Project
NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
Navigation
Downloads
Results for KLF16_SP2
Z-value: 1.43
Motif logo
Transcription factors associated with KLF16_SP2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF16 | hg19_v2_chr19_-_1863567_1863586 | 0.83 | 3.9e-02 | Click! |
| SP2 | hg19_v2_chr17_+_45973516_45973618 | -0.01 | 9.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF16_SP2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.5 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 3.1 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 0.3 | 2.6 | GO:0006021 | inositol biosynthetic process(GO:0006021) |
| 0.2 | 2.5 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 0.2 | 2.5 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.1 | 2.5 | GO:0030252 | growth hormone secretion(GO:0030252) |
| 0.0 | 2.4 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.2 | 2.3 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 0.0 | 2.2 | GO:0050650 | chondroitin sulfate proteoglycan biosynthetic process(GO:0050650) |
| 0.0 | 2.2 | GO:0090630 | activation of GTPase activity(GO:0090630) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.7 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 3.7 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 3.0 | GO:0005903 | brush border(GO:0005903) |
| 0.2 | 2.5 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.0 | 2.5 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 2.3 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.1 | 2.2 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.0 | 2.2 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 2.0 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.0 | 1.9 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.5 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.0 | 5.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 4.0 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 3.5 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 2.8 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.1 | 2.6 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.2 | 2.5 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 0.1 | 2.5 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.1 | 2.5 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.1 | 2.0 | GO:0005024 | transforming growth factor beta-activated receptor activity(GO:0005024) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 3.6 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.0 | 3.6 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.1 | 3.3 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 2.7 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 2.6 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 2.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.2 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 2.1 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 1.9 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.4 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 3.2 | REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY | Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| 0.1 | 2.9 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 2.8 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 2.5 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 2.5 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.0 | 2.2 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 2.1 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.1 | 1.8 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 1.8 | REACTOME EXTRACELLULAR MATRIX ORGANIZATION | Genes involved in Extracellular matrix organization |