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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for HIVEP1
Z-value: 1.52
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Transcription factors associated with HIVEP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HIVEP1 | hg19_v2_chr6_+_12012170_12012245 | -0.78 | 6.5e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_153066998 Show fit | 1.99 |
ENST00000368750.3
|
small proline-rich protein 2E |
|
| chr4_-_74864386 Show fit | 1.87 |
ENST00000296027.4
|
chemokine (C-X-C motif) ligand 5 |
|
| chr1_+_37940153 Show fit | 1.59 |
ENST00000373087.6
|
zinc finger CCCH-type containing 12A |
|
| chr5_-_150460914 Show fit | 1.50 |
ENST00000389378.2
|
TNFAIP3 interacting protein 1 |
|
| chr6_+_138188351 Show fit | 1.38 |
ENST00000421450.1
|
tumor necrosis factor, alpha-induced protein 3 |
|
| chr5_+_159895275 Show fit | 1.37 |
ENST00000517927.1
|
microRNA 146a |
|
| chr11_+_18287801 Show fit | 1.27 |
ENST00000532858.1
ENST00000405158.2 |
serum amyloid A1 |
|
| chr11_+_18287721 Show fit | 1.26 |
ENST00000356524.4
|
serum amyloid A1 |
|
| chr14_+_103589789 Show fit | 1.22 |
ENST00000558056.1
ENST00000560869.1 |
tumor necrosis factor, alpha-induced protein 2 |
|
| chr17_+_40440481 Show fit | 1.21 |
ENST00000590726.2
ENST00000452307.2 ENST00000444283.1 ENST00000588868.1 |
signal transducer and activator of transcription 5A |
Network of associatons between targets according to the STRING database.
First level regulatory network of HIVEP1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 3.3 | GO:0034147 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of osteoclast proliferation(GO:0090291) negative regulation of CD40 signaling pathway(GO:2000349) |
| 0.1 | 3.0 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.1 | 2.9 | GO:0048246 | macrophage chemotaxis(GO:0048246) |
| 0.5 | 2.4 | GO:0052250 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.0 | 2.2 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.3 | 1.7 | GO:0000255 | allantoin metabolic process(GO:0000255) |
| 0.5 | 1.6 | GO:2000625 | regulation of miRNA catabolic process(GO:2000625) positive regulation of miRNA catabolic process(GO:2000627) |
| 0.1 | 1.5 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.1 | 1.2 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.2 | 1.0 | GO:0070427 | nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.6 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.2 | 1.6 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.0 | 1.4 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 1.3 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.0 | 1.2 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 1.2 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.1 | 1.1 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.1 | 0.9 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.1 | 0.9 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 0.7 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.3 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.2 | 3.3 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.0 | 2.4 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.2 | 2.0 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.1 | 1.8 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
| 0.0 | 1.3 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 1.3 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 1.3 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 1.1 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 1.1 | GO:0030371 | translation repressor activity(GO:0030371) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.6 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.1 | 2.7 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.5 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 0.7 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 0.7 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.6 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 0.6 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 0.5 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.0 | 0.5 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.5 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.1 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.1 | 3.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 3.3 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.1 | 1.7 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 1.6 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.1 | 0.9 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.0 | 0.8 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.7 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.0 | 0.6 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.0 | 0.6 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter |