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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for IRF6_IRF4_IRF5

Z-value: 2.43

Motif logo

Transcription factors associated with IRF6_IRF4_IRF5

Gene Symbol Gene ID Gene Info
ENSG00000117595.6 IRF6
ENSG00000137265.10 IRF4
ENSG00000128604.14 IRF5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF6hg19_v2_chr1_-_209979465_2099794940.891.7e-02Click!
IRF5hg19_v2_chr7_+_128577972_128578047-0.128.2e-01Click!
IRF4hg19_v2_chr6_+_391739_391759-0.039.5e-01Click!

Activity profile of IRF6_IRF4_IRF5 motif

Sorted Z-values of IRF6_IRF4_IRF5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF6_IRF4_IRF5

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr21_+_42792442 5.34 ENST00000398600.2
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr21_+_42733870 4.87 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr12_+_113344582 4.50 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr21_+_42798094 4.44 ENST00000398598.3
ENST00000455164.2
ENST00000424365.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr11_-_615942 4.35 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
IRF7
interferon regulatory factor 7
chr12_+_113344811 3.33 ENST00000551241.1
ENST00000553185.1
ENST00000550689.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr21_+_42798124 2.97 ENST00000417963.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr21_+_42797958 2.73 ENST00000419044.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr17_+_6659354 2.73 ENST00000574907.1
XAF1
XIAP associated factor 1
chr3_-_146262352 2.63 ENST00000462666.1
PLSCR1
phospholipid scramblase 1
chr3_-_146262637 2.62 ENST00000472349.1
ENST00000342435.4
PLSCR1
phospholipid scramblase 1
chr12_+_113376157 2.58 ENST00000228928.7
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr3_-_146262428 2.52 ENST00000486631.1
PLSCR1
phospholipid scramblase 1
chr21_+_42798158 2.46 ENST00000441677.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr14_+_94577074 2.26 ENST00000444961.1
ENST00000448882.1
ENST00000557098.1
ENST00000554800.1
ENST00000556544.1
ENST00000298902.5
ENST00000555819.1
ENST00000557634.1
ENST00000555744.1
IFI27
interferon, alpha-inducible protein 27
chr3_-_146262365 2.07 ENST00000448787.2
PLSCR1
phospholipid scramblase 1
chr3_-_146262488 2.06 ENST00000487389.1
PLSCR1
phospholipid scramblase 1
chr11_-_321050 2.05 ENST00000399808.4
IFITM3
interferon induced transmembrane protein 3
chr17_+_25958174 1.94 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
LGALS9
lectin, galactoside-binding, soluble, 9
chr12_+_113376249 1.92 ENST00000551007.1
ENST00000548514.1
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr17_+_6659153 1.85 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XAF1
XIAP associated factor 1
chr13_-_43566301 1.84 ENST00000398762.3
ENST00000313640.7
ENST00000313624.7
EPSTI1
epithelial stromal interaction 1 (breast)
chr9_-_32526184 1.82 ENST00000545044.1
ENST00000379868.1
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr4_+_69917078 1.75 ENST00000502942.1
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr9_-_32526299 1.69 ENST00000379882.1
ENST00000379883.2
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr11_-_321340 1.65 ENST00000526811.1
IFITM3
interferon induced transmembrane protein 3
chr19_+_16254488 1.60 ENST00000588246.1
ENST00000593031.1
HSH2D
hematopoietic SH2 domain containing
chr11_-_615570 1.47 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr8_+_72755367 1.34 ENST00000537896.1
RP11-383H13.1
Protein LOC100132891; cDNA FLJ53548
chr3_-_122283100 1.11 ENST00000492382.1
ENST00000462315.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr3_-_122283079 1.07 ENST00000471785.1
ENST00000466126.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr11_+_72983246 0.95 ENST00000393590.2
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr3_-_122283424 0.94 ENST00000477522.2
ENST00000360356.2
PARP9
poly (ADP-ribose) polymerase family, member 9
chr1_+_948803 0.94 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr19_-_17516449 0.86 ENST00000252593.6
BST2
bone marrow stromal cell antigen 2
chr3_-_146262293 0.86 ENST00000448205.1
PLSCR1
phospholipid scramblase 1
chr20_-_62203808 0.76 ENST00000467148.1
HELZ2
helicase with zinc finger 2, transcriptional coactivator
chr11_-_57335280 0.74 ENST00000287156.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr7_-_77045617 0.70 ENST00000257626.7
GSAP
gamma-secretase activating protein
chr16_-_74734672 0.68 ENST00000306247.7
ENST00000575686.1
MLKL
mixed lineage kinase domain-like
chr15_+_74287035 0.67 ENST00000395132.2
ENST00000268059.6
ENST00000354026.6
ENST00000268058.3
ENST00000565898.1
ENST00000569477.1
ENST00000569965.1
ENST00000567543.1
ENST00000436891.3
ENST00000435786.2
ENST00000564428.1
ENST00000359928.4
PML
promyelocytic leukemia
chr3_-_182880541 0.65 ENST00000470251.1
ENST00000265598.3
LAMP3
lysosomal-associated membrane protein 3
chr16_+_3062457 0.64 ENST00000445369.2
CLDN9
claudin 9
chr8_+_23386557 0.61 ENST00000523930.1
SLC25A37
solute carrier family 25 (mitochondrial iron transporter), member 37
chr3_+_122283175 0.61 ENST00000383661.3
DTX3L
deltex 3-like (Drosophila)
chr18_+_3466248 0.60 ENST00000581029.1
ENST00000581442.1
ENST00000579007.1
RP11-838N2.4
RP11-838N2.4
chr1_-_169680745 0.60 ENST00000236147.4
SELL
selectin L
chr2_-_37384175 0.57 ENST00000411537.2
ENST00000233057.4
ENST00000395127.2
ENST00000390013.3
EIF2AK2
eukaryotic translation initiation factor 2-alpha kinase 2
chrM_+_10053 0.55 ENST00000361227.2
MT-ND3
mitochondrially encoded NADH dehydrogenase 3
chr2_-_7005785 0.55 ENST00000256722.5
ENST00000404168.1
ENST00000458098.1
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr2_-_191878874 0.55 ENST00000392322.3
ENST00000392323.2
ENST00000424722.1
ENST00000361099.3
STAT1
signal transducer and activator of transcription 1, 91kDa
chr4_-_18023350 0.55 ENST00000539056.1
ENST00000382226.5
ENST00000326877.4
LCORL
ligand dependent nuclear receptor corepressor-like
chr2_-_191878681 0.51 ENST00000409465.1
STAT1
signal transducer and activator of transcription 1, 91kDa
chr9_-_100881466 0.51 ENST00000341469.2
ENST00000342043.3
ENST00000375098.3
TRIM14
tripartite motif containing 14
chr8_+_39972170 0.48 ENST00000521257.1
RP11-359E19.2
RP11-359E19.2
chr7_+_141478242 0.47 ENST00000247881.2
TAS2R4
taste receptor, type 2, member 4
chr3_+_122283064 0.47 ENST00000296161.4
DTX3L
deltex 3-like (Drosophila)
chr6_+_106546808 0.47 ENST00000369089.3
PRDM1
PR domain containing 1, with ZNF domain
chr7_+_142985467 0.46 ENST00000392925.2
CASP2
caspase 2, apoptosis-related cysteine peptidase
chr18_+_13382553 0.46 ENST00000586222.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr11_+_695787 0.44 ENST00000526170.1
ENST00000488769.1
TMEM80
transmembrane protein 80
chr6_+_43738444 0.44 ENST00000324450.6
ENST00000417285.2
ENST00000413642.3
ENST00000372055.4
ENST00000482630.2
ENST00000425836.2
ENST00000372064.4
ENST00000372077.4
ENST00000519767.1
VEGFA
vascular endothelial growth factor A
chr19_-_36705547 0.43 ENST00000304116.5
ZNF565
zinc finger protein 565
chr11_-_118135160 0.42 ENST00000438295.2
MPZL2
myelin protein zero-like 2
chr15_-_45670924 0.42 ENST00000396659.3
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr10_+_75668916 0.41 ENST00000481390.1
PLAU
plasminogen activator, urokinase
chr3_+_187086120 0.41 ENST00000259030.2
RTP4
receptor (chemosensory) transporter protein 4
chr9_-_116062045 0.40 ENST00000478815.1
RNF183
ring finger protein 183
chr14_+_105266933 0.39 ENST00000555360.1
ZBTB42
zinc finger and BTB domain containing 42
chr2_-_152118276 0.38 ENST00000409092.1
RBM43
RNA binding motif protein 43
chr17_+_6658878 0.37 ENST00000574394.1
XAF1
XIAP associated factor 1
chr17_-_54991369 0.37 ENST00000537230.1
TRIM25
tripartite motif containing 25
chr17_+_41363854 0.37 ENST00000588693.1
ENST00000588659.1
ENST00000541594.1
ENST00000536052.1
ENST00000331615.3
TMEM106A
transmembrane protein 106A
chr11_-_57334732 0.36 ENST00000526659.1
ENST00000527022.1
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr11_-_86383650 0.35 ENST00000526944.1
ENST00000530335.1
ENST00000543262.1
ENST00000524826.1
ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr15_-_65117807 0.35 ENST00000559239.1
ENST00000268043.4
ENST00000333425.6
PIF1
PIF1 5'-to-3' DNA helicase
chr10_-_15139318 0.35 ENST00000378207.3
C10orf111
chromosome 10 open reading frame 111
chrX_-_110655391 0.35 ENST00000356915.2
ENST00000356220.3
DCX
doublecortin
chr11_+_128563652 0.34 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr4_+_57371509 0.34 ENST00000360096.2
ARL9
ADP-ribosylation factor-like 9
chr12_+_49760639 0.34 ENST00000549538.1
ENST00000548654.1
ENST00000550643.1
ENST00000548710.1
ENST00000549179.1
ENST00000548377.1
SPATS2
spermatogenesis associated, serine-rich 2
chr15_+_74287118 0.33 ENST00000563500.1
PML
promyelocytic leukemia
chr5_-_115890554 0.33 ENST00000509665.1
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr20_-_45318230 0.32 ENST00000372114.3
TP53RK
TP53 regulating kinase
chrM_+_9207 0.32 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr12_+_113344755 0.32 ENST00000550883.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr11_+_63655987 0.32 ENST00000509502.2
ENST00000512060.1
MARK2
MAP/microtubule affinity-regulating kinase 2
chr6_+_89791507 0.32 ENST00000354922.3
PNRC1
proline-rich nuclear receptor coactivator 1
chr16_+_30751953 0.32 ENST00000483578.1
RP11-2C24.4
RP11-2C24.4
chr2_-_163175133 0.31 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr11_+_5710919 0.31 ENST00000379965.3
ENST00000425490.1
TRIM22
tripartite motif containing 22
chr11_-_66056478 0.29 ENST00000431556.2
ENST00000528575.1
YIF1A
Yip1 interacting factor homolog A (S. cerevisiae)
chr21_-_34914394 0.28 ENST00000361093.5
ENST00000381815.4
GART
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
chr2_+_68962014 0.27 ENST00000467265.1
ARHGAP25
Rho GTPase activating protein 25
chr16_+_12059091 0.27 ENST00000562385.1
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr1_-_153514241 0.27 ENST00000368718.1
ENST00000359215.1
S100A5
S100 calcium binding protein A5
chr1_-_44497024 0.27 ENST00000372306.3
ENST00000372310.3
ENST00000475075.2
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr17_-_4167142 0.27 ENST00000570535.1
ENST00000574367.1
ENST00000341657.4
ENST00000433651.1
ANKFY1
ankyrin repeat and FYVE domain containing 1
chr11_+_65554493 0.27 ENST00000335987.3
OVOL1
ovo-like zinc finger 1
chr19_+_7600584 0.27 ENST00000600737.1
PNPLA6
patatin-like phospholipase domain containing 6
chr18_-_67624412 0.26 ENST00000580335.1
CD226
CD226 molecule
chr8_-_22926526 0.25 ENST00000347739.3
ENST00000542226.1
TNFRSF10B
tumor necrosis factor receptor superfamily, member 10b
chr3_+_9958758 0.25 ENST00000383812.4
ENST00000438091.1
ENST00000295981.3
ENST00000436503.1
ENST00000403601.3
ENST00000416074.2
ENST00000455057.1
IL17RC
interleukin 17 receptor C
chr15_+_41136734 0.25 ENST00000568580.1
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr7_-_107883678 0.25 ENST00000417701.1
NRCAM
neuronal cell adhesion molecule
chr11_-_67141090 0.25 ENST00000312438.7
CLCF1
cardiotrophin-like cytokine factor 1
chr3_-_39196049 0.24 ENST00000514182.1
CSRNP1
cysteine-serine-rich nuclear protein 1
chr10_+_135192695 0.24 ENST00000368539.4
ENST00000278060.5
ENST00000357296.3
PAOX
polyamine oxidase (exo-N4-amino)
chrX_+_23801280 0.24 ENST00000379251.3
ENST00000379253.3
ENST00000379254.1
ENST00000379270.4
SAT1
spermidine/spermine N1-acetyltransferase 1
chrX_-_45710920 0.24 ENST00000456532.1
RP5-1158E12.3
RP5-1158E12.3
chr7_-_148823387 0.24 ENST00000483014.1
ENST00000378061.2
ZNF425
zinc finger protein 425
chr10_+_134210672 0.24 ENST00000305233.5
ENST00000368609.4
PWWP2B
PWWP domain containing 2B
chr2_+_208423840 0.24 ENST00000539789.1
CREB1
cAMP responsive element binding protein 1
chr14_+_105267250 0.23 ENST00000342537.7
ZBTB42
zinc finger and BTB domain containing 42
chr7_+_99724317 0.23 ENST00000398075.2
ENST00000421390.1
MBLAC1
metallo-beta-lactamase domain containing 1
chr12_-_62653903 0.23 ENST00000552075.1
FAM19A2
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
chr1_+_59486059 0.23 ENST00000447329.1
RP4-794H19.4
RP4-794H19.4
chr8_+_82066514 0.23 ENST00000519412.1
ENST00000521953.1
RP11-1149M10.2
RP11-1149M10.2
chr17_-_79885576 0.23 ENST00000574686.1
ENST00000357736.4
MAFG
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
chr2_+_68961934 0.22 ENST00000409202.3
ARHGAP25
Rho GTPase activating protein 25
chr14_+_94547628 0.22 ENST00000555523.1
IFI27L1
interferon, alpha-inducible protein 27-like 1
chr4_-_100575781 0.22 ENST00000511828.1
RP11-766F14.2
Protein LOC285556
chr13_+_24144509 0.22 ENST00000248484.4
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr13_+_24144796 0.22 ENST00000403372.2
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr3_+_118892411 0.21 ENST00000479520.1
ENST00000494855.1
UPK1B
uroplakin 1B
chr6_-_27799305 0.21 ENST00000357549.2
HIST1H4K
histone cluster 1, H4k
chr2_+_68961905 0.21 ENST00000295381.3
ARHGAP25
Rho GTPase activating protein 25
chr9_-_133814527 0.20 ENST00000451466.1
FIBCD1
fibrinogen C domain containing 1
chr17_-_54991395 0.20 ENST00000316881.4
TRIM25
tripartite motif containing 25
chr18_-_67624160 0.20 ENST00000581982.1
ENST00000280200.4
CD226
CD226 molecule
chr20_+_20033158 0.19 ENST00000340348.6
ENST00000377309.2
ENST00000389656.3
ENST00000377306.1
ENST00000245957.5
ENST00000377303.2
ENST00000475466.1
C20orf26
chromosome 20 open reading frame 26
chr16_-_88851618 0.19 ENST00000301015.9
PIEZO1
piezo-type mechanosensitive ion channel component 1
chr19_-_4723761 0.19 ENST00000597849.1
ENST00000598800.1
ENST00000602161.1
ENST00000597726.1
ENST00000601130.1
ENST00000262960.9
DPP9
dipeptidyl-peptidase 9
chr7_+_18330035 0.18 ENST00000413509.2
HDAC9
histone deacetylase 9
chr4_-_164534657 0.18 ENST00000339875.5
MARCH1
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr19_-_57183114 0.18 ENST00000537055.2
ENST00000601659.1
ZNF835
zinc finger protein 835
chr12_+_8850277 0.18 ENST00000539923.1
ENST00000537189.1
RIMKLB
ribosomal modification protein rimK-like family member B
chr15_+_41136586 0.18 ENST00000431806.1
SPINT1
serine peptidase inhibitor, Kunitz type 1
chrX_-_48858630 0.18 ENST00000376425.3
ENST00000376444.3
GRIPAP1
GRIP1 associated protein 1
chr19_-_6393216 0.18 ENST00000595047.1
GTF2F1
general transcription factor IIF, polypeptide 1, 74kDa
chr19_-_48389651 0.17 ENST00000222002.3
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr7_-_150779995 0.17 ENST00000462940.1
ENST00000492838.1
ENST00000392818.3
ENST00000488752.1
ENST00000476627.1
TMUB1
transmembrane and ubiquitin-like domain containing 1
chr2_-_32390801 0.17 ENST00000608489.1
RP11-563N4.1
RP11-563N4.1
chr9_+_112542572 0.17 ENST00000374530.3
PALM2-AKAP2
PALM2-AKAP2 readthrough
chr19_+_42300369 0.17 ENST00000357396.3
ENST00000221999.4
CEACAM3
carcinoembryonic antigen-related cell adhesion molecule 3
chr11_-_66056596 0.17 ENST00000471387.2
ENST00000359461.6
ENST00000376901.4
YIF1A
Yip1 interacting factor homolog A (S. cerevisiae)
chr12_-_51664058 0.17 ENST00000605627.1
SMAGP
small cell adhesion glycoprotein
chr11_-_2162468 0.17 ENST00000434045.2
IGF2
insulin-like growth factor 2 (somatomedin A)
chr11_+_5711010 0.17 ENST00000454828.1
TRIM22
tripartite motif containing 22
chr2_-_111435610 0.16 ENST00000447014.1
ENST00000420328.1
ENST00000535254.1
ENST00000409311.1
ENST00000302759.6
BUB1
BUB1 mitotic checkpoint serine/threonine kinase
chr10_+_71561630 0.16 ENST00000398974.3
ENST00000398971.3
ENST00000398968.3
ENST00000398966.3
ENST00000398964.3
ENST00000398969.3
ENST00000356340.3
ENST00000398972.3
ENST00000398973.3
COL13A1
collagen, type XIII, alpha 1
chr11_+_809961 0.16 ENST00000530797.1
RPLP2
ribosomal protein, large, P2
chr16_+_28962128 0.16 ENST00000564978.1
ENST00000320805.4
NFATC2IP
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
chr17_-_7164410 0.16 ENST00000574070.1
CLDN7
claudin 7
chr2_-_220252068 0.15 ENST00000430206.1
ENST00000429013.1
DNPEP
aspartyl aminopeptidase
chr19_-_36545128 0.15 ENST00000538849.1
THAP8
THAP domain containing 8
chr19_+_58898627 0.15 ENST00000598098.1
ENST00000598495.1
ENST00000196551.3
ENST00000596046.1
RPS5
ribosomal protein S5
chr7_-_130597935 0.15 ENST00000447307.1
ENST00000418546.1
MIR29B1
microRNA 29a
chr12_-_56753858 0.15 ENST00000314128.4
ENST00000557235.1
ENST00000418572.2
STAT2
signal transducer and activator of transcription 2, 113kDa
chr14_+_31046959 0.14 ENST00000547532.1
ENST00000555429.1
G2E3
G2/M-phase specific E3 ubiquitin protein ligase
chr15_+_74287009 0.14 ENST00000395135.3
PML
promyelocytic leukemia
chr3_+_118892362 0.14 ENST00000497685.1
ENST00000264234.3
UPK1B
uroplakin 1B
chr15_+_90544532 0.14 ENST00000268154.4
ZNF710
zinc finger protein 710
chr18_-_51884204 0.14 ENST00000577499.1
ENST00000584040.1
ENST00000581310.1
STARD6
StAR-related lipid transfer (START) domain containing 6
chr5_+_156569944 0.14 ENST00000521769.1
ITK
IL2-inducible T-cell kinase
chr17_-_36981556 0.14 ENST00000536127.1
ENST00000225428.5
CWC25
CWC25 spliceosome-associated protein homolog (S. cerevisiae)
chr16_+_89642120 0.14 ENST00000268720.5
ENST00000319518.8
CPNE7
copine VII
chr6_-_26285737 0.14 ENST00000377727.1
ENST00000289352.1
HIST1H4H
histone cluster 1, H4h
chr15_+_91643442 0.14 ENST00000394232.1
SV2B
synaptic vesicle glycoprotein 2B
chr11_+_126139005 0.14 ENST00000263578.5
ENST00000442061.2
ENST00000532125.1
FOXRED1
FAD-dependent oxidoreductase domain containing 1
chr17_+_40118805 0.14 ENST00000591072.1
ENST00000587679.1
ENST00000393888.1
ENST00000441615.2
CNP
2',3'-cyclic nucleotide 3' phosphodiesterase
chr9_-_90589402 0.14 ENST00000375871.4
ENST00000605159.1
ENST00000336654.5
CDK20
cyclin-dependent kinase 20
chr3_+_9958870 0.14 ENST00000413608.1
IL17RC
interleukin 17 receptor C
chr19_+_17516531 0.13 ENST00000528911.1
ENST00000528604.1
ENST00000595892.1
ENST00000500836.2
ENST00000598546.1
ENST00000600369.1
ENST00000598356.1
ENST00000594426.1
MVB12A
CTD-2521M24.9
multivesicular body subunit 12A
CTD-2521M24.9
chr17_-_4643161 0.13 ENST00000574412.1
CXCL16
chemokine (C-X-C motif) ligand 16
chrX_-_119077695 0.13 ENST00000371410.3
NKAP
NFKB activating protein
chr5_-_159797627 0.13 ENST00000393975.3
C1QTNF2
C1q and tumor necrosis factor related protein 2
chr12_+_58176525 0.13 ENST00000543727.1
ENST00000540550.1
ENST00000323833.8
ENST00000350762.5
ENST00000550559.1
ENST00000548851.1
ENST00000434359.1
ENST00000457189.1
TSFM
Ts translation elongation factor, mitochondrial
chr2_-_106810783 0.13 ENST00000283148.7
UXS1
UDP-glucuronate decarboxylase 1
chr10_+_71562180 0.13 ENST00000517713.1
ENST00000522165.1
ENST00000520133.1
COL13A1
collagen, type XIII, alpha 1
chr3_-_151176497 0.13 ENST00000282466.3
IGSF10
immunoglobulin superfamily, member 10
chr10_+_24528108 0.13 ENST00000438429.1
KIAA1217
KIAA1217
chr10_+_15139330 0.13 ENST00000378202.5
ENST00000378197.4
RPP38
ribonuclease P/MRP 38kDa subunit
chr11_-_2162162 0.13 ENST00000381389.1
IGF2
insulin-like growth factor 2 (somatomedin A)
chr17_+_40118773 0.13 ENST00000472031.1
CNP
2',3'-cyclic nucleotide 3' phosphodiesterase
chr11_+_695614 0.13 ENST00000608174.1
ENST00000397512.3
TMEM80
transmembrane protein 80
chr6_-_128222103 0.13 ENST00000434358.1
ENST00000543064.1
ENST00000368248.2
THEMIS
thymocyte selection associated
chr12_+_4758264 0.13 ENST00000266544.5
NDUFA9
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
chr9_-_133814455 0.13 ENST00000448616.1
FIBCD1
fibrinogen C domain containing 1
chr19_-_9649303 0.12 ENST00000253115.2
ZNF426
zinc finger protein 426
chr19_+_10196781 0.12 ENST00000253110.11
C19orf66
chromosome 19 open reading frame 66
chr1_+_46016465 0.12 ENST00000434299.1
AKR1A1
aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr1_+_46016703 0.12 ENST00000481885.1
ENST00000351829.4
ENST00000471651.1
AKR1A1
aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr2_+_219125714 0.12 ENST00000522678.1
ENST00000519574.1
ENST00000521462.1
GPBAR1
G protein-coupled bile acid receptor 1
chr5_-_176057518 0.11 ENST00000393693.2
SNCB
synuclein, beta
chr16_+_3068393 0.11 ENST00000573001.1
TNFRSF12A
tumor necrosis factor receptor superfamily, member 12A
chr10_-_10836865 0.11 ENST00000446372.2
SFTA1P
surfactant associated 1, pseudogene
chr10_+_71561649 0.11 ENST00000398978.3
ENST00000354547.3
ENST00000357811.3
COL13A1
collagen, type XIII, alpha 1
chr11_-_71823266 0.11 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
ANAPC15
anaphase promoting complex subunit 15
chr1_-_238108575 0.11 ENST00000604646.1
MTRNR2L11
MT-RNR2-like 11 (pseudogene)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 5.8 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
1.3 12.8 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
1.1 22.8 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
1.0 3.8 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.6 1.9 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.4 4.5 GO:0060700 regulation of ribonuclease activity(GO:0060700)
0.3 0.9 GO:0002731 negative regulation of dendritic cell cytokine production(GO:0002731)
0.3 1.1 GO:0072308 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
0.3 8.4 GO:0035456 response to interferon-beta(GO:0035456)
0.2 2.7 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.2 0.6 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.2 0.5 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.1 0.4 GO:1903570 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.1 1.6 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.1 1.7 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 1.1 GO:0030578 PML body organization(GO:0030578)
0.1 0.5 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.1 0.5 GO:0009447 putrescine catabolic process(GO:0009447)
0.1 0.5 GO:0006601 creatine biosynthetic process(GO:0006601)
0.1 0.3 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 0.4 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 9.1 GO:0071357 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.1 0.5 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)
0.1 1.2 GO:0035455 response to interferon-alpha(GO:0035455)
0.1 1.7 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 0.3 GO:0044771 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.1 0.2 GO:0033320 UDP-D-xylose metabolic process(GO:0033319) UDP-D-xylose biosynthetic process(GO:0033320)
0.1 0.2 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.1 0.9 GO:0030321 transepithelial chloride transport(GO:0030321)
0.1 0.2 GO:0019853 L-ascorbic acid biosynthetic process(GO:0019853)
0.1 0.4 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.0 0.4 GO:0097398 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.0 0.1 GO:0098727 stem cell population maintenance(GO:0019827) maintenance of cell number(GO:0098727)
0.0 0.4 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.0 0.3 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.0 0.4 GO:0072592 oxygen metabolic process(GO:0072592)
0.0 0.1 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.0 0.9 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.2 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.0 0.1 GO:0038183 bile acid signaling pathway(GO:0038183)
0.0 0.5 GO:0010990 regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.2 GO:0030573 bile acid catabolic process(GO:0030573)
0.0 0.3 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
0.0 0.2 GO:1904550 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.0 0.1 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.1 GO:0045957 regulation of complement activation, alternative pathway(GO:0030451) negative regulation of complement activation, alternative pathway(GO:0045957) positive regulation of serine-type endopeptidase activity(GO:1900005) positive regulation of serine-type peptidase activity(GO:1902573)
0.0 0.3 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.6 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 0.2 GO:0048295 positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.0 0.1 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.0 0.3 GO:2000467 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0 0.4 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.0 0.3 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.3 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 0.1 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 0.4 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 1.0 GO:0010390 histone monoubiquitination(GO:0010390)
0.0 0.1 GO:0019075 virus maturation(GO:0019075)
0.0 0.5 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.0 0.1 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.0 0.5 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.3 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.0 0.3 GO:0007010 cytoskeleton organization(GO:0007010)
0.0 0.1 GO:0048706 embryonic skeletal system development(GO:0048706)
0.0 0.1 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0 0.3 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.1 GO:0036269 swimming behavior(GO:0036269)
0.0 0.6 GO:0033198 response to ATP(GO:0033198)
0.0 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 0.3 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.0 GO:0006382 adenosine to inosine editing(GO:0006382) IDP metabolic process(GO:0046707) IDP catabolic process(GO:0046709) negative regulation of ribosome biogenesis(GO:0090071)
0.0 0.0 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.2 0.6 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.1 0.5 GO:0005600 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.1 0.3 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.1 0.2 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.1 4.9 GO:0005643 nuclear pore(GO:0005643)
0.0 0.3 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.0 0.3 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.3 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 19.6 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.3 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.2 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.0 0.2 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 0.1 GO:0032798 Swi5-Sfr1 complex(GO:0032798)
0.0 13.8 GO:0045121 membrane raft(GO:0045121)
0.0 0.1 GO:0034686 integrin alphav-beta6 complex(GO:0034685) integrin alphav-beta8 complex(GO:0034686)
0.0 0.3 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.3 GO:0097427 microtubule bundle(GO:0097427)
0.0 3.2 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.1 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.1 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.1 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.0 0.3 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.7 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.1 GO:0030485 smooth muscle contractile fiber(GO:0030485)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 12.6 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.6 12.8 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.3 1.9 GO:0005534 galactose binding(GO:0005534)
0.2 0.5 GO:0015067 amidinotransferase activity(GO:0015067) glycine amidinotransferase activity(GO:0015068)
0.1 0.5 GO:0009041 uridylate kinase activity(GO:0009041)
0.1 0.9 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.1 0.4 GO:0033677 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) DNA/RNA helicase activity(GO:0033677)
0.1 0.4 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 0.6 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.1 2.9 GO:0070403 NAD+ binding(GO:0070403)
0.1 0.6 GO:0043208 glycosphingolipid binding(GO:0043208)
0.1 1.1 GO:0031386 protein tag(GO:0031386)
0.1 0.3 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 0.2 GO:0004145 diamine N-acetyltransferase activity(GO:0004145) polyamine binding(GO:0019808)
0.1 0.3 GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113)
0.1 0.8 GO:0042296 ISG15 transferase activity(GO:0042296)
0.1 0.4 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 0.3 GO:0004637 phosphoribosylamine-glycine ligase activity(GO:0004637) phosphoribosylformylglycinamidine cyclo-ligase activity(GO:0004641) phosphoribosylglycinamide formyltransferase activity(GO:0004644)
0.1 0.3 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.1 0.2 GO:0072591 citrate-L-glutamate ligase activity(GO:0072591)
0.1 0.4 GO:0004473 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.1 0.3 GO:0045569 TRAIL binding(GO:0045569)
0.1 2.3 GO:0005521 lamin binding(GO:0005521)
0.1 0.6 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 6.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 22.7 GO:0008017 microtubule binding(GO:0008017)
0.0 0.1 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.0 1.8 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.4 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.1 GO:0038181 bile acid receptor activity(GO:0038181)
0.0 0.9 GO:0032183 SUMO binding(GO:0032183)
0.0 0.1 GO:0070984 SET domain binding(GO:0070984)
0.0 3.9 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.2 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.6 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.1 GO:0004877 complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877)
0.0 0.9 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.2 GO:1990763 arrestin family protein binding(GO:1990763)
0.0 0.2 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.0 0.6 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.1 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.3 GO:0008061 chitin binding(GO:0008061)
0.0 0.3 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.1 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 0.2 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.1 GO:1903136 cuprous ion binding(GO:1903136)
0.0 0.3 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.2 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.0 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.3 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.1 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 0.1 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.9 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.5 GO:0070412 R-SMAD binding(GO:0070412)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.4 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 4.3 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.1 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.6 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.9 PID MYC PATHWAY C-MYC pathway
0.0 0.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.5 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 53.9 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.3 4.4 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 1.5 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 0.9 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.4 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.5 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.7 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.8 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.3 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 1.1 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.8 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.2 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII