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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for IRF9

Z-value: 3.25

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Transcription factors associated with IRF9

Gene Symbol Gene ID Gene Info
IRF9
ENSG00000213928.4 interferon regulatory factor 9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF9hg19_v2_chr14_+_24630465_246305310.962.7e-03Click!

Activity profile of IRF9 motif

Sorted Z-values of IRF9 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr21_+_42733870 11.09 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr21_+_42798094 10.78 ENST00000398598.3
ENST00000455164.2
ENST00000424365.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr1_+_79086088 8.72 ENST00000370751.5
ENST00000342282.3
IFI44L
interferon-induced protein 44-like
chr21_+_42798124 7.32 ENST00000417963.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr21_+_42797958 6.56 ENST00000419044.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr14_+_94577074 6.41 ENST00000444961.1
ENST00000448882.1
ENST00000557098.1
ENST00000554800.1
ENST00000556544.1
ENST00000298902.5
ENST00000555819.1
ENST00000557634.1
ENST00000555744.1
IFI27
interferon, alpha-inducible protein 27
chr21_+_42798158 6.26 ENST00000441677.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr17_+_6659354 6.12 ENST00000574907.1
XAF1
XIAP associated factor 1
chr12_+_113344582 4.80 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr17_+_6659153 4.04 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XAF1
XIAP associated factor 1
chr12_+_113344811 3.82 ENST00000551241.1
ENST00000553185.1
ENST00000550689.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr19_-_17516449 3.73 ENST00000252593.6
BST2
bone marrow stromal cell antigen 2
chr12_+_113376157 3.35 ENST00000228928.7
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr14_+_24630465 3.23 ENST00000557894.1
ENST00000559284.1
ENST00000560275.1
IRF9
interferon regulatory factor 9
chr13_-_43566301 3.15 ENST00000398762.3
ENST00000313640.7
ENST00000313624.7
EPSTI1
epithelial stromal interaction 1 (breast)
chr11_-_615942 2.88 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
IRF7
interferon regulatory factor 7
chr11_-_615570 2.73 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr1_+_948803 2.73 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr12_+_113376249 2.61 ENST00000551007.1
ENST00000548514.1
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr1_+_79115503 2.40 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr4_-_76944621 2.08 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr3_-_146262637 1.84 ENST00000472349.1
ENST00000342435.4
PLSCR1
phospholipid scramblase 1
chr3_-_146262352 1.84 ENST00000462666.1
PLSCR1
phospholipid scramblase 1
chr3_-_146262428 1.71 ENST00000486631.1
PLSCR1
phospholipid scramblase 1
chr10_+_91092241 1.68 ENST00000371811.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr3_-_122283100 1.67 ENST00000492382.1
ENST00000462315.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr3_-_122283079 1.61 ENST00000471785.1
ENST00000466126.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr9_-_32526184 1.58 ENST00000545044.1
ENST00000379868.1
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr3_-_122283424 1.47 ENST00000477522.2
ENST00000360356.2
PARP9
poly (ADP-ribose) polymerase family, member 9
chr3_-_146262365 1.43 ENST00000448787.2
PLSCR1
phospholipid scramblase 1
chr3_-_146262488 1.41 ENST00000487389.1
PLSCR1
phospholipid scramblase 1
chr19_+_16254488 1.40 ENST00000588246.1
ENST00000593031.1
HSH2D
hematopoietic SH2 domain containing
chr18_+_13382553 1.39 ENST00000586222.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr9_+_5510558 1.23 ENST00000397747.3
PDCD1LG2
programmed cell death 1 ligand 2
chr17_+_6658878 1.12 ENST00000574394.1
XAF1
XIAP associated factor 1
chr15_+_74287035 1.10 ENST00000395132.2
ENST00000268059.6
ENST00000354026.6
ENST00000268058.3
ENST00000565898.1
ENST00000569477.1
ENST00000569965.1
ENST00000567543.1
ENST00000436891.3
ENST00000435786.2
ENST00000564428.1
ENST00000359928.4
PML
promyelocytic leukemia
chr17_-_54991369 1.08 ENST00000537230.1
TRIM25
tripartite motif containing 25
chr6_+_106546808 1.08 ENST00000369089.3
PRDM1
PR domain containing 1, with ZNF domain
chr2_-_163175133 0.98 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr2_+_33701684 0.98 ENST00000442390.1
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr2_-_7005785 0.97 ENST00000256722.5
ENST00000404168.1
ENST00000458098.1
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr16_-_74734672 0.96 ENST00000306247.7
ENST00000575686.1
MLKL
mixed lineage kinase domain-like
chr6_+_126240442 0.95 ENST00000448104.1
ENST00000438495.1
ENST00000444128.1
NCOA7
nuclear receptor coactivator 7
chr3_+_122283175 0.90 ENST00000383661.3
DTX3L
deltex 3-like (Drosophila)
chr3_-_130745403 0.85 ENST00000504725.1
ENST00000509060.1
ASTE1
asteroid homolog 1 (Drosophila)
chr9_-_32526299 0.83 ENST00000379882.1
ENST00000379883.2
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr1_+_59486059 0.81 ENST00000447329.1
RP4-794H19.4
RP4-794H19.4
chr18_-_67624412 0.79 ENST00000580335.1
CD226
CD226 molecule
chr9_+_74764278 0.76 ENST00000238018.4
ENST00000376989.3
GDA
guanine deaminase
chr11_-_57334732 0.75 ENST00000526659.1
ENST00000527022.1
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr3_+_122283064 0.71 ENST00000296161.4
DTX3L
deltex 3-like (Drosophila)
chr11_-_67141090 0.70 ENST00000312438.7
CLCF1
cardiotrophin-like cytokine factor 1
chr6_-_32806483 0.70 ENST00000374899.4
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr8_-_27941380 0.68 ENST00000413272.2
ENST00000341513.6
NUGGC
nuclear GTPase, germinal center associated
chr19_+_17516531 0.67 ENST00000528911.1
ENST00000528604.1
ENST00000595892.1
ENST00000500836.2
ENST00000598546.1
ENST00000600369.1
ENST00000598356.1
ENST00000594426.1
MVB12A
CTD-2521M24.9
multivesicular body subunit 12A
CTD-2521M24.9
chr3_-_146262293 0.64 ENST00000448205.1
PLSCR1
phospholipid scramblase 1
chr11_-_57335280 0.62 ENST00000287156.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr1_-_150738261 0.62 ENST00000448301.2
ENST00000368985.3
CTSS
cathepsin S
chr17_-_54991395 0.60 ENST00000316881.4
TRIM25
tripartite motif containing 25
chr17_+_41363854 0.59 ENST00000588693.1
ENST00000588659.1
ENST00000541594.1
ENST00000536052.1
ENST00000331615.3
TMEM106A
transmembrane protein 106A
chr15_+_74287118 0.58 ENST00000563500.1
PML
promyelocytic leukemia
chr3_+_187086120 0.58 ENST00000259030.2
RTP4
receptor (chemosensory) transporter protein 4
chr9_+_5510492 0.57 ENST00000397745.2
PDCD1LG2
programmed cell death 1 ligand 2
chr18_-_67624160 0.57 ENST00000581982.1
ENST00000280200.4
CD226
CD226 molecule
chr2_-_152118276 0.56 ENST00000409092.1
RBM43
RNA binding motif protein 43
chr6_-_110736742 0.55 ENST00000368924.3
ENST00000368923.3
DDO
D-aspartate oxidase
chr4_-_169401628 0.52 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr6_-_31324943 0.51 ENST00000412585.2
ENST00000434333.1
HLA-B
major histocompatibility complex, class I, B
chr3_-_121379739 0.51 ENST00000428394.2
ENST00000314583.3
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr17_-_40264692 0.49 ENST00000591220.1
ENST00000251642.3
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr19_+_17516494 0.48 ENST00000534306.1
CTD-2521M24.9
CTD-2521M24.9
chr13_+_50070491 0.48 ENST00000496612.1
ENST00000357596.3
ENST00000485919.1
ENST00000442195.1
PHF11
PHD finger protein 11
chr12_-_56753858 0.47 ENST00000314128.4
ENST00000557235.1
ENST00000418572.2
STAT2
signal transducer and activator of transcription 2, 113kDa
chr3_+_122399444 0.45 ENST00000474629.2
PARP14
poly (ADP-ribose) polymerase family, member 14
chr9_+_74764340 0.45 ENST00000376986.1
ENST00000358399.3
GDA
guanine deaminase
chr19_+_17516909 0.44 ENST00000601007.1
ENST00000594913.1
ENST00000599975.1
ENST00000600514.1
CTD-2521M24.9
MVB12A
CTD-2521M24.9
multivesicular body subunit 12A
chr11_-_86383650 0.44 ENST00000526944.1
ENST00000530335.1
ENST00000543262.1
ENST00000524826.1
ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr2_-_37384175 0.43 ENST00000411537.2
ENST00000233057.4
ENST00000395127.2
ENST00000390013.3
EIF2AK2
eukaryotic translation initiation factor 2-alpha kinase 2
chr5_-_59481406 0.40 ENST00000546160.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr13_+_50070077 0.37 ENST00000378319.3
ENST00000426879.1
PHF11
PHD finger protein 11
chr12_-_121476959 0.35 ENST00000339275.5
OASL
2'-5'-oligoadenylate synthetase-like
chr1_-_154580616 0.33 ENST00000368474.4
ADAR
adenosine deaminase, RNA-specific
chr6_-_32806506 0.33 ENST00000374897.2
ENST00000452392.2
TAP2
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr7_+_18535893 0.33 ENST00000432645.2
ENST00000441542.2
HDAC9
histone deacetylase 9
chr3_-_141747439 0.30 ENST00000467667.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr12_+_113344755 0.29 ENST00000550883.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr2_-_106810783 0.29 ENST00000283148.7
UXS1
UDP-glucuronate decarboxylase 1
chr17_-_4167142 0.28 ENST00000570535.1
ENST00000574367.1
ENST00000341657.4
ENST00000433651.1
ANKFY1
ankyrin repeat and FYVE domain containing 1
chr1_+_241695424 0.27 ENST00000366558.3
ENST00000366559.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr15_+_74287009 0.24 ENST00000395135.3
PML
promyelocytic leukemia
chr17_-_74489215 0.24 ENST00000585701.1
ENST00000591192.1
ENST00000589526.1
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr8_+_39770803 0.23 ENST00000518237.1
IDO1
indoleamine 2,3-dioxygenase 1
chr3_-_28390120 0.23 ENST00000334100.6
AZI2
5-azacytidine induced 2
chr3_+_122399697 0.23 ENST00000494811.1
PARP14
poly (ADP-ribose) polymerase family, member 14
chr15_-_26108355 0.23 ENST00000356865.6
ATP10A
ATPase, class V, type 10A
chr2_-_220252068 0.21 ENST00000430206.1
ENST00000429013.1
DNPEP
aspartyl aminopeptidase
chr1_+_66820058 0.20 ENST00000480109.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr17_+_38296576 0.20 ENST00000264645.7
CASC3
cancer susceptibility candidate 3
chr17_+_54230819 0.19 ENST00000318698.2
ENST00000566473.2
ANKFN1
ankyrin-repeat and fibronectin type III domain containing 1
chr11_-_4414880 0.19 ENST00000254436.7
ENST00000543625.1
TRIM21
tripartite motif containing 21
chr15_+_91643442 0.17 ENST00000394232.1
SV2B
synaptic vesicle glycoprotein 2B
chr12_-_121477039 0.17 ENST00000257570.5
OASL
2'-5'-oligoadenylate synthetase-like
chr2_+_33701707 0.17 ENST00000425210.1
ENST00000444784.1
ENST00000423159.1
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr9_+_70971815 0.16 ENST00000396392.1
ENST00000396396.1
PGM5
phosphoglucomutase 5
chr18_-_67623906 0.15 ENST00000583955.1
CD226
CD226 molecule
chr11_-_86383157 0.15 ENST00000393324.3
ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr2_-_106810742 0.15 ENST00000409501.3
ENST00000428048.2
ENST00000441952.1
ENST00000457835.1
ENST00000540130.1
UXS1
UDP-glucuronate decarboxylase 1
chrX_-_48858630 0.14 ENST00000376425.3
ENST00000376444.3
GRIPAP1
GRIP1 associated protein 1
chr16_+_28962128 0.14 ENST00000564978.1
ENST00000320805.4
NFATC2IP
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
chr6_-_33282024 0.13 ENST00000475304.1
ENST00000489157.1
TAPBP
TAP binding protein (tapasin)
chr3_-_27764190 0.13 ENST00000537516.1
EOMES
eomesodermin
chr2_-_220252530 0.12 ENST00000521459.1
DNPEP
aspartyl aminopeptidase
chr6_+_37400974 0.11 ENST00000455891.1
ENST00000373451.4
CMTR1
cap methyltransferase 1
chr5_-_95297678 0.10 ENST00000237853.4
ELL2
elongation factor, RNA polymerase II, 2
chr6_+_72922590 0.08 ENST00000523963.1
RIMS1
regulating synaptic membrane exocytosis 1
chr1_-_234667504 0.08 ENST00000421207.1
ENST00000435574.1
RP5-855F14.1
RP5-855F14.1
chr18_+_42260861 0.08 ENST00000282030.5
SETBP1
SET binding protein 1
chr6_+_72922505 0.07 ENST00000401910.3
RIMS1
regulating synaptic membrane exocytosis 1
chrX_-_48858667 0.07 ENST00000376423.4
ENST00000376441.1
GRIPAP1
GRIP1 associated protein 1
chr22_+_40297079 0.06 ENST00000344138.4
ENST00000543252.1
GRAP2
GRB2-related adaptor protein 2
chr4_-_147442982 0.06 ENST00000511374.1
ENST00000264986.3
SLC10A7
solute carrier family 10, member 7
chr19_-_12807422 0.06 ENST00000380339.3
ENST00000544494.1
ENST00000393261.3
FBXW9
F-box and WD repeat domain containing 9
chr1_+_162602244 0.05 ENST00000367922.3
ENST00000367921.3
DDR2
discoidin domain receptor tyrosine kinase 2
chr6_-_33281979 0.03 ENST00000426633.2
ENST00000467025.1
TAPBP
TAP binding protein (tapasin)
chr16_-_15736881 0.03 ENST00000540441.2
KIAA0430
KIAA0430
chr14_+_100531615 0.02 ENST00000392920.3
EVL
Enah/Vasp-like
chr1_-_207119738 0.02 ENST00000356495.4
PIGR
polymeric immunoglobulin receptor
chr19_+_10196981 0.02 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr17_+_7211656 0.02 ENST00000416016.2
EIF5A
eukaryotic translation initiation factor 5A
chr3_-_28390415 0.00 ENST00000414162.1
ENST00000420543.2
AZI2
5-azacytidine induced 2

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 42.0 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
1.4 5.6 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
1.2 3.7 GO:0002731 negative regulation of dendritic cell cytokine production(GO:0002731)
0.9 8.9 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.7 3.4 GO:0035549 positive regulation of interferon-beta secretion(GO:0035549)
0.5 6.0 GO:0060700 regulation of ribonuclease activity(GO:0060700)
0.4 1.2 GO:0006147 guanine catabolic process(GO:0006147)
0.4 4.7 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.4 1.1 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.3 1.0 GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476)
0.3 3.6 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.3 9.7 GO:0035456 response to interferon-beta(GO:0035456)
0.3 1.5 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)
0.2 1.0 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.2 1.9 GO:0030578 PML body organization(GO:0030578)
0.2 2.1 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.2 17.0 GO:0060337 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.2 1.1 GO:0019075 virus maturation(GO:0019075)
0.1 0.4 GO:0033320 UDP-D-xylose metabolic process(GO:0033319) UDP-D-xylose biosynthetic process(GO:0033320)
0.1 1.4 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.1 1.4 GO:0010990 regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 0.5 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.1 1.8 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.1 1.9 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.1 0.7 GO:0048295 positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.1 0.1 GO:0060809 mesodermal to mesenchymal transition involved in gastrulation(GO:0060809)
0.1 0.6 GO:0072592 oxygen metabolic process(GO:0072592)
0.1 0.5 GO:0007320 insemination(GO:0007320)
0.1 0.2 GO:0036269 swimming behavior(GO:0036269)
0.0 0.4 GO:0019049 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 0.1 GO:0050822 peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823)
0.0 1.0 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.6 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.1 GO:0036451 cap mRNA methylation(GO:0036451)
0.0 0.2 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.0 0.3 GO:0048549 endosome localization(GO:0032439) positive regulation of pinocytosis(GO:0048549)
0.0 0.5 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 1.0 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.2 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
0.0 0.6 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 1.2 GO:0010390 histone monoubiquitination(GO:0010390)
0.0 0.6 GO:0010447 response to acidic pH(GO:0010447)
0.0 6.1 GO:0051607 defense response to virus(GO:0051607)
0.0 0.3 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.9 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.2 0.7 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.2 1.2 GO:0042825 TAP complex(GO:0042825)
0.1 0.6 GO:0036021 endolysosome lumen(GO:0036021)
0.1 37.3 GO:0031965 nuclear membrane(GO:0031965)
0.1 11.1 GO:0005643 nuclear pore(GO:0005643)
0.1 0.2 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.1 1.1 GO:0000813 ESCRT I complex(GO:0000813)
0.1 0.3 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 3.7 GO:0005771 multivesicular body(GO:0005771)
0.0 1.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.3 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.5 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.0 GO:0012505 endomembrane system(GO:0012505)
0.0 8.4 GO:0045121 membrane raft(GO:0045121)
0.0 0.5 GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 2.1 GO:0032587 ruffle membrane(GO:0032587)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 14.9 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.5 2.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.4 8.9 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.4 1.2 GO:0008892 guanine deaminase activity(GO:0008892)
0.2 1.0 GO:0009041 uridylate kinase activity(GO:0009041)
0.2 1.2 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
0.2 2.9 GO:0031386 protein tag(GO:0031386)
0.2 5.2 GO:0070403 NAD+ binding(GO:0070403)
0.2 6.4 GO:0005521 lamin binding(GO:0005521)
0.1 0.6 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 3.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 42.0 GO:0008017 microtubule binding(GO:0008017)
0.1 0.8 GO:0042296 ISG15 transferase activity(GO:0042296)
0.1 0.6 GO:0004473 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.1 0.7 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 0.2 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.1 1.7 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 0.4 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 1.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.0 4.2 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 1.4 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.8 GO:0071949 FAD binding(GO:0071949)
0.0 1.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.2 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 2.9 GO:0001047 core promoter binding(GO:0001047)
0.0 3.0 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 1.9 GO:0046332 SMAD binding(GO:0046332)
0.0 0.4 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 9.4 GO:0005525 GTP binding(GO:0005525)
0.0 0.6 GO:0043394 proteoglycan binding(GO:0043394)
0.0 0.5 GO:0042605 peptide antigen binding(GO:0042605)
0.0 1.0 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.3 GO:0031078 NAD-dependent histone deacetylase activity(GO:0017136) histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) NAD-dependent protein deacetylase activity(GO:0034979)
0.0 1.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.7 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 1.9 PID MYC PATHWAY C-MYC pathway
0.0 5.9 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.8 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 2.1 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 3.5 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.2 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 87.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.3 5.1 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.2 0.6 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.1 1.8 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 2.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.0 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.5 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 1.2 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 1.5 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.8 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling