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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ISL2

Z-value: 0.30

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Transcription factors associated with ISL2

Gene Symbol Gene ID Gene Info
ISL2
ENSG00000159556.5 ISL LIM homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ISL2hg19_v2_chr15_+_76629064_766290730.197.1e-01Click!

Activity profile of ISL2 motif

Sorted Z-values of ISL2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_64798826 0.17 ENST00000540203.1
XPOT
exportin, tRNA
chr15_+_90735145 0.13 ENST00000559792.1
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr4_+_169013666 0.12 ENST00000359299.3
ANXA10
annexin A10
chr8_-_116504448 0.11 ENST00000518018.1
TRPS1
trichorhinophalangeal syndrome I
chr7_-_111032971 0.10 ENST00000450877.1
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr3_-_150421752 0.10 ENST00000498386.1
FAM194A
family with sequence similarity 194, member A
chr3_+_169629354 0.08 ENST00000428432.2
ENST00000335556.3
SAMD7
sterile alpha motif domain containing 7
chr11_+_327171 0.07 ENST00000534483.1
ENST00000524824.1
ENST00000531076.1
RP11-326C3.12
RP11-326C3.12
chr3_+_172468505 0.07 ENST00000427830.1
ENST00000417960.1
ENST00000428567.1
ENST00000366090.2
ENST00000426894.1
ECT2
epithelial cell transforming sequence 2 oncogene
chr14_-_51027838 0.07 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr6_-_138833630 0.07 ENST00000533765.1
NHSL1
NHS-like 1
chr3_+_172468472 0.07 ENST00000232458.5
ENST00000392692.3
ECT2
epithelial cell transforming sequence 2 oncogene
chr11_-_8892900 0.07 ENST00000526155.1
ENST00000524757.1
ENST00000527392.1
ENST00000534665.1
ENST00000525169.1
ENST00000527516.1
ENST00000533471.1
ST5
suppression of tumorigenicity 5
chr15_+_58702742 0.06 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr12_-_118628315 0.06 ENST00000540561.1
TAOK3
TAO kinase 3
chr2_-_10587897 0.06 ENST00000405333.1
ENST00000443218.1
ODC1
ornithine decarboxylase 1
chr2_-_190446738 0.06 ENST00000427419.1
ENST00000455320.1
SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr4_+_26344754 0.06 ENST00000515573.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr18_-_64271316 0.06 ENST00000540086.1
ENST00000580157.1
CDH19
cadherin 19, type 2
chr4_+_15471489 0.06 ENST00000424120.1
ENST00000413206.1
ENST00000438599.2
ENST00000511544.1
ENST00000512702.1
ENST00000507954.1
ENST00000515124.1
ENST00000503292.1
ENST00000503658.1
CC2D2A
coiled-coil and C2 domain containing 2A
chr18_+_61575200 0.06 ENST00000238508.3
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr2_+_88047606 0.06 ENST00000359481.4
PLGLB2
plasminogen-like B2
chr12_-_51422017 0.06 ENST00000394904.3
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr2_+_105050794 0.06 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
AC013402.2
long intergenic non-protein coding RNA 1102
chr5_-_139726181 0.06 ENST00000507104.1
ENST00000230990.6
HBEGF
heparin-binding EGF-like growth factor
chr10_-_27529486 0.06 ENST00000375888.1
ACBD5
acyl-CoA binding domain containing 5
chr13_-_46716969 0.05 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr12_+_59194154 0.05 ENST00000548969.1
RP11-362K2.2
Protein LOC100506869
chr12_+_64798095 0.05 ENST00000332707.5
XPOT
exportin, tRNA
chr12_+_122356488 0.05 ENST00000397454.2
WDR66
WD repeat domain 66
chr2_-_136633940 0.05 ENST00000264156.2
MCM6
minichromosome maintenance complex component 6
chr20_-_33735070 0.05 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr7_-_107883678 0.04 ENST00000417701.1
NRCAM
neuronal cell adhesion molecule
chr12_-_49581152 0.04 ENST00000550811.1
TUBA1A
tubulin, alpha 1a
chr9_-_99540328 0.04 ENST00000223428.4
ENST00000375231.1
ENST00000374641.3
ZNF510
zinc finger protein 510
chr12_-_12715266 0.04 ENST00000228862.2
DUSP16
dual specificity phosphatase 16
chr8_-_133772870 0.04 ENST00000522334.1
ENST00000519016.1
TMEM71
transmembrane protein 71
chr11_-_92931098 0.04 ENST00000326402.4
SLC36A4
solute carrier family 36 (proton/amino acid symporter), member 4
chr5_-_130500922 0.04 ENST00000513012.1
ENST00000508488.1
ENST00000506908.1
ENST00000304043.5
HINT1
histidine triad nucleotide binding protein 1
chr2_+_113825547 0.04 ENST00000341010.2
ENST00000337569.3
IL1F10
interleukin 1 family, member 10 (theta)
chr17_-_47786375 0.04 ENST00000511657.1
SLC35B1
solute carrier family 35, member B1
chr19_+_29456034 0.04 ENST00000589921.1
LINC00906
long intergenic non-protein coding RNA 906
chr4_+_71108300 0.04 ENST00000304954.3
CSN3
casein kappa
chr11_-_107729887 0.04 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr8_+_133909919 0.04 ENST00000518505.1
TG
thyroglobulin
chr1_-_202897724 0.03 ENST00000435533.3
ENST00000367258.1
KLHL12
kelch-like family member 12
chr12_+_75784850 0.03 ENST00000550916.1
ENST00000435775.1
ENST00000378689.2
ENST00000378692.3
ENST00000320460.4
ENST00000547164.1
GLIPR1L2
GLI pathogenesis-related 1 like 2
chr9_+_35042205 0.03 ENST00000312292.5
ENST00000378745.3
C9orf131
chromosome 9 open reading frame 131
chr7_+_16700806 0.03 ENST00000446596.1
ENST00000438834.1
BZW2
basic leucine zipper and W2 domains 2
chr3_+_138327542 0.03 ENST00000360570.3
ENST00000393035.2
FAIM
Fas apoptotic inhibitory molecule
chr8_+_70404996 0.03 ENST00000402687.4
ENST00000419716.3
SULF1
sulfatase 1
chr2_+_234668894 0.03 ENST00000305208.5
ENST00000608383.1
ENST00000360418.3
UGT1A8
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
UDP glucuronosyltransferase 1 family, polypeptide A8
chr13_-_20806440 0.03 ENST00000400066.3
ENST00000400065.3
ENST00000356192.6
GJB6
gap junction protein, beta 6, 30kDa
chr5_+_68860949 0.03 ENST00000507595.1
GTF2H2C
general transcription factor IIH, polypeptide 2C
chr14_-_53258314 0.03 ENST00000216410.3
ENST00000557604.1
GNPNAT1
glucosamine-phosphate N-acetyltransferase 1
chr4_+_26324474 0.03 ENST00000514675.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr21_-_46534873 0.03 ENST00000596207.1
PRED58
PRED58
chr11_-_28129656 0.03 ENST00000263181.6
KIF18A
kinesin family member 18A
chr4_+_25162253 0.03 ENST00000512921.1
PI4K2B
phosphatidylinositol 4-kinase type 2 beta
chr17_-_33390667 0.03 ENST00000378516.2
ENST00000268850.7
ENST00000394597.2
RFFL
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr2_+_231921574 0.03 ENST00000308696.6
ENST00000373635.4
ENST00000440838.1
ENST00000409643.1
PSMD1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr14_-_55907334 0.03 ENST00000247219.5
TBPL2
TATA box binding protein like 2
chr1_+_149871171 0.03 ENST00000369150.1
BOLA1
bolA family member 1
chr14_-_74025625 0.03 ENST00000553558.1
ENST00000563329.1
ENST00000334988.2
ENST00000560393.1
HEATR4
HEAT repeat containing 4
chr1_+_152178320 0.03 ENST00000429352.1
RP11-107M16.2
RP11-107M16.2
chr21_+_15588499 0.03 ENST00000400577.3
RBM11
RNA binding motif protein 11
chr11_+_86085778 0.03 ENST00000354755.1
ENST00000278487.3
ENST00000531271.1
ENST00000445632.2
CCDC81
coiled-coil domain containing 81
chr6_+_130339710 0.03 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr7_-_151330218 0.02 ENST00000476632.1
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr6_+_29555683 0.02 ENST00000383640.2
OR2H2
olfactory receptor, family 2, subfamily H, member 2
chr17_-_4710288 0.02 ENST00000571067.1
RP11-81A22.5
RP11-81A22.5
chr15_+_64680003 0.02 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chr4_+_95128748 0.02 ENST00000359052.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr7_-_81635106 0.02 ENST00000443883.1
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr4_+_86525299 0.02 ENST00000512201.1
ARHGAP24
Rho GTPase activating protein 24
chr8_-_121457608 0.02 ENST00000306185.3
MRPL13
mitochondrial ribosomal protein L13
chr12_+_26164645 0.02 ENST00000542004.1
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr10_-_95242044 0.02 ENST00000371501.4
ENST00000371502.4
ENST00000371489.1
MYOF
myoferlin
chr14_+_92789498 0.02 ENST00000531433.1
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr10_+_63422695 0.02 ENST00000330194.2
ENST00000389639.3
C10orf107
chromosome 10 open reading frame 107
chr15_+_79166065 0.02 ENST00000559690.1
ENST00000559158.1
MORF4L1
mortality factor 4 like 1
chr12_-_110937351 0.02 ENST00000552130.2
VPS29
vacuolar protein sorting 29 homolog (S. cerevisiae)
chr3_-_20227619 0.02 ENST00000425061.1
ENST00000443724.1
ENST00000421451.1
ENST00000452020.1
ENST00000417364.1
ENST00000306698.2
ENST00000419233.2
ENST00000263753.4
ENST00000383774.1
ENST00000437051.1
ENST00000412868.1
ENST00000429446.3
ENST00000442720.1
SGOL1
shugoshin-like 1 (S. pombe)
chr3_+_136649311 0.02 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1
chr11_+_12132117 0.02 ENST00000256194.4
MICAL2
microtubule associated monooxygenase, calponin and LIM domain containing 2
chr3_+_134514093 0.02 ENST00000398015.3
EPHB1
EPH receptor B1
chr6_+_31105426 0.02 ENST00000547221.1
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr21_+_39644395 0.02 ENST00000398934.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chrX_-_77225135 0.02 ENST00000458128.1
PGAM4
phosphoglycerate mutase family member 4
chr14_-_90798273 0.02 ENST00000357904.3
NRDE2
NRDE-2, necessary for RNA interference, domain containing
chrX_-_100872911 0.02 ENST00000361910.4
ENST00000539247.1
ENST00000538627.1
ARMCX6
armadillo repeat containing, X-linked 6
chr1_-_93257951 0.02 ENST00000543509.1
ENST00000370331.1
ENST00000540033.1
EVI5
ecotropic viral integration site 5
chr1_-_232651312 0.02 ENST00000262861.4
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr17_+_1674982 0.02 ENST00000572048.1
ENST00000573763.1
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr11_+_28129795 0.02 ENST00000406787.3
ENST00000342303.5
ENST00000403099.1
ENST00000407364.3
METTL15
methyltransferase like 15
chr4_-_90756769 0.02 ENST00000345009.4
ENST00000505199.1
ENST00000502987.1
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr14_-_67878917 0.02 ENST00000216446.4
PLEK2
pleckstrin 2
chr4_+_95128996 0.02 ENST00000457823.2
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr6_+_42989344 0.02 ENST00000244496.5
RRP36
ribosomal RNA processing 36 homolog (S. cerevisiae)
chr11_+_73498898 0.02 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48
mitochondrial ribosomal protein L48
chr11_-_107729504 0.02 ENST00000265836.7
SLC35F2
solute carrier family 35, member F2
chr21_-_30445886 0.02 ENST00000431234.1
ENST00000540844.1
ENST00000286788.4
CCT8
chaperonin containing TCP1, subunit 8 (theta)
chr2_-_207078086 0.02 ENST00000442134.1
GPR1
G protein-coupled receptor 1
chr5_-_54988448 0.01 ENST00000503817.1
ENST00000512595.1
SLC38A9
solute carrier family 38, member 9
chr9_-_95298254 0.01 ENST00000444490.2
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr13_+_49551020 0.01 ENST00000541916.1
FNDC3A
fibronectin type III domain containing 3A
chr3_-_183145873 0.01 ENST00000447025.2
ENST00000414362.2
ENST00000328913.3
MCF2L2
MCF.2 cell line derived transforming sequence-like 2
chr4_+_74576019 0.01 ENST00000436089.1
AC112518.3
AC112518.3
chr1_+_66820058 0.01 ENST00000480109.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr17_+_7155819 0.01 ENST00000570322.1
ENST00000576496.1
ENST00000574841.2
ELP5
elongator acetyltransferase complex subunit 5
chrX_-_32173579 0.01 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
DMD
dystrophin
chrX_+_108779004 0.01 ENST00000218004.1
NXT2
nuclear transport factor 2-like export factor 2
chr6_+_151561085 0.01 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr10_-_95241951 0.01 ENST00000358334.5
ENST00000359263.4
ENST00000371488.3
MYOF
myoferlin
chr1_+_234765057 0.01 ENST00000429269.1
LINC00184
long intergenic non-protein coding RNA 184
chr17_-_48785216 0.01 ENST00000285243.6
ANKRD40
ankyrin repeat domain 40
chrX_-_84634737 0.01 ENST00000262753.4
POF1B
premature ovarian failure, 1B
chrX_-_84634708 0.01 ENST00000373145.3
POF1B
premature ovarian failure, 1B
chr7_-_115670804 0.01 ENST00000320239.7
TFEC
transcription factor EC
chr14_+_57671888 0.01 ENST00000391612.1
AL391152.1
AL391152.1
chr3_+_138327417 0.01 ENST00000338446.4
FAIM
Fas apoptotic inhibitory molecule
chr20_-_50722183 0.01 ENST00000371523.4
ZFP64
ZFP64 zinc finger protein
chr12_+_104337515 0.01 ENST00000550595.1
HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr1_+_99127225 0.01 ENST00000370189.5
ENST00000529992.1
SNX7
sorting nexin 7
chrX_+_55478538 0.01 ENST00000342972.1
MAGEH1
melanoma antigen family H, 1
chr9_+_12693336 0.01 ENST00000381137.2
ENST00000388918.5
TYRP1
tyrosinase-related protein 1
chr6_+_53964336 0.01 ENST00000447836.2
ENST00000511678.1
MLIP
muscular LMNA-interacting protein
chr14_-_90798418 0.01 ENST00000354366.3
NRDE2
NRDE-2, necessary for RNA interference, domain containing
chr13_-_45768841 0.01 ENST00000379108.1
KCTD4
potassium channel tetramerization domain containing 4
chr21_+_39644305 0.01 ENST00000398930.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr6_-_111804905 0.01 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr2_-_166060382 0.01 ENST00000409101.3
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr15_-_75748115 0.01 ENST00000360439.4
SIN3A
SIN3 transcription regulator family member A
chr15_-_42500351 0.01 ENST00000348544.4
ENST00000318006.5
VPS39
vacuolar protein sorting 39 homolog (S. cerevisiae)
chr5_+_140201183 0.01 ENST00000529619.1
ENST00000529859.1
ENST00000378126.3
PCDHA5
protocadherin alpha 5
chr7_-_37488777 0.01 ENST00000445322.1
ENST00000448602.1
ELMO1
engulfment and cell motility 1
chr1_-_174992544 0.01 ENST00000476371.1
MRPS14
mitochondrial ribosomal protein S14
chr6_+_26087509 0.01 ENST00000397022.3
ENST00000353147.5
ENST00000352392.4
ENST00000349999.4
ENST00000317896.7
ENST00000357618.5
ENST00000470149.1
ENST00000336625.8
ENST00000461397.1
ENST00000488199.1
HFE
hemochromatosis
chr6_+_161123270 0.01 ENST00000366924.2
ENST00000308192.9
ENST00000418964.1
PLG
plasminogen
chr1_-_95391315 0.01 ENST00000545882.1
ENST00000415017.1
CNN3
calponin 3, acidic
chr12_-_95945246 0.00 ENST00000258499.3
USP44
ubiquitin specific peptidase 44
chr1_-_168464875 0.00 ENST00000422253.1
RP5-968D22.3
RP5-968D22.3
chr7_-_115670792 0.00 ENST00000265440.7
ENST00000393485.1
TFEC
transcription factor EC
chr6_+_26440700 0.00 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr11_+_113779704 0.00 ENST00000537778.1
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
chr2_-_217559517 0.00 ENST00000449583.1
IGFBP5
insulin-like growth factor binding protein 5
chr15_-_72563585 0.00 ENST00000287196.9
ENST00000260376.7
PARP6
poly (ADP-ribose) polymerase family, member 6
chr2_-_87248975 0.00 ENST00000409310.2
ENST00000355705.3
PLGLB1
plasminogen-like B1
chr4_+_169418195 0.00 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr9_-_28670283 0.00 ENST00000379992.2
LINGO2
leucine rich repeat and Ig domain containing 2
chr7_-_37488834 0.00 ENST00000310758.4
ELMO1
engulfment and cell motility 1
chr2_+_234580525 0.00 ENST00000609637.1
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A8
chr19_+_49199209 0.00 ENST00000522966.1
ENST00000425340.2
ENST00000391876.4
FUT2
fucosyltransferase 2 (secretor status included)
chr4_+_113568207 0.00 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chr8_-_30706608 0.00 ENST00000256246.2
TEX15
testis expressed 15
chr19_+_4402659 0.00 ENST00000301280.5
ENST00000585854.1
CHAF1A
chromatin assembly factor 1, subunit A (p150)
chr17_-_4938712 0.00 ENST00000254853.5
ENST00000424747.1
SLC52A1
solute carrier family 52 (riboflavin transporter), member 1
chrX_+_102840408 0.00 ENST00000468024.1
ENST00000472484.1
ENST00000415568.2
ENST00000490644.1
ENST00000459722.1
ENST00000472745.1
ENST00000494801.1
ENST00000434216.2
ENST00000425011.1
TCEAL4
transcription elongation factor A (SII)-like 4
chr2_-_145277569 0.00 ENST00000303660.4
ZEB2
zinc finger E-box binding homeobox 2
chr4_-_69111401 0.00 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr7_-_55930443 0.00 ENST00000388975.3
SEPT14
septin 14
chr1_-_21377383 0.00 ENST00000374935.3
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr5_+_40841410 0.00 ENST00000381677.3
CARD6
caspase recruitment domain family, member 6

Network of associatons between targets according to the STRING database.

First level regulatory network of ISL2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 0.1 GO:0070839 regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) divalent metal ion export(GO:0070839)
0.0 0.1 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.0 0.1 GO:1901189 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.1 GO:0051541 elastin metabolic process(GO:0051541)
0.0 0.0 GO:0045209 MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209)
0.0 0.1 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.1 GO:0097149 centralspindlin complex(GO:0097149)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 0.1 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)