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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for HOXB4_LHX9
Z-value: 0.68
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Transcription factors associated with HOXB4_LHX9
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXB4 | hg19_v2_chr17_-_46657473_46657473 | -0.23 | 6.6e-01 | Click! |
| LHX9 | hg19_v2_chr1_+_197881592_197881635 | 0.19 | 7.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_36239576 Show fit | 0.43 |
ENST00000587751.1
|
lin-37 homolog (C. elegans) |
|
| chr8_-_116504448 Show fit | 0.36 |
ENST00000518018.1
|
trichorhinophalangeal syndrome I |
|
| chr5_+_81575281 Show fit | 0.31 |
ENST00000380167.4
|
ATPase, H+ transporting, lysosomal accessory protein 1-like |
|
| chr14_+_67831576 Show fit | 0.29 |
ENST00000555876.1
|
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa |
|
| chr19_+_54466179 Show fit | 0.26 |
ENST00000270458.2
|
calcium channel, voltage-dependent, gamma subunit 8 |
|
| chr18_-_51750948 Show fit | 0.25 |
ENST00000583046.1
ENST00000398398.2 |
methyl-CpG binding domain protein 2 |
|
| chr19_-_14064114 Show fit | 0.24 |
ENST00000585607.1
ENST00000538517.2 ENST00000587458.1 ENST00000538371.2 |
podocan-like 1 |
|
| chr8_-_93978309 Show fit | 0.24 |
ENST00000517858.1
ENST00000378861.5 |
triple QxxK/R motif containing |
|
| chr15_+_96904487 Show fit | 0.24 |
ENST00000600790.1
|
Uncharacterized protein |
|
| chr12_+_34175398 Show fit | 0.24 |
ENST00000538927.1
|
ALG10, alpha-1,2-glucosyltransferase |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB4_LHX9
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.3 | GO:1990737 | response to manganese-induced endoplasmic reticulum stress(GO:1990737) |
| 0.0 | 0.3 | GO:0031860 | telomeric 3' overhang formation(GO:0031860) |
| 0.0 | 0.3 | GO:0002759 | regulation of antimicrobial humoral response(GO:0002759) |
| 0.0 | 0.3 | GO:0042711 | maternal behavior(GO:0042711) parental behavior(GO:0060746) |
| 0.0 | 0.2 | GO:1901979 | regulation of inward rectifier potassium channel activity(GO:1901979) |
| 0.0 | 0.2 | GO:0045337 | geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337) |
| 0.0 | 0.2 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.0 | 0.2 | GO:1903826 | arginine transmembrane transport(GO:1903826) |
| 0.0 | 0.2 | GO:0070777 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.0 | 0.2 | GO:0042420 | dopamine catabolic process(GO:0042420) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.1 | 0.3 | GO:0043614 | multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993) |
| 0.0 | 0.3 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.0 | 0.3 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.0 | 0.1 | GO:0034685 | integrin alphav-beta6 complex(GO:0034685) |
| 0.0 | 0.1 | GO:0071821 | FANCM-MHF complex(GO:0071821) |
| 0.0 | 0.1 | GO:0000444 | MIS12/MIND type complex(GO:0000444) |
| 0.0 | 0.1 | GO:0042720 | mitochondrial inner membrane peptidase complex(GO:0042720) |
| 0.0 | 0.1 | GO:0016935 | glycine-gated chloride channel complex(GO:0016935) |
| 0.0 | 0.1 | GO:1990730 | VCP-NSFL1C complex(GO:1990730) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.5 | GO:0004583 | dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583) |
| 0.0 | 0.3 | GO:0003696 | satellite DNA binding(GO:0003696) |
| 0.0 | 0.3 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.0 | 0.3 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.1 | 0.2 | GO:0016005 | phospholipase A2 activator activity(GO:0016005) |
| 0.0 | 0.2 | GO:0047273 | galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273) |
| 0.0 | 0.2 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 0.0 | 0.2 | GO:0004161 | dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337) |
| 0.0 | 0.2 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.0 | 0.2 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.0 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 0.3 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 0.2 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |