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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for KLF6

Z-value: 0.91

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Transcription factors associated with KLF6

Gene Symbol Gene ID Gene Info
KLF6
ENSG00000067082.10 Kruppel like factor 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
KLF6hg19_v2_chr10_-_3827417_3827473-0.572.4e-01Click!

Activity profile of KLF6 motif

Sorted Z-values of KLF6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_42994283 0.66 ENST00000593179.1
GFAP
glial fibrillary acidic protein
chr16_-_30134441 0.56 ENST00000395200.1
MAPK3
mitogen-activated protein kinase 3
chr16_-_30134266 0.45 ENST00000484663.1
ENST00000478356.1
MAPK3
mitogen-activated protein kinase 3
chr20_+_31350184 0.41 ENST00000328111.2
ENST00000353855.2
ENST00000348286.2
DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta
chr1_-_156698181 0.35 ENST00000313146.6
ISG20L2
interferon stimulated exonuclease gene 20kDa-like 2
chr17_-_42277203 0.35 ENST00000587097.1
ATXN7L3
ataxin 7-like 3
chr17_-_53499218 0.33 ENST00000571578.1
MMD
monocyte to macrophage differentiation-associated
chr16_-_30134524 0.33 ENST00000395202.1
ENST00000395199.3
ENST00000263025.4
ENST00000322266.5
ENST00000403394.1
MAPK3
mitogen-activated protein kinase 3
chr19_+_45504688 0.32 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
RELB
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr17_-_73874654 0.32 ENST00000254816.2
TRIM47
tripartite motif containing 47
chr1_+_43148059 0.31 ENST00000321358.7
ENST00000332220.6
YBX1
Y box binding protein 1
chr1_+_169075554 0.29 ENST00000367815.4
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr3_+_49711777 0.28 ENST00000442186.1
ENST00000438011.1
ENST00000457042.1
APEH
acylaminoacyl-peptide hydrolase
chr19_+_54372877 0.27 ENST00000414489.1
MYADM
myeloid-associated differentiation marker
chr20_-_31172598 0.27 ENST00000201961.2
C20orf112
chromosome 20 open reading frame 112
chr1_-_156698591 0.26 ENST00000368219.1
ISG20L2
interferon stimulated exonuclease gene 20kDa-like 2
chr20_+_48807351 0.26 ENST00000303004.3
CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr17_+_4854375 0.25 ENST00000521811.1
ENST00000519602.1
ENST00000323997.6
ENST00000522249.1
ENST00000519584.1
ENO3
enolase 3 (beta, muscle)
chr1_+_198126209 0.25 ENST00000367383.1
NEK7
NIMA-related kinase 7
chr11_+_71238313 0.25 ENST00000398536.4
KRTAP5-7
keratin associated protein 5-7
chr3_+_49711391 0.24 ENST00000296456.5
ENST00000449966.1
APEH
acylaminoacyl-peptide hydrolase
chr20_+_34680698 0.24 ENST00000447825.1
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr1_-_115632035 0.23 ENST00000433172.1
ENST00000369514.2
ENST00000369516.2
ENST00000369515.2
TSPAN2
tetraspanin 2
chr6_+_11537910 0.23 ENST00000543875.1
TMEM170B
transmembrane protein 170B
chr9_+_129987488 0.23 ENST00000446764.1
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr1_+_43148625 0.23 ENST00000436427.1
YBX1
Y box binding protein 1
chr18_-_51750948 0.22 ENST00000583046.1
ENST00000398398.2
MBD2
methyl-CpG binding domain protein 2
chr11_+_94706804 0.22 ENST00000335080.5
KDM4D
lysine (K)-specific demethylase 4D
chr1_-_38273840 0.22 ENST00000373044.2
YRDC
yrdC N(6)-threonylcarbamoyltransferase domain containing
chr4_-_103789996 0.21 ENST00000508238.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr19_+_36545833 0.21 ENST00000401500.2
ENST00000270301.7
ENST00000427823.2
WDR62
WD repeat domain 62
chr6_-_32811771 0.21 ENST00000395339.3
ENST00000374882.3
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8
chr15_-_75743915 0.20 ENST00000394949.4
SIN3A
SIN3 transcription regulator family member A
chr18_+_3449821 0.20 ENST00000407501.2
ENST00000405385.3
ENST00000546979.1
TGIF1
TGFB-induced factor homeobox 1
chr3_-_51533966 0.20 ENST00000504652.1
VPRBP
Vpr (HIV-1) binding protein
chr6_+_83073952 0.20 ENST00000543496.1
TPBG
trophoblast glycoprotein
chr14_+_75230011 0.20 ENST00000552421.1
ENST00000325680.7
ENST00000238571.3
YLPM1
YLP motif containing 1
chr7_-_72936608 0.20 ENST00000404251.1
BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr17_-_42276574 0.20 ENST00000589805.1
ATXN7L3
ataxin 7-like 3
chr9_-_115249484 0.19 ENST00000457681.1
C9orf147
chromosome 9 open reading frame 147
chr11_+_64052944 0.19 ENST00000535675.1
ENST00000543383.1
GPR137
G protein-coupled receptor 137
chr17_-_53499310 0.19 ENST00000262065.3
MMD
monocyte to macrophage differentiation-associated
chr19_+_36545781 0.18 ENST00000388999.3
WDR62
WD repeat domain 62
chr3_-_170626376 0.18 ENST00000487522.1
ENST00000474417.1
EIF5A2
eukaryotic translation initiation factor 5A2
chr8_-_33424636 0.18 ENST00000256257.1
RNF122
ring finger protein 122
chr15_-_72612470 0.18 ENST00000287202.5
CELF6
CUGBP, Elav-like family member 6
chr20_+_30555805 0.17 ENST00000562532.2
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr14_-_73925225 0.17 ENST00000356296.4
ENST00000355058.3
ENST00000359560.3
ENST00000557597.1
ENST00000554394.1
ENST00000555238.1
ENST00000535282.1
ENST00000555987.1
ENST00000555394.1
ENST00000554546.1
NUMB
numb homolog (Drosophila)
chr15_-_75744014 0.17 ENST00000394947.3
ENST00000565264.1
SIN3A
SIN3 transcription regulator family member A
chr1_-_156051789 0.17 ENST00000532414.2
MEX3A
mex-3 RNA binding family member A
chr1_+_40506255 0.17 ENST00000421589.1
CAP1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr19_+_38879061 0.17 ENST00000587013.1
SPRED3
sprouty-related, EVH1 domain containing 3
chr6_+_24495067 0.17 ENST00000357578.3
ENST00000546278.1
ENST00000491546.1
ALDH5A1
aldehyde dehydrogenase 5 family, member A1
chr11_+_64053005 0.17 ENST00000538032.1
GPR137
G protein-coupled receptor 137
chr6_-_31697563 0.17 ENST00000375789.2
ENST00000416410.1
DDAH2
dimethylarginine dimethylaminohydrolase 2
chr2_-_159313214 0.16 ENST00000409889.1
ENST00000283233.5
ENST00000536771.1
CCDC148
coiled-coil domain containing 148
chr12_+_52445191 0.16 ENST00000243050.1
ENST00000394825.1
ENST00000550763.1
ENST00000394824.2
ENST00000548232.1
ENST00000562373.1
NR4A1
nuclear receptor subfamily 4, group A, member 1
chr9_+_100745615 0.16 ENST00000339399.4
ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr19_-_14201507 0.16 ENST00000533683.2
SAMD1
sterile alpha motif domain containing 1
chr3_-_53080047 0.16 ENST00000482396.1
ENST00000358080.2
ENST00000296295.6
ENST00000394752.3
SFMBT1
Scm-like with four mbt domains 1
chr22_+_35653445 0.16 ENST00000420166.1
ENST00000444518.2
ENST00000455359.1
ENST00000216106.5
HMGXB4
HMG box domain containing 4
chr6_-_110500905 0.16 ENST00000392587.2
WASF1
WAS protein family, member 1
chr6_-_110501200 0.16 ENST00000392586.1
ENST00000419252.1
ENST00000392589.1
ENST00000392588.1
ENST00000359451.2
WASF1
WAS protein family, member 1
chr1_+_156698743 0.16 ENST00000524343.1
RRNAD1
ribosomal RNA adenine dimethylase domain containing 1
chr18_+_3449695 0.16 ENST00000343820.5
TGIF1
TGFB-induced factor homeobox 1
chr1_-_6321035 0.16 ENST00000377893.2
GPR153
G protein-coupled receptor 153
chr3_-_170626418 0.16 ENST00000474096.1
ENST00000295822.2
EIF5A2
eukaryotic translation initiation factor 5A2
chr3_+_10289707 0.16 ENST00000287652.4
TATDN2
TatD DNase domain containing 2
chr11_-_9482010 0.16 ENST00000596206.1
AC132192.1
LOC644656 protein; Uncharacterized protein
chr20_+_57466629 0.15 ENST00000371081.1
ENST00000338783.6
GNAS
GNAS complex locus
chr10_+_104474353 0.15 ENST00000602647.1
ENST00000602439.1
ENST00000602764.1
SFXN2
sideroflexin 2
chr11_+_94706973 0.15 ENST00000536741.1
KDM4D
lysine (K)-specific demethylase 4D
chr1_+_6673745 0.15 ENST00000377648.4
PHF13
PHD finger protein 13
chr19_+_13906250 0.15 ENST00000254323.2
ZSWIM4
zinc finger, SWIM-type containing 4
chr3_+_184032313 0.15 ENST00000392537.2
ENST00000444134.1
ENST00000450424.1
ENST00000421110.1
ENST00000382330.3
ENST00000426123.1
ENST00000350481.5
ENST00000455679.1
ENST00000440448.1
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr17_+_6926339 0.15 ENST00000293805.5
BCL6B
B-cell CLL/lymphoma 6, member B
chr14_+_94640671 0.15 ENST00000328839.3
PPP4R4
protein phosphatase 4, regulatory subunit 4
chr16_+_30406423 0.15 ENST00000524644.1
ZNF48
zinc finger protein 48
chr10_+_45869652 0.14 ENST00000542434.1
ENST00000374391.2
ALOX5
arachidonate 5-lipoxygenase
chr17_-_36762095 0.14 ENST00000578925.1
ENST00000264659.7
SRCIN1
SRC kinase signaling inhibitor 1
chr3_+_10290596 0.14 ENST00000448281.2
TATDN2
TatD DNase domain containing 2
chr17_+_45771420 0.14 ENST00000578982.1
TBKBP1
TBK1 binding protein 1
chr5_+_38845960 0.14 ENST00000502536.1
OSMR
oncostatin M receptor
chr15_-_83316254 0.14 ENST00000567678.1
ENST00000450751.2
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr17_-_16395328 0.14 ENST00000470794.1
FAM211A
family with sequence similarity 211, member A
chr19_-_10047219 0.14 ENST00000264833.4
OLFM2
olfactomedin 2
chr2_+_48667983 0.13 ENST00000449090.2
PPP1R21
protein phosphatase 1, regulatory subunit 21
chr9_+_34989638 0.13 ENST00000453597.3
ENST00000335998.3
ENST00000312316.5
DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr2_+_48667898 0.13 ENST00000281394.4
ENST00000294952.8
PPP1R21
protein phosphatase 1, regulatory subunit 21
chr17_-_36956155 0.13 ENST00000269554.3
PIP4K2B
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
chr14_+_100705322 0.13 ENST00000262238.4
YY1
YY1 transcription factor
chr15_-_75743991 0.13 ENST00000567289.1
SIN3A
SIN3 transcription regulator family member A
chr16_-_49315731 0.13 ENST00000219197.6
CBLN1
cerebellin 1 precursor
chr3_+_184032283 0.13 ENST00000346169.2
ENST00000414031.1
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr16_+_75032901 0.13 ENST00000335325.4
ENST00000320619.6
ZNRF1
zinc and ring finger 1, E3 ubiquitin protein ligase
chr17_-_7518145 0.13 ENST00000250113.7
ENST00000571597.1
FXR2
fragile X mental retardation, autosomal homolog 2
chr17_+_8339340 0.13 ENST00000580012.1
NDEL1
nudE neurodevelopment protein 1-like 1
chrX_-_47479246 0.13 ENST00000295987.7
ENST00000340666.4
SYN1
synapsin I
chr10_-_101380121 0.13 ENST00000370495.4
SLC25A28
solute carrier family 25 (mitochondrial iron transporter), member 28
chr6_+_43739697 0.13 ENST00000230480.6
VEGFA
vascular endothelial growth factor A
chr11_+_129939779 0.13 ENST00000533195.1
ENST00000533713.1
ENST00000528499.1
ENST00000539648.1
ENST00000263574.5
APLP2
amyloid beta (A4) precursor-like protein 2
chr12_+_70132632 0.13 ENST00000378815.6
ENST00000483530.2
ENST00000325555.9
RAB3IP
RAB3A interacting protein
chr5_-_168006591 0.13 ENST00000239231.6
PANK3
pantothenate kinase 3
chr6_+_160390102 0.13 ENST00000356956.1
IGF2R
insulin-like growth factor 2 receptor
chr1_-_205649580 0.13 ENST00000367145.3
SLC45A3
solute carrier family 45, member 3
chr6_+_31126291 0.13 ENST00000376257.3
ENST00000376255.4
TCF19
transcription factor 19
chr8_+_73449625 0.13 ENST00000523207.1
KCNB2
potassium voltage-gated channel, Shab-related subfamily, member 2
chr2_+_10442993 0.13 ENST00000423674.1
ENST00000307845.3
HPCAL1
hippocalcin-like 1
chr10_+_35416223 0.13 ENST00000489321.1
ENST00000427847.2
ENST00000345491.3
ENST00000395895.2
ENST00000374728.3
ENST00000487132.1
CREM
cAMP responsive element modulator
chr19_+_39989535 0.13 ENST00000356433.5
DLL3
delta-like 3 (Drosophila)
chr3_+_160473343 0.13 ENST00000497343.1
PPM1L
protein phosphatase, Mg2+/Mn2+ dependent, 1L
chr3_+_38495333 0.13 ENST00000352511.4
ACVR2B
activin A receptor, type IIB
chr6_+_99282570 0.13 ENST00000328345.5
POU3F2
POU class 3 homeobox 2
chrX_+_37430822 0.13 ENST00000378621.3
ENST00000378619.3
LANCL3
LanC lantibiotic synthetase component C-like 3 (bacterial)
chr3_-_88108212 0.13 ENST00000482016.1
CGGBP1
CGG triplet repeat binding protein 1
chr14_-_73924954 0.12 ENST00000555307.1
ENST00000554818.1
NUMB
numb homolog (Drosophila)
chr22_+_38005033 0.12 ENST00000447515.1
ENST00000406772.1
ENST00000431745.1
GGA1
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
chr20_+_60813535 0.12 ENST00000358053.2
ENST00000313733.3
ENST00000439951.2
OSBPL2
oxysterol binding protein-like 2
chr1_-_182361327 0.12 ENST00000331872.6
ENST00000311223.5
GLUL
glutamate-ammonia ligase
chr17_+_43299241 0.12 ENST00000328118.3
FMNL1
formin-like 1
chr4_+_89444961 0.12 ENST00000513325.1
HERC3
HECT and RLD domain containing E3 ubiquitin protein ligase 3
chr1_+_40506392 0.12 ENST00000414893.1
ENST00000414281.1
ENST00000420216.1
ENST00000372792.2
ENST00000372798.1
ENST00000340450.3
ENST00000372805.3
ENST00000435719.1
ENST00000427843.1
ENST00000417287.1
ENST00000424977.1
ENST00000446031.1
CAP1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr19_-_47734448 0.12 ENST00000439096.2
BBC3
BCL2 binding component 3
chr20_+_2673383 0.12 ENST00000380648.4
ENST00000342725.5
EBF4
early B-cell factor 4
chr6_-_44095183 0.12 ENST00000372014.3
MRPL14
mitochondrial ribosomal protein L14
chr19_+_15218180 0.12 ENST00000342784.2
ENST00000597977.1
ENST00000600440.1
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr1_+_156698234 0.12 ENST00000368218.4
ENST00000368216.4
RRNAD1
ribosomal RNA adenine dimethylase domain containing 1
chr4_-_77819002 0.12 ENST00000334306.2
SOWAHB
sosondowah ankyrin repeat domain family member B
chr1_+_107682629 0.12 ENST00000370074.4
ENST00000370073.2
ENST00000370071.2
ENST00000542803.1
ENST00000370061.3
ENST00000370072.3
ENST00000370070.2
NTNG1
netrin G1
chr11_+_57365150 0.12 ENST00000457869.1
ENST00000340687.6
ENST00000378323.4
ENST00000378324.2
ENST00000403558.1
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr12_-_31479107 0.12 ENST00000542983.1
FAM60A
family with sequence similarity 60, member A
chr17_+_43299156 0.12 ENST00000331495.3
FMNL1
formin-like 1
chr2_+_74781828 0.12 ENST00000340004.6
DOK1
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
chr15_-_74726283 0.12 ENST00000543145.2
SEMA7A
semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
chr6_+_37787704 0.12 ENST00000474522.1
ZFAND3
zinc finger, AN1-type domain 3
chr3_+_184079492 0.11 ENST00000456318.1
ENST00000412877.1
ENST00000438240.1
POLR2H
polymerase (RNA) II (DNA directed) polypeptide H
chr12_-_92539614 0.11 ENST00000256015.3
BTG1
B-cell translocation gene 1, anti-proliferative
chr8_-_38034192 0.11 ENST00000520755.1
LSM1
LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr19_+_38880695 0.11 ENST00000587947.1
ENST00000338502.4
SPRED3
sprouty-related, EVH1 domain containing 3
chr1_-_205904950 0.11 ENST00000340781.4
SLC26A9
solute carrier family 26 (anion exchanger), member 9
chr14_-_21945057 0.11 ENST00000397762.1
RAB2B
RAB2B, member RAS oncogene family
chr21_-_35987438 0.11 ENST00000313806.4
RCAN1
regulator of calcineurin 1
chr20_-_524415 0.11 ENST00000400217.2
CSNK2A1
casein kinase 2, alpha 1 polypeptide
chr11_+_64008525 0.11 ENST00000449942.2
FKBP2
FK506 binding protein 2, 13kDa
chr17_+_7452336 0.11 ENST00000293826.4
TNFSF12-TNFSF13
TNFSF12-TNFSF13 readthrough
chr17_-_74449252 0.11 ENST00000319380.7
UBE2O
ubiquitin-conjugating enzyme E2O
chr17_-_60885645 0.11 ENST00000544856.2
MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr1_+_113615794 0.11 ENST00000361127.5
LRIG2
leucine-rich repeats and immunoglobulin-like domains 2
chrX_+_64887512 0.11 ENST00000360270.5
MSN
moesin
chr6_+_44238203 0.11 ENST00000451188.2
TMEM151B
transmembrane protein 151B
chr11_+_111473108 0.11 ENST00000304987.3
SIK2
salt-inducible kinase 2
chr1_+_151512775 0.11 ENST00000368849.3
ENST00000392712.3
ENST00000353024.3
ENST00000368848.2
ENST00000538902.1
TUFT1
tuftelin 1
chr1_-_154531095 0.10 ENST00000292211.4
UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr11_-_89224638 0.10 ENST00000535633.1
ENST00000263317.4
NOX4
NADPH oxidase 4
chr20_-_56284816 0.10 ENST00000395819.3
ENST00000341744.3
PMEPA1
prostate transmembrane protein, androgen induced 1
chr17_+_7452442 0.10 ENST00000557233.1
TNFSF12
tumor necrosis factor (ligand) superfamily, member 12
chr6_+_31588478 0.10 ENST00000376007.4
ENST00000376033.2
PRRC2A
proline-rich coiled-coil 2A
chr11_+_65769946 0.10 ENST00000533166.1
BANF1
barrier to autointegration factor 1
chr7_+_128379449 0.10 ENST00000479257.1
CALU
calumenin
chrX_+_69674943 0.10 ENST00000542398.1
DLG3
discs, large homolog 3 (Drosophila)
chr11_-_94706705 0.10 ENST00000279839.6
CWC15
CWC15 spliceosome-associated protein homolog (S. cerevisiae)
chr20_-_20693131 0.10 ENST00000202677.7
RALGAPA2
Ral GTPase activating protein, alpha subunit 2 (catalytic)
chr1_-_200992827 0.10 ENST00000332129.2
ENST00000422435.2
KIF21B
kinesin family member 21B
chr2_-_30144432 0.10 ENST00000389048.3
ALK
anaplastic lymphoma receptor tyrosine kinase
chr4_+_6202448 0.10 ENST00000508601.1
RP11-586D19.1
RP11-586D19.1
chrX_+_21958814 0.10 ENST00000379404.1
ENST00000415881.2
SMS
spermine synthase
chr5_+_141016969 0.10 ENST00000518856.1
RELL2
RELT-like 2
chr19_+_532049 0.10 ENST00000606136.1
CDC34
cell division cycle 34
chr7_-_107643674 0.10 ENST00000222399.6
LAMB1
laminin, beta 1
chr5_+_138089100 0.10 ENST00000520339.1
ENST00000355078.5
ENST00000302763.7
ENST00000518910.1
CTNNA1
catenin (cadherin-associated protein), alpha 1, 102kDa
chr15_+_41221536 0.09 ENST00000249749.5
DLL4
delta-like 4 (Drosophila)
chr8_-_74884511 0.09 ENST00000518127.1
TCEB1
transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
chr14_-_62162541 0.09 ENST00000557544.1
HIF1A-AS1
HIF1A antisense RNA 1
chr11_-_47870019 0.09 ENST00000378460.2
NUP160
nucleoporin 160kDa
chr12_-_112856623 0.09 ENST00000551291.2
RPL6
ribosomal protein L6
chr9_-_131038266 0.09 ENST00000490628.1
ENST00000421699.2
ENST00000450617.1
GOLGA2
golgin A2
chr17_-_58469687 0.09 ENST00000590133.1
USP32
ubiquitin specific peptidase 32
chr19_+_54372693 0.09 ENST00000391768.2
MYADM
myeloid-associated differentiation marker
chr11_-_65626753 0.09 ENST00000526975.1
ENST00000531413.1
CFL1
cofilin 1 (non-muscle)
chr7_-_72936531 0.09 ENST00000339594.4
BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr12_+_112856690 0.09 ENST00000392597.1
ENST00000351677.2
PTPN11
protein tyrosine phosphatase, non-receptor type 11
chr18_+_55102917 0.09 ENST00000491143.2
ONECUT2
one cut homeobox 2
chr10_-_75634219 0.09 ENST00000305762.7
CAMK2G
calcium/calmodulin-dependent protein kinase II gamma
chr15_-_80215984 0.09 ENST00000485386.1
ENST00000479961.1
ST20
ST20-MTHFS
suppressor of tumorigenicity 20
ST20-MTHFS readthrough
chr20_-_524340 0.09 ENST00000400227.3
CSNK2A1
casein kinase 2, alpha 1 polypeptide
chrX_+_48660287 0.09 ENST00000444343.2
ENST00000376610.2
ENST00000334136.5
ENST00000376619.2
HDAC6
histone deacetylase 6
chr19_+_16435625 0.09 ENST00000248071.5
ENST00000592003.1
KLF2
Kruppel-like factor 2
chr11_-_113345842 0.09 ENST00000346454.3
DRD2
dopamine receptor D2
chr12_-_107487604 0.09 ENST00000008527.5
CRY1
cryptochrome 1 (photolyase-like)
chr9_-_130517522 0.09 ENST00000373274.3
ENST00000420366.1
SH2D3C
SH2 domain containing 3C
chr1_-_160040038 0.09 ENST00000368089.3
KCNJ10
potassium inwardly-rectifying channel, subfamily J, member 10
chr19_-_39340563 0.09 ENST00000601813.1
HNRNPL
heterogeneous nuclear ribonucleoprotein L
chr12_-_49351148 0.09 ENST00000398092.4
ENST00000539611.1
RP11-302B13.5
ARF3
ADP-ribosylation factor 3
ADP-ribosylation factor 3
chr7_-_27213893 0.09 ENST00000283921.4
HOXA10
homeobox A10
chr5_-_176037105 0.09 ENST00000303991.4
GPRIN1
G protein regulated inducer of neurite outgrowth 1
chr1_+_167190066 0.09 ENST00000367866.2
ENST00000429375.2
ENST00000452019.1
ENST00000420254.3
ENST00000541643.3
POU2F1
POU class 2 homeobox 1
chr4_-_153700864 0.09 ENST00000304337.2
TIGD4
tigger transposable element derived 4
chr11_+_64053311 0.09 ENST00000540370.1
GPR137
G protein-coupled receptor 137
chr17_+_38296576 0.09 ENST00000264645.7
CASC3
cancer susceptibility candidate 3
chr17_-_7120498 0.09 ENST00000485100.1
DLG4
discs, large homolog 4 (Drosophila)

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:2000656 regulation of apolipoprotein binding(GO:2000656) negative regulation of apolipoprotein binding(GO:2000657)
0.1 0.5 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.1 0.1 GO:0042092 type 2 immune response(GO:0042092)
0.1 0.2 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.1 0.3 GO:0006597 spermine biosynthetic process(GO:0006597)
0.1 0.3 GO:0030862 positive regulation of polarized epithelial cell differentiation(GO:0030862)
0.1 0.6 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 0.2 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.1 0.4 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.0 0.4 GO:0032776 DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0 0.4 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.0 0.2 GO:0051796 regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910)
0.0 0.1 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.0 0.1 GO:1903570 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.0 0.3 GO:1903281 protein transport into plasma membrane raft(GO:0044861) positive regulation of calcium:sodium antiporter activity(GO:1903281) positive regulation of potassium ion import(GO:1903288)
0.0 0.2 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.0 0.3 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.2 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.0 0.1 GO:0019285 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.1 GO:0070843 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.0 0.2 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.0 0.2 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
0.0 0.7 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.0 0.1 GO:0061582 intestinal epithelial cell migration(GO:0061582)
0.0 0.1 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.0 0.1 GO:0032848 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.0 0.1 GO:1903597 negative regulation of gap junction assembly(GO:1903597)
0.0 0.1 GO:0032707 negative regulation of interleukin-23 production(GO:0032707)
0.0 0.1 GO:1904617 negative regulation of actin filament binding(GO:1904530) negative regulation of actin binding(GO:1904617)
0.0 0.1 GO:0036269 swimming behavior(GO:0036269)
0.0 0.1 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.4 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.0 0.1 GO:0008050 female courtship behavior(GO:0008050)
0.0 0.1 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.0 0.0 GO:0071878 negative regulation of adrenergic receptor signaling pathway(GO:0071878)
0.0 0.5 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.0 0.1 GO:2000784 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.0 0.1 GO:0034499 late endosome to Golgi transport(GO:0034499)
0.0 0.1 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.0 0.1 GO:0060434 bronchus morphogenesis(GO:0060434)
0.0 0.1 GO:0090166 Golgi disassembly(GO:0090166)
0.0 0.1 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.1 GO:0090170 regulation of Golgi inheritance(GO:0090170)
0.0 0.1 GO:0015862 uridine transport(GO:0015862)
0.0 0.6 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.1 GO:1903526 negative regulation of membrane tubulation(GO:1903526)
0.0 0.1 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0 0.4 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.2 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.1 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.1 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.0 0.1 GO:0051944 glial cell-derived neurotrophic factor secretion(GO:0044467) positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944) negative regulation of dopamine receptor signaling pathway(GO:0060160) regulation of locomotion involved in locomotory behavior(GO:0090325) regulation of glial cell-derived neurotrophic factor secretion(GO:1900166) positive regulation of glial cell-derived neurotrophic factor secretion(GO:1900168)
0.0 0.1 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.1 GO:0038162 erythropoietin-mediated signaling pathway(GO:0038162)
0.0 0.2 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.3 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 0.1 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0 0.1 GO:0090261 positive regulation of inclusion body assembly(GO:0090261)
0.0 0.1 GO:0060579 ventral spinal cord interneuron fate commitment(GO:0060579) cell fate commitment involved in pattern specification(GO:0060581) regulation of neural retina development(GO:0061074)
0.0 0.1 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.2 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.0 0.1 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.0 0.1 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0 0.1 GO:2001300 lipoxin metabolic process(GO:2001300)
0.0 0.0 GO:0097676 histone H3-K36 trimethylation(GO:0097198) histone H3-K36 dimethylation(GO:0097676)
0.0 0.0 GO:0006425 glutaminyl-tRNA aminoacylation(GO:0006425)
0.0 0.1 GO:0019074 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.0 0.0 GO:0000189 MAPK import into nucleus(GO:0000189)
0.0 0.2 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 0.1 GO:0071486 cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.0 0.0 GO:0016574 histone ubiquitination(GO:0016574)
0.0 0.2 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.1 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.0 0.1 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.1 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.0 0.0 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.0 0.1 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501)
0.0 0.2 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.1 GO:0051935 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.0 0.0 GO:2000138 positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138)
0.0 0.5 GO:0019835 cytolysis(GO:0019835)
0.0 0.1 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.0 0.1 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.1 GO:0070572 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0 0.1 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.0 0.1 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0 0.1 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.1 GO:0061107 prostate gland stromal morphogenesis(GO:0060741) seminal vesicle development(GO:0061107)
0.0 0.1 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0 0.0 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.1 GO:0003415 chondrocyte hypertrophy(GO:0003415)
0.0 0.1 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
0.0 0.2 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.1 GO:0032927 foregut morphogenesis(GO:0007440) positive regulation of activin receptor signaling pathway(GO:0032927) embryonic foregut morphogenesis(GO:0048617)
0.0 0.1 GO:0043335 protein unfolding(GO:0043335)
0.0 0.0 GO:0055099 response to high density lipoprotein particle(GO:0055099)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0043257 laminin-8 complex(GO:0043257)
0.1 0.5 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.1 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 1.4 GO:0031143 pseudopodium(GO:0031143)
0.0 0.3 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.5 GO:0000124 SAGA complex(GO:0000124)
0.0 0.1 GO:0009346 citrate lyase complex(GO:0009346)
0.0 0.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.1 GO:0005960 glycine cleavage complex(GO:0005960)
0.0 0.1 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.0 0.2 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.8 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.1 GO:0032021 NELF complex(GO:0032021)
0.0 0.3 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.1 GO:0032798 Swi5-Sfr1 complex(GO:0032798)
0.0 0.1 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.0 0.2 GO:0016589 NURF complex(GO:0016589)
0.0 0.1 GO:0045160 myosin I complex(GO:0045160)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.7 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.2 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.0 0.2 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.1 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 0.4 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0030175 filopodium(GO:0030175)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)
0.0 0.2 GO:0032059 bleb(GO:0032059)
0.0 0.2 GO:0097386 glial cell projection(GO:0097386)
0.0 0.4 GO:0071011 precatalytic spliceosome(GO:0071011)
0.0 0.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.1 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0016768 spermine synthase activity(GO:0016768)
0.1 0.2 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 0.4 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.2 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 1.3 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.1 GO:0070012 oligopeptidase activity(GO:0070012)
0.0 0.2 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.1 GO:0008184 purine nucleobase binding(GO:0002060) glycogen phosphorylase activity(GO:0008184)
0.0 0.1 GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity(GO:0030272)
0.0 0.1 GO:0003878 ATP citrate synthase activity(GO:0003878)
0.0 0.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.1 GO:0031711 bradykinin receptor binding(GO:0031711)
0.0 0.1 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.0 0.1 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.0 0.2 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.1 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.1 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.1 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.0 0.1 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.0 0.5 GO:0008242 omega peptidase activity(GO:0008242)
0.0 0.3 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.4 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.3 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.1 GO:0051022 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.4 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.0 GO:0003863 alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863)
0.0 0.2 GO:0031748 D1 dopamine receptor binding(GO:0031748)
0.0 0.0 GO:0004819 glutamine-tRNA ligase activity(GO:0004819)
0.0 0.1 GO:0017002 activin-activated receptor activity(GO:0017002)
0.0 0.3 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.0 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.1 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.1 GO:0035197 siRNA binding(GO:0035197)
0.0 0.1 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.0 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.0 0.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.1 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 0.0 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.0 0.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.1 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.1 PID EPO PATHWAY EPO signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.1 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.4 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.3 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.7 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease