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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HOXB5

Z-value: 0.23

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Transcription factors associated with HOXB5

Gene Symbol Gene ID Gene Info
HOXB5
ENSG00000120075.5 homeobox B5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB5hg19_v2_chr17_-_46671323_466713230.029.6e-01Click!

Activity profile of HOXB5 motif

Sorted Z-values of HOXB5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_46970134 0.13 ENST00000503641.1
ENST00000514808.1
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr16_-_58004992 0.10 ENST00000564448.1
ENST00000251102.8
ENST00000311183.4
CNGB1
cyclic nucleotide gated channel beta 1
chr7_+_5322561 0.09 ENST00000396872.3
ENST00000444741.1
ENST00000297195.4
ENST00000406453.3
SLC29A4
solute carrier family 29 (equilibrative nucleoside transporter), member 4
chr20_-_6034672 0.08 ENST00000378858.4
LRRN4
leucine rich repeat neuronal 4
chr17_+_46970127 0.08 ENST00000355938.5
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr9_-_130700080 0.07 ENST00000373110.4
DPM2
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
chr3_+_187420101 0.07 ENST00000449623.1
ENST00000437407.1
RP11-211G3.3
Uncharacterized protein
chr19_-_12267524 0.07 ENST00000455799.1
ENST00000355738.1
ENST00000439556.2
ENST00000542938.1
ZNF625
zinc finger protein 625
chr12_+_56915713 0.06 ENST00000262031.5
ENST00000552247.2
RBMS2
RNA binding motif, single stranded interacting protein 2
chr12_+_57984943 0.06 ENST00000422156.3
PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr3_+_45986511 0.05 ENST00000458629.1
ENST00000457814.1
CXCR6
chemokine (C-X-C motif) receptor 6
chr1_+_41157361 0.05 ENST00000427410.2
ENST00000447388.3
ENST00000425457.2
ENST00000453631.1
ENST00000456393.2
NFYC
nuclear transcription factor Y, gamma
chr14_-_102704783 0.05 ENST00000522534.1
MOK
MOK protein kinase
chr17_+_46970178 0.05 ENST00000393366.2
ENST00000506855.1
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr12_+_56915776 0.05 ENST00000550726.1
ENST00000542360.1
RBMS2
RNA binding motif, single stranded interacting protein 2
chr6_-_31509506 0.05 ENST00000449757.1
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr7_+_155090271 0.05 ENST00000476756.1
INSIG1
insulin induced gene 1
chr1_+_157963391 0.05 ENST00000359209.6
ENST00000416935.2
KIRREL
kin of IRRE like (Drosophila)
chr14_+_38660185 0.04 ENST00000555655.1
CTD-2142D14.1
CTD-2142D14.1
chr1_+_155579979 0.04 ENST00000452804.2
ENST00000538143.1
ENST00000245564.2
ENST00000368341.4
MSTO1
misato 1, mitochondrial distribution and morphology regulator
chr18_-_33077556 0.04 ENST00000589273.1
ENST00000586489.1
INO80C
INO80 complex subunit C
chr6_-_32820529 0.04 ENST00000425148.2
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr1_+_41157421 0.04 ENST00000372654.1
NFYC
nuclear transcription factor Y, gamma
chr6_+_30749649 0.04 ENST00000422944.1
HCG20
HLA complex group 20 (non-protein coding)
chr1_-_155658260 0.04 ENST00000368339.5
ENST00000405763.3
ENST00000368340.5
ENST00000454523.1
ENST00000443231.1
ENST00000347088.5
ENST00000361831.5
ENST00000355499.4
YY1AP1
YY1 associated protein 1
chr3_-_127541194 0.04 ENST00000453507.2
MGLL
monoglyceride lipase
chr9_-_112970436 0.04 ENST00000400613.4
C9orf152
chromosome 9 open reading frame 152
chr1_+_41157671 0.04 ENST00000534399.1
ENST00000372653.1
NFYC
nuclear transcription factor Y, gamma
chr19_-_42724261 0.03 ENST00000595337.1
DEDD2
death effector domain containing 2
chr15_-_72523454 0.03 ENST00000565154.1
ENST00000565184.1
ENST00000389093.3
ENST00000449901.2
ENST00000335181.5
ENST00000319622.6
PKM
pyruvate kinase, muscle
chr3_+_51422478 0.03 ENST00000528157.1
MANF
mesencephalic astrocyte-derived neurotrophic factor
chr4_-_114900831 0.03 ENST00000315366.7
ARSJ
arylsulfatase family, member J
chr1_+_155658849 0.03 ENST00000368336.5
ENST00000343043.3
ENST00000421487.2
ENST00000535183.1
ENST00000465375.1
ENST00000470830.1
DAP3
death associated protein 3
chr16_-_84651647 0.03 ENST00000564057.1
COTL1
coactosin-like 1 (Dictyostelium)
chrX_+_47077632 0.03 ENST00000457458.2
CDK16
cyclin-dependent kinase 16
chr14_-_24020858 0.03 ENST00000419474.3
ZFHX2
zinc finger homeobox 2
chr1_-_155658518 0.03 ENST00000404643.1
ENST00000359205.5
ENST00000407221.1
YY1AP1
YY1 associated protein 1
chr12_+_53693466 0.02 ENST00000267103.5
ENST00000548632.1
C12orf10
chromosome 12 open reading frame 10
chr6_-_31509714 0.02 ENST00000456662.1
ENST00000431908.1
ENST00000456976.1
ENST00000428450.1
ENST00000453105.2
ENST00000418897.1
ENST00000415382.2
ENST00000449074.2
ENST00000419020.1
ENST00000428098.1
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr2_-_70409953 0.02 ENST00000419381.1
C2orf42
chromosome 2 open reading frame 42
chr1_-_155658766 0.02 ENST00000295566.4
ENST00000368330.2
YY1AP1
YY1 associated protein 1
chrX_+_135230712 0.02 ENST00000535737.1
FHL1
four and a half LIM domains 1
chr8_-_133097902 0.02 ENST00000262283.5
OC90
Otoconin-90
chr17_-_29233221 0.02 ENST00000580840.1
TEFM
transcription elongation factor, mitochondrial
chr1_-_155658085 0.02 ENST00000311573.5
ENST00000438245.2
YY1AP1
YY1 associated protein 1
chr1_-_161193349 0.02 ENST00000469730.2
ENST00000463273.1
ENST00000464492.1
ENST00000367990.3
ENST00000470459.2
ENST00000468465.1
ENST00000463812.1
APOA2
apolipoprotein A-II
chr3_-_195538728 0.02 ENST00000349607.4
ENST00000346145.4
MUC4
mucin 4, cell surface associated
chr11_-_57089774 0.02 ENST00000527207.1
TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr6_-_31510181 0.02 ENST00000458640.1
ENST00000396172.1
ENST00000417556.2
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr15_-_102264619 0.02 ENST00000335968.3
TARSL2
threonyl-tRNA synthetase-like 2
chr8_+_118147498 0.01 ENST00000519688.1
ENST00000456015.2
SLC30A8
solute carrier family 30 (zinc transporter), member 8
chr3_-_164914640 0.01 ENST00000241274.3
SLITRK3
SLIT and NTRK-like family, member 3
chr19_-_16045220 0.01 ENST00000326742.8
CYP4F11
cytochrome P450, family 4, subfamily F, polypeptide 11
chr5_+_133842243 0.01 ENST00000515627.2
AC005355.2
AC005355.2
chr17_+_2496971 0.01 ENST00000397195.5
PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr16_-_30381580 0.01 ENST00000409939.3
TBC1D10B
TBC1 domain family, member 10B
chr5_-_141061777 0.01 ENST00000239440.4
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr19_+_7571968 0.01 ENST00000599312.1
CTD-2207O23.12
Uncharacterized protein
chr15_-_75017711 0.01 ENST00000567032.1
ENST00000564596.1
ENST00000566503.1
ENST00000395049.4
ENST00000395048.2
ENST00000379727.3
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chr2_-_47168906 0.01 ENST00000444761.2
ENST00000409147.1
MCFD2
multiple coagulation factor deficiency 2
chr18_+_32558380 0.01 ENST00000588349.2
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr5_+_149569520 0.01 ENST00000230671.2
ENST00000524041.1
SLC6A7
solute carrier family 6 (neurotransmitter transporter), member 7
chr10_+_114135952 0.01 ENST00000356116.1
ENST00000433418.1
ENST00000354273.4
ACSL5
acyl-CoA synthetase long-chain family member 5
chr20_+_44074071 0.01 ENST00000595203.1
AL031663.2
CDNA FLJ26875 fis, clone PRS08969; Uncharacterized protein
chr1_+_248223984 0.01 ENST00000359959.3
OR2L3
olfactory receptor, family 2, subfamily L, member 3
chr11_-_57089671 0.01 ENST00000532437.1
TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr5_-_141061759 0.01 ENST00000508305.1
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr2_-_47168850 0.01 ENST00000409207.1
MCFD2
multiple coagulation factor deficiency 2
chr16_-_50402836 0.01 ENST00000394688.3
BRD7
bromodomain containing 7
chr12_+_54955235 0.01 ENST00000550620.1
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr3_-_195538760 0.01 ENST00000475231.1
MUC4
mucin 4, cell surface associated
chr12_+_66217911 0.01 ENST00000403681.2
HMGA2
high mobility group AT-hook 2
chr12_-_75601778 0.01 ENST00000550433.1
ENST00000548513.1
KCNC2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr8_-_93107827 0.01 ENST00000520724.1
ENST00000518844.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr13_-_54706954 0.01 ENST00000606706.1
ENST00000607494.1
ENST00000427299.2
ENST00000423442.2
ENST00000451744.1
LINC00458
long intergenic non-protein coding RNA 458
chr1_-_119530428 0.01 ENST00000369429.3
TBX15
T-box 15
chr1_+_154229547 0.01 ENST00000428595.1
UBAP2L
ubiquitin associated protein 2-like
chr10_-_103603523 0.01 ENST00000370046.1
KCNIP2
Kv channel interacting protein 2
chr16_-_9770700 0.01 ENST00000561538.1
RP11-297M9.1
Uncharacterized protein
chr17_+_6679528 0.01 ENST00000321535.4
FBXO39
F-box protein 39
chr12_-_6798616 0.01 ENST00000355772.4
ENST00000417772.3
ENST00000396801.3
ENST00000396799.2
ZNF384
zinc finger protein 384
chr14_+_21945335 0.00 ENST00000262709.3
ENST00000457430.2
ENST00000448790.2
TOX4
TOX high mobility group box family member 4
chr17_-_42143963 0.00 ENST00000585388.1
ENST00000293406.3
LSM12
LSM12 homolog (S. cerevisiae)
chr12_-_56101647 0.00 ENST00000347027.6
ENST00000257879.6
ENST00000257880.7
ENST00000394230.2
ENST00000394229.2
ITGA7
integrin, alpha 7
chr15_+_41913690 0.00 ENST00000563576.1
MGA
MGA, MAX dimerization protein
chr1_+_145576007 0.00 ENST00000369298.1
PIAS3
protein inhibitor of activated STAT, 3
chr8_-_93107443 0.00 ENST00000360348.2
ENST00000520428.1
ENST00000518992.1
ENST00000520556.1
ENST00000518317.1
ENST00000521319.1
ENST00000521375.1
ENST00000518449.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr19_-_50143452 0.00 ENST00000246792.3
RRAS
related RAS viral (r-ras) oncogene homolog
chr8_-_93107696 0.00 ENST00000436581.2
ENST00000520583.1
ENST00000519061.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr1_+_145575980 0.00 ENST00000393045.2
PIAS3
protein inhibitor of activated STAT, 3
chr12_-_53614155 0.00 ENST00000543726.1
RARG
retinoic acid receptor, gamma

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.0 0.0 GO:0046967 cytosol to ER transport(GO:0046967)
0.0 0.1 GO:0019348 dolichol metabolic process(GO:0019348)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.0 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 0.1 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling