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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HOXB13

Z-value: 0.37

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Transcription factors associated with HOXB13

Gene Symbol Gene ID Gene Info
HOXB13
ENSG00000159184.7 homeobox B13

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB13hg19_v2_chr17_-_46806540_468065580.937.4e-03Click!

Activity profile of HOXB13 motif

Sorted Z-values of HOXB13 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_27782548 0.22 ENST00000333151.3
HIST1H2AJ
histone cluster 1, H2aj
chr1_-_12679171 0.21 ENST00000606790.1
RP11-474O21.5
RP11-474O21.5
chr16_-_2205352 0.19 ENST00000563192.1
RP11-304L19.5
RP11-304L19.5
chr17_-_46806540 0.16 ENST00000290295.7
HOXB13
homeobox B13
chrM_-_14670 0.13 ENST00000361681.2
MT-ND6
mitochondrially encoded NADH dehydrogenase 6
chr18_-_73967160 0.13 ENST00000579714.1
RP11-94B19.7
RP11-94B19.7
chr17_-_10560619 0.11 ENST00000583535.1
MYH3
myosin, heavy chain 3, skeletal muscle, embryonic
chr22_-_38240316 0.10 ENST00000411961.2
ENST00000434930.1
ANKRD54
ankyrin repeat domain 54
chr17_-_73663168 0.10 ENST00000578201.1
ENST00000423245.2
RECQL5
RecQ protein-like 5
chr3_-_195310802 0.10 ENST00000421243.1
ENST00000453131.1
APOD
apolipoprotein D
chr4_+_110749143 0.10 ENST00000317735.4
RRH
retinal pigment epithelium-derived rhodopsin homolog
chrM_+_12331 0.10 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH dehydrogenase 5
chrM_+_14741 0.09 ENST00000361789.2
MT-CYB
mitochondrially encoded cytochrome b
chr7_+_128784712 0.09 ENST00000289407.4
TSPAN33
tetraspanin 33
chr14_-_50583271 0.09 ENST00000395860.2
ENST00000395859.2
VCPKMT
valosin containing protein lysine (K) methyltransferase
chr5_-_126409159 0.09 ENST00000607731.1
ENST00000535381.1
ENST00000296662.5
ENST00000509733.3
C5orf63
chromosome 5 open reading frame 63
chr22_-_38240412 0.08 ENST00000215941.4
ANKRD54
ankyrin repeat domain 54
chr9_+_44868935 0.07 ENST00000448436.2
RP11-160N1.10
RP11-160N1.10
chr8_+_97597148 0.07 ENST00000521590.1
SDC2
syndecan 2
chr3_-_114790179 0.07 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr16_+_30669720 0.07 ENST00000356166.6
FBRS
fibrosin
chr16_-_71610985 0.07 ENST00000355962.4
TAT
tyrosine aminotransferase
chr14_-_68000442 0.07 ENST00000554278.1
TMEM229B
transmembrane protein 229B
chr17_-_73663245 0.06 ENST00000584999.1
ENST00000317905.5
ENST00000420326.2
ENST00000340830.5
RECQL5
RecQ protein-like 5
chr3_+_89156799 0.06 ENST00000452448.2
ENST00000494014.1
EPHA3
EPH receptor A3
chr17_+_18086392 0.06 ENST00000541285.1
ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr11_-_102714534 0.06 ENST00000299855.5
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr1_-_45956868 0.05 ENST00000451835.2
TESK2
testis-specific kinase 2
chr11_+_118401706 0.05 ENST00000411589.2
ENST00000442938.2
ENST00000359862.4
TMEM25
transmembrane protein 25
chr1_-_54879140 0.04 ENST00000525990.1
SSBP3
single stranded DNA binding protein 3
chr9_-_107367951 0.04 ENST00000542196.1
OR13C2
olfactory receptor, family 13, subfamily C, member 2
chr14_+_76776957 0.04 ENST00000512784.1
ESRRB
estrogen-related receptor beta
chr9_+_22646189 0.04 ENST00000436786.1
RP11-399D6.2
RP11-399D6.2
chr6_-_116833500 0.04 ENST00000356128.4
TRAPPC3L
trafficking protein particle complex 3-like
chr19_+_35634146 0.04 ENST00000586063.1
ENST00000270310.2
ENST00000588265.1
FXYD7
FXYD domain containing ion transport regulator 7
chr18_-_52989217 0.03 ENST00000570287.2
TCF4
transcription factor 4
chr1_-_45956800 0.03 ENST00000538496.1
TESK2
testis-specific kinase 2
chr4_+_169575875 0.03 ENST00000503457.1
PALLD
palladin, cytoskeletal associated protein
chr6_-_43021612 0.03 ENST00000535468.1
CUL7
cullin 7
chr11_-_102826434 0.03 ENST00000340273.4
ENST00000260302.3
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr22_+_35462129 0.03 ENST00000404699.2
ENST00000308700.6
ISX
intestine-specific homeobox
chr4_-_69111401 0.03 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr7_-_11871815 0.03 ENST00000423059.4
THSD7A
thrombospondin, type I, domain containing 7A
chr1_+_23037323 0.02 ENST00000544305.1
ENST00000374630.3
ENST00000400191.3
ENST00000374632.3
EPHB2
EPH receptor B2
chr1_+_78769549 0.02 ENST00000370758.1
PTGFR
prostaglandin F receptor (FP)
chr8_-_114449112 0.02 ENST00000455883.2
ENST00000352409.3
ENST00000297405.5
CSMD3
CUB and Sushi multiple domains 3
chr15_+_71839566 0.02 ENST00000357769.4
THSD4
thrombospondin, type I, domain containing 4
chr1_-_45956822 0.02 ENST00000372086.3
ENST00000341771.6
TESK2
testis-specific kinase 2
chr13_+_28813645 0.02 ENST00000282391.5
PAN3
PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr18_+_68002675 0.02 ENST00000584919.1
RP11-41O4.1
Uncharacterized protein
chr21_+_30673091 0.02 ENST00000447177.1
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr9_+_125132803 0.02 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr6_-_139613269 0.02 ENST00000358430.3
TXLNB
taxilin beta
chr16_+_2205755 0.02 ENST00000326181.6
TRAF7
TNF receptor-associated factor 7, E3 ubiquitin protein ligase
chr9_-_14180778 0.02 ENST00000380924.1
ENST00000543693.1
NFIB
nuclear factor I/B
chr8_+_77593448 0.02 ENST00000521891.2
ZFHX4
zinc finger homeobox 4
chr1_-_149783914 0.02 ENST00000369167.1
ENST00000427880.2
ENST00000545683.1
HIST2H2BF
histone cluster 2, H2bf
chr9_+_125795788 0.01 ENST00000373643.5
RABGAP1
RAB GTPase activating protein 1
chr12_+_8309630 0.01 ENST00000396570.3
ZNF705A
zinc finger protein 705A
chr2_-_175629135 0.01 ENST00000409542.1
ENST00000409219.1
CHRNA1
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr1_+_66458072 0.01 ENST00000423207.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr15_-_55541227 0.01 ENST00000566877.1
RAB27A
RAB27A, member RAS oncogene family
chr3_+_89156674 0.01 ENST00000336596.2
EPHA3
EPH receptor A3
chr1_-_36863481 0.01 ENST00000315732.2
LSM10
LSM10, U7 small nuclear RNA associated
chr9_+_123884038 0.01 ENST00000373847.1
CNTRL
centriolin
chr9_+_125133315 0.01 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr2_-_136288113 0.01 ENST00000401392.1
ZRANB3
zinc finger, RAN-binding domain containing 3
chr16_-_24942273 0.01 ENST00000571406.1
ARHGAP17
Rho GTPase activating protein 17
chr12_+_70219052 0.01 ENST00000552032.2
ENST00000547771.2
MYRFL
myelin regulatory factor-like
chr2_+_74685527 0.01 ENST00000393972.3
ENST00000409737.1
ENST00000428943.1
WBP1
WW domain binding protein 1
chr3_-_123710199 0.01 ENST00000184183.4
ROPN1
rhophilin associated tail protein 1
chr15_+_66994561 0.01 ENST00000288840.5
SMAD6
SMAD family member 6
chr16_-_24942411 0.01 ENST00000571843.1
ARHGAP17
Rho GTPase activating protein 17
chr8_+_35649365 0.01 ENST00000437887.1
AC012215.1
Uncharacterized protein
chr1_-_155880672 0.01 ENST00000609492.1
ENST00000368322.3
RIT1
Ras-like without CAAX 1
chr8_+_119294456 0.00 ENST00000366457.2
AC023590.1
Uncharacterized protein
chr1_+_52682052 0.00 ENST00000371591.1
ZFYVE9
zinc finger, FYVE domain containing 9
chr13_-_45768841 0.00 ENST00000379108.1
KCTD4
potassium channel tetramerization domain containing 4
chr9_-_104198042 0.00 ENST00000374855.4
ALDOB
aldolase B, fructose-bisphosphate
chr9_+_103947311 0.00 ENST00000395056.2
LPPR1
Lipid phosphate phosphatase-related protein type 1
chr13_-_103719196 0.00 ENST00000245312.3
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter), member 2
chr2_-_51259292 0.00 ENST00000401669.2
NRXN1
neurexin 1
chr8_+_77593474 0.00 ENST00000455469.2
ENST00000050961.6
ZFHX4
zinc finger homeobox 4
chr7_-_50860565 0.00 ENST00000403097.1
GRB10
growth factor receptor-bound protein 10

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB13

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.2 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0 0.1 GO:2000097 negative regulation of lipoprotein oxidation(GO:0034443) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0 0.1 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.0 0.0 GO:0097065 anterior head development(GO:0097065) regulation of anterior head development(GO:2000742) positive regulation of anterior head development(GO:2000744)
0.0 0.1 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.1 GO:0035513 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.1 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.1 GO:0008218 bioluminescence(GO:0008218)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0 0.2 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.1 GO:0017018 myosin phosphatase activity(GO:0017018)
0.0 0.1 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.1 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME OPSINS Genes involved in Opsins