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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for HOXC13
Z-value: 0.87
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Transcription factors associated with HOXC13
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXC13 | hg19_v2_chr12_+_54332535_54332636 | 0.30 | 5.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_176433565 Show fit | 0.71 |
ENST00000428382.2
|
ubiquitin interaction motif containing 1 |
|
| chr8_-_82608409 Show fit | 0.68 |
ENST00000518568.1
|
solute carrier family 10, member 5 |
|
| chr9_+_67977438 Show fit | 0.51 |
ENST00000456982.1
|
Protein LOC644249 |
|
| chr3_+_158449972 Show fit | 0.49 |
ENST00000486568.1
|
major facilitator superfamily domain containing 1 |
|
| chr1_+_152730499 Show fit | 0.48 |
ENST00000368773.1
|
keratinocyte proline-rich protein |
|
| chr1_+_219347203 Show fit | 0.46 |
ENST00000366927.3
|
lysophospholipase-like 1 |
|
| chr5_-_79287060 Show fit | 0.44 |
ENST00000512560.1
ENST00000509852.1 ENST00000512528.1 |
metaxin 3 |
|
| chr1_+_219347186 Show fit | 0.43 |
ENST00000366928.5
|
lysophospholipase-like 1 |
|
| chr7_-_64023441 Show fit | 0.42 |
ENST00000309683.6
|
zinc finger protein 680 |
|
| chr17_-_74639730 Show fit | 0.42 |
ENST00000589992.1
|
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXC13
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:0002084 | protein depalmitoylation(GO:0002084) |
| 0.1 | 0.8 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.0 | 0.8 | GO:0043486 | histone exchange(GO:0043486) |
| 0.1 | 0.7 | GO:0070537 | histone H2A K63-linked deubiquitination(GO:0070537) |
| 0.0 | 0.7 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 0.1 | 0.6 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.0 | 0.6 | GO:0060083 | smooth muscle contraction involved in micturition(GO:0060083) |
| 0.1 | 0.5 | GO:1900264 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
| 0.1 | 0.5 | GO:0006235 | dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) |
| 0.0 | 0.5 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.1 | 0.7 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 0.1 | 0.5 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
| 0.0 | 0.5 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.1 | 0.4 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.0 | 0.4 | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
| 0.0 | 0.3 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.0 | 0.3 | GO:0032982 | myosin filament(GO:0032982) |
| 0.1 | 0.2 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 0.0 | 0.2 | GO:0030478 | actin cap(GO:0030478) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.0 | 0.8 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 0.1 | 0.7 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 0.1 | 0.7 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.0 | 0.7 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.1 | 0.6 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.1 | 0.6 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.0 | 0.5 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
| 0.0 | 0.5 | GO:0033170 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.0 | 0.4 | GO:0015165 | pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.3 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.5 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |
| 0.0 | 0.5 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 0.2 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |