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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for HES7_HES5
Z-value: 0.73
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Transcription factors associated with HES7_HES5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HES5 | hg19_v2_chr1_-_2461684_2461710 | 0.48 | 3.3e-01 | Click! |
| HES7 | hg19_v2_chr17_-_8027402_8027432 | -0.47 | 3.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HES7_HES5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 0.1 | 0.4 | GO:0035281 | pre-miRNA export from nucleus(GO:0035281) |
| 0.1 | 0.4 | GO:0086021 | SA node cell to atrial cardiac muscle cell communication by electrical coupling(GO:0086021) |
| 0.0 | 0.4 | GO:0033623 | regulation of integrin activation(GO:0033623) |
| 0.1 | 0.3 | GO:0048203 | vesicle targeting, trans-Golgi to endosome(GO:0048203) |
| 0.1 | 0.3 | GO:0019464 | glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464) |
| 0.0 | 0.3 | GO:1903943 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 0.0 | 0.3 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.0 | 0.3 | GO:0002031 | G-protein coupled receptor internalization(GO:0002031) |
| 0.1 | 0.2 | GO:0001543 | ovarian follicle rupture(GO:0001543) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0042565 | nuclear RNA export factor complex(GO:0042272) RNA nuclear export complex(GO:0042565) |
| 0.0 | 0.4 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342) |
| 0.0 | 0.4 | GO:0005922 | connexon complex(GO:0005922) |
| 0.1 | 0.3 | GO:0005960 | glycine cleavage complex(GO:0005960) |
| 0.0 | 0.3 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
| 0.0 | 0.1 | GO:0009346 | citrate lyase complex(GO:0009346) |
| 0.0 | 0.1 | GO:0043614 | multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993) |
| 0.0 | 0.1 | GO:0009368 | endopeptidase Clp complex(GO:0009368) |
| 0.0 | 0.1 | GO:0000221 | vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) |
| 0.0 | 0.1 | GO:0034688 | integrin alphaM-beta2 complex(GO:0034688) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.5 | GO:0030144 | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144) |
| 0.1 | 0.5 | GO:0016262 | protein N-acetylglucosaminyltransferase activity(GO:0016262) |
| 0.0 | 0.5 | GO:0031005 | filamin binding(GO:0031005) |
| 0.1 | 0.4 | GO:0090631 | pre-miRNA transporter activity(GO:0090631) |
| 0.1 | 0.4 | GO:0086020 | gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020) |
| 0.1 | 0.3 | GO:0004047 | aminomethyltransferase activity(GO:0004047) |
| 0.1 | 0.3 | GO:0035650 | AP-1 adaptor complex binding(GO:0035650) |
| 0.1 | 0.3 | GO:0004703 | G-protein coupled receptor kinase activity(GO:0004703) |
| 0.0 | 0.1 | GO:0000224 | peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity(GO:0000224) |
| 0.0 | 0.1 | GO:0004827 | glutamate-tRNA ligase activity(GO:0004818) proline-tRNA ligase activity(GO:0004827) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 0.4 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.0 | 0.4 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |