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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HOXA4

Z-value: 0.54

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Transcription factors associated with HOXA4

Gene Symbol Gene ID Gene Info
HOXA4
ENSG00000197576.9 homeobox A4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXA4hg19_v2_chr7_-_27169801_271698440.749.4e-02Click!

Activity profile of HOXA4 motif

Sorted Z-values of HOXA4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_38065052 0.39 ENST00000556845.1
TTC6
tetratricopeptide repeat domain 6
chr5_+_150406527 0.37 ENST00000520059.1
GPX3
glutathione peroxidase 3 (plasma)
chr10_-_92681033 0.26 ENST00000371697.3
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr9_-_3469181 0.24 ENST00000366116.2
AL365202.1
Uncharacterized protein
chr5_+_66300464 0.23 ENST00000436277.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr16_+_67280799 0.22 ENST00000566345.2
SLC9A5
solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
chr3_+_69134124 0.22 ENST00000478935.1
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr17_-_38928414 0.21 ENST00000335552.4
KRT26
keratin 26
chr8_-_42358742 0.21 ENST00000517366.1
SLC20A2
solute carrier family 20 (phosphate transporter), member 2
chr12_+_72058130 0.19 ENST00000547843.1
THAP2
THAP domain containing, apoptosis associated protein 2
chr7_-_75241096 0.18 ENST00000420909.1
HIP1
huntingtin interacting protein 1
chr2_-_163099546 0.17 ENST00000447386.1
FAP
fibroblast activation protein, alpha
chr8_-_95449155 0.17 ENST00000481490.2
FSBP
fibrinogen silencer binding protein
chr3_+_88188254 0.16 ENST00000309495.5
ZNF654
zinc finger protein 654
chr5_+_49962495 0.16 ENST00000515175.1
PARP8
poly (ADP-ribose) polymerase family, member 8
chr1_+_151739131 0.15 ENST00000400999.1
OAZ3
ornithine decarboxylase antizyme 3
chr5_+_133562095 0.15 ENST00000602919.1
CTD-2410N18.3
CTD-2410N18.3
chr4_-_109541539 0.13 ENST00000509984.1
ENST00000507248.1
ENST00000506795.1
RPL34-AS1
RPL34 antisense RNA 1 (head to head)
chr5_+_159343688 0.12 ENST00000306675.3
ADRA1B
adrenoceptor alpha 1B
chr10_+_77056181 0.12 ENST00000526759.1
ENST00000533822.1
ZNF503-AS1
ZNF503 antisense RNA 1
chr4_-_41884620 0.12 ENST00000504870.1
LINC00682
long intergenic non-protein coding RNA 682
chr11_-_104480019 0.12 ENST00000536529.1
ENST00000545630.1
ENST00000538641.1
RP11-886D15.1
RP11-886D15.1
chr6_-_116833500 0.12 ENST00000356128.4
TRAPPC3L
trafficking protein particle complex 3-like
chr2_+_53994927 0.11 ENST00000295304.4
CHAC2
ChaC, cation transport regulator homolog 2 (E. coli)
chr17_-_2117600 0.11 ENST00000572369.1
SMG6
SMG6 nonsense mediated mRNA decay factor
chr6_+_63921351 0.11 ENST00000370659.1
FKBP1C
FK506 binding protein 1C
chr6_+_31514622 0.10 ENST00000376146.4
NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr7_-_27170352 0.10 ENST00000428284.2
ENST00000360046.5
HOXA4
homeobox A4
chr5_-_1882858 0.09 ENST00000511126.1
ENST00000231357.2
IRX4
iroquois homeobox 4
chr12_+_29376673 0.09 ENST00000547116.1
FAR2
fatty acyl CoA reductase 2
chr12_+_29376592 0.09 ENST00000182377.4
FAR2
fatty acyl CoA reductase 2
chr11_+_128563652 0.08 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr7_+_95115210 0.08 ENST00000428113.1
ENST00000325885.5
ASB4
ankyrin repeat and SOCS box containing 4
chr10_-_95462265 0.08 ENST00000536233.1
ENST00000359204.4
ENST00000371430.2
ENST00000394100.2
FRA10AC1
fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1
chr18_-_53019208 0.08 ENST00000562607.1
TCF4
transcription factor 4
chr3_+_121311966 0.08 ENST00000338040.4
FBXO40
F-box protein 40
chr11_-_27494279 0.07 ENST00000379214.4
LGR4
leucine-rich repeat containing G protein-coupled receptor 4
chr2_+_113825547 0.07 ENST00000341010.2
ENST00000337569.3
IL1F10
interleukin 1 family, member 10 (theta)
chr3_-_57233966 0.07 ENST00000473921.1
ENST00000295934.3
HESX1
HESX homeobox 1
chr1_-_204329013 0.07 ENST00000272203.3
ENST00000414478.1
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr8_+_22424551 0.07 ENST00000523348.1
SORBS3
sorbin and SH3 domain containing 3
chr1_-_100643765 0.06 ENST00000370137.1
ENST00000370138.1
ENST00000342895.3
LRRC39
leucine rich repeat containing 39
chr19_-_42806919 0.06 ENST00000595530.1
ENST00000538771.1
ENST00000601865.1
PAFAH1B3
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chr1_+_81771806 0.06 ENST00000370721.1
ENST00000370727.1
ENST00000370725.1
ENST00000370723.1
ENST00000370728.1
ENST00000370730.1
LPHN2
latrophilin 2
chr5_+_66300446 0.06 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr11_-_27494309 0.06 ENST00000389858.4
LGR4
leucine-rich repeat containing G protein-coupled receptor 4
chr14_+_101359265 0.06 ENST00000599197.1
AL117190.3
Esophagus cancer-related gene-2 interaction susceptibility protein; Uncharacterized protein
chr11_+_12766583 0.05 ENST00000361985.2
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr14_+_59100774 0.05 ENST00000556859.1
ENST00000421793.1
DACT1
dishevelled-binding antagonist of beta-catenin 1
chr14_+_39734482 0.05 ENST00000554392.1
ENST00000555716.1
ENST00000341749.3
ENST00000557038.1
CTAGE5
CTAGE family, member 5
chr10_+_118305435 0.05 ENST00000369221.2
PNLIP
pancreatic lipase
chr5_+_147582348 0.05 ENST00000514389.1
SPINK6
serine peptidase inhibitor, Kazal type 6
chr18_-_21017817 0.05 ENST00000542162.1
ENST00000383233.3
ENST00000582336.1
ENST00000450466.2
ENST00000578520.1
ENST00000399707.1
TMEM241
transmembrane protein 241
chr5_+_60933634 0.05 ENST00000505642.1
C5orf64
chromosome 5 open reading frame 64
chrX_-_19689106 0.04 ENST00000379716.1
SH3KBP1
SH3-domain kinase binding protein 1
chr19_+_12949251 0.04 ENST00000251472.4
MAST1
microtubule associated serine/threonine kinase 1
chr19_-_1021113 0.04 ENST00000333175.5
ENST00000356663.3
TMEM259
transmembrane protein 259
chr6_-_31514333 0.04 ENST00000376151.4
ATP6V1G2
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr5_-_88179302 0.04 ENST00000504921.2
MEF2C
myocyte enhancer factor 2C
chr7_+_141418962 0.04 ENST00000493845.1
WEE2
WEE1 homolog 2 (S. pombe)
chr12_+_54447637 0.04 ENST00000609810.1
ENST00000430889.2
HOXC4
HOXC4
homeobox C4
Homeobox protein Hox-C4
chr21_+_17442799 0.04 ENST00000602580.1
ENST00000458468.1
ENST00000602935.1
LINC00478
long intergenic non-protein coding RNA 478
chr4_+_189060573 0.04 ENST00000332517.3
TRIML1
tripartite motif family-like 1
chr8_-_99954788 0.04 ENST00000523601.1
STK3
serine/threonine kinase 3
chr17_-_39211463 0.03 ENST00000542910.1
ENST00000398477.1
KRTAP2-2
keratin associated protein 2-2
chr10_+_77056134 0.03 ENST00000528121.1
ENST00000416398.1
ZNF503-AS1
ZNF503 antisense RNA 1
chr20_+_32150140 0.03 ENST00000344201.3
ENST00000346541.3
ENST00000397800.1
ENST00000397798.2
ENST00000492345.1
CBFA2T2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr21_+_22370717 0.03 ENST00000284894.7
NCAM2
neural cell adhesion molecule 2
chr5_+_140810132 0.03 ENST00000252085.3
PCDHGA12
protocadherin gamma subfamily A, 12
chr5_-_38557561 0.03 ENST00000511561.1
LIFR
leukemia inhibitory factor receptor alpha
chr4_-_185139062 0.03 ENST00000296741.2
ENPP6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr5_+_66254698 0.03 ENST00000405643.1
ENST00000407621.1
ENST00000432426.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr11_-_40315640 0.03 ENST00000278198.2
LRRC4C
leucine rich repeat containing 4C
chr5_+_152870106 0.03 ENST00000285900.5
GRIA1
glutamate receptor, ionotropic, AMPA 1
chr9_+_44867571 0.03 ENST00000377548.2
RP11-160N1.10
RP11-160N1.10
chr2_-_145278475 0.03 ENST00000558170.2
ZEB2
zinc finger E-box binding homeobox 2
chr18_-_70532906 0.03 ENST00000299430.2
ENST00000397929.1
NETO1
neuropilin (NRP) and tolloid (TLL)-like 1
chr15_+_90744533 0.03 ENST00000411539.2
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr20_+_57464200 0.03 ENST00000604005.1
GNAS
GNAS complex locus
chr18_+_42260059 0.03 ENST00000426838.4
SETBP1
SET binding protein 1
chr2_+_54683419 0.03 ENST00000356805.4
SPTBN1
spectrin, beta, non-erythrocytic 1
chr11_+_128563948 0.03 ENST00000534087.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr1_-_156460391 0.02 ENST00000360595.3
MEF2D
myocyte enhancer factor 2D
chr1_-_159832438 0.02 ENST00000368100.1
VSIG8
V-set and immunoglobulin domain containing 8
chr18_-_56985776 0.02 ENST00000587244.1
CPLX4
complexin 4
chr14_+_37131058 0.02 ENST00000361487.6
PAX9
paired box 9
chr17_-_48785216 0.02 ENST00000285243.6
ANKRD40
ankyrin repeat domain 40
chr14_+_45605157 0.02 ENST00000542564.2
FANCM
Fanconi anemia, complementation group M
chr14_-_36988882 0.02 ENST00000498187.2
NKX2-1
NK2 homeobox 1
chr8_-_28347737 0.02 ENST00000517673.1
ENST00000518734.1
ENST00000346498.2
ENST00000380254.2
FBXO16
F-box protein 16
chr3_+_159557637 0.02 ENST00000445224.2
SCHIP1
schwannomin interacting protein 1
chr12_+_56521840 0.02 ENST00000394048.5
ESYT1
extended synaptotagmin-like protein 1
chr2_-_163100045 0.02 ENST00000188790.4
FAP
fibroblast activation protein, alpha
chrX_-_84634737 0.02 ENST00000262753.4
POF1B
premature ovarian failure, 1B
chr7_+_144052381 0.02 ENST00000498580.1
ENST00000056217.5
ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr14_-_38064198 0.02 ENST00000250448.2
FOXA1
forkhead box A1
chr2_-_163099885 0.02 ENST00000443424.1
FAP
fibroblast activation protein, alpha
chrX_+_123097014 0.01 ENST00000394478.1
STAG2
stromal antigen 2
chr1_+_26348259 0.01 ENST00000374280.3
EXTL1
exostosin-like glycosyltransferase 1
chr2_+_101437487 0.01 ENST00000427413.1
ENST00000542504.1
NPAS2
neuronal PAS domain protein 2
chr12_+_111537227 0.01 ENST00000397643.3
CUX2
cut-like homeobox 2
chr17_-_10452929 0.01 ENST00000532183.2
ENST00000397183.2
ENST00000420805.1
MYH2
myosin, heavy chain 2, skeletal muscle, adult
chrX_-_119445263 0.01 ENST00000309720.5
TMEM255A
transmembrane protein 255A
chr7_-_130598059 0.01 ENST00000432045.2
MIR29B1
microRNA 29a
chr2_+_87135076 0.01 ENST00000409776.2
RGPD1
RANBP2-like and GRIP domain containing 1
chr5_-_13944652 0.01 ENST00000265104.4
DNAH5
dynein, axonemal, heavy chain 5
chr6_-_116447283 0.01 ENST00000452729.1
ENST00000243222.4
COL10A1
collagen, type X, alpha 1
chr7_+_129015484 0.01 ENST00000490911.1
AHCYL2
adenosylhomocysteinase-like 2
chr1_+_28586006 0.01 ENST00000253063.3
SESN2
sestrin 2
chr12_-_57444957 0.01 ENST00000433964.1
MYO1A
myosin IA
chr4_+_84457529 0.01 ENST00000264409.4
AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr4_+_84457250 0.01 ENST00000395226.2
AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr1_+_167298281 0.01 ENST00000367862.5
POU2F1
POU class 2 homeobox 1
chr1_+_170632250 0.01 ENST00000367760.3
PRRX1
paired related homeobox 1
chr1_+_214161272 0.01 ENST00000498508.2
ENST00000366958.4
PROX1
prospero homeobox 1
chr7_+_18330035 0.01 ENST00000413509.2
HDAC9
histone deacetylase 9
chr9_-_113341985 0.01 ENST00000374469.1
SVEP1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr10_+_11047259 0.01 ENST00000379261.4
ENST00000416382.2
CELF2
CUGBP, Elav-like family member 2
chr3_+_52448539 0.01 ENST00000461861.1
PHF7
PHD finger protein 7
chr18_+_28956740 0.01 ENST00000308128.4
ENST00000359747.4
DSG4
desmoglein 4
chr12_-_68845165 0.00 ENST00000360485.3
ENST00000441255.2
RP11-81H14.2
RP11-81H14.2
chr21_+_17961006 0.00 ENST00000602323.1
LINC00478
long intergenic non-protein coding RNA 478
chr17_-_10421853 0.00 ENST00000226207.5
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr12_+_12938541 0.00 ENST00000356591.4
APOLD1
apolipoprotein L domain containing 1
chr14_+_45605127 0.00 ENST00000556036.1
ENST00000267430.5
FANCM
Fanconi anemia, complementation group M
chr7_+_117251671 0.00 ENST00000468795.1
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr15_+_80351977 0.00 ENST00000559157.1
ENST00000561012.1
ENST00000564367.1
ENST00000558494.1
ZFAND6
zinc finger, AN1-type domain 6
chr11_+_120971882 0.00 ENST00000392793.1
TECTA
tectorin alpha
chr7_+_100273736 0.00 ENST00000412215.1
ENST00000393924.1
GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr12_-_11091862 0.00 ENST00000537503.1
TAS2R14
taste receptor, type 2, member 14

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1902362 melanocyte apoptotic process(GO:1902362)
0.1 0.4 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.1 0.2 GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000588)
0.0 0.1 GO:0061289 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.0 0.2 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 0.2 GO:0010166 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.0 0.2 GO:0002036 regulation of L-glutamate transport(GO:0002036)
0.0 0.2 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.0 GO:0035038 female pronucleus assembly(GO:0035038)
0.0 0.2 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.0 0.2 GO:0071438 invadopodium membrane(GO:0071438)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 0.2 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.2 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 0.1 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.1 GO:0004936 alpha-adrenergic receptor activity(GO:0004936)
0.0 0.2 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.4 GO:0008430 selenium binding(GO:0008430)
0.0 0.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.2 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 0.1 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)