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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for IRF3
Z-value: 0.90
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Transcription factors associated with IRF3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF3 | hg19_v2_chr19_-_50169064_50169132 | -0.62 | 1.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr21_+_42792442 Show fit | 1.32 |
ENST00000398600.2
|
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
|
| chr12_+_113376249 Show fit | 0.91 |
ENST00000551007.1
ENST00000548514.1 |
2'-5'-oligoadenylate synthetase 3, 100kDa |
|
| chr12_+_113416191 Show fit | 0.87 |
ENST00000342315.4
ENST00000392583.2 |
2'-5'-oligoadenylate synthetase 2, 69/71kDa |
|
| chr4_-_85771168 Show fit | 0.86 |
ENST00000514071.1
|
WD repeat and FYVE domain containing 3 |
|
| chr12_+_113376157 Show fit | 0.82 |
ENST00000228928.7
|
2'-5'-oligoadenylate synthetase 3, 100kDa |
|
| chr12_+_113416340 Show fit | 0.79 |
ENST00000552756.1
|
2'-5'-oligoadenylate synthetase 2, 69/71kDa |
|
| chr17_+_6659354 Show fit | 0.70 |
ENST00000574907.1
|
XIAP associated factor 1 |
|
| chr6_+_32821924 Show fit | 0.62 |
ENST00000374859.2
ENST00000453265.2 |
proteasome (prosome, macropain) subunit, beta type, 9 |
|
| chr5_-_95158375 Show fit | 0.53 |
ENST00000512469.2
ENST00000379979.4 ENST00000505427.1 ENST00000508780.1 |
glutaredoxin (thioltransferase) |
|
| chr1_+_79115503 Show fit | 0.53 |
ENST00000370747.4
ENST00000438486.1 ENST00000545124.1 |
interferon-induced protein 44 |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.1 | GO:0018377 | protein myristoylation(GO:0018377) |
| 0.1 | 1.7 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
| 0.1 | 1.3 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 0.0 | 1.3 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.0 | 1.1 | GO:0035456 | response to interferon-beta(GO:0035456) |
| 0.1 | 0.9 | GO:0035973 | aggrephagy(GO:0035973) |
| 0.2 | 0.8 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 0.0 | 0.8 | GO:0045838 | positive regulation of membrane potential(GO:0045838) |
| 0.2 | 0.5 | GO:0002731 | negative regulation of dendritic cell cytokine production(GO:0002731) |
| 0.1 | 0.5 | GO:0034344 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.9 | GO:0097635 | extrinsic component of autophagosome membrane(GO:0097635) |
| 0.1 | 0.9 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.1 | 0.4 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 0.4 | GO:0016589 | NURF complex(GO:0016589) |
| 0.0 | 0.4 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 0.3 | GO:0042825 | TAP complex(GO:0042825) |
| 0.0 | 0.3 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.0 | 0.3 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.0 | 0.1 | GO:0042824 | MHC class I peptide loading complex(GO:0042824) |
| 0.0 | 0.1 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.8 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 0.9 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.1 | 0.9 | GO:0003831 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831) |
| 0.1 | 0.8 | GO:0015038 | glutathione disulfide oxidoreductase activity(GO:0015038) |
| 0.0 | 0.8 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 0.5 | GO:0008035 | high-density lipoprotein particle binding(GO:0008035) |
| 0.0 | 0.5 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.0 | 0.5 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 0.4 | GO:0005534 | galactose binding(GO:0005534) |
| 0.0 | 0.4 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.6 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.0 | 0.8 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.5 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.0 | 0.2 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.0 | 0.2 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |