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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HSF1

Z-value: 0.58

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Transcription factors associated with HSF1

Gene Symbol Gene ID Gene Info
HSF1
ENSG00000185122.6 heat shock transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HSF1hg19_v2_chr8_+_145515263_145515299-0.138.1e-01Click!

Activity profile of HSF1 motif

Sorted Z-values of HSF1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_113735575 0.66 ENST00000376489.2
ENST00000259205.4
IL36G
interleukin 36, gamma
chr19_-_6720686 0.53 ENST00000245907.6
C3
complement component 3
chr2_+_228678550 0.50 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr1_-_153363452 0.49 ENST00000368732.1
ENST00000368733.3
S100A8
S100 calcium binding protein A8
chr20_+_43803517 0.44 ENST00000243924.3
PI3
peptidase inhibitor 3, skin-derived
chr11_+_69061594 0.43 ENST00000441339.2
ENST00000308946.3
ENST00000535407.1
MYEOV
myeloma overexpressed
chr19_+_3762703 0.41 ENST00000589174.1
MRPL54
mitochondrial ribosomal protein L54
chr10_+_15001430 0.40 ENST00000407572.1
MEIG1
meiosis/spermiogenesis associated 1
chr11_-_105010320 0.39 ENST00000532895.1
ENST00000530950.1
CARD18
caspase recruitment domain family, member 18
chr19_+_782755 0.36 ENST00000606242.1
ENST00000586061.1
AC006273.5
AC006273.5
chr2_+_132044330 0.35 ENST00000416266.1
CYP4F31P
cytochrome P450, family 4, subfamily F, polypeptide 31, pseudogene
chr21_+_42733870 0.33 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr17_-_54911250 0.29 ENST00000575658.1
ENST00000397861.2
C17orf67
chromosome 17 open reading frame 67
chr5_-_150466692 0.27 ENST00000315050.7
ENST00000523338.1
ENST00000522100.1
TNIP1
TNFAIP3 interacting protein 1
chr4_+_76481258 0.25 ENST00000311623.4
ENST00000435974.2
C4orf26
chromosome 4 open reading frame 26
chr17_+_45331184 0.25 ENST00000559488.1
ENST00000571680.1
ENST00000435993.2
ITGB3
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
chr6_-_38607628 0.24 ENST00000498633.1
BTBD9
BTB (POZ) domain containing 9
chr7_-_139763521 0.24 ENST00000263549.3
PARP12
poly (ADP-ribose) polymerase family, member 12
chr16_-_2770216 0.23 ENST00000302641.3
PRSS27
protease, serine 27
chr3_-_10334617 0.22 ENST00000429122.1
ENST00000425479.1
ENST00000335542.8
GHRL
ghrelin/obestatin prepropeptide
chr2_+_40973618 0.22 ENST00000420187.1
AC007317.1
AC007317.1
chr7_-_150020814 0.21 ENST00000477871.1
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr19_+_3762645 0.21 ENST00000330133.4
MRPL54
mitochondrial ribosomal protein L54
chr2_-_191878162 0.20 ENST00000540176.1
STAT1
signal transducer and activator of transcription 1, 91kDa
chr5_+_131630117 0.19 ENST00000200652.3
SLC22A4
solute carrier family 22 (organic cation/zwitterion transporter), member 4
chr5_-_150467221 0.19 ENST00000522226.1
TNIP1
TNFAIP3 interacting protein 1
chr4_+_57396766 0.19 ENST00000512175.2
THEGL
theg spermatid protein-like
chr19_-_2085323 0.19 ENST00000591638.1
MOB3A
MOB kinase activator 3A
chr1_-_183538319 0.18 ENST00000420553.1
ENST00000419402.1
NCF2
neutrophil cytosolic factor 2
chr19_+_49055332 0.18 ENST00000201586.2
SULT2B1
sulfotransferase family, cytosolic, 2B, member 1
chr6_-_29648887 0.18 ENST00000376883.1
ZFP57
ZFP57 zinc finger protein
chr2_+_102624977 0.18 ENST00000441002.1
IL1R2
interleukin 1 receptor, type II
chr2_-_220142892 0.17 ENST00000427737.1
TUBA4A
tubulin, alpha 4a
chr3_-_10334585 0.17 ENST00000430179.1
ENST00000449238.2
ENST00000437422.2
ENST00000287656.7
ENST00000457360.1
ENST00000439975.2
ENST00000446937.2
GHRL
ghrelin/obestatin prepropeptide
chr6_-_32812420 0.17 ENST00000374881.2
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8
chr6_-_31782813 0.16 ENST00000375654.4
HSPA1L
heat shock 70kDa protein 1-like
chr15_-_86338134 0.16 ENST00000337975.5
KLHL25
kelch-like family member 25
chr11_-_102714534 0.16 ENST00000299855.5
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr1_+_92683467 0.16 ENST00000370375.3
ENST00000370373.2
C1orf146
chromosome 1 open reading frame 146
chr7_+_150020363 0.16 ENST00000359623.4
ENST00000493307.1
LRRC61
leucine rich repeat containing 61
chr11_-_47870091 0.16 ENST00000526870.1
NUP160
nucleoporin 160kDa
chr20_-_43753104 0.16 ENST00000372785.3
WFDC12
WAP four-disulfide core domain 12
chr2_-_191878681 0.16 ENST00000409465.1
STAT1
signal transducer and activator of transcription 1, 91kDa
chr19_+_56905024 0.15 ENST00000591172.1
ENST00000589888.1
ENST00000587979.1
ENST00000585659.1
ENST00000593109.1
ZNF582-AS1
ZNF582 antisense RNA 1 (head to head)
chr2_-_191878874 0.15 ENST00000392322.3
ENST00000392323.2
ENST00000424722.1
ENST00000361099.3
STAT1
signal transducer and activator of transcription 1, 91kDa
chrX_-_100662881 0.15 ENST00000218516.3
GLA
galactosidase, alpha
chr14_+_101293687 0.15 ENST00000455286.1
MEG3
maternally expressed 3 (non-protein coding)
chr14_-_81425828 0.15 ENST00000555529.1
ENST00000556042.1
ENST00000556981.1
CEP128
centrosomal protein 128kDa
chr1_+_212782012 0.15 ENST00000341491.4
ENST00000366985.1
ATF3
activating transcription factor 3
chr2_-_238499131 0.14 ENST00000538644.1
RAB17
RAB17, member RAS oncogene family
chr6_-_112081113 0.14 ENST00000517419.1
FYN
FYN oncogene related to SRC, FGR, YES
chr14_-_75083313 0.14 ENST00000556652.1
ENST00000555313.1
CTD-2207P18.2
CTD-2207P18.2
chr15_+_67390920 0.14 ENST00000559092.1
ENST00000560175.1
SMAD3
SMAD family member 3
chr20_+_2633269 0.14 ENST00000445139.1
NOP56
NOP56 ribonucleoprotein
chr3_+_112930946 0.14 ENST00000462425.1
BOC
BOC cell adhesion associated, oncogene regulated
chr12_+_51632666 0.14 ENST00000604900.1
DAZAP2
DAZ associated protein 2
chr8_+_119294456 0.14 ENST00000366457.2
AC023590.1
Uncharacterized protein
chr5_-_56778635 0.13 ENST00000423391.1
ACTBL2
actin, beta-like 2
chr1_+_202830876 0.13 ENST00000456105.2
RP11-480I12.7
RP11-480I12.7
chr21_+_35445811 0.13 ENST00000399312.2
MRPS6
mitochondrial ribosomal protein S6
chr1_+_212738676 0.13 ENST00000366981.4
ENST00000366987.2
ATF3
activating transcription factor 3
chr3_-_120400960 0.13 ENST00000476082.2
HGD
homogentisate 1,2-dioxygenase
chr2_-_191885686 0.13 ENST00000432058.1
STAT1
signal transducer and activator of transcription 1, 91kDa
chr19_-_55791563 0.13 ENST00000588971.1
ENST00000255631.5
ENST00000587551.1
HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr8_+_142402089 0.13 ENST00000521578.1
ENST00000520105.1
ENST00000523147.1
PTP4A3
protein tyrosine phosphatase type IVA, member 3
chr19_+_8740061 0.13 ENST00000593792.1
CTD-2586B10.1
CTD-2586B10.1
chr18_-_71815051 0.13 ENST00000582526.1
ENST00000419743.2
FBXO15
F-box protein 15
chrX_-_128782722 0.13 ENST00000427399.1
APLN
apelin
chr1_-_27682962 0.13 ENST00000486046.1
MAP3K6
mitogen-activated protein kinase kinase kinase 6
chr18_-_71814999 0.12 ENST00000269500.5
FBXO15
F-box protein 15
chr11_+_809961 0.12 ENST00000530797.1
RPLP2
ribosomal protein, large, P2
chr11_+_94706804 0.12 ENST00000335080.5
KDM4D
lysine (K)-specific demethylase 4D
chr16_+_2016821 0.12 ENST00000569210.2
ENST00000569714.1
RNF151
ring finger protein 151
chr6_-_161695074 0.12 ENST00000457520.2
ENST00000366906.5
ENST00000320285.4
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4
chr2_+_58655461 0.12 ENST00000429095.1
ENST00000429664.1
ENST00000452840.1
AC007092.1
long intergenic non-protein coding RNA 1122
chr2_+_223162866 0.12 ENST00000295226.1
CCDC140
coiled-coil domain containing 140
chr16_-_57831914 0.12 ENST00000421376.2
KIFC3
kinesin family member C3
chr16_-_12184159 0.12 ENST00000312019.2
RP11-276H1.3
RP11-276H1.3
chr11_+_34645791 0.12 ENST00000529527.1
ENST00000531728.1
ENST00000525253.1
EHF
ets homologous factor
chr19_+_35417939 0.12 ENST00000601142.1
ENST00000426813.2
ZNF30
zinc finger protein 30
chr7_+_141478242 0.12 ENST00000247881.2
TAS2R4
taste receptor, type 2, member 4
chr6_-_32811771 0.11 ENST00000395339.3
ENST00000374882.3
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8
chr2_-_43266680 0.11 ENST00000425212.1
ENST00000422351.1
ENST00000449766.1
AC016735.2
AC016735.2
chr22_-_50708781 0.11 ENST00000449719.2
ENST00000330651.6
MAPK11
mitogen-activated protein kinase 11
chr22_-_36556821 0.11 ENST00000531095.1
ENST00000397293.2
ENST00000349314.2
APOL3
apolipoprotein L, 3
chrX_+_77359726 0.11 ENST00000442431.1
PGK1
phosphoglycerate kinase 1
chr12_+_120933859 0.11 ENST00000242577.6
ENST00000548214.1
ENST00000392508.2
DYNLL1
dynein, light chain, LC8-type 1
chr19_+_49458107 0.11 ENST00000539787.1
ENST00000345358.7
ENST00000391871.3
ENST00000415969.2
ENST00000354470.3
ENST00000506183.1
ENST00000293288.8
BAX
BCL2-associated X protein
chr12_+_48147699 0.11 ENST00000548498.1
SLC48A1
solute carrier family 48 (heme transporter), member 1
chr11_+_60145948 0.11 ENST00000300184.3
ENST00000358246.1
MS4A7
membrane-spanning 4-domains, subfamily A, member 7
chr4_-_170192000 0.11 ENST00000502315.1
SH3RF1
SH3 domain containing ring finger 1
chr5_+_40909354 0.11 ENST00000313164.9
C7
complement component 7
chr2_+_232826211 0.11 ENST00000325385.7
ENST00000360410.4
DIS3L2
DIS3 mitotic control homolog (S. cerevisiae)-like 2
chr17_+_77019030 0.11 ENST00000580454.1
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr7_-_150754935 0.10 ENST00000297518.4
CDK5
cyclin-dependent kinase 5
chr19_+_8429031 0.10 ENST00000301455.2
ENST00000541807.1
ENST00000393962.2
ANGPTL4
angiopoietin-like 4
chr9_+_74764278 0.10 ENST00000238018.4
ENST00000376989.3
GDA
guanine deaminase
chr6_+_10694900 0.10 ENST00000379568.3
PAK1IP1
PAK1 interacting protein 1
chr5_-_141016382 0.10 ENST00000523088.1
ENST00000305264.3
HDAC3
histone deacetylase 3
chr7_+_157129660 0.10 ENST00000429029.2
ENST00000262177.4
ENST00000417758.1
ENST00000452797.2
ENST00000443280.1
DNAJB6
DnaJ (Hsp40) homolog, subfamily B, member 6
chr19_-_55672037 0.10 ENST00000588076.1
DNAAF3
dynein, axonemal, assembly factor 3
chr19_+_45174994 0.10 ENST00000403660.3
CEACAM19
carcinoembryonic antigen-related cell adhesion molecule 19
chr7_+_2393714 0.10 ENST00000431643.1
EIF3B
eukaryotic translation initiation factor 3, subunit B
chr6_+_161123270 0.10 ENST00000366924.2
ENST00000308192.9
ENST00000418964.1
PLG
plasminogen
chr6_-_161695042 0.10 ENST00000366908.5
ENST00000366911.5
ENST00000366905.3
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4
chr19_+_35417844 0.10 ENST00000601957.1
ZNF30
zinc finger protein 30
chr17_+_73996987 0.10 ENST00000588812.1
ENST00000448471.1
CDK3
cyclin-dependent kinase 3
chr17_+_75452447 0.10 ENST00000591472.2
SEPT9
septin 9
chr17_-_39928106 0.10 ENST00000540235.1
JUP
junction plakoglobin
chr6_+_44215603 0.10 ENST00000371554.1
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr4_-_154681108 0.10 ENST00000508248.1
ENST00000274068.4
RNF175
ring finger protein 175
chr3_+_52245458 0.10 ENST00000459884.1
ALAS1
aminolevulinate, delta-, synthase 1
chr6_+_30294612 0.10 ENST00000440271.1
ENST00000396551.3
ENST00000376656.4
ENST00000540416.1
ENST00000428728.1
ENST00000396548.1
ENST00000428404.1
TRIM39
tripartite motif containing 39
chr8_-_49533521 0.10 ENST00000523038.1
RP11-567J20.1
RP11-567J20.1
chr19_-_2739992 0.10 ENST00000545664.1
ENST00000589363.1
ENST00000455372.2
SLC39A3
solute carrier family 39 (zinc transporter), member 3
chr1_-_155948890 0.10 ENST00000471589.1
ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr6_-_41909191 0.10 ENST00000512426.1
ENST00000372987.4
CCND3
cyclin D3
chr2_-_241831424 0.10 ENST00000402775.2
ENST00000307486.8
C2orf54
chromosome 2 open reading frame 54
chr14_-_21493123 0.10 ENST00000556147.1
ENST00000554489.1
ENST00000555657.1
ENST00000557274.1
ENST00000555158.1
ENST00000554833.1
ENST00000555384.1
ENST00000556420.1
ENST00000554893.1
ENST00000553503.1
ENST00000555733.1
ENST00000553867.1
ENST00000397856.3
ENST00000397855.3
ENST00000556008.1
ENST00000557182.1
ENST00000554483.1
ENST00000556688.1
ENST00000397853.3
ENST00000556329.2
ENST00000554143.1
ENST00000397851.2
ENST00000555142.1
ENST00000557676.1
ENST00000556924.1
NDRG2
NDRG family member 2
chr1_+_67773527 0.10 ENST00000541374.1
ENST00000544434.1
IL12RB2
interleukin 12 receptor, beta 2
chr5_-_171615315 0.09 ENST00000176763.5
STK10
serine/threonine kinase 10
chr9_-_97090926 0.09 ENST00000335456.7
ENST00000253262.4
ENST00000341207.4
NUTM2F
NUT family member 2F
chr7_-_100860851 0.09 ENST00000223127.3
PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr12_+_10460417 0.09 ENST00000381908.3
ENST00000336164.4
ENST00000350274.5
KLRD1
killer cell lectin-like receptor subfamily D, member 1
chr22_+_39101728 0.09 ENST00000216044.5
ENST00000484657.1
GTPBP1
GTP binding protein 1
chr19_+_36602104 0.09 ENST00000585332.1
ENST00000262637.4
OVOL3
ovo-like zinc finger 3
chr3_+_38347427 0.09 ENST00000273173.4
SLC22A14
solute carrier family 22, member 14
chr14_-_24615805 0.09 ENST00000560410.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr18_-_72264805 0.09 ENST00000577806.1
LINC00909
long intergenic non-protein coding RNA 909
chr19_-_42721819 0.09 ENST00000336034.4
ENST00000598200.1
ENST00000598727.1
ENST00000596251.1
DEDD2
death effector domain containing 2
chr12_-_47219733 0.09 ENST00000547477.1
ENST00000447411.1
ENST00000266579.4
SLC38A4
solute carrier family 38, member 4
chr14_-_77787198 0.09 ENST00000261534.4
POMT2
protein-O-mannosyltransferase 2
chr3_+_38323785 0.09 ENST00000466887.1
ENST00000448498.1
SLC22A14
solute carrier family 22, member 14
chr21_+_35445827 0.09 ENST00000608209.1
ENST00000381151.3
SLC5A3
SLC5A3
sodium/myo-inositol cotransporter
solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
chr1_+_18958008 0.09 ENST00000420770.2
ENST00000400661.3
PAX7
paired box 7
chr10_-_74114714 0.09 ENST00000338820.3
ENST00000394903.2
ENST00000444643.2
DNAJB12
DnaJ (Hsp40) homolog, subfamily B, member 12
chr5_+_141016508 0.09 ENST00000444782.1
ENST00000521367.1
ENST00000297164.3
RELL2
RELT-like 2
chr6_-_85473073 0.09 ENST00000606621.1
TBX18
T-box 18
chr22_-_46644182 0.09 ENST00000404583.1
ENST00000404744.1
CDPF1
cysteine-rich, DPF motif domain containing 1
chr1_-_17445930 0.09 ENST00000375486.4
ENST00000375481.1
ENST00000444885.2
PADI2
peptidyl arginine deiminase, type II
chrX_-_152989798 0.09 ENST00000441714.1
ENST00000442093.1
ENST00000429550.1
ENST00000345046.6
BCAP31
B-cell receptor-associated protein 31
chr21_+_39644214 0.09 ENST00000438657.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr12_+_2904102 0.09 ENST00000001008.4
FKBP4
FK506 binding protein 4, 59kDa
chr6_+_32811885 0.09 ENST00000458296.1
ENST00000413039.1
ENST00000429600.1
ENST00000412095.1
ENST00000415067.1
ENST00000395330.1
TAPSAR1
PSMB9
TAP1 and PSMB8 antisense RNA 1
proteasome (prosome, macropain) subunit, beta type, 9
chr7_+_26591441 0.09 ENST00000420912.1
ENST00000457000.1
ENST00000430426.1
AC004947.2
AC004947.2
chr9_+_6716478 0.09 ENST00000452643.1
RP11-390F4.3
RP11-390F4.3
chrX_-_152989531 0.09 ENST00000458587.2
ENST00000416815.1
BCAP31
B-cell receptor-associated protein 31
chr9_+_470288 0.09 ENST00000382303.1
KANK1
KN motif and ankyrin repeat domains 1
chr11_+_10471836 0.09 ENST00000444303.2
AMPD3
adenosine monophosphate deaminase 3
chr5_-_172755056 0.08 ENST00000520648.1
STC2
stanniocalcin 2
chr7_-_150020750 0.08 ENST00000539352.1
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr5_+_179078298 0.08 ENST00000418535.2
ENST00000425471.1
AC136604.1
Uncharacterized protein
chr14_-_24610779 0.08 ENST00000560403.1
ENST00000419198.2
ENST00000216799.4
EMC9
ER membrane protein complex subunit 9
chr6_+_89674246 0.08 ENST00000369474.1
AL079342.1
Uncharacterized protein; cDNA FLJ27030 fis, clone SLV07741
chr9_+_33025209 0.08 ENST00000330899.4
ENST00000544625.1
DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr17_+_77070978 0.08 ENST00000539857.2
ENST00000579016.1
ENST00000311595.9
ENGASE
endo-beta-N-acetylglucosaminidase
chr4_-_147442982 0.08 ENST00000511374.1
ENST00000264986.3
SLC10A7
solute carrier family 10, member 7
chr8_-_38386175 0.08 ENST00000437935.2
ENST00000358138.1
C8orf86
chromosome 8 open reading frame 86
chr1_-_161193349 0.08 ENST00000469730.2
ENST00000463273.1
ENST00000464492.1
ENST00000367990.3
ENST00000470459.2
ENST00000468465.1
ENST00000463812.1
APOA2
apolipoprotein A-II
chr8_+_22853345 0.08 ENST00000522948.1
RHOBTB2
Rho-related BTB domain containing 2
chr2_+_88047606 0.08 ENST00000359481.4
PLGLB2
plasminogen-like B2
chr6_-_127840048 0.08 ENST00000467753.1
SOGA3
SOGA family member 3
chr2_+_232826394 0.08 ENST00000409401.3
ENST00000441279.1
DIS3L2
DIS3 mitotic control homolog (S. cerevisiae)-like 2
chr20_+_47835884 0.08 ENST00000371764.4
DDX27
DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
chr19_-_14629224 0.08 ENST00000254322.2
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr11_+_65770227 0.08 ENST00000527348.1
BANF1
barrier to autointegration factor 1
chr17_-_62208169 0.08 ENST00000606895.1
ERN1
endoplasmic reticulum to nucleus signaling 1
chr6_-_131277510 0.08 ENST00000525193.1
ENST00000527659.1
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr16_+_30662085 0.08 ENST00000569864.1
PRR14
proline rich 14
chr22_-_42526802 0.08 ENST00000359033.4
ENST00000389970.3
ENST00000360608.5
CYP2D6
cytochrome P450, family 2, subfamily D, polypeptide 6
chr17_+_8339340 0.08 ENST00000580012.1
NDEL1
nudE neurodevelopment protein 1-like 1
chr2_-_139259244 0.08 ENST00000414911.1
ENST00000431985.1
AC097721.2
AC097721.2
chr19_+_13842559 0.08 ENST00000586600.1
CCDC130
coiled-coil domain containing 130
chrX_+_49020121 0.08 ENST00000415364.1
ENST00000376338.3
ENST00000425285.1
MAGIX
MAGI family member, X-linked
chr3_-_51533966 0.08 ENST00000504652.1
VPRBP
Vpr (HIV-1) binding protein
chr1_-_79472365 0.08 ENST00000370742.3
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr17_+_5323492 0.08 ENST00000405578.4
ENST00000574003.1
RPAIN
RPA interacting protein
chr2_-_9563216 0.08 ENST00000467606.1
ENST00000494563.1
ENST00000460001.1
ITGB1BP1
integrin beta 1 binding protein 1
chr7_+_150065278 0.08 ENST00000519397.1
ENST00000479668.1
ENST00000540729.1
REPIN1
replication initiator 1
chr11_+_61197572 0.07 ENST00000542074.1
ENST00000534878.1
ENST00000537782.1
ENST00000543265.1
SDHAF2
succinate dehydrogenase complex assembly factor 2
chr19_-_1132207 0.07 ENST00000438103.2
SBNO2
strawberry notch homolog 2 (Drosophila)
chr17_+_4901199 0.07 ENST00000320785.5
ENST00000574165.1
KIF1C
kinesin family member 1C
chr12_+_6898638 0.07 ENST00000011653.4
CD4
CD4 molecule
chr9_-_130667592 0.07 ENST00000447681.1
ST6GALNAC6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr12_+_50794891 0.07 ENST00000517559.1
LARP4
La ribonucleoprotein domain family, member 4
chr6_+_31465849 0.07 ENST00000399150.3
MICB
MHC class I polypeptide-related sequence B
chr11_-_47870019 0.07 ENST00000378460.2
NUP160
nucleoporin 160kDa
chr7_-_102715263 0.07 ENST00000379305.3
FBXL13
F-box and leucine-rich repeat protein 13
chr7_+_129007964 0.07 ENST00000460109.1
ENST00000474594.1
ENST00000446212.1
AHCYL2
adenosylhomocysteinase-like 2
chr1_+_21877753 0.07 ENST00000374832.1
ALPL
alkaline phosphatase, liver/bone/kidney
chr4_-_77819002 0.07 ENST00000334306.2
SOWAHB
sosondowah ankyrin repeat domain family member B
chr10_+_24528108 0.07 ENST00000438429.1
KIAA1217
KIAA1217
chr19_-_55660561 0.07 ENST00000587758.1
ENST00000356783.5
ENST00000291901.8
ENST00000588426.1
ENST00000588147.1
ENST00000536926.1
ENST00000588981.1
TNNT1
troponin T type 1 (skeletal, slow)
chr13_-_79979919 0.07 ENST00000267229.7
RBM26
RNA binding motif protein 26
chr19_+_45349630 0.07 ENST00000252483.5
PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr17_+_65027509 0.07 ENST00000375684.1
AC005544.1
Uncharacterized protein
chr11_+_94706973 0.07 ENST00000536741.1
KDM4D
lysine (K)-specific demethylase 4D
chr6_+_10521574 0.07 ENST00000495262.1
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr18_-_70931689 0.07 ENST00000581862.1
RP11-169F17.1
Protein LOC400655
chr1_+_67773044 0.07 ENST00000262345.1
ENST00000371000.1
IL12RB2
interleukin 12 receptor, beta 2

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0002894 positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894)
0.2 0.5 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.2 0.6 GO:0072308 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
0.1 0.4 GO:0040010 positive regulation of growth rate(GO:0040010) negative regulation of circadian sleep/wake cycle, REM sleep(GO:0042322) positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010) regulation of gastric mucosal blood circulation(GO:1904344) positive regulation of gastric mucosal blood circulation(GO:1904346) gastric mucosal blood circulation(GO:1990768)
0.1 0.3 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.1 0.5 GO:0044501 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.1 0.2 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.1 0.2 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.0 0.2 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.2 GO:0032690 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.0 0.6 GO:0032119 sequestering of zinc ion(GO:0032119)
0.0 0.1 GO:0043396 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) positive regulation of corticotropin-releasing hormone secretion(GO:0051466) regulation of G-protein coupled receptor internalization(GO:1904020)
0.0 0.1 GO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827) negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.0 0.0 GO:1904000 positive regulation of eating behavior(GO:1904000)
0.0 0.1 GO:0002352 B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597) positive regulation of apoptotic DNA fragmentation(GO:1902512)
0.0 0.1 GO:0036482 enzyme active site formation(GO:0018307) neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) detoxification of mercury ion(GO:0050787) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384) negative regulation of ubiquitin-specific protease activity(GO:2000157)
0.0 0.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.0 0.2 GO:1904154 positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.0 0.1 GO:0035723 interleukin-15-mediated signaling pathway(GO:0035723) cellular response to interleukin-15(GO:0071350)
0.0 0.1 GO:0006147 guanine catabolic process(GO:0006147)
0.0 0.1 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.0 0.2 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.0 0.4 GO:0007620 copulation(GO:0007620)
0.0 0.1 GO:0030300 regulation of intestinal cholesterol absorption(GO:0030300) regulation of intestinal lipid absorption(GO:1904729)
0.0 0.2 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.2 GO:0042748 circadian sleep/wake cycle, non-REM sleep(GO:0042748) regulation of synaptic vesicle endocytosis(GO:1900242)
0.0 0.4 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)
0.0 0.1 GO:0071529 cementum mineralization(GO:0071529)
0.0 0.1 GO:0046946 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.0 0.0 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.1 GO:1901624 negative regulation of lymphocyte chemotaxis(GO:1901624)
0.0 0.1 GO:0035698 CD8-positive, alpha-beta T cell extravasation(GO:0035697) CD8-positive, alpha-beta cytotoxic T cell extravasation(GO:0035698) T cell extravasation(GO:0072683) regulation of T cell extravasation(GO:2000407) regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000449) regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation(GO:2000452)
0.0 0.1 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.0 0.0 GO:0000729 DNA double-strand break processing(GO:0000729)
0.0 0.0 GO:1990770 regulation of small intestine smooth muscle contraction(GO:1904347) positive regulation of small intestine smooth muscle contraction(GO:1904349) small intestine smooth muscle contraction(GO:1990770)
0.0 0.1 GO:0090345 alkaloid catabolic process(GO:0009822) cellular organohalogen metabolic process(GO:0090345) cellular organofluorine metabolic process(GO:0090346)
0.0 0.1 GO:2001184 positive regulation of interleukin-12 secretion(GO:2001184)
0.0 0.1 GO:0071348 cellular response to interleukin-11(GO:0071348)
0.0 0.1 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.0 0.1 GO:1904098 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.0 0.0 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.0 0.1 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.0 0.1 GO:0034552 respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.0 0.3 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.0 0.0 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.0 0.2 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
0.0 0.1 GO:1903487 epithelial cell differentiation involved in salivary gland development(GO:0060690) epithelial cell maturation involved in salivary gland development(GO:0060691) regulation of plasma cell differentiation(GO:1900098) positive regulation of plasma cell differentiation(GO:1900100) regulation of lactation(GO:1903487) positive regulation of lactation(GO:1903489)
0.0 0.1 GO:0005986 sucrose biosynthetic process(GO:0005986)
0.0 0.0 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.0 0.1 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.0 GO:0002305 gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305)
0.0 0.0 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.0 0.1 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.0 0.1 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.0 GO:0035750 protein localization to myelin sheath abaxonal region(GO:0035750)
0.0 0.1 GO:1903721 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721)
0.0 0.2 GO:0015074 DNA integration(GO:0015074)
0.0 0.1 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 0.2 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.2 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.0 0.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.1 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.0 0.1 GO:1903421 regulation of synaptic vesicle recycling(GO:1903421)
0.0 0.2 GO:0051001 glycoside catabolic process(GO:0016139) glycosylceramide catabolic process(GO:0046477) negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0 0.1 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.0 0.1 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.0 0.2 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.0 0.1 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0 0.1 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.0 0.1 GO:1904823 pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.0 0.1 GO:0015798 myo-inositol transport(GO:0015798)
0.0 0.0 GO:0030264 nuclear fragmentation involved in apoptotic nuclear change(GO:0030264)
0.0 0.1 GO:0006196 AMP catabolic process(GO:0006196)
0.0 0.2 GO:0043045 DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.0 0.0 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0 0.3 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 0.0 GO:0006844 acyl carnitine transport(GO:0006844) acyl carnitine transmembrane transport(GO:1902616)
0.0 0.0 GO:0048294 negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0 0.1 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.0 0.1 GO:0075525 viral translational termination-reinitiation(GO:0075525)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.1 0.2 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.4 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.2 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.1 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.0 0.1 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 0.1 GO:0071665 gamma-catenin-TCF7L2 complex(GO:0071665)
0.0 0.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.2 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.1 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.1 GO:0044279 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.0 0.2 GO:0032010 phagolysosome(GO:0032010)
0.0 0.3 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.1 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.1 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.0 0.1 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.1 0.4 GO:0031768 growth hormone-releasing hormone activity(GO:0016608) ghrelin receptor binding(GO:0031768)
0.1 0.5 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.1 0.2 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.1 0.2 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
0.0 0.3 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.2 GO:0001884 pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) sulfonylurea receptor binding(GO:0017098) pyrimidine ribonucleoside binding(GO:0032551)
0.0 0.1 GO:0070012 oligopeptidase activity(GO:0070012)
0.0 0.2 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.0 0.1 GO:1904854 proteasome core complex binding(GO:1904854)
0.0 0.1 GO:0016749 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.0 0.1 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
0.0 0.1 GO:0008892 guanine deaminase activity(GO:0008892)
0.0 0.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.4 GO:0089720 caspase binding(GO:0089720)
0.0 0.1 GO:0005365 myo-inositol transmembrane transporter activity(GO:0005365)
0.0 0.2 GO:0016936 galactoside binding(GO:0016936)
0.0 0.1 GO:0032767 copper-dependent protein binding(GO:0032767)
0.0 0.2 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0 0.1 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532)
0.0 0.1 GO:0005199 structural constituent of cell wall(GO:0005199)
0.0 0.2 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.0 0.1 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) procollagen galactosyltransferase activity(GO:0050211)
0.0 0.1 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.0 0.1 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 0.1 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.1 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
0.0 0.1 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.1 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.1 GO:0050146 nucleoside phosphotransferase activity(GO:0050146)
0.0 0.1 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.0 0.0 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.1 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.1 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.7 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.1 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.0 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.0 GO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101)
0.0 0.0 GO:0001156 TFIIIC-class transcription factor binding(GO:0001156)
0.0 0.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.0 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.0 0.0 GO:0017082 mineralocorticoid receptor activity(GO:0017082)
0.0 0.1 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0 0.0 GO:0090541 MIT domain binding(GO:0090541)
0.0 0.1 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.0 0.1 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.0 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
0.0 0.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.4 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.5 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.2 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.4 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.4 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines