ISMARA results: HIC2

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HIC2

Z-value: 2.83

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Transcription factors associated with HIC2

Gene Symbol	Gene ID	Gene Info
HIC2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000169635.5	HIC ZBTB transcriptional repressor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HIC2	hg19_v2_chr22_+_21771656_21771693	0.24	6.5e-01	Click!

Activity profile of HIC2 motif

Sorted Z-values of HIC2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_+_131409476 Show fit	3.68	ENST00000296871.2	CSF2 Ensembl NCBI GeneCards UniProt NextProt Show fit	colony stimulating factor 2 (granulocyte-macrophage)
chr1_-_47655686 Show fit	2.55	ENST00000294338.2	PDZK1IP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	PDZK1 interacting protein 1
chr17_+_37821593 Show fit	2.31	ENST00000578283.1	TCAP Ensembl NCBI GeneCards UniProt NextProt Show fit	titin-cap
chr15_+_31658349 Show fit	1.85	ENST00000558844.1	KLF13 Ensembl NCBI GeneCards UniProt NextProt Show fit	Kruppel-like factor 13
chr1_-_153363452 Show fit	1.53	ENST00000368732.1 ENST00000368733.3	S100A8 Ensembl NCBI GeneCards UniProt NextProt Show fit	S100 calcium binding protein A8
chr19_-_45579762 Show fit	1.50	ENST00000303809.2	ZNF296 Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger protein 296
chr22_-_37415475 Show fit	1.42	ENST00000403892.3 ENST00000249042.3 ENST00000438203.1	TST Ensembl NCBI GeneCards UniProt NextProt Show fit	thiosulfate sulfurtransferase (rhodanese)
chr12_-_7245125 Show fit	1.33	ENST00000542285.1 ENST00000540610.1	C1R Ensembl NCBI GeneCards UniProt NextProt Show fit	complement component 1, r subcomponent
chr17_-_42994283 Show fit	1.29	ENST00000593179.1	GFAP Ensembl NCBI GeneCards UniProt NextProt Show fit	glial fibrillary acidic protein
chr16_-_18441131 Show fit	1.25	ENST00000339303.5	NPIPA8 Ensembl NCBI GeneCards UniProt NextProt Show fit	nuclear pore complex interacting protein family, member A8

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HIC2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.9	GO:0006958	complement activation, classical pathway(GO:0006958)
1.2	3.7	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.7	3.4	GO:0009440	cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440)
0.0	2.8	GO:0006501	C-terminal protein lipidation(GO:0006501)
0.1	2.5	GO:0002544	chronic inflammatory response(GO:0002544)
0.0	2.4	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.8	2.3	GO:0030241	skeletal muscle myosin thick filament assembly(GO:0030241)
0.1	2.3	GO:1904714	regulation of chaperone-mediated autophagy(GO:1904714)
0.1	2.1	GO:1902857	positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.1	2.0	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)

Showing 1 to 10 of 520 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.1	GO:0072562	blood microparticle(GO:0072562)
0.0	2.6	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.0	2.5	GO:0031225	anchored component of membrane(GO:0031225)
0.0	2.2	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
0.0	2.0	GO:0045271	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0	1.8	GO:1904724	tertiary granule lumen(GO:1904724)
0.0	1.8	GO:0034707	chloride channel complex(GO:0034707)
0.1	1.7	GO:0061689	tricellular tight junction(GO:0061689)
0.1	1.6	GO:0071438	invadopodium membrane(GO:0071438)
0.0	1.4	GO:0005666	DNA-directed RNA polymerase III complex(GO:0005666)

Showing 1 to 10 of 169 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	9.7	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	6.6	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0	3.6	GO:0017124	SH3 domain binding(GO:0017124)
0.0	3.5	GO:0033613	activating transcription factor binding(GO:0033613)
0.6	3.4	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.0	3.0	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0	2.9	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.0	2.8	GO:0005125	cytokine activity(GO:0005125)
0.1	2.5	GO:0015245	fatty acid transporter activity(GO:0015245)
0.5	2.4	GO:0051373	FATZ binding(GO:0051373)

Showing 1 to 10 of 351 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.9	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.1	3.4	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	2.6	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	2.0	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	1.9	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	1.9	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	1.6	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	1.5	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	1.5	PID P73PATHWAY	p73 transcription factor network
0.0	1.4	PID RHOA REG PATHWAY	Regulation of RhoA activity

Showing 1 to 10 of 49 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.4	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.0	4.2	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	3.7	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	3.3	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4
0.0	2.3	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	2.1	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	2.1	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	2.0	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	1.9	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	1.9	REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	Genes involved in Cyclin E associated events during G1/S transition

Showing 1 to 10 of 97 entries

Results for HIC2

Z-value: 2.83

Motif logo

Transcription factors associated with HIC2

Activity-expression correlation:

Activity profile of HIC2 motif

Sorted Z-values of HIC2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HIC2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: