Project
NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
Navigation
Downloads
Results for KLF3
Z-value: 1.32
Motif logo
Transcription factors associated with KLF3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF3 | hg19_v2_chr4_+_38665810_38665827 | -0.52 | 2.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.1 | GO:0030223 | neutrophil differentiation(GO:0030223) |
| 0.2 | 2.5 | GO:2001268 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268) |
| 0.0 | 1.3 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.4 | 1.2 | GO:0017186 | peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186) |
| 0.1 | 1.0 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.1 | 0.9 | GO:0000023 | maltose metabolic process(GO:0000023) |
| 0.1 | 0.8 | GO:0010989 | negative regulation of low-density lipoprotein particle clearance(GO:0010989) |
| 0.0 | 0.8 | GO:0007620 | copulation(GO:0007620) |
| 0.0 | 0.8 | GO:0006636 | unsaturated fatty acid biosynthetic process(GO:0006636) |
| 0.1 | 0.7 | GO:0071603 | endothelial cell-cell adhesion(GO:0071603) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 1.2 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 1.1 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.0 | 1.0 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.0 | 1.0 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.2 | 0.7 | GO:0071665 | gamma-catenin-TCF7L2 complex(GO:0071665) |
| 0.1 | 0.7 | GO:0010370 | perinucleolar chromocenter(GO:0010370) |
| 0.0 | 0.7 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.0 | 0.7 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.2 | 0.6 | GO:0035525 | NF-kappaB p50/p65 complex(GO:0035525) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.6 | GO:0070851 | growth factor receptor binding(GO:0070851) |
| 0.0 | 3.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.4 | 1.2 | GO:0016603 | glutaminyl-peptide cyclotransferase activity(GO:0016603) |
| 0.2 | 1.1 | GO:0030377 | urokinase plasminogen activator receptor activity(GO:0030377) |
| 0.0 | 1.1 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.0 | 1.0 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.1 | 0.9 | GO:0004558 | alpha-1,4-glucosidase activity(GO:0004558) maltose alpha-glucosidase activity(GO:0032450) |
| 0.1 | 0.9 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 0.8 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.0 | 0.8 | GO:0043495 | protein anchor(GO:0043495) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 1.7 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.0 | 1.4 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 1.2 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.0 | 1.0 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.0 | 0.7 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 0.6 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.0 | 0.6 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.4 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.4 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 1.3 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 1.1 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.0 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.8 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.0 | 0.8 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 0.6 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.0 | 0.6 | REACTOME REGULATED PROTEOLYSIS OF P75NTR | Genes involved in Regulated proteolysis of p75NTR |
| 0.0 | 0.5 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.5 | REACTOME HEMOSTASIS | Genes involved in Hemostasis |