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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for IRF3

Z-value: 0.90

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Transcription factors associated with IRF3

Gene Symbol Gene ID Gene Info
IRF3
ENSG00000126456.11 interferon regulatory factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF3hg19_v2_chr19_-_50169064_50169132-0.621.9e-01Click!

Activity profile of IRF3 motif

Sorted Z-values of IRF3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr21_+_42792442 1.32 ENST00000398600.2
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr12_+_113376249 0.91 ENST00000551007.1
ENST00000548514.1
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr12_+_113416191 0.87 ENST00000342315.4
ENST00000392583.2
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr4_-_85771168 0.86 ENST00000514071.1
WDFY3
WD repeat and FYVE domain containing 3
chr12_+_113376157 0.82 ENST00000228928.7
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr12_+_113416340 0.79 ENST00000552756.1
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr17_+_6659354 0.70 ENST00000574907.1
XAF1
XIAP associated factor 1
chr6_+_32821924 0.62 ENST00000374859.2
ENST00000453265.2
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr5_-_95158375 0.53 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
GLRX
glutaredoxin (thioltransferase)
chr1_+_79115503 0.53 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr6_-_36355513 0.53 ENST00000340181.4
ENST00000373737.4
ETV7
ets variant 7
chr19_-_17516449 0.49 ENST00000252593.6
BST2
bone marrow stromal cell antigen 2
chr2_-_163175133 0.45 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr10_+_91087651 0.45 ENST00000371818.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr12_+_113416265 0.44 ENST00000449768.2
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr11_-_615942 0.40 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
IRF7
interferon regulatory factor 7
chr17_+_25958174 0.40 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
LGALS9
lectin, galactoside-binding, soluble, 9
chr2_-_214017151 0.40 ENST00000452786.1
IKZF2
IKAROS family zinc finger 2 (Helios)
chr10_+_91092241 0.37 ENST00000371811.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr6_-_36355486 0.36 ENST00000538992.1
ETV7
ets variant 7
chr11_-_615570 0.36 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr7_-_944631 0.33 ENST00000453175.2
ADAP1
ArfGAP with dual PH domains 1
chr17_+_6659153 0.32 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XAF1
XIAP associated factor 1
chr12_-_133787772 0.31 ENST00000545350.1
AC226150.4
Uncharacterized protein
chr14_+_24605361 0.31 ENST00000206451.6
ENST00000559123.1
PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr5_-_95158644 0.29 ENST00000237858.6
GLRX
glutaredoxin (thioltransferase)
chr19_+_17516494 0.28 ENST00000534306.1
CTD-2521M24.9
CTD-2521M24.9
chr14_+_24605389 0.27 ENST00000382708.3
ENST00000561435.1
PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr14_+_73525265 0.27 ENST00000525161.1
RBM25
RNA binding motif protein 25
chr3_-_122283079 0.26 ENST00000471785.1
ENST00000466126.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr3_-_122283100 0.26 ENST00000492382.1
ENST00000462315.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr2_-_73869508 0.25 ENST00000272425.3
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr5_+_131746575 0.25 ENST00000337752.2
ENST00000378947.3
ENST00000407797.1
C5orf56
chromosome 5 open reading frame 56
chr10_-_22292675 0.25 ENST00000376946.1
DNAJC1
DnaJ (Hsp40) homolog, subfamily C, member 1
chr6_+_28227063 0.24 ENST00000343684.3
NKAPL
NFKB activating protein-like
chr3_-_122283424 0.23 ENST00000477522.2
ENST00000360356.2
PARP9
poly (ADP-ribose) polymerase family, member 9
chr22_-_36635225 0.22 ENST00000529194.1
APOL2
apolipoprotein L, 2
chr11_-_4414880 0.22 ENST00000254436.7
ENST00000543625.1
TRIM21
tripartite motif containing 21
chr7_-_92777606 0.22 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L
sterile alpha motif domain containing 9-like
chr12_-_133613794 0.21 ENST00000443154.3
RP11-386I8.6
RP11-386I8.6
chr8_-_65730127 0.21 ENST00000522106.1
RP11-1D12.2
RP11-1D12.2
chr9_+_74764278 0.20 ENST00000238018.4
ENST00000376989.3
GDA
guanine deaminase
chr2_-_220252603 0.20 ENST00000322176.7
ENST00000273075.4
DNPEP
aspartyl aminopeptidase
chr22_-_36635598 0.19 ENST00000454728.1
APOL2
apolipoprotein L, 2
chr1_-_161015752 0.19 ENST00000435396.1
ENST00000368021.3
USF1
upstream transcription factor 1
chr19_+_50431959 0.19 ENST00000595125.1
ATF5
activating transcription factor 5
chr6_-_32821599 0.18 ENST00000354258.4
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr10_+_35416223 0.18 ENST00000489321.1
ENST00000427847.2
ENST00000345491.3
ENST00000395895.2
ENST00000374728.3
ENST00000487132.1
CREM
cAMP responsive element modulator
chr2_-_220252530 0.18 ENST00000521459.1
DNPEP
aspartyl aminopeptidase
chr3_-_53079281 0.18 ENST00000394750.1
SFMBT1
Scm-like with four mbt domains 1
chr5_-_60139347 0.18 ENST00000511799.1
ELOVL7
ELOVL fatty acid elongase 7
chr14_-_24615805 0.18 ENST00000560410.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr22_-_36556821 0.17 ENST00000531095.1
ENST00000397293.2
ENST00000349314.2
APOL3
apolipoprotein L, 3
chr20_-_47894936 0.17 ENST00000371754.4
ZNFX1
zinc finger, NFX1-type containing 1
chr19_+_17516531 0.17 ENST00000528911.1
ENST00000528604.1
ENST00000595892.1
ENST00000500836.2
ENST00000598546.1
ENST00000600369.1
ENST00000598356.1
ENST00000594426.1
MVB12A
CTD-2521M24.9
multivesicular body subunit 12A
CTD-2521M24.9
chr22_+_39436862 0.16 ENST00000381565.2
ENST00000452957.2
APOBEC3F
APOBEC3G
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr9_+_77112244 0.16 ENST00000376896.3
RORB
RAR-related orphan receptor B
chr1_-_161039647 0.16 ENST00000368013.3
ARHGAP30
Rho GTPase activating protein 30
chr7_-_32931387 0.16 ENST00000304056.4
KBTBD2
kelch repeat and BTB (POZ) domain containing 2
chr1_-_161015663 0.15 ENST00000534633.1
USF1
upstream transcription factor 1
chr1_-_161039753 0.15 ENST00000368015.1
ARHGAP30
Rho GTPase activating protein 30
chr19_+_49977466 0.15 ENST00000596435.1
ENST00000344019.3
ENST00000597551.1
ENST00000204637.2
ENST00000600429.1
FLT3LG
fms-related tyrosine kinase 3 ligand
chr12_+_4758264 0.15 ENST00000266544.5
NDUFA9
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
chr7_-_139756791 0.14 ENST00000489809.1
PARP12
poly (ADP-ribose) polymerase family, member 12
chr20_-_47894569 0.14 ENST00000371744.1
ENST00000371752.1
ENST00000396105.1
ZNFX1
zinc finger, NFX1-type containing 1
chr4_+_156587853 0.14 ENST00000506455.1
ENST00000511108.1
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr3_+_122283064 0.14 ENST00000296161.4
DTX3L
deltex 3-like (Drosophila)
chr14_-_91976874 0.14 ENST00000557018.1
SMEK1
SMEK homolog 1, suppressor of mek1 (Dictyostelium)
chr10_-_49701686 0.14 ENST00000417247.2
ARHGAP22
Rho GTPase activating protein 22
chr2_+_99771527 0.13 ENST00000415142.1
ENST00000436234.1
LIPT1
lipoyltransferase 1
chr14_+_73525144 0.13 ENST00000261973.7
ENST00000540173.1
RBM25
RNA binding motif protein 25
chr20_+_46988646 0.12 ENST00000416742.1
ENST00000425021.1
LINC00494
long intergenic non-protein coding RNA 494
chr8_+_145438870 0.12 ENST00000527931.1
FAM203B
family with sequence similarity 203, member B
chr14_-_24615523 0.12 ENST00000559056.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr9_-_100954910 0.12 ENST00000375077.4
CORO2A
coronin, actin binding protein, 2A
chr2_+_201980961 0.12 ENST00000342795.5
CFLAR
CASP8 and FADD-like apoptosis regulator
chr11_-_57335280 0.12 ENST00000287156.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr1_+_948803 0.12 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr1_-_154580616 0.12 ENST00000368474.4
ADAR
adenosine deaminase, RNA-specific
chr3_+_122283175 0.11 ENST00000383661.3
DTX3L
deltex 3-like (Drosophila)
chr3_-_27764190 0.11 ENST00000537516.1
EOMES
eomesodermin
chr11_-_57334732 0.11 ENST00000526659.1
ENST00000527022.1
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr1_+_25598872 0.11 ENST00000328664.4
RHD
Rh blood group, D antigen
chr3_+_122399444 0.11 ENST00000474629.2
PARP14
poly (ADP-ribose) polymerase family, member 14
chr1_-_161014731 0.11 ENST00000368020.1
USF1
upstream transcription factor 1
chr10_+_35415978 0.10 ENST00000429130.3
ENST00000469949.2
ENST00000460270.1
CREM
cAMP responsive element modulator
chr2_+_201981119 0.10 ENST00000395148.2
CFLAR
CASP8 and FADD-like apoptosis regulator
chr10_+_92980517 0.10 ENST00000336126.5
PCGF5
polycomb group ring finger 5
chr19_+_17516909 0.10 ENST00000601007.1
ENST00000594913.1
ENST00000599975.1
ENST00000600514.1
CTD-2521M24.9
MVB12A
CTD-2521M24.9
multivesicular body subunit 12A
chr19_-_47735918 0.10 ENST00000449228.1
ENST00000300880.7
ENST00000341983.4
BBC3
BCL2 binding component 3
chr11_+_125461607 0.10 ENST00000527606.1
STT3A
STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
chr9_+_125026882 0.10 ENST00000297908.3
ENST00000373730.3
ENST00000546115.1
ENST00000344641.3
MRRF
mitochondrial ribosome recycling factor
chr4_+_100495864 0.10 ENST00000265517.5
ENST00000422897.2
MTTP
microsomal triglyceride transfer protein
chr14_+_73525229 0.10 ENST00000527432.1
ENST00000531500.1
ENST00000525321.1
ENST00000526754.1
RBM25
RNA binding motif protein 25
chr22_+_36649170 0.09 ENST00000438034.1
ENST00000427990.1
ENST00000347595.7
ENST00000397279.4
ENST00000433768.1
ENST00000440669.2
APOL1
apolipoprotein L, 1
chr17_+_8316442 0.09 ENST00000582812.1
NDEL1
nudE neurodevelopment protein 1-like 1
chr20_-_33872548 0.09 ENST00000374443.3
EIF6
eukaryotic translation initiation factor 6
chr4_+_156588115 0.09 ENST00000455639.2
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chrX_+_77154935 0.09 ENST00000481445.1
COX7B
cytochrome c oxidase subunit VIIb
chr4_+_156587979 0.09 ENST00000511507.1
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr20_-_43589109 0.09 ENST00000372813.3
TOMM34
translocase of outer mitochondrial membrane 34
chr3_+_51977294 0.08 ENST00000498510.1
PARP3
poly (ADP-ribose) polymerase family, member 3
chr16_-_28223166 0.08 ENST00000304658.5
XPO6
exportin 6
chr14_-_100841794 0.08 ENST00000556295.1
ENST00000554820.1
WARS
tryptophanyl-tRNA synthetase
chr2_-_231084617 0.08 ENST00000409815.2
SP110
SP110 nuclear body protein
chr6_+_26402465 0.08 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
BTN3A1
butyrophilin, subfamily 3, member A1
chr6_+_28193037 0.08 ENST00000531981.1
ENST00000425468.2
ENST00000252207.5
ENST00000531979.1
ENST00000527436.1
ZSCAN9
zinc finger and SCAN domain containing 9
chr2_+_219125714 0.08 ENST00000522678.1
ENST00000519574.1
ENST00000521462.1
GPBAR1
G protein-coupled bile acid receptor 1
chr14_-_100841670 0.08 ENST00000557297.1
ENST00000555813.1
ENST00000557135.1
ENST00000556698.1
ENST00000554509.1
ENST00000555410.1
WARS
tryptophanyl-tRNA synthetase
chr4_+_156588350 0.07 ENST00000296518.7
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr2_-_220252068 0.07 ENST00000430206.1
ENST00000429013.1
DNPEP
aspartyl aminopeptidase
chr1_+_200011711 0.07 ENST00000544748.1
NR5A2
nuclear receptor subfamily 5, group A, member 2
chr19_+_10196781 0.07 ENST00000253110.11
C19orf66
chromosome 19 open reading frame 66
chr2_-_152118276 0.07 ENST00000409092.1
RBM43
RNA binding motif protein 43
chr5_-_96143602 0.07 ENST00000443439.2
ENST00000503921.1
ENST00000508227.1
ENST00000507154.1
ERAP1
endoplasmic reticulum aminopeptidase 1
chr16_-_75681522 0.07 ENST00000568378.1
ENST00000568682.1
ENST00000570215.1
ENST00000319410.5
ENST00000302445.3
KARS
lysyl-tRNA synthetase
chr2_+_69240415 0.07 ENST00000409829.3
ANTXR1
anthrax toxin receptor 1
chr14_-_75518129 0.07 ENST00000556257.1
ENST00000557648.1
ENST00000553263.1
ENST00000355774.2
ENST00000380968.2
ENST00000238662.7
MLH3
mutL homolog 3
chr19_+_13051206 0.07 ENST00000586760.1
CALR
calreticulin
chr19_+_49977818 0.07 ENST00000594009.1
ENST00000595510.1
FLT3LG
fms-related tyrosine kinase 3 ligand
chr14_+_86401039 0.07 ENST00000557195.1
CTD-2341M24.1
CTD-2341M24.1
chrX_+_57313113 0.07 ENST00000374900.4
FAAH2
fatty acid amide hydrolase 2
chr12_-_4758159 0.07 ENST00000545990.2
AKAP3
A kinase (PRKA) anchor protein 3
chr8_+_70476088 0.07 ENST00000525999.1
SULF1
sulfatase 1
chr4_+_87856129 0.06 ENST00000395146.4
ENST00000507468.1
AFF1
AF4/FMR2 family, member 1
chr19_+_10196981 0.06 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr6_-_32806483 0.06 ENST00000374899.4
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr6_-_32806506 0.06 ENST00000374897.2
ENST00000452392.2
TAP2
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr8_-_7274385 0.06 ENST00000318157.2
DEFB4B
defensin, beta 4B
chr6_+_42018614 0.06 ENST00000465926.1
ENST00000482432.1
TAF8
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr17_-_7166500 0.05 ENST00000575313.1
ENST00000397317.4
CLDN7
claudin 7
chr2_-_231084820 0.05 ENST00000258382.5
ENST00000338556.3
SP110
SP110 nuclear body protein
chr1_-_11042094 0.05 ENST00000377004.4
ENST00000377008.4
C1orf127
chromosome 1 open reading frame 127
chr6_-_90529418 0.05 ENST00000439638.1
ENST00000369393.3
ENST00000428876.1
MDN1
MDN1, midasin homolog (yeast)
chr22_-_36635684 0.05 ENST00000358502.5
APOL2
apolipoprotein L, 2
chr1_-_159046617 0.05 ENST00000368130.4
AIM2
absent in melanoma 2
chr5_-_180288248 0.05 ENST00000512132.1
ENST00000506439.1
ENST00000502412.1
ENST00000359141.6
ZFP62
ZFP62 zinc finger protein
chr8_+_7752151 0.05 ENST00000302247.2
DEFB4A
defensin, beta 4A
chr10_+_6130966 0.05 ENST00000437845.2
ENST00000432931.1
RBM17
RNA binding motif protein 17
chr1_+_112298514 0.05 ENST00000536167.1
DDX20
DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
chr6_-_27840099 0.04 ENST00000328488.2
HIST1H3I
histone cluster 1, H3i
chr4_+_156588249 0.04 ENST00000393832.3
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr10_-_135187193 0.04 ENST00000368547.3
ECHS1
enoyl CoA hydratase, short chain, 1, mitochondrial
chr9_+_74764340 0.04 ENST00000376986.1
ENST00000358399.3
GDA
guanine deaminase
chr2_-_231084659 0.04 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
SP110
SP110 nuclear body protein
chr2_+_239756671 0.04 ENST00000448943.2
TWIST2
twist family bHLH transcription factor 2
chr12_-_99288536 0.04 ENST00000549797.1
ENST00000333732.7
ENST00000341752.7
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr8_+_39770803 0.04 ENST00000518237.1
IDO1
indoleamine 2,3-dioxygenase 1
chr2_-_37384175 0.04 ENST00000411537.2
ENST00000233057.4
ENST00000395127.2
ENST00000390013.3
EIF2AK2
eukaryotic translation initiation factor 2-alpha kinase 2
chr20_-_33872518 0.04 ENST00000374436.3
EIF6
eukaryotic translation initiation factor 6
chr11_+_93861993 0.04 ENST00000227638.3
ENST00000436171.2
PANX1
pannexin 1
chr1_+_59486059 0.03 ENST00000447329.1
RP4-794H19.4
RP4-794H19.4
chr2_+_113672770 0.03 ENST00000311328.2
IL37
interleukin 37
chr3_+_122399697 0.03 ENST00000494811.1
PARP14
poly (ADP-ribose) polymerase family, member 14
chr15_-_88799948 0.03 ENST00000394480.2
NTRK3
neurotrophic tyrosine kinase, receptor, type 3
chr11_+_124735282 0.03 ENST00000397801.1
ROBO3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr1_+_150480576 0.03 ENST00000346569.6
ECM1
extracellular matrix protein 1
chr2_-_145275228 0.03 ENST00000427902.1
ENST00000409487.3
ENST00000470879.1
ENST00000435831.1
ZEB2
zinc finger E-box binding homeobox 2
chr1_+_25598989 0.03 ENST00000454452.2
RHD
Rh blood group, D antigen
chr1_+_150480551 0.03 ENST00000369049.4
ENST00000369047.4
ECM1
extracellular matrix protein 1
chrX_+_80457442 0.03 ENST00000373212.5
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr5_+_140071178 0.03 ENST00000508522.1
ENST00000448069.2
HARS2
histidyl-tRNA synthetase 2, mitochondrial
chr19_+_50432400 0.03 ENST00000423777.2
ENST00000600336.1
ENST00000597227.1
ATF5
activating transcription factor 5
chr2_+_201980827 0.03 ENST00000309955.3
ENST00000443227.1
ENST00000341222.6
ENST00000355558.4
ENST00000340870.5
ENST00000341582.6
CFLAR
CASP8 and FADD-like apoptosis regulator
chr21_-_43346790 0.02 ENST00000329623.7
C2CD2
C2 calcium-dependent domain containing 2
chr2_-_166651152 0.02 ENST00000431484.1
ENST00000412248.1
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr2_+_201981527 0.02 ENST00000441224.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr6_+_72922505 0.02 ENST00000401910.3
RIMS1
regulating synaptic membrane exocytosis 1
chr14_-_100841930 0.02 ENST00000555031.1
ENST00000553395.1
ENST00000553545.1
ENST00000344102.5
ENST00000556338.1
ENST00000392882.2
ENST00000553934.1
WARS
tryptophanyl-tRNA synthetase
chr6_+_72922590 0.02 ENST00000523963.1
RIMS1
regulating synaptic membrane exocytosis 1
chr6_-_28226984 0.02 ENST00000423974.2
ZKSCAN4
zinc finger with KRAB and SCAN domains 4
chrX_+_146993648 0.02 ENST00000370470.1
FMR1
fragile X mental retardation 1
chr1_-_177939041 0.02 ENST00000308284.6
SEC16B
SEC16 homolog B (S. cerevisiae)
chr17_+_6658878 0.01 ENST00000574394.1
XAF1
XIAP associated factor 1
chr6_+_42018251 0.01 ENST00000372978.3
ENST00000494547.1
ENST00000456846.2
ENST00000372982.4
ENST00000472818.1
ENST00000372977.3
TAF8
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr4_+_118955500 0.01 ENST00000296499.5
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr4_-_169401628 0.01 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr9_-_32526184 0.01 ENST00000545044.1
ENST00000379868.1
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr22_-_36635563 0.01 ENST00000451256.2
APOL2
apolipoprotein L, 2
chr22_+_31892373 0.01 ENST00000443011.1
ENST00000400289.1
ENST00000444859.1
ENST00000400288.2
SFI1
Sfi1 homolog, spindle assembly associated (yeast)
chr1_+_151129135 0.01 ENST00000602841.1
SCNM1
sodium channel modifier 1
chr19_+_18284477 0.01 ENST00000407280.3
IFI30
interferon, gamma-inducible protein 30
chr3_-_125803105 0.01 ENST00000346785.5
ENST00000315891.6
SLC41A3
solute carrier family 41, member 3
chr10_-_14996017 0.01 ENST00000378241.1
ENST00000456122.1
ENST00000418843.1
ENST00000378249.1
ENST00000396817.2
ENST00000378255.1
ENST00000378254.1
ENST00000378278.2
ENST00000357717.2
DCLRE1C
DNA cross-link repair 1C
chr1_+_159931002 0.01 ENST00000443364.1
ENST00000423943.1
RP11-48O20.4
long intergenic non-protein coding RNA 1133
chrX_+_154610428 0.00 ENST00000354514.4
H2AFB2
H2A histone family, member B2
chr2_-_166651191 0.00 ENST00000392701.3
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr9_-_32526299 0.00 ENST00000379882.1
ENST00000379883.2
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr11_+_118230287 0.00 ENST00000252108.3
ENST00000431736.2
UBE4A
ubiquitination factor E4A
chr6_+_134758827 0.00 ENST00000431422.1
LINC01010
long intergenic non-protein coding RNA 1010
chr12_+_12224331 0.00 ENST00000396367.1
ENST00000266434.4
ENST00000396369.1
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr9_+_140083099 0.00 ENST00000322310.5
SSNA1
Sjogren syndrome nuclear autoantigen 1
chr7_-_122526499 0.00 ENST00000412584.2
CADPS2
Ca++-dependent secretion activator 2
chr3_-_160283348 0.00 ENST00000334256.4
KPNA4
karyopherin alpha 4 (importin alpha 3)

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.2 2.1 GO:0018377 protein myristoylation(GO:0018377)
0.2 0.5 GO:0002731 negative regulation of dendritic cell cytokine production(GO:0002731)
0.1 1.7 GO:0060700 regulation of ribonuclease activity(GO:0060700)
0.1 0.4 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361) natural killer cell tolerance induction(GO:0002519) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.1 0.5 GO:0034344 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.1 0.2 GO:0006147 guanine catabolic process(GO:0006147)
0.1 0.3 GO:0046967 cytosol to ER transport(GO:0046967)
0.1 0.4 GO:0052551 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.1 0.9 GO:0035973 aggrephagy(GO:0035973)
0.1 0.4 GO:0000430 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.1 1.3 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.1 0.2 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.1 0.2 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885)
0.0 0.5 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.3 GO:0019075 virus maturation(GO:0019075)
0.0 0.5 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.0 0.2 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.0 0.8 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.0 0.1 GO:1900368 regulation of RNA interference(GO:1900368)
0.0 0.1 GO:0038183 bile acid signaling pathway(GO:0038183)
0.0 0.1 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.0 1.1 GO:0035456 response to interferon-beta(GO:0035456)
0.0 0.1 GO:0002276 basophil activation involved in immune response(GO:0002276) basophil activation(GO:0045575)
0.0 0.2 GO:0070383 DNA cytosine deamination(GO:0070383)
0.0 0.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.3 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0 0.1 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.0 0.2 GO:0046549 amacrine cell differentiation(GO:0035881) retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.1 GO:0043686 co-translational protein modification(GO:0043686)
0.0 0.1 GO:0060809 mesodermal to mesenchymal transition involved in gastrulation(GO:0060809)
0.0 0.1 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501)
0.0 0.2 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.2 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.0 1.3 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 0.0 GO:0052026 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.0 0.1 GO:0061113 pancreas morphogenesis(GO:0061113)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0097635 extrinsic component of autophagosome membrane(GO:0097635)
0.1 0.9 GO:0008537 proteasome activator complex(GO:0008537)
0.1 0.4 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.3 GO:0042825 TAP complex(GO:0042825)
0.0 0.1 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.4 GO:0016589 NURF complex(GO:0016589)
0.0 0.1 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.1 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.0 0.1 GO:0005712 chiasma(GO:0005712)
0.0 0.3 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.3 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.8 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 0.9 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 0.2 GO:0008892 guanine deaminase activity(GO:0008892)
0.1 0.9 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.1 0.8 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.1 0.4 GO:0005534 galactose binding(GO:0005534)
0.0 0.3 GO:0015440 peptide-transporting ATPase activity(GO:0015440) TAP binding(GO:0046977) TAP1 binding(GO:0046978)
0.0 0.2 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.0 0.3 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.3 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.2 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.0 0.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.1 GO:0038181 bile acid receptor activity(GO:0038181)
0.0 0.1 GO:0070012 oligopeptidase activity(GO:0070012)
0.0 0.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.5 GO:0008035 high-density lipoprotein particle binding(GO:0008035)
0.0 0.1 GO:0016979 lipoate-protein ligase activity(GO:0016979)
0.0 0.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.2 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.0 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.0 0.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.2 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.4 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.0 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.5 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.8 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.6 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.0 0.2 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism