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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for IRX3

Z-value: 0.81

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Transcription factors associated with IRX3

Gene Symbol Gene ID Gene Info
IRX3
ENSG00000177508.11 iroquois homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX3hg19_v2_chr16_-_54320675_543207150.325.4e-01Click!

Activity profile of IRX3 motif

Sorted Z-values of IRX3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_58329819 0.66 ENST00000551421.1
RP11-620J15.3
RP11-620J15.3
chr15_-_56757329 0.56 ENST00000260453.3
MNS1
meiosis-specific nuclear structural 1
chr17_+_18380051 0.47 ENST00000581545.1
ENST00000582333.1
ENST00000328114.6
ENST00000412421.2
ENST00000583322.1
ENST00000584941.1
LGALS9C
lectin, galactoside-binding, soluble, 9C
chr13_+_97928395 0.46 ENST00000445661.2
MBNL2
muscleblind-like splicing regulator 2
chr9_-_4679419 0.42 ENST00000609131.1
ENST00000607997.1
RP11-6J24.6
RP11-6J24.6
chr13_+_113030658 0.40 ENST00000414180.1
ENST00000443541.1
SPACA7
sperm acrosome associated 7
chr14_+_73563735 0.38 ENST00000532192.1
RBM25
RNA binding motif protein 25
chr16_-_25122735 0.37 ENST00000563176.1
RP11-449H11.1
RP11-449H11.1
chr22_+_30821732 0.36 ENST00000355143.4
MTFP1
mitochondrial fission process 1
chr6_+_71104588 0.36 ENST00000418403.1
RP11-462G2.1
RP11-462G2.1
chr10_+_9012087 0.34 ENST00000456526.1
RP11-428L9.2
RP11-428L9.2
chr1_+_171060018 0.34 ENST00000367755.4
ENST00000392085.2
ENST00000542847.1
ENST00000538429.1
ENST00000479749.1
FMO3
flavin containing monooxygenase 3
chr4_+_141264597 0.33 ENST00000338517.4
ENST00000394203.3
ENST00000506322.1
SCOC
short coiled-coil protein
chr4_-_69434245 0.33 ENST00000317746.2
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B17
chr10_+_90484301 0.32 ENST00000404190.1
LIPK
lipase, family member K
chr11_+_827248 0.29 ENST00000527089.1
ENST00000530183.1
EFCAB4A
EF-hand calcium binding domain 4A
chr2_+_181988620 0.28 ENST00000428474.1
ENST00000424655.1
AC104820.2
AC104820.2
chr15_+_41057818 0.28 ENST00000558467.1
GCHFR
GTP cyclohydrolase I feedback regulator
chr5_+_169011033 0.28 ENST00000513795.1
SPDL1
spindle apparatus coiled-coil protein 1
chr2_-_70189397 0.27 ENST00000320256.4
ASPRV1
aspartic peptidase, retroviral-like 1
chr2_+_38177575 0.27 ENST00000407257.1
ENST00000417700.2
ENST00000234195.3
ENST00000442857.1
RMDN2
regulator of microtubule dynamics 2
chr2_-_16804320 0.26 ENST00000355549.2
FAM49A
family with sequence similarity 49, member A
chr4_+_71091786 0.26 ENST00000317987.5
FDCSP
follicular dendritic cell secreted protein
chr10_+_82009466 0.26 ENST00000356374.4
AL359195.1
Uncharacterized protein; cDNA FLJ46261 fis, clone TESTI4025062
chr5_+_128300810 0.26 ENST00000262462.4
SLC27A6
solute carrier family 27 (fatty acid transporter), member 6
chr3_-_139195350 0.26 ENST00000232217.2
RBP2
retinol binding protein 2, cellular
chr2_+_114163945 0.25 ENST00000453673.3
IGKV1OR2-108
immunoglobulin kappa variable 1/OR2-108 (non-functional)
chr5_+_81601166 0.25 ENST00000439350.1
ATP6AP1L
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr4_+_144312659 0.24 ENST00000509992.1
GAB1
GRB2-associated binding protein 1
chr11_+_31531291 0.23 ENST00000350638.5
ENST00000379163.5
ENST00000395934.2
ELP4
elongator acetyltransferase complex subunit 4
chr1_+_87012753 0.23 ENST00000370563.3
CLCA4
chloride channel accessory 4
chr1_+_149239529 0.23 ENST00000457216.2
RP11-403I13.4
RP11-403I13.4
chr6_+_63921399 0.23 ENST00000356170.3
FKBP1C
FK506 binding protein 1C
chr3_+_14058794 0.22 ENST00000424053.1
ENST00000528067.1
ENST00000429201.1
TPRXL
tetra-peptide repeat homeobox-like
chr16_+_48657361 0.22 ENST00000565072.1
RP11-42I10.1
RP11-42I10.1
chr12_+_55248289 0.22 ENST00000308796.6
MUCL1
mucin-like 1
chr3_+_111697843 0.21 ENST00000534857.1
ENST00000273359.3
ENST00000494817.1
ABHD10
abhydrolase domain containing 10
chr1_+_87458692 0.21 ENST00000370548.2
ENST00000356813.4
RP5-1052I5.2
HS2ST1
Heparan sulfate 2-O-sulfotransferase 1
heparan sulfate 2-O-sulfotransferase 1
chr12_+_21207503 0.21 ENST00000545916.1
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr6_+_26217159 0.21 ENST00000303910.2
HIST1H2AE
histone cluster 1, H2ae
chr17_+_74729060 0.20 ENST00000587459.1
RP11-318A15.7
Uncharacterized protein
chr4_-_70725856 0.20 ENST00000226444.3
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr14_+_39944025 0.20 ENST00000554328.1
ENST00000556620.1
ENST00000557197.1
RP11-111A21.1
RP11-111A21.1
chr4_+_70894130 0.19 ENST00000526767.1
ENST00000530128.1
ENST00000381057.3
HTN3
histatin 3
chr19_-_22379753 0.19 ENST00000397121.2
ZNF676
zinc finger protein 676
chr3_+_186383741 0.19 ENST00000232003.4
HRG
histidine-rich glycoprotein
chr9_+_135937365 0.19 ENST00000372080.4
ENST00000351304.7
CEL
carboxyl ester lipase
chr1_+_81001398 0.19 ENST00000418041.1
ENST00000443104.1
RP5-887A10.1
RP5-887A10.1
chr18_-_53303123 0.18 ENST00000569357.1
ENST00000565124.1
ENST00000398339.1
TCF4
transcription factor 4
chr9_+_26746951 0.18 ENST00000523363.1
RP11-18A15.1
RP11-18A15.1
chr3_+_177159695 0.18 ENST00000442937.1
LINC00578
long intergenic non-protein coding RNA 578
chr6_-_26108355 0.18 ENST00000338379.4
HIST1H1T
histone cluster 1, H1t
chr7_-_35013217 0.18 ENST00000446375.1
DPY19L1
dpy-19-like 1 (C. elegans)
chrX_+_109602039 0.18 ENST00000520821.1
RGAG1
retrotransposon gag domain containing 1
chr15_+_49170083 0.17 ENST00000530028.2
EID1
EP300 interacting inhibitor of differentiation 1
chr22_+_20877924 0.17 ENST00000445189.1
MED15
mediator complex subunit 15
chr5_+_136070614 0.17 ENST00000502421.1
CTB-1I21.1
CTB-1I21.1
chr1_-_186365908 0.17 ENST00000598663.1
AL596220.1
Uncharacterized protein
chr4_+_130017268 0.17 ENST00000425929.1
ENST00000508673.1
ENST00000508622.1
C4orf33
chromosome 4 open reading frame 33
chr10_-_90712520 0.17 ENST00000224784.6
ACTA2
actin, alpha 2, smooth muscle, aorta
chr9_-_139258159 0.17 ENST00000371739.3
DNLZ
DNL-type zinc finger
chr20_+_43990576 0.16 ENST00000372727.1
ENST00000414310.1
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr20_-_36156264 0.16 ENST00000445723.1
ENST00000414080.1
BLCAP
bladder cancer associated protein
chr15_-_100258029 0.16 ENST00000378904.2
DKFZP779J2370
DKFZP779J2370
chr18_-_69246186 0.16 ENST00000568095.1
RP11-510D19.1
RP11-510D19.1
chr12_-_71182695 0.16 ENST00000342084.4
PTPRR
protein tyrosine phosphatase, receptor type, R
chr8_-_50466973 0.16 ENST00000520800.1
RP11-738G5.2
Uncharacterized protein
chr6_-_26199471 0.16 ENST00000341023.1
HIST1H2AD
histone cluster 1, H2ad
chr12_-_10573149 0.15 ENST00000381904.2
ENST00000381903.2
ENST00000396439.2
KLRC3
killer cell lectin-like receptor subfamily C, member 3
chr7_-_55583740 0.15 ENST00000453256.1
VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr20_-_18477862 0.15 ENST00000337227.4
RBBP9
retinoblastoma binding protein 9
chr10_+_35484793 0.15 ENST00000488741.1
ENST00000474931.1
ENST00000468236.1
ENST00000344351.5
ENST00000490511.1
CREM
cAMP responsive element modulator
chr18_-_69246167 0.15 ENST00000566582.1
RP11-510D19.1
RP11-510D19.1
chr5_-_146833803 0.15 ENST00000512722.1
DPYSL3
dihydropyrimidinase-like 3
chr3_-_100566492 0.15 ENST00000528490.1
ABI3BP
ABI family, member 3 (NESH) binding protein
chr3_+_178865887 0.14 ENST00000477735.1
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr1_-_179457805 0.14 ENST00000600581.1
AL160286.1
Uncharacterized protein
chr12_-_100486668 0.14 ENST00000550544.1
ENST00000551980.1
ENST00000548045.1
ENST00000545232.2
ENST00000551973.1
UHRF1BP1L
UHRF1 binding protein 1-like
chr13_-_38172863 0.14 ENST00000541481.1
ENST00000379743.4
ENST00000379742.4
ENST00000379749.4
ENST00000541179.1
ENST00000379747.4
POSTN
periostin, osteoblast specific factor
chr16_-_21442874 0.14 ENST00000534903.1
NPIPB3
nuclear pore complex interacting protein family, member B3
chr3_-_48659193 0.14 ENST00000330862.3
TMEM89
transmembrane protein 89
chr1_-_62190793 0.14 ENST00000371177.2
ENST00000606498.1
TM2D1
TM2 domain containing 1
chr11_-_111782484 0.14 ENST00000533971.1
CRYAB
crystallin, alpha B
chr1_+_1846519 0.13 ENST00000378604.3
CALML6
calmodulin-like 6
chr19_-_45004556 0.13 ENST00000587047.1
ENST00000391956.4
ENST00000221327.4
ENST00000586637.1
ENST00000591064.1
ENST00000592529.1
ZNF180
zinc finger protein 180
chr12_+_69742121 0.13 ENST00000261267.2
ENST00000549690.1
ENST00000548839.1
LYZ
lysozyme
chr6_-_26199499 0.13 ENST00000377831.5
HIST1H3D
histone cluster 1, H3d
chr13_+_50589390 0.13 ENST00000360473.4
ENST00000312942.1
KCNRG
potassium channel regulator
chr11_-_63330842 0.13 ENST00000255695.1
HRASLS2
HRAS-like suppressor 2
chr11_+_114166536 0.13 ENST00000299964.3
NNMT
nicotinamide N-methyltransferase
chr7_+_80267973 0.13 ENST00000394788.3
ENST00000447544.2
CD36
CD36 molecule (thrombospondin receptor)
chr1_-_3566627 0.13 ENST00000419924.2
ENST00000270708.7
WRAP73
WD repeat containing, antisense to TP73
chr17_-_39459103 0.13 ENST00000391353.1
KRTAP29-1
keratin associated protein 29-1
chr9_+_130026756 0.13 ENST00000314904.5
ENST00000373387.4
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr11_+_34999328 0.12 ENST00000526309.1
PDHX
pyruvate dehydrogenase complex, component X
chr14_-_23623577 0.12 ENST00000422941.2
ENST00000453702.1
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr11_+_74303612 0.12 ENST00000527458.1
ENST00000532497.1
ENST00000530511.1
POLD3
polymerase (DNA-directed), delta 3, accessory subunit
chr21_-_30047095 0.12 ENST00000452028.1
ENST00000433310.2
AF131217.1
AF131217.1
chr3_-_48936272 0.12 ENST00000544097.1
ENST00000430379.1
ENST00000319017.4
SLC25A20
solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
chr6_+_127587755 0.12 ENST00000368314.1
ENST00000476956.1
ENST00000609447.1
ENST00000356799.2
ENST00000477776.1
ENST00000609944.1
RNF146
ring finger protein 146
chr17_-_29641104 0.12 ENST00000577894.1
ENST00000330927.4
EVI2B
ecotropic viral integration site 2B
chr19_+_20959098 0.12 ENST00000360204.5
ENST00000594534.1
ZNF66
zinc finger protein 66
chr12_-_52867569 0.12 ENST00000252250.6
KRT6C
keratin 6C
chr8_+_95731904 0.12 ENST00000522422.1
DPY19L4
dpy-19-like 4 (C. elegans)
chr11_+_27062502 0.12 ENST00000263182.3
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chrX_-_83757399 0.12 ENST00000373177.2
ENST00000297977.5
ENST00000506585.2
ENST00000449553.2
HDX
highly divergent homeobox
chr3_+_186692745 0.11 ENST00000438590.1
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr7_+_80253387 0.11 ENST00000438020.1
CD36
CD36 molecule (thrombospondin receptor)
chr4_-_75695366 0.11 ENST00000512743.1
BTC
betacellulin
chr1_+_81106951 0.11 ENST00000443565.1
RP5-887A10.1
RP5-887A10.1
chr5_+_41904431 0.11 ENST00000381647.2
C5orf51
chromosome 5 open reading frame 51
chr1_-_154909329 0.11 ENST00000368467.3
PMVK
phosphomevalonate kinase
chrX_+_12809463 0.11 ENST00000380663.3
ENST00000380668.5
ENST00000398491.2
ENST00000489404.1
PRPS2
phosphoribosyl pyrophosphate synthetase 2
chr15_-_83680325 0.11 ENST00000508990.2
ENST00000510873.2
ENST00000538348.2
ENST00000451195.3
ENST00000513601.2
ENST00000304177.5
ENST00000565712.1
C15orf40
chromosome 15 open reading frame 40
chr14_-_23624511 0.11 ENST00000529705.2
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr4_-_185694872 0.11 ENST00000505492.1
ACSL1
acyl-CoA synthetase long-chain family member 1
chr3_-_178969403 0.11 ENST00000314235.5
ENST00000392685.2
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr8_-_101724989 0.11 ENST00000517403.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr19_+_38779778 0.10 ENST00000590738.1
ENST00000587519.2
ENST00000591889.1
SPINT2
CTB-102L5.4
serine peptidase inhibitor, Kunitz type, 2
CTB-102L5.4
chr7_-_33080506 0.10 ENST00000381626.2
ENST00000409467.1
ENST00000449201.1
NT5C3A
5'-nucleotidase, cytosolic IIIA
chr3_+_8543533 0.10 ENST00000454244.1
LMCD1
LIM and cysteine-rich domains 1
chr11_-_104480019 0.10 ENST00000536529.1
ENST00000545630.1
ENST00000538641.1
RP11-886D15.1
RP11-886D15.1
chr2_+_9983483 0.10 ENST00000263663.5
TAF1B
TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa
chr1_-_114355083 0.10 ENST00000261441.5
RSBN1
round spermatid basic protein 1
chr11_-_82444892 0.10 ENST00000329203.3
FAM181B
family with sequence similarity 181, member B
chr19_+_56187987 0.10 ENST00000411543.2
EPN1
epsin 1
chr4_+_106631966 0.10 ENST00000360505.5
ENST00000510865.1
ENST00000509336.1
GSTCD
glutathione S-transferase, C-terminal domain containing
chr8_+_52730143 0.10 ENST00000415643.1
AC090186.1
Uncharacterized protein
chrX_-_100129128 0.10 ENST00000372960.4
ENST00000372964.1
ENST00000217885.5
NOX1
NADPH oxidase 1
chr7_+_125078119 0.10 ENST00000458437.1
ENST00000415896.1
RP11-807H17.1
RP11-807H17.1
chr4_+_189321881 0.10 ENST00000512839.1
ENST00000513313.1
LINC01060
long intergenic non-protein coding RNA 1060
chr2_-_231989808 0.10 ENST00000258400.3
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr16_-_3493528 0.10 ENST00000301744.4
ZNF597
zinc finger protein 597
chr1_+_31883048 0.10 ENST00000536859.1
SERINC2
serine incorporator 2
chr19_-_49121054 0.10 ENST00000546623.1
ENST00000084795.5
RPL18
ribosomal protein L18
chr6_+_26199737 0.10 ENST00000359985.1
HIST1H2BF
histone cluster 1, H2bf
chr11_+_33037652 0.10 ENST00000311388.3
DEPDC7
DEP domain containing 7
chr6_-_41130914 0.10 ENST00000373113.3
ENST00000338469.3
TREM2
triggering receptor expressed on myeloid cells 2
chr3_-_58643483 0.10 ENST00000483787.1
FAM3D
family with sequence similarity 3, member D
chr1_-_201438282 0.10 ENST00000367311.3
ENST00000367309.1
PHLDA3
pleckstrin homology-like domain, family A, member 3
chr17_+_79849872 0.09 ENST00000584197.1
ENST00000583839.1
ANAPC11
anaphase promoting complex subunit 11
chr10_-_18944123 0.09 ENST00000606425.1
RP11-139J15.7
Uncharacterized protein
chr1_+_87012922 0.09 ENST00000263723.5
CLCA4
chloride channel accessory 4
chr4_-_69536346 0.09 ENST00000338206.5
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr1_-_85870177 0.09 ENST00000542148.1
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr17_-_29641084 0.09 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr6_-_135271219 0.09 ENST00000367847.2
ENST00000367845.2
ALDH8A1
aldehyde dehydrogenase 8 family, member A1
chr2_-_228497888 0.09 ENST00000264387.4
ENST00000409066.1
C2orf83
chromosome 2 open reading frame 83
chr3_+_8543561 0.09 ENST00000397386.3
LMCD1
LIM and cysteine-rich domains 1
chr17_-_42100474 0.09 ENST00000585950.1
ENST00000592127.1
ENST00000589334.1
TMEM101
transmembrane protein 101
chr6_-_135271260 0.09 ENST00000265605.2
ALDH8A1
aldehyde dehydrogenase 8 family, member A1
chr11_+_86013253 0.09 ENST00000533986.1
ENST00000278483.3
C11orf73
chromosome 11 open reading frame 73
chr9_-_3489406 0.09 ENST00000457373.1
RFX3
regulatory factor X, 3 (influences HLA class II expression)
chr19_-_38743878 0.09 ENST00000587515.1
PPP1R14A
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr3_+_171561127 0.09 ENST00000334567.5
ENST00000450693.1
TMEM212
transmembrane protein 212
chr11_-_111782696 0.09 ENST00000227251.3
ENST00000526180.1
CRYAB
crystallin, alpha B
chr14_+_21249200 0.09 ENST00000304677.2
RNASE6
ribonuclease, RNase A family, k6
chr14_+_104177607 0.09 ENST00000429169.1
AL049840.1
Uncharacterized protein; cDNA FLJ53535
chr2_-_206950996 0.09 ENST00000414320.1
INO80D
INO80 complex subunit D
chr6_-_144329531 0.09 ENST00000429150.1
ENST00000392309.1
ENST00000416623.1
ENST00000392307.1
PLAGL1
pleiomorphic adenoma gene-like 1
chr1_+_215747118 0.09 ENST00000448333.1
KCTD3
potassium channel tetramerization domain containing 3
chr16_+_4838412 0.09 ENST00000589327.1
SMIM22
small integral membrane protein 22
chr11_+_57531292 0.09 ENST00000524579.1
CTNND1
catenin (cadherin-associated protein), delta 1
chr11_-_62432641 0.09 ENST00000528405.1
ENST00000524958.1
ENST00000525675.1
RP11-831H9.11
C11orf48
Uncharacterized protein
chromosome 11 open reading frame 48
chr4_-_108204904 0.09 ENST00000510463.1
DKK2
dickkopf WNT signaling pathway inhibitor 2
chr12_-_10282742 0.09 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chr16_-_30032610 0.09 ENST00000574405.1
DOC2A
double C2-like domains, alpha
chr4_-_70653673 0.09 ENST00000512870.1
SULT1B1
sulfotransferase family, cytosolic, 1B, member 1
chr4_-_100212132 0.09 ENST00000209668.2
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr6_-_18122843 0.09 ENST00000340650.3
NHLRC1
NHL repeat containing E3 ubiquitin protein ligase 1
chr1_+_196788887 0.09 ENST00000320493.5
ENST00000367424.4
ENST00000367421.3
CFHR1
CFHR2
complement factor H-related 1
complement factor H-related 2
chr1_+_77333117 0.09 ENST00000477717.1
ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr2_+_109204909 0.09 ENST00000393310.1
LIMS1
LIM and senescent cell antigen-like domains 1
chr7_+_127527965 0.09 ENST00000486037.1
SND1
staphylococcal nuclease and tudor domain containing 1
chr6_+_159071015 0.08 ENST00000360448.3
SYTL3
synaptotagmin-like 3
chr12_+_1738363 0.08 ENST00000397196.2
WNT5B
wingless-type MMTV integration site family, member 5B
chr5_+_43602750 0.08 ENST00000505678.2
ENST00000512422.1
ENST00000264663.5
NNT
nicotinamide nucleotide transhydrogenase
chr10_-_96829246 0.08 ENST00000371270.3
ENST00000535898.1
ENST00000539050.1
CYP2C8
cytochrome P450, family 2, subfamily C, polypeptide 8
chr7_-_6388537 0.08 ENST00000313324.4
ENST00000530143.1
FAM220A
family with sequence similarity 220, member A
chr11_+_89764274 0.08 ENST00000448984.1
ENST00000432771.1
TRIM49C
tripartite motif containing 49C
chr8_+_70476088 0.08 ENST00000525999.1
SULF1
sulfatase 1
chr2_-_122262593 0.08 ENST00000418989.1
CLASP1
cytoplasmic linker associated protein 1
chr3_+_8543393 0.08 ENST00000157600.3
ENST00000415597.1
ENST00000535732.1
LMCD1
LIM and cysteine-rich domains 1
chr19_+_58193337 0.08 ENST00000601064.1
ENST00000282296.5
ENST00000356715.4
ZNF551
zinc finger protein 551
chr1_+_114473350 0.08 ENST00000503968.1
HIPK1
homeodomain interacting protein kinase 1
chr8_-_145060593 0.08 ENST00000313059.5
ENST00000524918.1
ENST00000313028.7
ENST00000525773.1
PARP10
poly (ADP-ribose) polymerase family, member 10
chr12_+_133757995 0.08 ENST00000536435.2
ENST00000228289.5
ENST00000541211.2
ENST00000500625.3
ENST00000539248.2
ENST00000542711.2
ENST00000536899.2
ENST00000542986.2
ENST00000537565.1
ENST00000541975.2
ZNF268
zinc finger protein 268
chr7_+_77469439 0.08 ENST00000450574.1
ENST00000416283.2
ENST00000248550.7
PHTF2
putative homeodomain transcription factor 2
chr12_+_51632638 0.08 ENST00000549732.2
DAZAP2
DAZ associated protein 2
chr7_-_112430647 0.08 ENST00000312814.6
TMEM168
transmembrane protein 168
chr20_-_23860373 0.08 ENST00000304710.4
CST5
cystatin D
chr8_+_132952112 0.08 ENST00000520362.1
ENST00000519656.1
EFR3A
EFR3 homolog A (S. cerevisiae)
chr1_+_63989004 0.08 ENST00000371088.4
EFCAB7
EF-hand calcium binding domain 7
chrX_+_107288280 0.08 ENST00000458383.1
VSIG1
V-set and immunoglobulin domain containing 1
chr17_-_46657473 0.08 ENST00000332503.5
HOXB4
homeobox B4
chr4_+_78829479 0.08 ENST00000504901.1
MRPL1
mitochondrial ribosomal protein L1
chr7_+_99425633 0.08 ENST00000354829.2
ENST00000421837.2
ENST00000417625.1
ENST00000342499.4
ENST00000444905.1
ENST00000415413.1
ENST00000312017.5
ENST00000222382.5
CYP3A43
cytochrome P450, family 3, subfamily A, polypeptide 43
chr12_+_117348742 0.08 ENST00000309909.5
ENST00000455858.2
FBXW8
F-box and WD repeat domain containing 8
chr22_-_43355858 0.08 ENST00000402229.1
ENST00000407585.1
ENST00000453079.1
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr12_-_92536433 0.08 ENST00000551563.2
ENST00000546975.1
ENST00000549802.1
C12orf79
chromosome 12 open reading frame 79

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0043095 regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105)
0.1 0.2 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
0.1 0.6 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.2 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.0 0.1 GO:0002071 glandular epithelial cell maturation(GO:0002071) type B pancreatic cell maturation(GO:0072560)
0.0 0.1 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.0 0.1 GO:0044029 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 0.2 GO:0090131 mesenchyme migration(GO:0090131)
0.0 0.1 GO:0002585 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) positive regulation of antigen processing and presentation of peptide antigen(GO:0002585) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588)
0.0 0.2 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.1 GO:0006844 acyl carnitine transport(GO:0006844) acyl carnitine transmembrane transport(GO:1902616)
0.0 0.1 GO:0045113 regulation of integrin biosynthetic process(GO:0045113) positive regulation of integrin biosynthetic process(GO:0045726)
0.0 0.1 GO:0032571 response to vitamin K(GO:0032571)
0.0 0.3 GO:0018406 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 0.1 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.0 0.1 GO:0001188 RNA polymerase I transcriptional preinitiation complex assembly(GO:0001188) RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript(GO:0001189)
0.0 0.6 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.1 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.5 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.1 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.1 GO:1902769 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
0.0 0.1 GO:0032053 ciliary basal body organization(GO:0032053)
0.0 0.2 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.0 0.1 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.3 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.2 GO:2000334 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0 0.3 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.1 GO:0046022 positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0 0.1 GO:0006562 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.0 0.1 GO:0061107 seminal vesicle development(GO:0061107)
0.0 0.1 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.0 0.1 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.0 0.1 GO:0046092 deoxycytidine metabolic process(GO:0046092)
0.0 0.1 GO:1904219 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0 0.1 GO:0070839 regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) divalent metal ion export(GO:0070839)
0.0 0.1 GO:0010847 regulation of chromatin assembly(GO:0010847) protein auto-ADP-ribosylation(GO:0070213)
0.0 0.1 GO:0021784 postganglionic parasympathetic fiber development(GO:0021784)
0.0 0.1 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.0 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.0 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.0 GO:0061740 protein targeting to lysosome involved in chaperone-mediated autophagy(GO:0061740)
0.0 0.1 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.0 0.1 GO:0060672 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.0 0.1 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.0 0.3 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.2 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 0.1 GO:0002933 lipid hydroxylation(GO:0002933)
0.0 0.0 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
0.0 0.1 GO:0070346 positive regulation of fat cell proliferation(GO:0070346)
0.0 0.3 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.4 GO:0014850 response to muscle activity(GO:0014850)
0.0 0.1 GO:0006740 NADPH regeneration(GO:0006740)
0.0 0.1 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.0 0.1 GO:1901189 arterial endothelial cell fate commitment(GO:0060844) positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.1 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.0 0.0 GO:1990927 calcium ion regulated lysosome exocytosis(GO:1990927)
0.0 0.1 GO:0032377 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005668 RNA polymerase transcription factor SL1 complex(GO:0005668)
0.0 0.1 GO:0036025 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.0 0.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.1 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.0 0.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.1 GO:0031592 centrosomal corona(GO:0031592)
0.0 0.1 GO:0097179 protease inhibitor complex(GO:0097179)
0.0 0.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.1 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.0 0.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.0 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.2 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.1 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.0 0.0 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.0 0.0 GO:0071821 FANCM-MHF complex(GO:0071821)
0.0 0.1 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.0 0.1 GO:0030891 VCB complex(GO:0030891)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0044549 GTP cyclohydrolase binding(GO:0044549)
0.1 0.6 GO:0003796 lysozyme activity(GO:0003796)
0.1 0.2 GO:0035034 histone acetyltransferase regulator activity(GO:0035034)
0.1 0.3 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.5 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.2 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.1 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.1 GO:0004947 bradykinin receptor activity(GO:0004947)
0.0 0.1 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 0.1 GO:0008112 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.0 0.1 GO:0015227 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226) acyl carnitine transmembrane transporter activity(GO:0015227)
0.0 0.2 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.0 0.1 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.0 0.3 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.1 GO:0070538 oleic acid binding(GO:0070538)
0.0 0.2 GO:0004771 sterol esterase activity(GO:0004771)
0.0 0.2 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 0.1 GO:0008665 2'-phosphotransferase activity(GO:0008665)
0.0 0.2 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.1 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.0 0.1 GO:0052810 1-phosphatidylinositol-5-kinase activity(GO:0052810)
0.0 0.1 GO:0035529 phosphodiesterase I activity(GO:0004528) NADH pyrophosphatase activity(GO:0035529)
0.0 0.1 GO:0004137 deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)
0.0 0.3 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 0.1 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.1 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.1 GO:0034603 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 0.1 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.1 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0 0.2 GO:0019841 retinol binding(GO:0019841)
0.0 0.0 GO:0047888 fatty acid peroxidase activity(GO:0047888)
0.0 0.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.1 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.0 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0 0.0 GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity(GO:0010309)
0.0 0.1 GO:0032190 acrosin binding(GO:0032190)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.3 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.3 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.4 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis