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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HMGA2

Z-value: 0.51

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Transcription factors associated with HMGA2

Gene Symbol Gene ID Gene Info
HMGA2
ENSG00000149948.9 HMGA2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HMGA2hg19_v2_chr12_+_66218212_66218244-0.901.4e-02Click!

Activity profile of HMGA2 motif

Sorted Z-values of HMGA2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HMGA2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_+_65996599 0.53 ENST00000539116.1
ENST00000541391.1
 RP11-221N13.3
 RP11-221N13.3
chr14_+_50291993 0.21 ENST00000595378.1
 AL627171.2
 HCG1786899; PRO2610; Uncharacterized protein
chr1_-_67600639 0.19 ENST00000544837.1
ENST00000603691.1
 C1orf141
 chromosome 1 open reading frame 141
chr3_+_121774202 0.18 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
 CD86
 CD86 molecule
chr6_+_116892641 0.18 ENST00000487832.2
ENST00000518117.1
 RWDD1
 RWD domain containing 1
chr18_-_14132422 0.17 ENST00000589498.1
ENST00000590202.1
 ZNF519
 zinc finger protein 519
chr1_+_227751231 0.16 ENST00000343776.5
ENST00000608949.1
ENST00000397097.3
 ZNF678
 zinc finger protein 678
chr22_+_22676808 0.15 ENST00000390290.2
 IGLV1-51
 immunoglobulin lambda variable 1-51
chr19_+_44455368 0.14 ENST00000591168.1
ENST00000587682.1
ENST00000251269.5
 ZNF221
 zinc finger protein 221
chr16_+_66442411 0.14 ENST00000499966.1
 LINC00920
 long intergenic non-protein coding RNA 920
chr1_+_227751281 0.13 ENST00000440339.1
 ZNF678
 zinc finger protein 678
chr12_-_10573149 0.12 ENST00000381904.2
ENST00000381903.2
ENST00000396439.2
 KLRC3
 killer cell lectin-like receptor subfamily C, member 3
chr6_+_111580508 0.12 ENST00000368847.4
 KIAA1919
 KIAA1919
chr13_+_50656307 0.11 ENST00000378180.4
 DLEU1
 deleted in lymphocytic leukemia 1 (non-protein coding)
chr11_-_18063973 0.10 ENST00000528338.1
 TPH1
 tryptophan hydroxylase 1
chr4_+_25378912 0.10 ENST00000510092.1
ENST00000505991.1
 ANAPC4
 anaphase promoting complex subunit 4
chr6_-_136571400 0.10 ENST00000418509.2
ENST00000420702.1
ENST00000451457.2
 MTFR2
 mitochondrial fission regulator 2
chr14_-_94759595 0.10 ENST00000261994.4
 SERPINA10
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr1_+_2487800 0.10 ENST00000355716.4
 TNFRSF14
 tumor necrosis factor receptor superfamily, member 14
chr3_-_123680246 0.10 ENST00000488653.2
 CCDC14
 coiled-coil domain containing 14
chr2_+_120436733 0.09 ENST00000401466.1
ENST00000424086.1
ENST00000272521.6
 TMEM177
 transmembrane protein 177
chr2_-_287299 0.09 ENST00000405290.1
 FAM150B
 family with sequence similarity 150, member B
chr2_+_170683979 0.09 ENST00000418381.1
 UBR3
 ubiquitin protein ligase E3 component n-recognin 3 (putative)
chr5_+_67485704 0.09 ENST00000520762.1
 RP11-404L6.2
 Uncharacterized protein
chr1_+_196621156 0.09 ENST00000359637.2
 CFH
 complement factor H
chr16_+_53483983 0.09 ENST00000544545.1
 RBL2
 retinoblastoma-like 2 (p130)
chr1_+_179263308 0.09 ENST00000426956.1
 SOAT1
 sterol O-acyltransferase 1
chr1_+_144989309 0.08 ENST00000596396.1
 AL590452.1
 Uncharacterized protein
chr2_+_120436760 0.08 ENST00000445518.1
ENST00000409951.1
 TMEM177
 transmembrane protein 177
chr10_-_62332357 0.08 ENST00000503366.1
 ANK3
 ankyrin 3, node of Ranvier (ankyrin G)
chr1_+_196621002 0.08 ENST00000367429.4
ENST00000439155.2
 CFH
 complement factor H
chr20_+_54967663 0.08 ENST00000452950.1
 CSTF1
 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr3_+_106959530 0.08 ENST00000466734.1
ENST00000463143.1
ENST00000490441.1
 LINC00883
 long intergenic non-protein coding RNA 883
chr1_+_55464600 0.08 ENST00000371265.4
 BSND
 Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr6_+_123110302 0.08 ENST00000368440.4
 SMPDL3A
 sphingomyelin phosphodiesterase, acid-like 3A
chr4_+_40058411 0.08 ENST00000261435.6
ENST00000515550.1
 N4BP2
 NEDD4 binding protein 2
chr14_+_45553296 0.08 ENST00000355765.6
ENST00000553605.1
 PRPF39
 pre-mRNA processing factor 39
chr9_-_115480303 0.07 ENST00000374234.1
ENST00000374238.1
ENST00000374236.1
ENST00000374242.4
 INIP
 INTS3 and NABP interacting protein
chr3_+_186501336 0.07 ENST00000323963.5
ENST00000440191.2
ENST00000356531.5
 EIF4A2
 eukaryotic translation initiation factor 4A2
chr13_+_51483814 0.07 ENST00000336617.3
ENST00000422660.1
 RNASEH2B
 ribonuclease H2, subunit B
chr4_-_299110 0.07 ENST00000419098.1
 ZNF732
 zinc finger protein 732
chr2_+_170683942 0.07 ENST00000272793.5
 UBR3
 ubiquitin protein ligase E3 component n-recognin 3 (putative)
chr6_-_127664736 0.07 ENST00000368291.2
ENST00000309620.9
ENST00000454859.3
 ECHDC1
 enoyl CoA hydratase domain containing 1
chr11_+_73661364 0.06 ENST00000339764.1
 DNAJB13
 DnaJ (Hsp40) homolog, subfamily B, member 13
chr2_-_183387064 0.06 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
 PDE1A
 phosphodiesterase 1A, calmodulin-dependent
chr5_+_36608422 0.06 ENST00000381918.3
 SLC1A3
 solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr21_+_38792602 0.06 ENST00000398960.2
ENST00000398956.2
 DYRK1A
 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr15_-_83018198 0.06 ENST00000557886.1
 RP13-996F3.4
 golgin A6 family-like 19
chr12_-_122751002 0.06 ENST00000267199.4
 VPS33A
 vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr2_-_287320 0.06 ENST00000401503.1
 FAM150B
 family with sequence similarity 150, member B
chr10_-_5046042 0.06 ENST00000421196.3
ENST00000455190.1
 AKR1C2
 aldo-keto reductase family 1, member C2
chrX_-_7895755 0.05 ENST00000444736.1
ENST00000537427.1
ENST00000442940.1
 PNPLA4
 patatin-like phospholipase domain containing 4
chr15_-_32747835 0.05 ENST00000509311.2
ENST00000414865.2
 GOLGA8O
 golgin A8 family, member O
chr12_-_10324716 0.05 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
 OLR1
 oxidized low density lipoprotein (lectin-like) receptor 1
chr9_+_42704004 0.05 ENST00000457288.1
 CBWD7
 COBW domain containing 7
chr15_+_84904525 0.05 ENST00000510439.2
 GOLGA6L4
 golgin A6 family-like 4
chr18_+_11851383 0.05 ENST00000526991.2
 CHMP1B
 charged multivesicular body protein 1B
chr15_-_70994612 0.05 ENST00000558758.1
ENST00000379983.2
ENST00000560441.1
 UACA
 uveal autoantigen with coiled-coil domains and ankyrin repeats
chr6_-_127664683 0.05 ENST00000528402.1
ENST00000454591.2
 ECHDC1
 enoyl CoA hydratase domain containing 1
chr15_-_82939157 0.05 ENST00000559949.1
 RP13-996F3.5
 golgin A6 family-like 18
chr1_+_64014588 0.04 ENST00000371086.2
ENST00000340052.3
 DLEU2L
 deleted in lymphocytic leukemia 2-like
chr19_-_38146289 0.04 ENST00000392144.1
ENST00000591444.1
ENST00000351218.2
ENST00000587809.1
 ZFP30
 ZFP30 zinc finger protein
chr10_+_96305535 0.04 ENST00000419900.1
ENST00000348459.5
ENST00000394045.1
ENST00000394044.1
ENST00000394036.1
 HELLS
 helicase, lymphoid-specific
chr17_-_30186328 0.04 ENST00000302362.6
 COPRS
 coordinator of PRMT5, differentiation stimulator
chr20_+_46130671 0.04 ENST00000371998.3
ENST00000371997.3
 NCOA3
 nuclear receptor coactivator 3
chr12_+_21207503 0.04 ENST00000545916.1
 SLCO1B7
 solute carrier organic anion transporter family, member 1B7 (non-functional)
chr7_-_102985035 0.04 ENST00000426036.2
ENST00000249270.7
ENST00000454277.1
ENST00000412522.1
 DNAJC2
 DnaJ (Hsp40) homolog, subfamily C, member 2
chr15_+_83098710 0.04 ENST00000561062.1
ENST00000358583.3
 GOLGA6L9
 golgin A6 family-like 20
chr20_+_46130619 0.04 ENST00000372004.3
 NCOA3
 nuclear receptor coactivator 3
chrX_+_2670153 0.04 ENST00000509484.2
 XG
 Xg blood group
chr4_+_184826418 0.04 ENST00000308497.4
ENST00000438269.1
 STOX2
 storkhead box 2
chr1_+_2487402 0.04 ENST00000451778.1
 TNFRSF14
 tumor necrosis factor receptor superfamily, member 14
chr9_+_104296122 0.04 ENST00000389120.3
 RNF20
 ring finger protein 20, E3 ubiquitin protein ligase
chr11_-_130786400 0.04 ENST00000265909.4
 SNX19
 sorting nexin 19
chr10_+_90484301 0.03 ENST00000404190.1
 LIPK
 lipase, family member K
chr18_-_29340827 0.03 ENST00000269205.5
 SLC25A52
 solute carrier family 25, member 52
chrX_+_117480036 0.03 ENST00000371822.5
ENST00000254029.3
ENST00000371825.3
 WDR44
 WD repeat domain 44
chr9_+_2157655 0.03 ENST00000452193.1
 SMARCA2
 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr15_+_82722225 0.03 ENST00000300515.8
 GOLGA6L9
 golgin A6 family-like 9
chr14_-_94759361 0.03 ENST00000393096.1
 SERPINA10
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr2_+_177134201 0.03 ENST00000452865.1
 MTX2
 metaxin 2
chrX_-_135962876 0.03 ENST00000431446.3
ENST00000570135.1
ENST00000320676.7
ENST00000562646.1
 RBMX
 RNA binding motif protein, X-linked
chrX_+_2924654 0.03 ENST00000381130.2
 ARSH
 arylsulfatase family, member H
chr6_-_160209471 0.03 ENST00000539948.1
 TCP1
 t-complex 1
chr15_-_74659978 0.03 ENST00000541301.1
ENST00000416978.1
ENST00000268053.6
 CYP11A1
 cytochrome P450, family 11, subfamily A, polypeptide 1
chr19_-_43099070 0.03 ENST00000244336.5
 CEACAM8
 carcinoembryonic antigen-related cell adhesion molecule 8
chr10_-_36813162 0.03 ENST00000440465.1
 NAMPTL
 nicotinamide phosphoribosyltransferase-like
chr2_+_235887329 0.03 ENST00000409212.1
ENST00000344528.4
ENST00000444916.1
 SH3BP4
 SH3-domain binding protein 4
chr1_-_76398077 0.03 ENST00000284142.6
 ASB17
 ankyrin repeat and SOCS box containing 17
chrX_-_77150985 0.03 ENST00000358075.6
 MAGT1
 magnesium transporter 1
chr12_+_18414446 0.02 ENST00000433979.1
 PIK3C2G
 phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
chr5_+_150827143 0.02 ENST00000243389.3
ENST00000517945.1
ENST00000521925.1
 SLC36A1
 solute carrier family 36 (proton/amino acid symporter), member 1
chr14_-_94759408 0.02 ENST00000554723.1
 SERPINA10
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr20_+_46130601 0.02 ENST00000341724.6
 NCOA3
 nuclear receptor coactivator 3
chr2_+_220144052 0.02 ENST00000425450.1
ENST00000392086.4
ENST00000421532.1
 DNAJB2
 DnaJ (Hsp40) homolog, subfamily B, member 2
chrX_-_7895479 0.02 ENST00000381042.4
 PNPLA4
 patatin-like phospholipase domain containing 4
chr6_+_31887761 0.02 ENST00000413154.1
 C2
 complement component 2
chr7_-_102985288 0.01 ENST00000379263.3
 DNAJC2
 DnaJ (Hsp40) homolog, subfamily C, member 2
chr15_+_88120158 0.01 ENST00000560153.1
 LINC00052
 long intergenic non-protein coding RNA 52
chr11_-_130786333 0.01 ENST00000533214.1
ENST00000528555.1
ENST00000530356.1
ENST00000539184.1
 SNX19
 sorting nexin 19
chrX_+_2670066 0.01 ENST00000381174.5
ENST00000419513.2
ENST00000426774.1
 XG
 Xg blood group
chr2_+_172544182 0.01 ENST00000409197.1
ENST00000456808.1
ENST00000409317.1
ENST00000409773.1
ENST00000411953.1
ENST00000409453.1
 DYNC1I2
 dynein, cytoplasmic 1, intermediate chain 2
chr14_+_37641012 0.01 ENST00000556667.1
 SLC25A21-AS1
 SLC25A21 antisense RNA 1
chr8_-_105479270 0.01 ENST00000521573.2
ENST00000351513.2
 DPYS
 dihydropyrimidinase
chr6_-_52926539 0.01 ENST00000350082.5
ENST00000356971.3
 ICK
 intestinal cell (MAK-like) kinase
chr2_-_183387430 0.01 ENST00000410103.1
 PDE1A
 phosphodiesterase 1A, calmodulin-dependent
chr17_-_76220740 0.01 ENST00000600484.1
 AC087645.1
 Uncharacterized protein
chr2_+_39117010 0.00 ENST00000409978.1
 ARHGEF33
 Rho guanine nucleotide exchange factor (GEF) 33
chr15_+_58702742 0.00 ENST00000356113.6
ENST00000414170.3
 LIPC
 lipase, hepatic
chr7_+_80275953 0.00 ENST00000538969.1
ENST00000544133.1
ENST00000433696.2
 CD36
 CD36 molecule (thrombospondin receptor)
chr10_-_101673782 0.00 ENST00000422692.1
 DNMBP
 dynamin binding protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0032641 lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.1 0.2 GO:0051037 regulation of transcription involved in meiotic cell cycle(GO:0051037)
0.0 0.2 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.1 GO:0042427 serotonin biosynthetic process(GO:0042427)
0.0 0.2 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.0 0.2 GO:0008218 bioluminescence(GO:0008218)
0.0 0.1 GO:0035624 receptor transactivation(GO:0035624)
0.0 0.1 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.0 0.1 GO:0072660 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.1 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.0 0.0 GO:1990502 dense core granule maturation(GO:1990502)
0.0 0.1 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.0 0.0 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.0 0.1 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0032299 ribonuclease H2 complex(GO:0032299)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0034736 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.0 0.1 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.0 0.1 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.0 0.1 GO:0030627 pre-mRNA 5'-splice site binding(GO:0030627)
0.0 0.1 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.1 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)