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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for KLF7

Z-value: 0.31

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Transcription factors associated with KLF7

Gene Symbol Gene ID Gene Info
KLF7
ENSG00000118263.10 Kruppel like factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
KLF7hg19_v2_chr2_-_208030647_208030689-0.786.8e-02Click!

Activity profile of KLF7 motif

Sorted Z-values of KLF7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_19229218 0.18 ENST00000432718.1
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr16_+_81772633 0.15 ENST00000566191.1
ENST00000565272.1
ENST00000563954.1
ENST00000565054.1
RP11-960L18.1
PLCG2
RP11-960L18.1
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr17_+_19282064 0.14 ENST00000603493.1
MAPK7
mitogen-activated protein kinase 7
chr17_-_48277552 0.13 ENST00000507689.1
COL1A1
collagen, type I, alpha 1
chr12_-_49581152 0.12 ENST00000550811.1
TUBA1A
tubulin, alpha 1a
chr6_-_109703663 0.11 ENST00000368961.5
CD164
CD164 molecule, sialomucin
chr19_-_7694417 0.10 ENST00000358368.4
ENST00000534844.1
XAB2
XPA binding protein 2
chr1_-_19229014 0.09 ENST00000538839.1
ENST00000290597.5
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr9_-_35812140 0.09 ENST00000497810.1
ENST00000396638.2
ENST00000484764.1
SPAG8
sperm associated antigen 8
chr1_-_6453426 0.08 ENST00000545482.1
ACOT7
acyl-CoA thioesterase 7
chr1_-_6453399 0.08 ENST00000608083.1
ACOT7
acyl-CoA thioesterase 7
chr8_+_17104401 0.08 ENST00000324815.3
ENST00000518038.1
VPS37A
vacuolar protein sorting 37 homolog A (S. cerevisiae)
chr2_-_74710078 0.08 ENST00000290418.4
CCDC142
coiled-coil domain containing 142
chr1_-_19229248 0.07 ENST00000375341.3
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr17_+_38375528 0.06 ENST00000583268.1
WIPF2
WAS/WASL interacting protein family, member 2
chr2_+_67624430 0.05 ENST00000272342.5
ETAA1
Ewing tumor-associated antigen 1
chr20_+_2821366 0.04 ENST00000453689.1
ENST00000417508.1
VPS16
vacuolar protein sorting 16 homolog (S. cerevisiae)
chr19_+_39390320 0.04 ENST00000576510.1
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr19_+_39390587 0.03 ENST00000572515.1
ENST00000392079.3
ENST00000575359.1
ENST00000313582.5
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr12_-_49582837 0.03 ENST00000547939.1
ENST00000546918.1
ENST00000552924.1
TUBA1A
tubulin, alpha 1a
chr22_-_30987849 0.03 ENST00000402284.3
ENST00000354694.7
PES1
pescadillo ribosomal biogenesis factor 1
chr3_+_178865887 0.03 ENST00000477735.1
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr5_+_173315283 0.03 ENST00000265085.5
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr12_-_49582593 0.02 ENST00000295766.5
TUBA1A
tubulin, alpha 1a
chr20_+_2821340 0.02 ENST00000380445.3
ENST00000380469.3
VPS16
vacuolar protein sorting 16 homolog (S. cerevisiae)
chr22_-_30987837 0.02 ENST00000335214.6
PES1
pescadillo ribosomal biogenesis factor 1
chr7_-_47492782 0.02 ENST00000413551.1
TNS3
tensin 3
chr6_-_33239712 0.02 ENST00000436044.2
VPS52
vacuolar protein sorting 52 homolog (S. cerevisiae)
chr2_-_188430478 0.02 ENST00000421427.1
TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr7_+_27779714 0.02 ENST00000265393.6
ENST00000409980.1
ENST00000433216.2
ENST00000396319.2
TAX1BP1
Tax1 (human T-cell leukemia virus type I) binding protein 1
chr17_+_41476327 0.02 ENST00000320033.4
ARL4D
ADP-ribosylation factor-like 4D
chr1_+_28157273 0.02 ENST00000311772.5
ENST00000236412.7
ENST00000373931.4
PPP1R8
protein phosphatase 1, regulatory subunit 8
chr14_+_38660185 0.02 ENST00000555655.1
CTD-2142D14.1
CTD-2142D14.1
chr9_+_130565147 0.02 ENST00000373247.2
ENST00000373245.1
ENST00000393706.2
ENST00000373228.1
FPGS
folylpolyglutamate synthase
chr2_-_61765732 0.01 ENST00000443240.1
ENST00000436018.1
XPO1
exportin 1 (CRM1 homolog, yeast)
chr5_+_141348721 0.01 ENST00000507163.1
ENST00000394519.1
RNF14
ring finger protein 14
chr19_-_39390212 0.01 ENST00000437828.1
SIRT2
sirtuin 2
chr16_+_20499024 0.01 ENST00000593357.1
AC137056.1
Uncharacterized protein; cDNA FLJ34659 fis, clone KIDNE2018863
chr13_-_111522162 0.01 ENST00000538077.1
LINC00346
long intergenic non-protein coding RNA 346
chrX_+_102631844 0.01 ENST00000372634.1
ENST00000299872.7
NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr17_+_18218587 0.01 ENST00000406438.3
SMCR8
Smith-Magenis syndrome chromosome region, candidate 8
chr1_-_161102367 0.01 ENST00000464113.1
DEDD
death effector domain containing
chr6_-_33239612 0.01 ENST00000482399.1
ENST00000445902.2
VPS52
vacuolar protein sorting 52 homolog (S. cerevisiae)
chr17_+_38375574 0.01 ENST00000323571.4
ENST00000585043.1
ENST00000394103.3
ENST00000536600.1
WIPF2
WAS/WASL interacting protein family, member 2
chr20_-_2821271 0.01 ENST00000448755.1
ENST00000360652.2
PCED1A
PC-esterase domain containing 1A
chr14_+_29234870 0.00 ENST00000382535.3
FOXG1
forkhead box G1
chrX_-_92928557 0.00 ENST00000373079.3
ENST00000475430.2
NAP1L3
nucleosome assembly protein 1-like 3
chr17_-_4269768 0.00 ENST00000396981.2
UBE2G1
ubiquitin-conjugating enzyme E2G 1
chr8_-_17104356 0.00 ENST00000361272.4
ENST00000523917.1
CNOT7
CCR4-NOT transcription complex, subunit 7
chr11_+_18417948 0.00 ENST00000542179.1
LDHA
lactate dehydrogenase A
chr16_+_11439286 0.00 ENST00000312499.5
ENST00000576027.1
RMI2
RecQ mediated genome instability 2
chr3_+_178866199 0.00 ENST00000263967.3
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr17_-_18218270 0.00 ENST00000321105.5
TOP3A
topoisomerase (DNA) III alpha
chr20_-_2821756 0.00 ENST00000356872.3
ENST00000439542.1
PCED1A
PC-esterase domain containing 1A
chr19_-_40931891 0.00 ENST00000357949.4
SERTAD1
SERTA domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0010133 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.0 0.1 GO:0070376 regulation of ERK5 cascade(GO:0070376) negative regulation of ERK5 cascade(GO:0070377)
0.0 0.2 GO:0036114 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.0 0.1 GO:0002316 follicular B cell differentiation(GO:0002316)
0.0 0.1 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.0 0.1 GO:0044691 tooth eruption(GO:0044691)
0.0 0.1 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005584 collagen type I trimer(GO:0005584)
0.0 0.1 GO:0071012 catalytic step 1 spliceosome(GO:0071012)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity(GO:0003842)
0.0 0.2 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)