ISMARA results: HMGA1

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HMGA1

Z-value: 1.14

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Transcription factors associated with HMGA1

Gene Symbol	Gene ID	Gene Info
HMGA1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000137309.15	high mobility group AT-hook 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HMGA1	hg19_v2_chr6_+_34204642_34204664	-0.07	9.0e-01	Click!

Activity profile of HMGA1 motif

Sorted Z-values of HMGA1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_-_3469181 Show fit	1.50	ENST00000366116.2	AL365202.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	Uncharacterized protein
chr4_+_74301880 Show fit	1.45	ENST00000395792.2 ENST00000226359.2	AFP Ensembl NCBI GeneCards UniProt NextProt Show fit	alpha-fetoprotein
chr12_+_28605426 Show fit	1.29	ENST00000542801.1	CCDC91 Ensembl NCBI GeneCards UniProt NextProt Show fit	coiled-coil domain containing 91
chr7_-_35013217 Show fit	1.28	ENST00000446375.1	DPY19L1 Ensembl NCBI GeneCards UniProt NextProt Show fit	dpy-19-like 1 (C. elegans)
chr8_-_90993869 Show fit	0.85	ENST00000517772.1	NBN Ensembl NCBI GeneCards UniProt NextProt Show fit	nibrin
chr2_-_188312971 Show fit	0.71	ENST00000410068.1 ENST00000447403.1 ENST00000410102.1	CALCRL Ensembl NCBI GeneCards UniProt NextProt Show fit	calcitonin receptor-like
chr7_+_116654958 Show fit	0.67	ENST00000449366.1	ST7 Ensembl NCBI GeneCards UniProt NextProt Show fit	suppression of tumorigenicity 7
chr12_+_65996599 Show fit	0.62	ENST00000539116.1 ENST00000541391.1	RP11-221N13.3 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-221N13.3
chr6_-_56492816 Show fit	0.62	ENST00000522360.1	DST Ensembl NCBI GeneCards UniProt NextProt Show fit	dystonin
chr2_-_98972468 Show fit	0.61	ENST00000454230.1	AC092675.3 Ensembl NCBI GeneCards UniProt NextProt Show fit	Uncharacterized protein

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HMGA1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.4	GO:0090160	Golgi to lysosome transport(GO:0090160)
0.1	1.3	GO:0018317	protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.1	1.3	GO:0001542	ovulation from ovarian follicle(GO:0001542)
0.1	1.0	GO:1903764	regulation of potassium ion export across plasma membrane(GO:1903764)
0.1	0.9	GO:0031860	telomeric 3' overhang formation(GO:0031860)
0.0	0.9	GO:0006958	complement activation, classical pathway(GO:0006958)
0.0	0.9	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1	0.8	GO:0002084	protein depalmitoylation(GO:0002084)
0.0	0.8	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.1	0.7	GO:0034285	response to sucrose(GO:0009744) response to disaccharide(GO:0034285)

Showing 1 to 10 of 140 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.4	GO:0005637	nuclear inner membrane(GO:0005637)
0.0	1.3	GO:0044295	axonal growth cone(GO:0044295)
0.1	1.0	GO:0043219	lateral loop(GO:0043219)
0.1	0.7	GO:0030870	Mre11 complex(GO:0030870)
0.1	0.6	GO:0031673	H zone(GO:0031673)
0.1	0.6	GO:1990452	Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0	0.6	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0	0.5	GO:0070531	BRCA1-A complex(GO:0070531)
0.1	0.4	GO:0000308	cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0	0.4	GO:0071438	invadopodium membrane(GO:0071438)

Showing 1 to 10 of 51 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.6	GO:0000030	mannosyltransferase activity(GO:0000030)
0.1	1.0	GO:0097016	L27 domain binding(GO:0097016)
0.0	0.9	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.1	0.8	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.8	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.2	0.7	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.7	GO:0001671	ATPase activator activity(GO:0001671)
0.0	0.7	GO:0070888	E-box binding(GO:0070888)
0.0	0.7	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.1	0.6	GO:0050816	phosphothreonine binding(GO:0050816)

Showing 1 to 10 of 90 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
1.9	PID ATM PATHWAY	ATM pathway
1.5	PID AR PATHWAY	Coregulation of Androgen receptor activity
1.4	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
1.1	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
1.0	PID AURORA B PATHWAY	Aurora B signaling
0.9	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.7	PID MYC PATHWAY	C-MYC pathway
0.6	PID CD40 PATHWAY	CD40/CD40L signaling
0.6	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway

Showing 1 to 9 of 9 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
1.3	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
1.0	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
1.0	REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.9	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.8	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.6	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.5	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.3	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.3	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.3	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells

Showing 1 to 10 of 14 entries

Results for HMGA1

Z-value: 1.14

Motif logo

Transcription factors associated with HMGA1

Activity-expression correlation:

Activity profile of HMGA1 motif

Sorted Z-values of HMGA1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HMGA1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: