NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)


Results for HOXA4

Z-value: 0.54

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Transcription factors associated with HOXA4

Gene Symbol Gene ID Gene Info
ENSG00000197576.9 homeobox A4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of HOXA4 motif

Sorted Z-values of HOXA4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_38065052 0.39 ENST00000556845.1
tetratricopeptide repeat domain 6
chr5_+_150406527 0.37 ENST00000520059.1
glutathione peroxidase 3 (plasma)
chr10_-_92681033 0.26 ENST00000371697.3
ankyrin repeat domain 1 (cardiac muscle)
chr9_-_3469181 0.24 ENST00000366116.2
Uncharacterized protein
chr5_+_66300464 0.23 ENST00000436277.1
microtubule associated serine/threonine kinase family member 4
chr16_+_67280799 0.22 ENST00000566345.2
solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
chr3_+_69134124 0.22 ENST00000478935.1
ADP-ribosylation-like factor 6 interacting protein 5
chr17_-_38928414 0.21 ENST00000335552.4
keratin 26
chr8_-_42358742 0.21 ENST00000517366.1
solute carrier family 20 (phosphate transporter), member 2
chr12_+_72058130 0.19 ENST00000547843.1
THAP domain containing, apoptosis associated protein 2
chr7_-_75241096 0.18 ENST00000420909.1
huntingtin interacting protein 1
chr2_-_163099546 0.17 ENST00000447386.1
fibroblast activation protein, alpha
chr8_-_95449155 0.17 ENST00000481490.2
fibrinogen silencer binding protein
chr3_+_88188254 0.16 ENST00000309495.5
zinc finger protein 654
chr5_+_49962495 0.16 ENST00000515175.1
poly (ADP-ribose) polymerase family, member 8
chr1_+_151739131 0.15 ENST00000400999.1
ornithine decarboxylase antizyme 3
chr5_+_133562095 0.15 ENST00000602919.1
chr4_-_109541539 0.13 ENST00000509984.1
RPL34 antisense RNA 1 (head to head)
chr5_+_159343688 0.12 ENST00000306675.3
adrenoceptor alpha 1B
chr10_+_77056181 0.12 ENST00000526759.1
ZNF503 antisense RNA 1
chr4_-_41884620 0.12 ENST00000504870.1
long intergenic non-protein coding RNA 682
chr11_-_104480019 0.12 ENST00000536529.1
chr6_-_116833500 0.12 ENST00000356128.4
trafficking protein particle complex 3-like
chr2_+_53994927 0.11 ENST00000295304.4
ChaC, cation transport regulator homolog 2 (E. coli)
chr17_-_2117600 0.11 ENST00000572369.1
SMG6 nonsense mediated mRNA decay factor
chr6_+_63921351 0.11 ENST00000370659.1
FK506 binding protein 1C
chr6_+_31514622 0.10 ENST00000376146.4
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr7_-_27170352 0.10 ENST00000428284.2
homeobox A4
chr5_-_1882858 0.09 ENST00000511126.1
iroquois homeobox 4
chr12_+_29376673 0.09 ENST00000547116.1
fatty acyl CoA reductase 2
chr12_+_29376592 0.09 ENST00000182377.4
fatty acyl CoA reductase 2
chr11_+_128563652 0.08 ENST00000527786.2
Fli-1 proto-oncogene, ETS transcription factor
chr7_+_95115210 0.08 ENST00000428113.1
ankyrin repeat and SOCS box containing 4
chr10_-_95462265 0.08 ENST00000536233.1
fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1
chr18_-_53019208 0.08 ENST00000562607.1
transcription factor 4
chr3_+_121311966 0.08 ENST00000338040.4
F-box protein 40
chr11_-_27494279 0.07 ENST00000379214.4
leucine-rich repeat containing G protein-coupled receptor 4
chr2_+_113825547 0.07 ENST00000341010.2
interleukin 1 family, member 10 (theta)
chr3_-_57233966 0.07 ENST00000473921.1
HESX homeobox 1
chr1_-_204329013 0.07 ENST00000272203.3
pleckstrin homology domain containing, family A member 6
chr8_+_22424551 0.07 ENST00000523348.1
sorbin and SH3 domain containing 3
chr1_-_100643765 0.06 ENST00000370137.1
leucine rich repeat containing 39
chr19_-_42806919 0.06 ENST00000595530.1
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chr1_+_81771806 0.06 ENST00000370721.1
latrophilin 2
chr5_+_66300446 0.06 ENST00000261569.7
microtubule associated serine/threonine kinase family member 4
chr11_-_27494309 0.06 ENST00000389858.4
leucine-rich repeat containing G protein-coupled receptor 4
chr14_+_101359265 0.06 ENST00000599197.1
Esophagus cancer-related gene-2 interaction susceptibility protein; Uncharacterized protein
chr11_+_12766583 0.05 ENST00000361985.2
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr14_+_59100774 0.05 ENST00000556859.1
dishevelled-binding antagonist of beta-catenin 1
chr14_+_39734482 0.05 ENST00000554392.1
CTAGE family, member 5
chr10_+_118305435 0.05 ENST00000369221.2
pancreatic lipase
chr5_+_147582348 0.05 ENST00000514389.1
serine peptidase inhibitor, Kazal type 6
chr18_-_21017817 0.05 ENST00000542162.1
transmembrane protein 241
chr5_+_60933634 0.05 ENST00000505642.1
chromosome 5 open reading frame 64
chrX_-_19689106 0.04 ENST00000379716.1
SH3-domain kinase binding protein 1
chr19_+_12949251 0.04 ENST00000251472.4
microtubule associated serine/threonine kinase 1
chr19_-_1021113 0.04 ENST00000333175.5
transmembrane protein 259
chr6_-_31514333 0.04 ENST00000376151.4
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr5_-_88179302 0.04 ENST00000504921.2
myocyte enhancer factor 2C
chr7_+_141418962 0.04 ENST00000493845.1
WEE1 homolog 2 (S. pombe)
chr12_+_54447637 0.04 ENST00000609810.1
homeobox C4
Homeobox protein Hox-C4
chr21_+_17442799 0.04 ENST00000602580.1
long intergenic non-protein coding RNA 478
chr4_+_189060573 0.04 ENST00000332517.3
tripartite motif family-like 1
chr8_-_99954788 0.04 ENST00000523601.1
serine/threonine kinase 3
chr17_-_39211463 0.03 ENST00000542910.1
keratin associated protein 2-2
chr10_+_77056134 0.03 ENST00000528121.1
ZNF503 antisense RNA 1
chr20_+_32150140 0.03 ENST00000344201.3
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr21_+_22370717 0.03 ENST00000284894.7
neural cell adhesion molecule 2
chr5_+_140810132 0.03 ENST00000252085.3
protocadherin gamma subfamily A, 12
chr5_-_38557561 0.03 ENST00000511561.1
leukemia inhibitory factor receptor alpha
chr4_-_185139062 0.03 ENST00000296741.2
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr5_+_66254698 0.03 ENST00000405643.1
microtubule associated serine/threonine kinase family member 4
chr11_-_40315640 0.03 ENST00000278198.2
leucine rich repeat containing 4C
chr5_+_152870106 0.03 ENST00000285900.5
glutamate receptor, ionotropic, AMPA 1
chr9_+_44867571 0.03 ENST00000377548.2
chr2_-_145278475 0.03 ENST00000558170.2
zinc finger E-box binding homeobox 2
chr18_-_70532906 0.03 ENST00000299430.2
neuropilin (NRP) and tolloid (TLL)-like 1
chr15_+_90744533 0.03 ENST00000411539.2
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr20_+_57464200 0.03 ENST00000604005.1
GNAS complex locus
chr18_+_42260059 0.03 ENST00000426838.4
SET binding protein 1
chr2_+_54683419 0.03 ENST00000356805.4
spectrin, beta, non-erythrocytic 1
chr11_+_128563948 0.03 ENST00000534087.2
Fli-1 proto-oncogene, ETS transcription factor
chr1_-_156460391 0.02 ENST00000360595.3
myocyte enhancer factor 2D
chr1_-_159832438 0.02 ENST00000368100.1
V-set and immunoglobulin domain containing 8
chr18_-_56985776 0.02 ENST00000587244.1
complexin 4
chr14_+_37131058 0.02 ENST00000361487.6
paired box 9
chr17_-_48785216 0.02 ENST00000285243.6
ankyrin repeat domain 40
chr14_+_45605157 0.02 ENST00000542564.2
Fanconi anemia, complementation group M
chr14_-_36988882 0.02 ENST00000498187.2
NK2 homeobox 1
chr8_-_28347737 0.02 ENST00000517673.1
F-box protein 16
chr3_+_159557637 0.02 ENST00000445224.2
schwannomin interacting protein 1
chr12_+_56521840 0.02 ENST00000394048.5
extended synaptotagmin-like protein 1
chr2_-_163100045 0.02 ENST00000188790.4
fibroblast activation protein, alpha
chrX_-_84634737 0.02 ENST00000262753.4
premature ovarian failure, 1B
chr7_+_144052381 0.02 ENST00000498580.1
Rho guanine nucleotide exchange factor (GEF) 5
chr14_-_38064198 0.02 ENST00000250448.2
forkhead box A1
chr2_-_163099885 0.02 ENST00000443424.1
fibroblast activation protein, alpha
chrX_+_123097014 0.01 ENST00000394478.1
stromal antigen 2
chr1_+_26348259 0.01 ENST00000374280.3
exostosin-like glycosyltransferase 1
chr2_+_101437487 0.01 ENST00000427413.1
neuronal PAS domain protein 2
chr12_+_111537227 0.01 ENST00000397643.3
cut-like homeobox 2
chr17_-_10452929 0.01 ENST00000532183.2
myosin, heavy chain 2, skeletal muscle, adult
chrX_-_119445263 0.01 ENST00000309720.5
transmembrane protein 255A
chr7_-_130598059 0.01 ENST00000432045.2
microRNA 29a
chr2_+_87135076 0.01 ENST00000409776.2
RANBP2-like and GRIP domain containing 1
chr5_-_13944652 0.01 ENST00000265104.4
dynein, axonemal, heavy chain 5
chr6_-_116447283 0.01 ENST00000452729.1
collagen, type X, alpha 1
chr7_+_129015484 0.01 ENST00000490911.1
adenosylhomocysteinase-like 2
chr1_+_28586006 0.01 ENST00000253063.3
sestrin 2
chr12_-_57444957 0.01 ENST00000433964.1
myosin IA
chr4_+_84457529 0.01 ENST00000264409.4
1-acylglycerol-3-phosphate O-acyltransferase 9
chr4_+_84457250 0.01 ENST00000395226.2
1-acylglycerol-3-phosphate O-acyltransferase 9
chr1_+_167298281 0.01 ENST00000367862.5
POU class 2 homeobox 1
chr1_+_170632250 0.01 ENST00000367760.3
paired related homeobox 1
chr1_+_214161272 0.01 ENST00000498508.2
prospero homeobox 1
chr7_+_18330035 0.01 ENST00000413509.2
histone deacetylase 9
chr9_-_113341985 0.01 ENST00000374469.1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr10_+_11047259 0.01 ENST00000379261.4
CUGBP, Elav-like family member 2
chr3_+_52448539 0.01 ENST00000461861.1
PHD finger protein 7
chr18_+_28956740 0.01 ENST00000308128.4
desmoglein 4
chr12_-_68845165 0.00 ENST00000360485.3
chr21_+_17961006 0.00 ENST00000602323.1
long intergenic non-protein coding RNA 478
chr17_-_10421853 0.00 ENST00000226207.5
myosin, heavy chain 1, skeletal muscle, adult
chr12_+_12938541 0.00 ENST00000356591.4
apolipoprotein L domain containing 1
chr14_+_45605127 0.00 ENST00000556036.1
Fanconi anemia, complementation group M
chr7_+_117251671 0.00 ENST00000468795.1
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr15_+_80351977 0.00 ENST00000559157.1
zinc finger, AN1-type domain 6
chr11_+_120971882 0.00 ENST00000392793.1
tectorin alpha
chr7_+_100273736 0.00 ENST00000412215.1
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr12_-_11091862 0.00 ENST00000537503.1
taste receptor, type 2, member 14

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1902362 melanocyte apoptotic process(GO:1902362)
0.1 0.4 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.1 0.2 GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000588)
0.0 0.1 GO:0061289 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.0 0.2 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 0.2 GO:0010166 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.0 0.2 GO:0002036 regulation of L-glutamate transport(GO:0002036)
0.0 0.2 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.0 GO:0035038 female pronucleus assembly(GO:0035038)
0.0 0.2 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.0 0.2 GO:0071438 invadopodium membrane(GO:0071438)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 0.2 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.2 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 0.1 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.1 GO:0004936 alpha-adrenergic receptor activity(GO:0004936)
0.0 0.2 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.4 GO:0008430 selenium binding(GO:0008430)
0.0 0.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.2 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 0.1 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)