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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for IRF9
Z-value: 3.25
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Transcription factors associated with IRF9
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF9 | hg19_v2_chr14_+_24630465_24630531 | 0.96 | 2.7e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF9
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 42.0 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 0.2 | 17.0 | GO:0060337 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.3 | 9.7 | GO:0035456 | response to interferon-beta(GO:0035456) |
| 0.9 | 8.9 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373) |
| 0.0 | 6.1 | GO:0051607 | defense response to virus(GO:0051607) |
| 0.5 | 6.0 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
| 1.4 | 5.6 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 0.4 | 4.7 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 1.2 | 3.7 | GO:0002731 | negative regulation of dendritic cell cytokine production(GO:0002731) |
| 0.3 | 3.6 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 37.3 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.1 | 11.1 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 8.4 | GO:0045121 | membrane raft(GO:0045121) |
| 0.1 | 3.7 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.0 | 2.1 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.3 | 1.9 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.2 | 1.2 | GO:0042825 | TAP complex(GO:0042825) |
| 0.1 | 1.1 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.0 | 1.1 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.0 | 1.0 | GO:0012505 | endomembrane system(GO:0012505) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 42.0 | GO:0008017 | microtubule binding(GO:0008017) |
| 1.2 | 14.9 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.0 | 9.4 | GO:0005525 | GTP binding(GO:0005525) |
| 0.4 | 8.9 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.2 | 6.4 | GO:0005521 | lamin binding(GO:0005521) |
| 0.2 | 5.2 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.0 | 4.2 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.1 | 3.7 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 3.0 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.2 | 2.9 | GO:0031386 | protein tag(GO:0031386) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.9 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.3 | 3.7 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.0 | 3.5 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 2.1 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 1.9 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 1.2 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 0.8 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 87.1 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.3 | 5.1 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.0 | 2.1 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 1.8 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.0 | 1.5 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 1.2 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 1.2 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 1.0 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 0.8 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.2 | 0.6 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |