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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for KLF1
Z-value: 1.01
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Transcription factors associated with KLF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF1 | hg19_v2_chr19_-_12997995_12998021 | 0.56 | 2.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.3 | GO:0030223 | neutrophil differentiation(GO:0030223) |
| 0.4 | 1.6 | GO:0002384 | hepatic immune response(GO:0002384) response to prolactin(GO:1990637) |
| 0.2 | 0.7 | GO:0072255 | metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936) |
| 0.1 | 0.7 | GO:0045905 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.2 | 0.6 | GO:1990654 | sebum secreting cell proliferation(GO:1990654) |
| 0.1 | 0.6 | GO:0060708 | spongiotrophoblast differentiation(GO:0060708) |
| 0.0 | 0.6 | GO:0031639 | plasminogen activation(GO:0031639) |
| 0.0 | 0.6 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
| 0.0 | 0.6 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.2 | 0.5 | GO:0006147 | guanine catabolic process(GO:0006147) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.6 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.0 | 0.8 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.0 | 0.6 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.0 | 0.5 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.1 | 0.4 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
| 0.1 | 0.3 | GO:0045160 | myosin I complex(GO:0045160) |
| 0.1 | 0.3 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.0 | 0.3 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.0 | 0.3 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
| 0.0 | 0.3 | GO:0005922 | connexon complex(GO:0005922) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | GO:0070851 | growth factor receptor binding(GO:0070851) |
| 0.0 | 2.7 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.2 | 1.6 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.0 | 0.7 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.0 | 0.7 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.2 | 0.6 | GO:0004108 | citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440) |
| 0.2 | 0.6 | GO:0005146 | leukemia inhibitory factor receptor binding(GO:0005146) |
| 0.0 | 0.6 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.0 | 0.6 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.2 | 0.5 | GO:0008892 | guanine deaminase activity(GO:0008892) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.0 | 1.2 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 1.1 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 0.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.3 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 0.1 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 1.6 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.6 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 0.6 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.0 | 0.6 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.5 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 0.5 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 0.3 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.0 | 0.3 | REACTOME SPRY REGULATION OF FGF SIGNALING | Genes involved in Spry regulation of FGF signaling |
| 0.0 | 0.3 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |