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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ID4_TCF4_SNAI2
Z-value: 1.83
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Transcription factors associated with ID4_TCF4_SNAI2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000172201.6 | inhibitor of DNA binding 4, HLH protein | |
| ENSG00000196628.9 | transcription factor 4 | |
| ENSG00000019549.4 | snail family transcriptional repressor 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TCF4 | hg19_v2_chr18_-_53257027_53257052 | -0.95 | 3.8e-03 | Click! |
| SNAI2 | hg19_v2_chr8_-_49834299_49834446 | -0.29 | 5.7e-01 | Click! |
| ID4 | hg19_v2_chr6_+_19837592_19837621 | -0.17 | 7.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ID4_TCF4_SNAI2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.0 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.6 | 3.2 | GO:0003069 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 0.4 | 2.9 | GO:2000860 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
| 0.1 | 2.9 | GO:0003373 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 0.6 | 2.2 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 0.1 | 2.1 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 0.1 | 2.0 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.1 | 1.9 | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) |
| 0.4 | 1.8 | GO:0085032 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.1 | 1.8 | GO:0032287 | peripheral nervous system myelin maintenance(GO:0032287) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.6 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 4.1 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 3.2 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 2.4 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 1.9 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 1.9 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 1.8 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 1.6 | GO:0042627 | chylomicron(GO:0042627) |
| 0.0 | 1.6 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 1.4 | GO:0002102 | podosome(GO:0002102) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.3 | 3.1 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.0 | 2.6 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 2.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.4 | 2.2 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.2 | 2.2 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.3 | 2.1 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.0 | 2.1 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 2.0 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.0 | 1.9 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 4.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 3.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 3.4 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.0 | 3.1 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 2.8 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 2.4 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.1 | 2.3 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 2.2 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 2.1 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.5 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 4.2 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 2.6 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.1 | 2.5 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 2.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 2.2 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 2.1 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 2.0 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 1.7 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 1.6 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |