ISMARA results: HIF1A

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HIF1A

Z-value: 1.36

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Transcription factors associated with HIF1A

Gene Symbol	Gene ID	Gene Info
HIF1A Ensembl NCBI GeneCards UniProt NextProt	ENSG00000100644.12	hypoxia inducible factor 1 subunit alpha

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HIF1A	hg19_v2_chr14_+_62164340_62164443	0.77	7.6e-02	Click!

Activity profile of HIF1A motif

Sorted Z-values of HIF1A motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_100436065 Show fit	1.27	ENST00000370153.1	SLC35A3 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
chr1_+_100435535 Show fit	1.18	ENST00000427993.2	SLC35A3 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
chr14_+_64970427 Show fit	1.09	ENST00000553583.1	ZBTB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger and BTB domain containing 1
chr16_-_81129845 Show fit	1.02	ENST00000569885.1 ENST00000566566.1	GCSH Ensembl NCBI GeneCards UniProt NextProt Show fit	glycine cleavage system protein H (aminomethyl carrier)
chr6_+_89791507 Show fit	0.99	ENST00000354922.3	PNRC1 Ensembl NCBI GeneCards UniProt NextProt Show fit	proline-rich nuclear receptor coactivator 1
chr14_+_64970662 Show fit	0.92	ENST00000556965.1 ENST00000554015.1	ZBTB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger and BTB domain containing 1
chr8_+_26240414 Show fit	0.81	ENST00000380629.2	BNIP3L Ensembl NCBI GeneCards UniProt NextProt Show fit	BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr8_+_6566206 Show fit	0.73	ENST00000518327.1	AGPAT5 Ensembl NCBI GeneCards UniProt NextProt Show fit	1-acylglycerol-3-phosphate O-acyltransferase 5
chr16_-_81129951 Show fit	0.73	ENST00000315467.3	GCSH Ensembl NCBI GeneCards UniProt NextProt Show fit	glycine cleavage system protein H (aminomethyl carrier)
chr8_-_54755789 Show fit	0.71	ENST00000359530.2	ATP6V1H Ensembl NCBI GeneCards UniProt NextProt Show fit	ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HIF1A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	2.5	GO:1990569	UDP-N-acetylglucosamine transport(GO:0015788) UDP-N-acetylglucosamine transmembrane transport(GO:1990569)
0.5	2.0	GO:2000176	regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176)
0.4	1.8	GO:0006546	glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0	1.3	GO:0007035	vacuolar acidification(GO:0007035)
0.1	1.0	GO:2000286	receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0	1.0	GO:0034975	protein folding in endoplasmic reticulum(GO:0034975)
0.1	0.9	GO:0031087	deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1	0.8	GO:0007079	mitotic chromosome movement towards spindle pole(GO:0007079)
0.0	0.8	GO:1900153	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.1	0.7	GO:0071596	ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)

Showing 1 to 10 of 102 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	1.8	GO:0005960	glycine cleavage complex(GO:0005960)
0.2	1.3	GO:0000221	vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.1	1.1	GO:0098559	cytoplasmic side of early endosome membrane(GO:0098559)
0.0	1.0	GO:0097228	sperm principal piece(GO:0097228)
0.1	0.9	GO:0072546	ER membrane protein complex(GO:0072546)
0.0	0.9	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.1	0.8	GO:0031313	extrinsic component of endosome membrane(GO:0031313)
0.0	0.8	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.1	0.6	GO:0070381	endosome to plasma membrane transport vesicle(GO:0070381)
0.0	0.6	GO:0030867	rough endoplasmic reticulum membrane(GO:0030867)

Showing 1 to 10 of 39 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	2.5	GO:0005462	UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462)
0.0	2.0	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.4	1.8	GO:0004047	aminomethyltransferase activity(GO:0004047)
0.0	1.3	GO:0046961	proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0	1.0	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.1	0.8	GO:0043515	kinetochore binding(GO:0043515)
0.2	0.7	GO:0015439	heme-transporting ATPase activity(GO:0015439)
0.2	0.7	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.7	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0	0.7	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)

Showing 1 to 10 of 72 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
2.7	PID PLK1 PATHWAY	PLK1 signaling events
1.0	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.6	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.5	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.4	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.4	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.3	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.2	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.2	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway

Showing 1 to 9 of 9 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.3	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0	1.3	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.0	1.3	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.1	1.1	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	1.0	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.0	0.9	REACTOME KINESINS	Genes involved in Kinesins
0.0	0.7	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.0	0.6	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.0	0.6	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	0.6	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription

Showing 1 to 10 of 21 entries

Results for HIF1A

Z-value: 1.36

Motif logo

Transcription factors associated with HIF1A

Activity-expression correlation:

Activity profile of HIF1A motif

Sorted Z-values of HIF1A motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HIF1A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: