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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for IRF6_IRF4_IRF5
Z-value: 2.43
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Transcription factors associated with IRF6_IRF4_IRF5
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000117595.6 | interferon regulatory factor 6 | |
| ENSG00000137265.10 | interferon regulatory factor 4 | |
| ENSG00000128604.14 | interferon regulatory factor 5 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF6 | hg19_v2_chr1_-_209979465_209979494 | 0.89 | 1.7e-02 | Click! |
| IRF5 | hg19_v2_chr7_+_128577972_128578047 | -0.12 | 8.2e-01 | Click! |
| IRF4 | hg19_v2_chr6_+_391739_391759 | -0.03 | 9.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr21_+_42792442 Show fit | 5.34 |
ENST00000398600.2
|
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
|
| chr21_+_42733870 Show fit | 4.87 |
ENST00000330714.3
ENST00000436410.1 ENST00000435611.1 |
myxovirus (influenza virus) resistance 2 (mouse) |
|
| chr12_+_113344582 Show fit | 4.50 |
ENST00000202917.5
ENST00000445409.2 ENST00000452357.2 |
2'-5'-oligoadenylate synthetase 1, 40/46kDa |
|
| chr21_+_42798094 Show fit | 4.44 |
ENST00000398598.3
ENST00000455164.2 ENST00000424365.1 |
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
|
| chr11_-_615942 Show fit | 4.35 |
ENST00000397562.3
ENST00000330243.5 ENST00000397570.1 ENST00000397574.2 |
interferon regulatory factor 7 |
|
| chr12_+_113344811 Show fit | 3.33 |
ENST00000551241.1
ENST00000553185.1 ENST00000550689.1 |
2'-5'-oligoadenylate synthetase 1, 40/46kDa |
|
| chr21_+_42798124 Show fit | 2.97 |
ENST00000417963.1
|
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
|
| chr21_+_42797958 Show fit | 2.73 |
ENST00000419044.1
|
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
|
| chr17_+_6659354 Show fit | 2.73 |
ENST00000574907.1
|
XIAP associated factor 1 |
|
| chr3_-_146262352 Show fit | 2.63 |
ENST00000462666.1
|
phospholipid scramblase 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF6_IRF4_IRF5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 22.8 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 1.3 | 12.8 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373) |
| 0.1 | 9.1 | GO:0071357 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.3 | 8.4 | GO:0035456 | response to interferon-beta(GO:0035456) |
| 1.5 | 5.8 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 0.4 | 4.5 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
| 1.0 | 3.8 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 0.2 | 2.7 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 0.6 | 1.9 | GO:0002361 | CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190) |
| 0.1 | 1.7 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.6 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 13.8 | GO:0045121 | membrane raft(GO:0045121) |
| 0.1 | 4.9 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 3.2 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.2 | 1.1 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.0 | 0.7 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.2 | 0.6 | GO:0097233 | lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233) |
| 0.1 | 0.5 | GO:0005600 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.1 | 0.3 | GO:0005674 | transcription factor TFIIF complex(GO:0005674) |
| 0.0 | 0.3 | GO:0098837 | postsynaptic recycling endosome(GO:0098837) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 22.7 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.6 | 12.8 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 1.1 | 12.6 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.0 | 6.4 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.0 | 3.9 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.1 | 2.9 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.1 | 2.3 | GO:0005521 | lamin binding(GO:0005521) |
| 0.3 | 1.9 | GO:0005534 | galactose binding(GO:0005534) |
| 0.0 | 1.8 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 1.1 | GO:0031386 | protein tag(GO:0031386) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.3 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 1.1 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.0 | 0.9 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 0.6 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.5 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.5 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 0.4 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 0.1 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 53.9 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.3 | 4.4 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.1 | 1.5 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 1.1 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 0.9 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 0.8 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 0.8 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 0.7 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.5 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 0.4 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |