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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for IRX3
Z-value: 0.81
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Transcription factors associated with IRX3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRX3 | hg19_v2_chr16_-_54320675_54320715 | 0.32 | 5.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_58329819 Show fit | 0.66 |
ENST00000551421.1
|
RP11-620J15.3 |
|
| chr15_-_56757329 Show fit | 0.56 |
ENST00000260453.3
|
meiosis-specific nuclear structural 1 |
|
| chr17_+_18380051 Show fit | 0.47 |
ENST00000581545.1
ENST00000582333.1 ENST00000328114.6 ENST00000412421.2 ENST00000583322.1 ENST00000584941.1 |
lectin, galactoside-binding, soluble, 9C |
|
| chr13_+_97928395 Show fit | 0.46 |
ENST00000445661.2
|
muscleblind-like splicing regulator 2 |
|
| chr9_-_4679419 Show fit | 0.42 |
ENST00000609131.1
ENST00000607997.1 |
RP11-6J24.6 |
|
| chr13_+_113030658 Show fit | 0.40 |
ENST00000414180.1
ENST00000443541.1 |
sperm acrosome associated 7 |
|
| chr14_+_73563735 Show fit | 0.38 |
ENST00000532192.1
|
RNA binding motif protein 25 |
|
| chr16_-_25122735 Show fit | 0.37 |
ENST00000563176.1
|
RP11-449H11.1 |
|
| chr22_+_30821732 Show fit | 0.36 |
ENST00000355143.4
|
mitochondrial fission process 1 |
|
| chr6_+_71104588 Show fit | 0.36 |
ENST00000418403.1
|
RP11-462G2.1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRX3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.6 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
| 0.0 | 0.6 | GO:0070986 | left/right axis specification(GO:0070986) |
| 0.0 | 0.5 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.0 | 0.4 | GO:0014850 | response to muscle activity(GO:0014850) |
| 0.1 | 0.3 | GO:0043095 | regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105) |
| 0.0 | 0.3 | GO:0018406 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.0 | 0.3 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
| 0.0 | 0.3 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
| 0.0 | 0.3 | GO:0034501 | protein localization to kinetochore(GO:0034501) |
| 0.0 | 0.3 | GO:0006068 | ethanol catabolic process(GO:0006068) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 0.3 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.0 | 0.2 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.0 | 0.2 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 0.1 | GO:0005668 | RNA polymerase transcription factor SL1 complex(GO:0005668) |
| 0.0 | 0.1 | GO:0036025 | protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183) |
| 0.0 | 0.1 | GO:0002189 | ribose phosphate diphosphokinase complex(GO:0002189) |
| 0.0 | 0.1 | GO:0031592 | centrosomal corona(GO:0031592) |
| 0.0 | 0.1 | GO:0097179 | protease inhibitor complex(GO:0097179) |
| 0.0 | 0.1 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.6 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.0 | 0.5 | GO:0043515 | kinetochore binding(GO:0043515) |
| 0.1 | 0.3 | GO:0044549 | GTP cyclohydrolase binding(GO:0044549) |
| 0.1 | 0.3 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.0 | 0.3 | GO:0004465 | lipoprotein lipase activity(GO:0004465) |
| 0.0 | 0.3 | GO:0015245 | fatty acid transporter activity(GO:0015245) |
| 0.1 | 0.2 | GO:0035034 | histone acetyltransferase regulator activity(GO:0035034) |
| 0.0 | 0.2 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.0 | 0.2 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294) |
| 0.0 | 0.2 | GO:0004771 | sterol esterase activity(GO:0004771) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 0.3 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.0 | 0.3 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 0.1 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |