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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for HOXB6_PRRX2
Z-value: 1.13
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Transcription factors associated with HOXB6_PRRX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PRRX2 | hg19_v2_chr9_+_132427883_132427951 | -0.72 | 1.1e-01 | Click! |
| HOXB6 | hg19_v2_chr17_-_46682321_46682362 | -0.59 | 2.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_84122033 Show fit | 2.23 |
ENST00000424555.1
|
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A |
|
| chr9_-_3469181 Show fit | 1.58 |
ENST00000366116.2
|
Uncharacterized protein |
|
| chr7_-_84121858 Show fit | 1.49 |
ENST00000448879.1
|
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A |
|
| chr1_+_61869748 Show fit | 0.99 |
ENST00000357977.5
|
nuclear factor I/A |
|
| chr17_+_39846114 Show fit | 0.97 |
ENST00000586699.1
|
eukaryotic translation initiation factor 1 |
|
| chr14_-_54418598 Show fit | 0.94 |
ENST00000609748.1
ENST00000558961.1 |
bone morphogenetic protein 4 |
|
| chr4_-_153274078 Show fit | 0.93 |
ENST00000263981.5
|
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase |
|
| chr5_-_24645078 Show fit | 0.93 |
ENST00000264463.4
|
cadherin 10, type 2 (T2-cadherin) |
|
| chr4_-_36245561 Show fit | 0.93 |
ENST00000506189.1
|
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
|
| chr18_-_53089723 Show fit | 0.92 |
ENST00000561992.1
ENST00000562512.2 |
transcription factor 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB6_PRRX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 3.6 | GO:1903045 | neural crest cell migration involved in sympathetic nervous system development(GO:1903045) |
| 0.0 | 2.4 | GO:0007286 | spermatid development(GO:0007286) |
| 0.1 | 1.6 | GO:0070257 | positive regulation of mucus secretion(GO:0070257) |
| 0.0 | 1.6 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 0.2 | 1.5 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.1 | 1.5 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 0.3 | 1.4 | GO:2000007 | apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007) |
| 0.3 | 1.1 | GO:0009956 | radial pattern formation(GO:0009956) |
| 0.2 | 1.1 | GO:2000639 | regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639) |
| 0.1 | 1.1 | GO:1903764 | regulation of potassium ion export across plasma membrane(GO:1903764) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.8 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 2.4 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 1.7 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 1.5 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.2 | 1.1 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.2 | 1.1 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.1 | 1.1 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.1 | 0.9 | GO:1990578 | perinuclear endoplasmic reticulum membrane(GO:1990578) |
| 0.1 | 0.8 | GO:0031673 | H zone(GO:0031673) |
| 0.0 | 0.8 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.7 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.2 | 3.0 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.0 | 2.9 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.1 | 1.5 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.0 | 1.5 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 1.2 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.0 | 1.2 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.1 | 1.1 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.0 | 1.1 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.0 | 1.1 | GO:0001972 | retinoic acid binding(GO:0001972) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.9 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 3.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 2.4 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.8 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 1.7 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 1.4 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 1.3 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 1.1 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 1.0 | PID ARF6 PATHWAY | Arf6 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.9 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 2.8 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 1.8 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 1.5 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.0 | 1.1 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.9 | REACTOME ACTIVATED POINT MUTANTS OF FGFR2 | Genes involved in Activated point mutants of FGFR2 |
| 0.0 | 0.9 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.8 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 0.8 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.7 | REACTOME ACYL CHAIN REMODELLING OF PG | Genes involved in Acyl chain remodelling of PG |