Project
NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
Navigation
Downloads
Results for IRF2_STAT2_IRF8_IRF1
Z-value: 5.02
Motif logo
Transcription factors associated with IRF2_STAT2_IRF8_IRF1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000168310.6 | interferon regulatory factor 2 | |
| ENSG00000170581.9 | signal transducer and activator of transcription 2 | |
| ENSG00000140968.6 | interferon regulatory factor 8 | |
| ENSG00000125347.9 | interferon regulatory factor 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| STAT2 | hg19_v2_chr12_-_56753858_56753930 | 0.94 | 5.4e-03 | Click! |
| IRF1 | hg19_v2_chr5_-_131826457_131826514 | 0.59 | 2.1e-01 | Click! |
| IRF2 | hg19_v2_chr4_-_185395672_185395734 | 0.16 | 7.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF2_STAT2_IRF8_IRF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 62.2 | GO:0060337 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 2.1 | 44.4 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 2.0 | 22.2 | GO:0018377 | protein myristoylation(GO:0018377) |
| 1.4 | 16.8 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
| 3.5 | 14.2 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 0.0 | 13.0 | GO:0051607 | defense response to virus(GO:0051607) |
| 0.1 | 12.6 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 1.1 | 12.0 | GO:1904180 | negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180) |
| 1.0 | 12.0 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.8 | 11.5 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 69.3 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 29.1 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.2 | 24.1 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.1 | 15.2 | GO:0005643 | nuclear pore(GO:0005643) |
| 1.8 | 14.1 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.1 | 9.0 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.2 | 7.8 | GO:0043657 | host(GO:0018995) host cell(GO:0043657) |
| 0.0 | 6.5 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.1 | 6.2 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 4.9 | GO:0045121 | membrane raft(GO:0045121) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 67.3 | GO:0005525 | GTP binding(GO:0005525) |
| 4.0 | 48.0 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.7 | 26.9 | GO:0005521 | lamin binding(GO:0005521) |
| 0.1 | 16.6 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.1 | 12.2 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.4 | 12.0 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.3 | 8.5 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.4 | 7.6 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.6 | 7.5 | GO:0031386 | protein tag(GO:0031386) |
| 0.3 | 7.5 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.6 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.1 | 12.0 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.6 | 8.0 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.1 | 6.0 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 4.0 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 3.6 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.0 | 3.3 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 2.8 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 2.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 2.1 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 211.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.2 | 12.9 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.2 | 11.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 10.5 | REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |
| 0.6 | 9.1 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.1 | 6.2 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.2 | 4.7 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.1 | 3.2 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 2.4 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.1 | 2.4 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |