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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for HLF_TEF
Z-value: 0.69
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Transcription factors associated with HLF_TEF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TEF | hg19_v2_chr22_+_41777927_41777971 | 0.83 | 4.2e-02 | Click! |
| HLF | hg19_v2_chr17_+_53342311_53342400 | -0.37 | 4.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_7844312 Show fit | 0.70 |
ENST00000377541.1
|
period circadian clock 3 |
|
| chr4_+_104346194 Show fit | 0.66 |
ENST00000510200.1
|
RP11-328K4.1 |
|
| chr1_+_154378049 Show fit | 0.52 |
ENST00000512471.1
|
interleukin 6 receptor |
|
| chr1_+_154377669 Show fit | 0.50 |
ENST00000368485.3
ENST00000344086.4 |
interleukin 6 receptor |
|
| chr12_-_46121554 Show fit | 0.48 |
ENST00000609803.1
|
long intergenic non-protein coding RNA 938 |
|
| chr3_-_158390282 Show fit | 0.46 |
ENST00000264265.3
|
latexin |
|
| chr8_-_27469383 Show fit | 0.43 |
ENST00000519742.1
|
clusterin |
|
| chr4_-_153274078 Show fit | 0.36 |
ENST00000263981.5
|
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase |
|
| chr8_-_27468717 Show fit | 0.35 |
ENST00000520796.1
ENST00000520491.1 |
clusterin |
|
| chr8_-_102217515 Show fit | 0.35 |
ENST00000520347.1
ENST00000523922.1 ENST00000520984.1 |
zinc finger protein 706 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HLF_TEF
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.6 | GO:1902998 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.3 | 1.0 | GO:0002384 | hepatic immune response(GO:0002384) |
| 0.1 | 0.9 | GO:1902455 | negative regulation of stem cell population maintenance(GO:1902455) |
| 0.0 | 0.7 | GO:0045187 | regulation of circadian sleep/wake cycle, sleep(GO:0045187) |
| 0.0 | 0.5 | GO:0050961 | detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965) |
| 0.1 | 0.4 | GO:2000638 | regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639) |
| 0.0 | 0.3 | GO:1904694 | negative regulation of vascular smooth muscle contraction(GO:1904694) |
| 0.0 | 0.3 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.0 | 0.3 | GO:0006999 | nuclear pore organization(GO:0006999) |
| 0.1 | 0.2 | GO:0035750 | protein localization to myelin sheath abaxonal region(GO:0035750) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.2 | 1.0 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.1 | 0.4 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.0 | 0.4 | GO:0043219 | lateral loop(GO:0043219) |
| 0.1 | 0.2 | GO:0016935 | glycine-gated chloride channel complex(GO:0016935) |
| 0.0 | 0.2 | GO:0097452 | GAIT complex(GO:0097452) |
| 0.0 | 0.2 | GO:0005827 | polar microtubule(GO:0005827) |
| 0.0 | 0.2 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.0 | 0.2 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.0 | 0.2 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.3 | 1.0 | GO:0070119 | ciliary neurotrophic factor binding(GO:0070119) |
| 0.1 | 0.5 | GO:0052829 | inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) |
| 0.1 | 0.5 | GO:0018479 | benzaldehyde dehydrogenase (NAD+) activity(GO:0018479) |
| 0.0 | 0.5 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 0.5 | GO:0016505 | peptidase activator activity involved in apoptotic process(GO:0016505) |
| 0.0 | 0.4 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.0 | 0.2 | GO:0031208 | POZ domain binding(GO:0031208) |
| 0.0 | 0.2 | GO:0032427 | GBD domain binding(GO:0032427) |
| 0.0 | 0.2 | GO:0008457 | beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | ST STAT3 PATHWAY | STAT3 Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.2 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.0 | 0.1 | REACTOME OPSINS | Genes involved in Opsins |