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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for HNF1A_HNF1B
Z-value: 0.85
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Transcription factors associated with HNF1A_HNF1B
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HNF1B | hg19_v2_chr17_-_36105009_36105060 | 0.71 | 1.1e-01 | Click! |
| HNF1A | hg19_v2_chr12_+_121416489_121416552 | 0.57 | 2.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_30899924 Show fit | 0.95 |
ENST00000359086.3
|
surfactant associated 2 |
|
| chr4_-_110723335 Show fit | 0.57 |
ENST00000394634.2
|
complement factor I |
|
| chr4_-_110723134 Show fit | 0.51 |
ENST00000510800.1
ENST00000512148.1 |
complement factor I |
|
| chr3_-_161089289 Show fit | 0.46 |
ENST00000497137.1
|
serine palmitoyltransferase, small subunit B |
|
| chr4_-_110723194 Show fit | 0.46 |
ENST00000394635.3
|
complement factor I |
|
| chr4_+_74301880 Show fit | 0.46 |
ENST00000395792.2
ENST00000226359.2 |
alpha-fetoprotein |
|
| chr16_-_69385681 Show fit | 0.36 |
ENST00000288025.3
|
transmembrane emp24 protein transport domain containing 6 |
|
| chr2_-_47572105 Show fit | 0.35 |
ENST00000419035.1
ENST00000448713.1 ENST00000450550.1 ENST00000413185.2 |
AC073283.4 |
|
| chr11_-_117170403 Show fit | 0.30 |
ENST00000504995.1
|
beta-site APP-cleaving enzyme 1 |
|
| chr2_-_47572207 Show fit | 0.27 |
ENST00000441997.1
|
AC073283.4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HNF1A_HNF1B
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 0.5 | GO:1904220 | regulation of serine C-palmitoyltransferase activity(GO:1904220) |
| 0.0 | 0.5 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
| 0.1 | 0.4 | GO:0002416 | IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416) |
| 0.1 | 0.3 | GO:1903412 | response to bile acid(GO:1903412) |
| 0.1 | 0.2 | GO:0050787 | detoxification of mercury ion(GO:0050787) |
| 0.1 | 0.2 | GO:0021779 | oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780) |
| 0.0 | 0.2 | GO:0090080 | positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080) |
| 0.0 | 0.2 | GO:1904970 | brush border assembly(GO:1904970) |
| 0.0 | 0.2 | GO:0050428 | purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:0017059 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 0.1 | 0.3 | GO:0070931 | Golgi-associated vesicle lumen(GO:0070931) |
| 0.0 | 0.2 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.0 | 0.1 | GO:0032311 | angiogenin-PRI complex(GO:0032311) |
| 0.0 | 0.1 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 0.5 | GO:0016454 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
| 0.1 | 0.4 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 0.0 | 0.4 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
| 0.1 | 0.3 | GO:0008798 | beta-aspartyl-peptidase activity(GO:0008798) |
| 0.0 | 0.3 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.0 | 0.2 | GO:0008422 | beta-glucosidase activity(GO:0008422) |
| 0.0 | 0.2 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
| 0.0 | 0.2 | GO:0043225 | anion transmembrane-transporting ATPase activity(GO:0043225) |
| 0.0 | 0.1 | GO:0047017 | geranylgeranyl reductase activity(GO:0045550) prostaglandin-F synthase activity(GO:0047017) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 0.3 | REACTOME FGFR4 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.0 | 0.3 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.2 | REACTOME FGFR LIGAND BINDING AND ACTIVATION | Genes involved in FGFR ligand binding and activation |
| 0.0 | 0.2 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |