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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ISX
Z-value: 0.67
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Transcription factors associated with ISX
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ISX | hg19_v2_chr22_+_35462129_35462156 | -0.18 | 7.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_153044083 Show fit | 0.70 |
ENST00000341611.2
|
small proline-rich protein 2B |
|
| chr7_+_37723336 Show fit | 0.65 |
ENST00000450180.1
|
G protein-coupled receptor 141 |
|
| chr16_-_55866997 Show fit | 0.59 |
ENST00000360526.3
ENST00000361503.4 |
carboxylesterase 1 |
|
| chr17_-_18266818 Show fit | 0.43 |
ENST00000583780.1
|
serine hydroxymethyltransferase 1 (soluble) |
|
| chr8_-_82395461 Show fit | 0.42 |
ENST00000256104.4
|
fatty acid binding protein 4, adipocyte |
|
| chr6_+_3259148 Show fit | 0.34 |
ENST00000419065.2
ENST00000473000.2 ENST00000451246.2 ENST00000454610.2 |
proteasome (prosome, macropain) assembly chaperone 4 |
|
| chr22_+_46476192 Show fit | 0.32 |
ENST00000443490.1
|
hsa-mir-4763 |
|
| chr16_-_55867146 Show fit | 0.28 |
ENST00000422046.2
|
carboxylesterase 1 |
|
| chr11_+_77532233 Show fit | 0.25 |
ENST00000525409.1
|
adipogenesis associated, Mth938 domain containing |
|
| chr18_-_67624412 Show fit | 0.22 |
ENST00000580335.1
|
CD226 molecule |
Network of associatons between targets according to the STRING database.
First level regulatory network of ISX
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.9 | GO:0090119 | vesicle-mediated cholesterol transport(GO:0090119) |
| 0.1 | 0.6 | GO:0010836 | negative regulation of protein ADP-ribosylation(GO:0010836) |
| 0.0 | 0.4 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
| 0.0 | 0.4 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.1 | 0.3 | GO:0006258 | UDP-glucose catabolic process(GO:0006258) |
| 0.1 | 0.3 | GO:1904481 | response to tetrahydrofolate(GO:1904481) cellular response to tetrahydrofolate(GO:1904482) |
| 0.1 | 0.3 | GO:0033383 | geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337) |
| 0.0 | 0.3 | GO:0002729 | positive regulation of natural killer cell cytokine production(GO:0002729) |
| 0.0 | 0.3 | GO:0031120 | snRNA pseudouridine synthesis(GO:0031120) |
| 0.0 | 0.3 | GO:0043248 | proteasome assembly(GO:0043248) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | GO:0010370 | perinucleolar chromocenter(GO:0010370) |
| 0.0 | 0.3 | GO:0072589 | box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661) |
| 0.0 | 0.3 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 0.2 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 0.1 | GO:0036338 | viral envelope(GO:0019031) viral membrane(GO:0036338) |
| 0.0 | 0.1 | GO:0031302 | intrinsic component of endosome membrane(GO:0031302) |
| 0.0 | 0.1 | GO:1990298 | mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298) |
| 0.0 | 0.1 | GO:0070826 | paraferritin complex(GO:0070826) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.9 | GO:0047374 | methylumbelliferyl-acetate deacetylase activity(GO:0047374) |
| 0.0 | 0.4 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.1 | 0.3 | GO:0070905 | serine binding(GO:0070905) |
| 0.1 | 0.3 | GO:0004337 | dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337) |
| 0.0 | 0.3 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 0.0 | 0.3 | GO:0070569 | uridylyltransferase activity(GO:0070569) |
| 0.1 | 0.2 | GO:0047536 | 2-aminoadipate transaminase activity(GO:0047536) |
| 0.1 | 0.2 | GO:0005277 | acetylcholine transmembrane transporter activity(GO:0005277) acetate ester transmembrane transporter activity(GO:1901375) |
| 0.0 | 0.2 | GO:0004382 | guanosine-diphosphatase activity(GO:0004382) |
| 0.0 | 0.2 | GO:0032554 | purine deoxyribonucleotide binding(GO:0032554) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 0.4 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.0 | 0.4 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.4 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.2 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.0 | 0.2 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |