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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for KLF14_SP8
Z-value: 1.83
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Transcription factors associated with KLF14_SP8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP8 | hg19_v2_chr7_-_20826504_20826526 | -0.59 | 2.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF14_SP8
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.6 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.8 | 2.4 | GO:1903461 | Okazaki fragment processing involved in mitotic DNA replication(GO:1903461) |
| 0.5 | 2.4 | GO:0090285 | negative regulation of protein glycosylation in Golgi(GO:0090285) |
| 0.1 | 2.1 | GO:0016926 | protein desumoylation(GO:0016926) |
| 0.1 | 1.4 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.1 | 1.2 | GO:0019614 | phenol-containing compound catabolic process(GO:0019336) catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
| 0.0 | 1.2 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.3 | 1.0 | GO:0046210 | nitrate catabolic process(GO:0043602) nitric oxide catabolic process(GO:0046210) |
| 0.1 | 1.0 | GO:0060355 | positive regulation of cell adhesion molecule production(GO:0060355) |
| 0.1 | 1.0 | GO:0032484 | Ral protein signal transduction(GO:0032484) regulation of Ral protein signal transduction(GO:0032485) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 2.2 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.1 | 2.2 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.1 | 1.4 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.1 | 1.3 | GO:0033263 | CORVET complex(GO:0033263) |
| 0.0 | 1.3 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.2 | 1.1 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.0 | 1.1 | GO:0030660 | Golgi-associated vesicle membrane(GO:0030660) |
| 0.1 | 1.0 | GO:0000796 | condensin complex(GO:0000796) |
| 0.0 | 1.0 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 2.4 | GO:0071633 | dihydroceramidase activity(GO:0071633) |
| 0.2 | 2.1 | GO:0003910 | DNA ligase (ATP) activity(GO:0003910) |
| 0.2 | 2.1 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.0 | 1.9 | GO:0030145 | manganese ion binding(GO:0030145) |
| 0.0 | 1.5 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.1 | 1.2 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 0.0 | 1.2 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.1 | 1.1 | GO:0030172 | troponin C binding(GO:0030172) |
| 0.3 | 1.0 | GO:0047726 | iron-cytochrome-c reductase activity(GO:0047726) |
| 0.1 | 1.0 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.1 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 0.9 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.0 | 0.8 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 0.6 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.0 | 0.6 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 0.6 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 0.5 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.5 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 0.4 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 2.4 | REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND | Genes involved in Processive synthesis on the lagging strand |
| 0.0 | 2.1 | REACTOME MUSCLE CONTRACTION | Genes involved in Muscle contraction |
| 0.0 | 1.5 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 1.1 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.0 | 1.1 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 1.0 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.9 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.8 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 0.8 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |