Project
NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
Navigation
Downloads
Results for KLF8
Z-value: 1.08
Motif logo
Transcription factors associated with KLF8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF8 | hg19_v2_chrX_+_56258844_56258882 | -0.70 | 1.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_2487631 Show fit | 0.72 |
ENST00000409119.1
|
tumor necrosis factor receptor superfamily, member 14 |
|
| chr21_-_44898015 Show fit | 0.59 |
ENST00000332440.3
|
long intergenic non-protein coding RNA 313 |
|
| chr20_+_19738792 Show fit | 0.48 |
ENST00000412571.1
|
RP1-122P22.2 |
|
| chr19_-_10024496 Show fit | 0.47 |
ENST00000593091.1
|
olfactomedin 2 |
|
| chr17_+_19920456 Show fit | 0.47 |
ENST00000582604.1
|
sperm antigen with calponin homology and coiled-coil domains 1 |
|
| chr8_-_145578505 Show fit | 0.41 |
ENST00000526263.1
ENST00000398633.3 |
transmembrane protein 249 |
|
| chr15_+_29211570 Show fit | 0.41 |
ENST00000558804.1
|
amyloid beta (A4) precursor protein-binding, family A, member 2 |
|
| chrX_-_153707246 Show fit | 0.41 |
ENST00000407062.1
|
L antigen family, member 3 |
|
| chr6_-_160114260 Show fit | 0.41 |
ENST00000367054.2
ENST00000367055.4 ENST00000444946.2 ENST00000452684.2 |
superoxide dismutase 2, mitochondrial |
|
| chr12_+_48152774 Show fit | 0.40 |
ENST00000549243.1
|
solute carrier family 48 (heme transporter), member 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF8
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.3 | GO:0009440 | cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440) |
| 0.0 | 1.2 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.0 | 0.7 | GO:2001268 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268) |
| 0.0 | 0.7 | GO:0006878 | cellular copper ion homeostasis(GO:0006878) |
| 0.0 | 0.7 | GO:0015886 | heme transport(GO:0015886) |
| 0.0 | 0.7 | GO:2001135 | regulation of endocytic recycling(GO:2001135) |
| 0.0 | 0.7 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 0.0 | 0.7 | GO:0006735 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.1 | 0.6 | GO:0003070 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 0.1 | 0.5 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 0.9 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 0.7 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.0 | 0.6 | GO:0046930 | pore complex(GO:0046930) |
| 0.0 | 0.6 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 0.5 | GO:0000408 | EKC/KEOPS complex(GO:0000408) |
| 0.1 | 0.5 | GO:0034688 | integrin alphaM-beta2 complex(GO:0034688) |
| 0.1 | 0.5 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.0 | 0.5 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.1 | 0.4 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.1 | GO:0016784 | 3-mercaptopyruvate sulfurtransferase activity(GO:0016784) |
| 0.0 | 0.8 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.1 | 0.7 | GO:0016721 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.1 | 0.6 | GO:0004645 | phosphorylase activity(GO:0004645) |
| 0.0 | 0.6 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.0 | 0.6 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.0 | 0.6 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.0 | 0.6 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.0 | 0.6 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 0.0 | 0.6 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 1.6 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.7 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.7 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 0.6 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 0.6 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 0.6 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 0.5 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 0.5 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.4 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.9 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.0 | 0.8 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 0.8 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 0.8 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.7 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 0.7 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.0 | 0.7 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.7 | REACTOME NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Neurotransmitter Release Cycle |
| 0.0 | 0.6 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |