), member 1
chr2_+_14772810 0.20 ENST00000295092.2
ENST00000331243.4
family with sequence similarity 84, member A
chr3_-_125655882 0.20 ENST00000340333.3
ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like
chr18_-_53019208 0.20 ENST00000562607.1
transcription factor 4
chr11_-_111794446 0.19 ENST00000527950.1
crystallin, alpha B
chr10_+_54074033 0.19 ENST00000373970.3
dickkopf WNT signaling pathway inhibitor 1
chr12_+_53491220 0.19 ENST00000548547.1
ENST00000301464.3
insulin-like growth factor binding protein 6
chr5_+_138210919 0.19 ENST00000522013.1
ENST00000520260.1
ENST00000523298.1
ENST00000520865.1
ENST00000519634.1
ENST00000517533.1
ENST00000523685.1
ENST00000519768.1
ENST00000517656.1
ENST00000521683.1
ENST00000521640.1
ENST00000519116.1
catenin (cadherin-associated protein), alpha 1, 102kDa
chr14_-_36990061 0.19 ENST00000546983.1
NK2 homeobox 1
chr14_-_23624511 0.19 ENST00000529705.2
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr1_+_164528866 0.18 ENST00000420696.2
pre-B-cell leukemia homeobox 1
chr11_-_85430163 0.18 ENST00000529581.1
ENST00000533577.1
synaptotagmin-like 2
chr1_+_100435535 0.18 ENST00000427993.2
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
chr6_+_35704855 0.18 ENST00000288065.2
ENST00000373866.3
armadillo repeat containing 12
chr17_+_38337491 0.17 ENST00000538981.1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr11_+_113930955 0.17 ENST00000535700.1
zinc finger and BTB domain containing 16
chr11_-_102323489 0.17 ENST00000361236.3
transmembrane protein 123
chr6_+_134274354 0.17 ENST00000367869.1
TBP-like 1
chr18_+_9136758 0.17 ENST00000383440.2
ENST00000262126.4
ENST00000577992.1
ankyrin repeat domain 12
chr7_+_116451100 0.17 ENST00000464223.1
ENST00000484325.1
capping protein (actin filament) muscle Z-line, alpha 2
chr7_-_84121858 0.17 ENST00000448879.1
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr1_+_78383813 0.17 ENST00000342754.5
nexilin (F actin binding protein)
chr12_+_21654714 0.17 ENST00000542038.1
ENST00000540141.1
ENST00000229314.5
golgi transport 1B
chr2_-_165697717 0.17 ENST00000439313.1
cordon-bleu WH2 repeat protein-like 1
chr11_-_111649074 0.17 ENST00000534218.1
RP11-108O10.2
chr3_+_149535022 0.17 ENST00000466795.1
ring finger protein 13
chr2_-_211341411 0.16 ENST00000233714.4
ENST00000443314.1
ENST00000441020.3
ENST00000450366.2
ENST00000431941.2
LanC lantibiotic synthetase component C-like 1 (bacterial)
chr9_+_97766469 0.16 ENST00000433691.2
chromosome 9 open reading frame 3
chr8_-_21988558 0.16 ENST00000312841.8
hair growth associated
chr17_-_56065540 0.16 ENST00000583932.1
vascular endothelial zinc finger 1
chr9_-_27005686 0.16 ENST00000380055.5
leucine rich repeat containing 19
chrX_-_109683446 0.16 ENST00000372057.1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr1_+_93645314 0.16 ENST00000343253.7
coiled-coil domain containing 18
chr1_+_100435315 0.16 ENST00000370155.3
ENST00000465289.1
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
chr1_-_244006528 0.16 ENST00000336199.5
ENST00000263826.5
v-akt murine thymoma viral oncogene homolog 3
chr15_-_35280426 0.16 ENST00000559564.1
ENST00000356321.4
zinc finger protein 770
chr12_-_76817036 0.16 ENST00000546946.1
oxysterol binding protein-like 8
chr20_+_36531499 0.16 ENST00000373458.3
ENST00000373461.4
ENST00000373459.4
V-set and transmembrane domain containing 2 like
chr11_-_18062335 0.15 ENST00000341556.2
tryptophan hydroxylase 1
chr2_-_170681375 0.15 ENST00000410097.1
ENST00000308099.3
ENST00000409837.1
ENST00000538491.1
ENST00000260953.5
ENST00000409965.1
ENST00000392640.2
methyltransferase like 5
chr18_+_29027696 0.15 ENST00000257189.4
desmoglein 3
chr1_+_27668505 0.15 ENST00000318074.5
synaptotagmin-like 1
chr15_-_52043722 0.15 ENST00000454181.2
LysM, putative peptidoglycan-binding, domain containing 2
chrX_-_138724677 0.15 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
MCF.2 cell line derived transforming sequence
chr5_+_65222438 0.15 ENST00000380938.2
erbb2 interacting protein
chr12_+_94071129 0.15 ENST00000552983.1
ENST00000332896.3
ENST00000552033.1
ENST00000548483.1
CASP2 and RIPK1 domain containing adaptor with death domain
chr17_+_67410832 0.15 ENST00000590474.1
mitogen-activated protein kinase kinase 6
chr2_-_170681324 0.15 ENST00000409340.1
methyltransferase like 5
chr1_+_84630053 0.15 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
protein kinase, cAMP-dependent, catalytic, beta
chr4_+_90033968 0.15 ENST00000317005.2
tigger transposable element derived 2
chr1_+_100818009 0.14 ENST00000370125.2
ENST00000361544.6
ENST00000370124.3
cell division cycle 14A
chr8_-_124553437 0.14 ENST00000517956.1
ENST00000443022.2
F-box protein 32
chr16_+_67143828 0.14 ENST00000563853.2
ENST00000569914.1
ENST00000569600.1
chromosome 16 open reading frame 70
chr1_-_219615984 0.14 ENST00000420762.1
RP11-95P13.1
chr2_-_152146385 0.14 ENST00000414946.1
ENST00000243346.5
N-myc (and STAT) interactor
chr9_-_94186131 0.14 ENST00000297689.3
nuclear factor, interleukin 3 regulated
chr2_+_220309379 0.14 ENST00000451076.1
SPEG complex locus
chr4_+_95129061 0.14 ENST00000354268.4
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr5_+_95066823 0.14 ENST00000506817.1
ENST00000379982.3
Rho-related BTB domain containing 3
chr11_-_46141338 0.14 ENST00000529782.1
ENST00000532010.1
ENST00000525438.1
ENST00000533757.1
ENST00000527782.1
PHD finger protein 21A
chr5_+_110073853 0.14 ENST00000513807.1
ENST00000509442.2
solute carrier family 25, member 46
chr2_+_17997763 0.14 ENST00000281047.3
mesogenin 1
chr18_-_53089723 0.14 ENST00000561992.1
ENST00000562512.2
transcription factor 4
chr10_+_18948311 0.14 ENST00000377275.3
ADP-ribosylation factor-like 5B
chr14_+_23025534 0.14 ENST00000557595.1
Uncharacterized protein
chr3_+_29323043 0.13 ENST00000452462.1
ENST00000456853.1
RNA binding motif, single stranded interacting protein 3
chr4_-_76649546 0.13 ENST00000508510.1
ENST00000509561.1
ENST00000499709.2
ENST00000511868.1
GTPase activating protein (SH3 domain) binding protein 2
chr13_-_39611956 0.13 ENST00000418503.1
proline and serine rich 1
chrX_+_95939638 0.13 ENST00000373061.3
ENST00000373054.4
ENST00000355827.4
diaphanous-related formin 2
chr16_+_57673348 0.13 ENST00000567915.1
ENST00000564103.1
ENST00000562467.1
G protein-coupled receptor 56
chr18_-_25616519 0.13 ENST00000399380.3
cadherin 2, type 1, N-cadherin (neuronal)
chr19_+_13135439 0.13 ENST00000586873.1
nuclear factor I/X (CCAAT-binding transcription factor)
chr14_-_35182994 0.13 ENST00000341223.3
cofilin 2 (muscle)
chr9_-_74525847 0.13 ENST00000377041.2
abhydrolase domain containing 17B
chr4_+_95128996 0.13 ENST00000457823.2
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr19_-_3029011 0.13 ENST00000590536.1
ENST00000587137.1
ENST00000455444.2
ENST00000262953.6
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr15_+_96873921 0.13 ENST00000394166.3
nuclear receptor subfamily 2, group F, member 2
chr6_-_153304148 0.13 ENST00000229758.3
F-box protein 5
chr11_-_102323740 0.13 ENST00000398136.2
transmembrane protein 123
chr11_+_130184888 0.13 ENST00000602376.1
ENST00000532116.3
ENST00000602310.1
RP11-121M22.1
chr4_+_86699834 0.13 ENST00000395183.2
Rho GTPase activating protein 24
chr1_-_93645818 0.13 ENST00000370280.1
ENST00000479918.1
transmembrane emp24 protein transport domain containing 5
chr6_-_134639042 0.13 ENST00000461976.2
serum/glucocorticoid regulated kinase 1
chr6_+_83777374 0.13 ENST00000349129.2
ENST00000237163.5
ENST00000536812.1
dopey family member 1
chr14_-_61124977 0.13 ENST00000554986.1
SIX homeobox 1
chrX_+_119737806 0.13 ENST00000371317.5
malignant T cell amplified sequence 1
chr6_-_153304697 0.12 ENST00000367241.3
F-box protein 5
chr4_+_95174445 0.12 ENST00000509418.1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr2_-_25194476 0.12 ENST00000534855.1
DnaJ (Hsp40) homolog, subfamily C, member 27
chr11_-_34535297 0.12 ENST00000532417.1
E74-like factor 5 (ets domain transcription factor)
chr14_-_92041383 0.12 ENST00000596306.1
Uncharacterized protein
chr3_-_18466026 0.12 ENST00000417717.2
SATB homeobox 1
chr10_+_123970670 0.12 ENST00000496913.2
transforming, acidic coiled-coil containing protein 2
chr3_+_69985734 0.12 ENST00000314557.6
ENST00000394351.3
microphthalmia-associated transcription factor
chr3_-_66024213 0.12 ENST00000483466.1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr9_+_128510454 0.12 ENST00000491787.3
ENST00000447726.2
pre-B-cell leukemia homeobox 3
chr17_+_48611853 0.12 ENST00000507709.1
ENST00000515126.1
ENST00000507467.1
epsin 3
chr3_-_148804275 0.12 ENST00000392912.2
ENST00000465259.1
ENST00000310053.5
ENST00000494055.1
helicase-like transcription factor
chr18_-_74728998 0.12 ENST00000359645.3
ENST00000397875.3
ENST00000397869.3
ENST00000578193.1
ENST00000578873.1
ENST00000397866.4
ENST00000528160.1
ENST00000527041.1
ENST00000526111.1
ENST00000397865.5
ENST00000382582.3
myelin basic protein
chr7_-_96654133 0.12 ENST00000486603.2
ENST00000222598.4
distal-less homeobox 5
chr4_+_95128748 0.12 ENST00000359052.4
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr12_-_109797249 0.12 ENST00000538041.1
RP11-256L11.1
chr5_-_146833803 0.12 ENST00000512722.1
dihydropyrimidinase-like 3
chr4_-_157892055 0.12 ENST00000422544.2
platelet derived growth factor C
chr3_-_149375783 0.12 ENST00000467467.1
ENST00000460517.1
ENST00000360632.3
WW domain containing transcription regulator 1
chr11_+_27076764 0.12 ENST00000525090.1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr3_+_183353356 0.11 ENST00000242810.6
ENST00000493074.1
ENST00000437402.1
ENST00000454495.2
ENST00000473045.1
ENST00000468101.1
ENST00000427201.2
ENST00000482138.1
ENST00000454652.2
kelch-like family member 24
chr5_+_170846640 0.11 ENST00000274625.5
fibroblast growth factor 18
chr2_+_181845843 0.11 ENST00000602710.1
ubiquitin-conjugating enzyme E2E 3
chr3_+_152017924 0.11 ENST00000465907.2
ENST00000492948.1
ENST00000485509.1
ENST00000464596.1
muscleblind-like splicing regulator 1
chr9_-_117150303 0.11 ENST00000312033.3
AT-hook transcription factor
chrX_-_119694538 0.11 ENST00000371322.5
cullin 4B
chr10_-_116444371 0.11 ENST00000533213.2
ENST00000369252.4
actin binding LIM protein 1
chr7_+_23146271 0.11 ENST00000545771.1
kelch-like family member 7
chr3_+_177159744 0.11 ENST00000439009.1
long intergenic non-protein coding RNA 578
chr3_-_112320749 0.11 ENST00000610103.1
RP11-572C15.6
chr9_+_97766409 0.11 ENST00000425634.2
chromosome 9 open reading frame 3
chr4_-_157892498 0.11 ENST00000502773.1
platelet derived growth factor C
chr1_+_12538594 0.11 ENST00000543710.1
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr10_-_21806759 0.11 ENST00000444772.3
SKI/DACH domain containing 1
chr16_-_3350614 0.11 ENST00000268674.2
tigger transposable element derived 7
chr7_+_151791095 0.11 ENST00000422997.2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chr14_+_54863682 0.11 ENST00000543789.2
ENST00000442975.2
ENST00000458126.2
ENST00000556102.2
cyclin-dependent kinase inhibitor 3
chr21_+_30672433 0.11 ENST00000451655.1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr4_+_160203650 0.11 ENST00000514565.1
Rap guanine nucleotide exchange factor (GEF) 2
chr17_-_37382105 0.11 ENST00000333461.5
SH3 and cysteine rich domain 2
chr5_+_137673200 0.10 ENST00000434981.2
family with sequence similarity 53, member C
chr1_+_100818156 0.10 ENST00000336454.3
cell division cycle 14A
chr11_-_85430356 0.10 ENST00000526999.1
synaptotagmin-like 2
chr7_-_27142290 0.10 ENST00000222718.5
homeobox A2
chr5_+_67586465 0.10 ENST00000336483.5
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_+_61548225 0.10 ENST00000371187.3
nuclear factor I/A
chr13_+_50589390 0.10 ENST00000360473.4
ENST00000312942.1
potassium channel regulator
chr1_+_196621156 0.10 ENST00000359637.2
complement factor H
chrX_+_38420783 0.10 ENST00000422612.2
ENST00000286824.6
ENST00000545599.1
tetraspanin 7
chr18_-_53089538 0.10 ENST00000566777.1
transcription factor 4
chrX_+_100353153 0.10 ENST00000423383.1
ENST00000218507.5
ENST00000403304.2
ENST00000435570.1
centromere protein I
chr14_-_23451467 0.10 ENST00000555074.1
ENST00000361265.4
RP11-298I3.5
ajuba LIM protein
chr14_-_31676674 0.10 ENST00000399332.1
ENST00000556224.1
HECT domain containing E3 ubiquitin protein ligase 1
chr4_-_111120334 0.10 ENST00000503885.1
ELOVL fatty acid elongase 6
chr15_-_41120896 0.10 ENST00000299174.5
ENST00000427255.2
protein phosphatase 1, regulatory (inhibitor) subunit 14D
chr9_+_36036430 0.10 ENST00000377966.3
reversion-inducing-cysteine-rich protein with kazal motifs
chrX_+_12993336 0.10 ENST00000380635.1
thymosin beta 4, X-linked
chrX_-_63425561 0.10 ENST00000374869.3
ENST00000330258.3
APC membrane recruitment protein 1
chr17_-_39526052 0.10 ENST00000251646.3
keratin 33B
chr2_+_172864490 0.10 ENST00000315796.4
methionyl aminopeptidase type 1D (mitochondrial)
chr7_+_7811992 0.10 ENST00000406829.1
RPA3 antisense RNA 1
chr9_-_98268883 0.10 ENST00000551630.1
ENST00000548420.1
patched 1
chr11_-_46848393 0.10 ENST00000526496.1
cytoskeleton associated protein 5
chr12_-_112443767 0.10 ENST00000550233.1
ENST00000546962.1
ENST00000550800.2
transmembrane protein 116
chr3_-_169381183 0.10 ENST00000494292.1
MDS1 and EVI1 complex locus
chr2_-_178129853 0.09 ENST00000397062.3
nuclear factor, erythroid 2-like 2
chr6_-_56707943 0.09 ENST00000370769.4
ENST00000421834.2
ENST00000312431.6
ENST00000361203.3
ENST00000523817.1
dystonin
chr2_+_201170999 0.09 ENST00000439395.1
ENST00000444012.1
spermatogenesis associated, serine-rich 2-like
chr14_+_57857262 0.09 ENST00000555166.1
ENST00000556492.1
ENST00000554703.1
N(alpha)-acetyltransferase 30, NatC catalytic subunit
chr11_-_118047376 0.09 ENST00000278947.5
sodium channel, voltage-gated, type II, beta subunit
chr4_-_184243561 0.09 ENST00000514470.1
ENST00000541814.1
claudin 24
chr1_+_87794150 0.09 ENST00000370544.5
LIM domain only 4

Network of associatons between targets according to the STRING database.

First level regulatory network of LEF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0009956 radial pattern formation(GO:0009956)
0.1 0.4 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.1 0.3 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) positive regulation of mitochondrial DNA metabolic process(GO:1901860) response to methionine(GO:1904640)
0.1 0.4 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.1 0.3 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057)
0.1 0.5 GO:1903788 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.1 0.3 GO:1990569 UDP-N-acetylglucosamine transport(GO:0015788) UDP-N-acetylglucosamine transmembrane transport(GO:1990569)
0.1 0.2 GO:0100012 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) negative regulation of mesodermal cell fate specification(GO:0042662) regulation of heart induction(GO:0090381) regulation of heart induction by canonical Wnt signaling pathway(GO:0100012) regulation of midbrain dopaminergic neuron differentiation(GO:1904956)
0.1 0.3 GO:0048392 BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134) apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.1 0.2 GO:0021569 rhombomere 3 development(GO:0021569)
0.1 0.4 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 0.2 GO:0051300 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.1 1.0 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.1 0.5 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.1 0.8 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.0 0.1 GO:0090191 mesenchymal cell proliferation involved in ureter development(GO:0072198) regulation of mesenchymal cell proliferation involved in ureter development(GO:0072199) negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191) positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.1 GO:0007388 anterior compartment pattern formation(GO:0007387) posterior compartment specification(GO:0007388)
0.0 0.1 GO:0060166 olfactory pit development(GO:0060166)
0.0 0.1 GO:0071895 odontoblast differentiation(GO:0071895)
0.0 0.2 GO:0042427 serotonin biosynthetic process(GO:0042427)
0.0 0.2 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.3 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.6 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.1 GO:0090149 mitochondrial membrane fission(GO:0090149)
0.0 0.3 GO:0097338 response to clozapine(GO:0097338)
0.0 0.3 GO:0006235 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
0.0 0.1 GO:0072709 cellular response to sorbitol(GO:0072709)
0.0 0.2 GO:0097501 detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0 0.1 GO:0045354 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
0.0 0.5 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.1 GO:0051138 positive regulation of NK T cell differentiation(GO:0051138)
0.0 0.1 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.0 0.2 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.0 0.1 GO:0010157 response to chlorate(GO:0010157)
0.0 0.6 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.1 GO:0046684 response to pyrethroid(GO:0046684)
0.0 0.1 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.1 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0 0.1 GO:0033386 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.0 0.1 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.0 0.2 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.0 0.6 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 0.2 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.1 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
0.0 0.1 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 0.1 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.1 GO:1904209 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.0 0.1 GO:0071879 positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.0 0.1 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.0 0.1 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
0.0 0.2 GO:0021759 globus pallidus development(GO:0021759)
0.0 0.1 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.2 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
0.0 0.1 GO:0070444 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.0 0.1 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.0 0.1 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0 0.1 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.0 0.6 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.0 0.0 GO:0021523 somatic motor neuron differentiation(GO:0021523)
0.0 0.1 GO:1900827 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.1 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.0 0.1 GO:1901189 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.1 GO:0060023 soft palate development(GO:0060023)
0.0 0.6 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.0 GO:0072095 regulation of branch elongation involved in ureteric bud branching(GO:0072095)
0.0 0.1 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
0.0 0.1 GO:0050893 sensory processing(GO:0050893)
0.0 0.1 GO:0034476 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.0 0.4 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 0.0 GO:0009996 negative regulation of cell fate specification(GO:0009996)
0.0 0.2 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.1 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.0 0.0 GO:0072086 specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
0.0 0.1 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.0 0.1 GO:1904684 negative regulation of metalloendopeptidase activity(GO:1904684)
0.0 0.3 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.2 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.0 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.0 0.2 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.1 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.1 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.4 GO:0051764 actin crosslink formation(GO:0051764)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.1 1.0 GO:0061700 GATOR2 complex(GO:0061700)
0.1 0.2 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.4 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.3 GO:0070695 FHF complex(GO:0070695)
0.0 0.6 GO:0016342 catenin complex(GO:0016342)
0.0 0.3 GO:0035976 AP1 complex(GO:0035976)
0.0 0.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.5 GO:0070938 contractile ring(GO:0070938)
0.0 0.2 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.1 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.0 0.1 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.1 GO:0075341 host cell PML body(GO:0075341)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 0.2 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.1 GO:0031673 H zone(GO:0031673)
0.0 0.2 GO:0060091 kinocilium(GO:0060091)
0.0 0.1 GO:0097422 tubular endosome(GO:0097422)
0.0 0.0 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.1 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.2 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.1 GO:0044294 dendritic growth cone(GO:0044294)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.1 0.3 GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462)
0.0 0.2 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.2 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.0 0.4 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.1 GO:0019150 D-ribulokinase activity(GO:0019150)
0.0 0.1 GO:1904713 beta-catenin destruction complex binding(GO:1904713)
0.0 0.2 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.0 0.1 GO:1990175 EH domain binding(GO:1990175)
0.0 0.5 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.8 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.3 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.0 0.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.5 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.5 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.1 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.3 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.1 GO:0005119 smoothened binding(GO:0005119)
0.0 0.7 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0070491 RNA polymerase II repressing transcription factor binding(GO:0001103) repressing transcription factor binding(GO:0070491)
0.0 0.1 GO:0030350 iron-responsive element binding(GO:0030350)
0.0 0.1 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 1.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.7 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.2 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.3 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.1 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.2 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.1 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 0.0 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 0.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.1 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 0.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.2 GO:0070513 death domain binding(GO:0070513)
0.0 0.0 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 0.1 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) chondroitin sulfotransferase activity(GO:0034481)
0.0 0.0 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.1 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.3 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.7 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.9 PID HNF3A PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.4 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.2 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.4 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors