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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for IKZF1
Z-value: 3.09
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Transcription factors associated with IKZF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IKZF1 | hg19_v2_chr7_+_50344289_50344378 | -0.10 | 8.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IKZF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.8 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.1 | 11.4 | GO:0034340 | response to type I interferon(GO:0034340) |
| 0.4 | 9.1 | GO:0003373 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 0.3 | 8.6 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 0.3 | 8.5 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.1 | 6.7 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.1 | 6.7 | GO:0070268 | cornification(GO:0070268) |
| 0.5 | 6.2 | GO:0030223 | neutrophil differentiation(GO:0030223) |
| 0.4 | 6.0 | GO:2001268 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268) |
| 1.0 | 5.0 | GO:0085032 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 37.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 15.3 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 10.8 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 8.1 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 7.1 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 6.6 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 6.4 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.2 | 5.1 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 4.6 | GO:0005761 | organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761) |
| 0.4 | 4.4 | GO:0032010 | phagolysosome(GO:0032010) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 25.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 15.9 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 8.6 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.1 | 8.5 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.0 | 8.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.6 | 7.8 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.6 | 7.4 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.0 | 7.3 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.6 | 4.9 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.1 | 4.3 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 38.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 8.5 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 7.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 6.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 6.2 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 5.2 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 4.7 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 4.0 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 3.9 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 3.6 | ST GA12 PATHWAY | G alpha 12 Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 36.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 10.6 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.2 | 10.1 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 9.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 8.0 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.1 | 6.5 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 6.0 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.1 | 5.3 | REACTOME PLATELET AGGREGATION PLUG FORMATION | Genes involved in Platelet Aggregation (Plug Formation) |
| 0.3 | 4.8 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.1 | 4.5 | REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION | Genes involved in Glucagon signaling in metabolic regulation |