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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for IRX5
Z-value: 1.23
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Transcription factors associated with IRX5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRX5 | hg19_v2_chr16_+_54964740_54964789 | -0.14 | 8.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_141264597 Show fit | 2.83 |
ENST00000338517.4
ENST00000394203.3 ENST00000506322.1 |
short coiled-coil protein |
|
| chr14_+_73563735 Show fit | 1.54 |
ENST00000532192.1
|
RNA binding motif protein 25 |
|
| chr6_+_71104588 Show fit | 1.32 |
ENST00000418403.1
|
RP11-462G2.1 |
|
| chr15_+_66585555 Show fit | 0.98 |
ENST00000319194.5
ENST00000525134.2 ENST00000441424.2 |
DIS3 mitotic control homolog (S. cerevisiae)-like |
|
| chr1_-_186365908 Show fit | 0.96 |
ENST00000598663.1
|
Uncharacterized protein |
|
| chr13_+_97928395 Show fit | 0.96 |
ENST00000445661.2
|
muscleblind-like splicing regulator 2 |
|
| chr16_+_48657361 Show fit | 0.89 |
ENST00000565072.1
|
RP11-42I10.1 |
|
| chr1_+_158969752 Show fit | 0.82 |
ENST00000566111.1
|
interferon, gamma-inducible protein 16 |
|
| chr14_+_39944025 Show fit | 0.74 |
ENST00000554328.1
ENST00000556620.1 ENST00000557197.1 |
RP11-111A21.1 |
|
| chr10_-_115904361 Show fit | 0.69 |
ENST00000428953.1
ENST00000543782.1 |
chromosome 10 open reading frame 118 |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRX5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.8 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
| 0.0 | 2.3 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.1 | 1.3 | GO:0016075 | rRNA catabolic process(GO:0016075) |
| 0.0 | 1.0 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 0.1 | 0.9 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
| 0.0 | 0.9 | GO:0030224 | monocyte differentiation(GO:0030224) |
| 0.2 | 0.6 | GO:0009786 | regulation of asymmetric cell division(GO:0009786) |
| 0.1 | 0.6 | GO:0032053 | ciliary basal body organization(GO:0032053) |
| 0.0 | 0.6 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.1 | 0.5 | GO:0032571 | response to vitamin K(GO:0032571) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.1 | 1.1 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.1 | 1.0 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.1 | 0.7 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.1 | 0.6 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
| 0.1 | 0.6 | GO:0072557 | IPAF inflammasome complex(GO:0072557) |
| 0.1 | 0.6 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.0 | 0.5 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.1 | 0.3 | GO:0002189 | ribose phosphate diphosphokinase complex(GO:0002189) |
| 0.0 | 0.3 | GO:0030891 | VCB complex(GO:0030891) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.1 | 1.1 | GO:0043515 | kinetochore binding(GO:0043515) |
| 0.0 | 0.8 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.0 | 0.8 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.1 | 0.6 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
| 0.0 | 0.6 | GO:0008408 | 3'-5' exonuclease activity(GO:0008408) |
| 0.0 | 0.6 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.2 | 0.5 | GO:0070538 | oleic acid binding(GO:0070538) |
| 0.0 | 0.4 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
| 0.0 | 0.4 | GO:0015245 | fatty acid transporter activity(GO:0015245) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 0.4 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.0 | 0.5 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 0.0 | 0.4 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.0 | 0.4 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 0.4 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.0 | 0.3 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.0 | 0.3 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.3 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 0.3 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 0.3 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |