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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for HNF4G
Z-value: 1.23
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Transcription factors associated with HNF4G
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HNF4G | hg19_v2_chr8_+_76452097_76452126 | -0.14 | 8.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_180235755 Show fit | 0.87 |
ENST00000502678.1
|
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase |
|
| chr11_-_66496655 Show fit | 0.81 |
ENST00000527010.1
|
spectrin, beta, non-erythrocytic 2 |
|
| chr5_-_176433565 Show fit | 0.80 |
ENST00000428382.2
|
ubiquitin interaction motif containing 1 |
|
| chr12_+_113354341 Show fit | 0.77 |
ENST00000553152.1
|
2'-5'-oligoadenylate synthetase 1, 40/46kDa |
|
| chr15_-_72668805 Show fit | 0.74 |
ENST00000268097.5
|
hexosaminidase A (alpha polypeptide) |
|
| chr16_-_75467274 Show fit | 0.67 |
ENST00000566254.1
|
craniofacial development protein 1 |
|
| chr11_+_65779283 Show fit | 0.64 |
ENST00000312134.2
|
cystatin E/M |
|
| chr22_-_37415475 Show fit | 0.62 |
ENST00000403892.3
ENST00000249042.3 ENST00000438203.1 |
thiosulfate sulfurtransferase (rhodanese) |
|
| chr12_-_106697974 Show fit | 0.60 |
ENST00000553039.1
|
cytoskeleton-associated protein 4 |
|
| chr8_-_145642267 Show fit | 0.55 |
ENST00000301305.3
|
solute carrier family 39 (zinc transporter), member 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HNF4G
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.5 | GO:0009440 | cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440) |
| 0.1 | 1.2 | GO:0006049 | UDP-N-acetylglucosamine catabolic process(GO:0006049) |
| 0.3 | 1.1 | GO:0034224 | cellular response to zinc ion starvation(GO:0034224) |
| 0.1 | 1.1 | GO:0021692 | cerebellar Purkinje cell layer morphogenesis(GO:0021692) |
| 0.1 | 0.8 | GO:0070537 | histone H2A K63-linked deubiquitination(GO:0070537) |
| 0.0 | 0.8 | GO:0032008 | positive regulation of TOR signaling(GO:0032008) |
| 0.1 | 0.7 | GO:2000270 | negative regulation of fibroblast apoptotic process(GO:2000270) |
| 0.0 | 0.7 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 0.0 | 0.7 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.1 | 0.6 | GO:0061760 | antifungal innate immune response(GO:0061760) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 1.1 | GO:0008091 | spectrin(GO:0008091) |
| 0.0 | 1.0 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 0.8 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 0.0 | 0.7 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.0 | 0.6 | GO:0042599 | lamellar body(GO:0042599) |
| 0.0 | 0.6 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 0.5 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.1 | 0.4 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.1 | 0.4 | GO:0071797 | LUBAC complex(GO:0071797) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.5 | GO:0004792 | thiosulfate sulfurtransferase activity(GO:0004792) |
| 0.1 | 1.2 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.1 | 0.8 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.0 | 0.8 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.1 | 0.7 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
| 0.0 | 0.7 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 0.6 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.2 | 0.5 | GO:0047536 | 2-aminoadipate transaminase activity(GO:0047536) |
| 0.2 | 0.5 | GO:0035539 | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity(GO:0008413) 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity(GO:0035539) |
| 0.2 | 0.5 | GO:0033878 | hormone-sensitive lipase activity(GO:0033878) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 0.7 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.7 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 0.3 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 1.0 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.0 | 0.9 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.8 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.7 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 0.7 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 0.6 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 0.4 | REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.0 | 0.4 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.0 | 0.4 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |