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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HOXA2_HOXB1

Z-value: 0.63

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Transcription factors associated with HOXA2_HOXB1

Gene Symbol Gene ID Gene Info
ENSG00000105996.5 homeobox A2
ENSG00000120094.6 homeobox B1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXA2hg19_v2_chr7_-_27142290_27142430-0.929.0e-03Click!
HOXB1hg19_v2_chr17_-_46608272_466083850.354.9e-01Click!

Activity profile of HOXA2_HOXB1 motif

Sorted Z-values of HOXA2_HOXB1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_7758374 0.40 ENST00000301599.6
ENST00000574668.1
transmembrane protein 88
chr20_+_52105495 0.35 ENST00000439873.2
Cell growth-inhibiting protein 7; HCG1784586; Uncharacterized protein
chr11_-_126174186 0.32 ENST00000524964.1
Uncharacterized protein
chr12_-_15038779 0.24 ENST00000228938.5
ENST00000539261.1
matrix Gla protein
chr5_+_147582348 0.22 ENST00000514389.1
serine peptidase inhibitor, Kazal type 6
chr16_-_67427389 0.22 ENST00000562206.1
ENST00000290942.5
ENST00000393957.2
tubulin polymerization-promoting protein family member 3
chr14_-_21516590 0.19 ENST00000555026.1
NDRG family member 2
chr10_+_102891048 0.19 ENST00000467928.2
T-cell leukemia homeobox 1
chr7_-_143956815 0.19 ENST00000493325.1
olfactory receptor, family 2, subfamily A, member 7
chr17_-_57229155 0.19 ENST00000584089.1
spindle and kinetochore associated complex subunit 2
chr12_+_21679220 0.18 ENST00000256969.2
chromosome 12 open reading frame 39
chr6_+_151561506 0.17 ENST00000253332.1
A kinase (PRKA) anchor protein 12
chr9_+_44867571 0.17 ENST00000377548.2
RP11-160N1.10
chr7_+_26591441 0.16 ENST00000420912.1
ENST00000457000.1
ENST00000430426.1
AC004947.2
chr6_+_155334780 0.16 ENST00000538270.1
ENST00000535231.1
T-cell lymphoma invasion and metastasis 2
chr6_+_151561085 0.15 ENST00000402676.2
A kinase (PRKA) anchor protein 12
chr17_-_46608272 0.15 ENST00000577092.1
ENST00000239174.6
homeobox B1
chr17_-_46623441 0.14 ENST00000330070.4
homeobox B2
chr15_-_64673630 0.13 ENST00000558008.1
ENST00000559519.1
ENST00000380258.2
KIAA0101
chr2_+_12857043 0.13 ENST00000381465.2
tribbles pseudokinase 2
chr11_-_2162162 0.12 ENST00000381389.1
insulin-like growth factor 2 (somatomedin A)
chr1_-_205391178 0.12 ENST00000367153.4
ENST00000367151.2
ENST00000391936.2
ENST00000367149.3
LEM domain containing 1
chr8_+_143530791 0.11 ENST00000517894.1
brain-specific angiogenesis inhibitor 1
chr3_+_239652 0.11 ENST00000435603.1
cell adhesion molecule L1-like
chr8_-_67874805 0.10 ENST00000563496.1
transcription factor 24
chr8_+_23386305 0.10 ENST00000519973.1
solute carrier family 25 (mitochondrial iron transporter), member 37
chr19_-_45735138 0.09 ENST00000252482.3
exocyst complex component 3-like 2
chr8_-_79717750 0.08 ENST00000263851.4
ENST00000379113.2
interleukin 7
chr5_-_125930929 0.08 ENST00000553117.1
ENST00000447989.2
ENST00000409134.3
aldehyde dehydrogenase 7 family, member A1
chr9_-_26946981 0.08 ENST00000523212.1
phospholipase A2-activating protein
chr15_-_64673665 0.08 ENST00000300035.4
KIAA0101
chr1_-_217804377 0.07 ENST00000366935.3
ENST00000366934.3
G patch domain containing 2
chr2_+_68961905 0.07 ENST00000295381.3
Rho GTPase activating protein 25
chr12_+_7023491 0.07 ENST00000541477.1
ENST00000229277.1
enolase 2 (gamma, neuronal)
chr14_-_54425475 0.07 ENST00000559642.1
bone morphogenetic protein 4
chr3_-_156877997 0.07 ENST00000295926.3
cyclin L1
chr2_+_68961934 0.07 ENST00000409202.3
Rho GTPase activating protein 25
chr17_-_42277203 0.07 ENST00000587097.1
ataxin 7-like 3
chr8_+_77596014 0.07 ENST00000523885.1
zinc finger homeobox 4
chr1_-_43833628 0.07 ENST00000413844.2
ENST00000372458.3
ELOVL fatty acid elongase 1
chr8_+_23386557 0.06 ENST00000523930.1
solute carrier family 25 (mitochondrial iron transporter), member 37
chr5_+_154181816 0.06 ENST00000518677.1
La ribonucleoprotein domain family, member 1
chr7_+_86273218 0.06 ENST00000361669.2
glutamate receptor, metabotropic 3
chr9_+_113431029 0.06 ENST00000189978.5
ENST00000374448.4
ENST00000374440.3
muscle, skeletal, receptor tyrosine kinase
chr2_+_68962014 0.06 ENST00000467265.1
Rho GTPase activating protein 25
chr9_-_26947220 0.06 ENST00000520884.1
phospholipase A2-activating protein
chr1_+_68150744 0.06 ENST00000370986.4
ENST00000370985.3
growth arrest and DNA-damage-inducible, alpha
chr6_+_32006042 0.06 ENST00000418967.2
cytochrome P450, family 21, subfamily A, polypeptide 2
chr2_+_12857015 0.06 ENST00000155926.4
tribbles pseudokinase 2
chr19_+_37997812 0.06 ENST00000542455.1
ENST00000587143.1
zinc finger protein 793
chr8_-_128231299 0.06 ENST00000500112.1
colon cancer associated transcript 1 (non-protein coding)
chr19_+_13051206 0.06 ENST00000586760.1
calreticulin
chr5_+_167181917 0.05 ENST00000519204.1
teneurin transmembrane protein 2
chr9_-_15250114 0.05 ENST00000507993.1
tetratricopeptide repeat domain 39B
chrX_+_41583408 0.05 ENST00000302548.4
G protein-coupled receptor 82
chr17_-_1588101 0.05 ENST00000577001.1
ENST00000572621.1
ENST00000304992.6
pre-mRNA processing factor 8
chr12_+_7022909 0.05 ENST00000537688.1
enolase 2 (gamma, neuronal)
chr11_-_93583697 0.05 ENST00000409977.1
V-set and transmembrane domain containing 5
chr9_+_140135665 0.05 ENST00000340384.4
tubulin, beta 4B class IVb
chrX_-_13835398 0.05 ENST00000475307.1
glycoprotein M6B
chr2_+_135011731 0.05 ENST00000281923.2
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
chr5_+_147582387 0.05 ENST00000325630.2
serine peptidase inhibitor, Kazal type 6
chr16_-_49890016 0.05 ENST00000563137.2
zinc finger protein 423
chr19_+_52074502 0.05 ENST00000545217.1
ENST00000262259.2
ENST00000596504.1
zinc finger protein 175
chr11_-_122930121 0.05 ENST00000524552.1
heat shock 70kDa protein 8
chr17_-_27418537 0.05 ENST00000408971.2
TGFB1-induced anti-apoptotic factor 1
chr11_+_57365150 0.05 ENST00000457869.1
ENST00000340687.6
ENST00000378323.4
ENST00000378324.2
ENST00000403558.1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr3_-_150264272 0.04 ENST00000491660.1
ENST00000487153.1
ENST00000239944.2
stress-associated endoplasmic reticulum protein 1
chr3_+_159481988 0.04 ENST00000472451.1
IQCJ-SCHIP1 readthrough
chr6_-_159065741 0.04 ENST00000367085.3
ENST00000367089.3
dynein, light chain, Tctex-type 1
chr10_-_98945515 0.04 ENST00000371070.4
slit homolog 1 (Drosophila)
chr9_-_26947453 0.04 ENST00000397292.3
phospholipase A2-activating protein
chr17_+_37824217 0.04 ENST00000394246.1
phenylethanolamine N-methyltransferase
chr15_-_74501360 0.04 ENST00000323940.5
stimulated by retinoic acid 6
chr2_-_242089677 0.04 ENST00000405260.1
PAS domain containing serine/threonine kinase
chr1_-_217250231 0.04 ENST00000493748.1
ENST00000463665.1
estrogen-related receptor gamma
chr11_-_122929699 0.04 ENST00000526686.1
heat shock 70kDa protein 8
chr13_+_52586517 0.04 ENST00000523764.1
ENST00000521508.1
ALG11, alpha-1,2-mannosyltransferase
chr11_+_133902547 0.03 ENST00000529070.1
RP11-713P17.3
chr13_+_36050881 0.03 ENST00000537702.1
neurobeachin
chr17_+_37824411 0.03 ENST00000269582.2
phenylethanolamine N-methyltransferase
chr15_-_38852251 0.03 ENST00000558432.1
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
chr12_-_28125638 0.03 ENST00000545234.1
parathyroid hormone-like hormone
chr1_-_109584608 0.03 ENST00000400794.3
ENST00000528747.1
ENST00000369962.3
ENST00000361054.3
WD repeat domain 47
chr1_-_109584768 0.03 ENST00000357672.3
WD repeat domain 47
chr10_-_98945677 0.03 ENST00000266058.4
ENST00000371041.3
slit homolog 1 (Drosophila)
chr12_-_28124903 0.03 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
parathyroid hormone-like hormone
chr17_-_42276574 0.03 ENST00000589805.1
ataxin 7-like 3
chr1_-_109584716 0.03 ENST00000531337.1
ENST00000529074.1
ENST00000369965.4
WD repeat domain 47
chr7_-_78400364 0.03 ENST00000535697.1
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr14_-_24733444 0.02 ENST00000560478.1
ENST00000560443.1
transglutaminase 1
chr2_+_114647504 0.02 ENST00000263238.2
ARP3 actin-related protein 3 homolog (yeast)
chr3_+_191046810 0.02 ENST00000392455.3
ENST00000392456.3
coiled-coil domain containing 50
chr9_+_113431059 0.02 ENST00000416899.2
muscle, skeletal, receptor tyrosine kinase
chr1_+_52082751 0.02 ENST00000447887.1
ENST00000435686.2
ENST00000428468.1
ENST00000453295.1
oxysterol binding protein-like 9
chr17_+_79495397 0.02 ENST00000417245.2
ENST00000334850.7
fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)
chr7_+_20370746 0.02 ENST00000222573.4
integrin, beta 8
chr12_-_86650077 0.02 ENST00000552808.2
ENST00000547225.1
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr1_+_243419306 0.02 ENST00000355875.4
ENST00000391846.1
ENST00000366541.3
ENST00000343783.6
serologically defined colon cancer antigen 8
chrX_-_30993201 0.02 ENST00000288422.2
ENST00000378932.2
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr12_+_10658489 0.02 ENST00000538173.1
Putative eukaryotic translation initiation factor 2 subunit 3-like protein
chr2_+_54684327 0.02 ENST00000389980.3
spectrin, beta, non-erythrocytic 1
chr5_+_98109322 0.02 ENST00000513185.1
repulsive guidance molecule family member b
chr2_+_242089833 0.02 ENST00000404405.3
ENST00000439916.1
ENST00000406106.3
ENST00000401987.1
protein phosphatase 1, regulatory subunit 7
chr4_-_90757364 0.02 ENST00000508895.1
synuclein, alpha (non A4 component of amyloid precursor)
chr10_+_124320156 0.02 ENST00000338354.3
ENST00000344338.3
ENST00000330163.4
ENST00000368909.3
ENST00000368955.3
ENST00000368956.2
deleted in malignant brain tumors 1
chr3_+_150264555 0.02 ENST00000406576.3
ENST00000482093.1
ENST00000273435.5
eukaryotic translation initiation factor 2A, 65kDa
chr5_+_133861790 0.02 ENST00000395003.1
jade family PHD finger 2
chr11_+_68228186 0.02 ENST00000393799.2
ENST00000393800.2
ENST00000528635.1
ENST00000533127.1
ENST00000529907.1
ENST00000529344.1
ENST00000534534.1
ENST00000524845.1
ENST00000265637.4
ENST00000524904.1
ENST00000393801.3
ENST00000265636.5
ENST00000529710.1
protein phosphatase 6, regulatory subunit 3
chr7_+_39017504 0.02 ENST00000403058.1
POU class 6 homeobox 2
chr12_-_114843889 0.02 ENST00000405440.2
T-box 5
chr3_+_150264458 0.02 ENST00000487799.1
ENST00000460851.1
eukaryotic translation initiation factor 2A, 65kDa
chr1_+_36621174 0.02 ENST00000429533.2
MAP7 domain containing 1
chr15_+_81591757 0.02 ENST00000558332.1
interleukin 16
chr20_+_30467600 0.02 ENST00000375934.4
ENST00000375922.4
tubulin tyrosine ligase-like family, member 9
chr17_+_43239191 0.01 ENST00000589230.1
hexamethylene bis-acetamide inducible 2
chrX_-_110655306 0.01 ENST00000371993.2
doublecortin
chr3_+_189507460 0.01 ENST00000434928.1
tumor protein p63
chr11_-_126870655 0.01 ENST00000525144.2
kin of IRRE like 3 (Drosophila)
chr11_-_128712362 0.01 ENST00000392664.2
potassium inwardly-rectifying channel, subfamily J, member 1
chr15_-_74501310 0.01 ENST00000423167.2
ENST00000432245.2
stimulated by retinoic acid 6
chr2_+_176995011 0.01 ENST00000548663.1
ENST00000450510.2
homeobox D8
chr19_-_51512804 0.01 ENST00000594211.1
ENST00000376832.4
kallikrein-related peptidase 9
chr21_-_43430440 0.01 ENST00000398505.3
ENST00000310826.5
ENST00000449949.1
ENST00000398499.1
ENST00000398497.2
ENST00000398511.3
zinc finger and BTB domain containing 21
chr10_-_98945264 0.01 ENST00000314867.5
slit homolog 1 (Drosophila)
chr21_+_19617140 0.01 ENST00000299295.2
ENST00000338326.3
chondrolectin
chr20_+_21284416 0.01 ENST00000539513.1
5'-3' exoribonuclease 2
chr9_-_73477826 0.01 ENST00000396285.1
ENST00000396292.4
ENST00000396280.5
ENST00000358082.3
ENST00000408909.2
ENST00000377097.3
transient receptor potential cation channel, subfamily M, member 3
chrX_+_95939711 0.01 ENST00000373049.4
ENST00000324765.8
diaphanous-related formin 2
chr13_-_36050819 0.01 ENST00000379919.4
mab-21-like 1 (C. elegans)
chr17_+_39975544 0.01 ENST00000544340.1
FK506 binding protein 10, 65 kDa
chr12_+_56414795 0.01 ENST00000431367.2
IKAROS family zinc finger 4 (Eos)
chr3_-_98619999 0.01 ENST00000449482.1
discoidin, CUB and LCCL domain containing 2
chr2_+_26624775 0.01 ENST00000288710.2
dynein regulatory complex subunit 1 homolog (Chlamydomonas)
chr5_-_125930877 0.01 ENST00000510111.2
ENST00000509270.1
aldehyde dehydrogenase 7 family, member A1
chr6_+_32006159 0.01 ENST00000478281.1
ENST00000471671.1
ENST00000435122.2
cytochrome P450, family 21, subfamily A, polypeptide 2
chr17_+_39975455 0.01 ENST00000455106.1
FK506 binding protein 10, 65 kDa
chr6_-_112575838 0.01 ENST00000455073.1
laminin, alpha 4
chr12_+_56414851 0.01 ENST00000547167.1
IKAROS family zinc finger 4 (Eos)
chr10_+_124320195 0.01 ENST00000359586.6
deleted in malignant brain tumors 1
chr20_+_21283941 0.01 ENST00000377191.3
ENST00000430571.2
5'-3' exoribonuclease 2
chr2_-_145278475 0.01 ENST00000558170.2
zinc finger E-box binding homeobox 2
chr6_-_64029879 0.01 ENST00000370658.5
ENST00000485906.2
ENST00000370657.4
lengsin, lens protein with glutamine synthetase domain
chr8_-_22550691 0.01 ENST00000519492.1
early growth response 3
chr4_-_90756769 0.01 ENST00000345009.4
ENST00000505199.1
ENST00000502987.1
synuclein, alpha (non A4 component of amyloid precursor)
chr3_+_189507432 0.00 ENST00000354600.5
tumor protein p63
chr1_-_92351666 0.00 ENST00000465892.2
ENST00000417833.2
transforming growth factor, beta receptor III
chrX_+_99899180 0.00 ENST00000373004.3
sushi-repeat containing protein, X-linked 2
chr2_-_197226875 0.00 ENST00000409111.1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr2_+_121493717 0.00 ENST00000418323.1
GLI family zinc finger 2
chr4_+_129732467 0.00 ENST00000413543.2
jade family PHD finger 1
chr4_+_77356248 0.00 ENST00000296043.6
shroom family member 3
chr12_+_101988774 0.00 ENST00000545503.2
ENST00000536007.1
ENST00000541119.1
ENST00000361466.2
ENST00000551300.1
ENST00000550270.1
myosin binding protein C, slow type
chr10_+_24755416 0.00 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217
chr12_+_101988627 0.00 ENST00000547405.1
ENST00000452455.2
ENST00000441232.1
ENST00000360610.2
ENST00000392934.3
ENST00000547509.1
ENST00000361685.2
ENST00000549145.1
ENST00000553190.1
myosin binding protein C, slow type
chrX_-_110655391 0.00 ENST00000356915.2
ENST00000356220.3
doublecortin
chr7_-_86595190 0.00 ENST00000398276.2
ENST00000416314.1
ENST00000425689.1
KIAA1324-like
chr6_+_33387868 0.00 ENST00000418600.2
synaptic Ras GTPase activating protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA2_HOXB1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0045081 negative regulation of interleukin-10 biosynthetic process(GO:0045081)
0.1 0.2 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.0 0.1 GO:0021571 rhombomere 5 development(GO:0021571)
0.0 0.1 GO:0031455 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.3 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.1 GO:0042418 epinephrine biosynthetic process(GO:0042418)
0.0 0.0 GO:0021569 rhombomere 3 development(GO:0021569)
0.0 0.1 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.0 0.1 GO:1904764 negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
0.0 0.1 GO:2000006 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.0 0.1 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0 0.1 GO:1990928 response to amino acid starvation(GO:1990928)
0.0 0.2 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.2 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.1 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0016005 phospholipase A2 activator activity(GO:0016005)
0.0 0.3 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.1 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.0 0.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)