ISMARA results: IRF7

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for IRF7

Z-value: 1.79

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Transcription factors associated with IRF7

Gene Symbol	Gene ID	Gene Info
IRF7 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000185507.15	interferon regulatory factor 7

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
IRF7	hg19_v2_chr11_-_615570_615728	-0.08	8.8e-01	Click!

Activity profile of IRF7 motif

Sorted Z-values of IRF7 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_55237484 Show fit	2.26	ENST00000394609.2	RTN4 Ensembl NCBI GeneCards UniProt NextProt Show fit	reticulon 4
chr4_+_103790462 Show fit	1.95	ENST00000503643.1	CISD2 Ensembl NCBI GeneCards UniProt NextProt Show fit	CDGSH iron sulfur domain 2
chr2_+_7017796 Show fit	1.30	ENST00000382040.3	RSAD2 Ensembl NCBI GeneCards UniProt NextProt Show fit	radical S-adenosyl methionine domain containing 2
chr19_+_39759154 Show fit	1.14	ENST00000331982.5	IFNL2 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon, lambda 2
chr3_-_28390298 Show fit	1.05	ENST00000457172.1	AZI2 Ensembl NCBI GeneCards UniProt NextProt Show fit	5-azacytidine induced 2
chr2_-_188419078 Show fit	1.00	ENST00000437725.1 ENST00000409676.1 ENST00000339091.4 ENST00000420747.1	TFPI Ensembl NCBI GeneCards UniProt NextProt Show fit	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr3_+_178865887 Show fit	1.00	ENST00000477735.1	PIK3CA Ensembl NCBI GeneCards UniProt NextProt Show fit	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr2_-_152118352 Show fit	0.98	ENST00000331426.5	RBM43 Ensembl NCBI GeneCards UniProt NextProt Show fit	RNA binding motif protein 43
chr15_+_35270552 Show fit	0.97	ENST00000391457.2	AC114546.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	HCG37415; PRO1914; Uncharacterized protein
chr17_-_57229155 Show fit	0.94	ENST00000584089.1	SKA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	spindle and kinetochore associated complex subunit 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF7

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	3.2	GO:0044565	dendritic cell proliferation(GO:0044565)
0.3	2.9	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
0.0	1.9	GO:0043555	regulation of translation in response to stress(GO:0043555)
0.0	1.9	GO:0010259	multicellular organism aging(GO:0010259)
0.3	1.6	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.5	1.5	GO:0010845	positive regulation of reciprocal meiotic recombination(GO:0010845)
0.1	1.5	GO:0030043	actin filament fragmentation(GO:0030043)
0.2	1.3	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
0.3	1.1	GO:0009956	radial pattern formation(GO:0009956)
0.1	1.1	GO:0034393	positive regulation of smooth muscle cell apoptotic process(GO:0034393)

Showing 1 to 10 of 206 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.7	GO:0071782	endoplasmic reticulum tubular network(GO:0071782)
0.0	1.7	GO:0005811	lipid particle(GO:0005811)
0.2	1.5	GO:0033503	HULC complex(GO:0033503)
0.1	1.5	GO:0005943	phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0	1.0	GO:0097539	ciliary transition fiber(GO:0097539)
0.1	0.9	GO:0097442	CA3 pyramidal cell dendrite(GO:0097442)
0.0	0.9	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.0	0.9	GO:0000795	synaptonemal complex(GO:0000795)
0.1	0.8	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	0.8	GO:0005689	U12-type spliceosomal complex(GO:0005689)

Showing 1 to 10 of 75 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.0	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)
0.0	2.0	GO:0061650	ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.0	2.0	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	1.9	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	1.5	GO:0042169	SH2 domain binding(GO:0042169)
0.4	1.1	GO:0030626	U12 snRNA binding(GO:0030626)
0.0	1.1	GO:0051539	4 iron, 4 sulfur cluster binding(GO:0051539)
0.0	1.1	GO:0015144	carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.0	1.0	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.9	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)

Showing 1 to 10 of 122 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.6	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.0	3.1	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.1	1.7	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	1.6	PID ATM PATHWAY	ATM pathway
0.0	1.5	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	1.4	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	1.2	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.0	1.0	PID IL27 PATHWAY	IL27-mediated signaling events
0.0	1.0	PID INSULIN PATHWAY	Insulin Pathway
0.0	0.7	PID ARF6 PATHWAY	Arf6 signaling events

Showing 1 to 10 of 16 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
2.8	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
1.5	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
1.4	REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE	Genes involved in Formation of Fibrin Clot (Clotting Cascade)
1.4	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
1.4	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
1.3	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
1.1	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
1.0	REACTOME G1 PHASE	Genes involved in G1 Phase
0.9	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.9	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing

Showing 1 to 10 of 40 entries

Results for IRF7

Z-value: 1.79

Motif logo

Transcription factors associated with IRF7

Activity-expression correlation:

Activity profile of IRF7 motif

Sorted Z-values of IRF7 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF7

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: